Reproducibility of telomere length assessment: An international collaborative study

International Journal of Epidemiology

Volumn 44, Issue 5, 2015, Pages 1673-1683

  Martin Ruiz, Carmen M ^a   Baird, Duncan ^b   Roger, Laureline ^b   Boukamp, Petra ^c   Krunic, Damir ^c   Cawthon, Richard ^d   Dokter, Martin M ^e   Van der Harst, Pim ^e   Bekaert, Sofie ^f   De Meyer, Tim ^g   Roos, Goran ^h   Svenson, Ulrika ^h   Codd, Veryan ⁱ   Samani, Nilesh J ⁱ   McGlynn, Liane ^j   Shiels, Paul G ^j   Pooley, Karen A ^k   Dunning, Alison M ^k   Cooper, Rachel ^l   Wong, Andrew ^l   Kingston, Andrew ^a   von Zglinicki, Thomas ^a   more..

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^d UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^f GHENT UNIVERSITY HOSPITAL   (Belgium)

^g GHENT UNIVERSITY   (Belgium)

^h UMEÅ UNIVERSITY   (Sweden)

ⁱ UNIVERSITY OF LEICESTER   (United Kingdom)

^j UNIVERSITY OF GLASGOW   (United Kingdom)

^k UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^l UNIVERSITY COLLEGE LONDON   (United Kingdom)

more..

Author keywords

Ageing; Biomarker; Human; Telomeres; Variation

Indexed keywords

DNA; BIOLOGICAL MARKER;

AGING; BIOMARKER; CHROMOSOME; DNA; MORBIDITY; MORTALITY; POPULATION DYNAMICS; REPRODUCTIVE PRODUCTIVITY;

ARTICLE; CORRELATION COEFFICIENT; HUMAN; LABORATORY; NUCLEIC ACID ANALYSIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REPRODUCIBILITY; SINGLE TELOMERE LENGTH ANALYSIS; SOUTHERN BLOTTING; TELOMERE; TELOMERE HOMEOSTASIS; AGING; GENETICS; INTERNATIONAL COOPERATION;

AGING; BIOMARKERS; BLOTTING, SOUTHERN; DNA; HUMANS; INTERNATIONAL COOPERATION; REAL-TIME POLYMERASE CHAIN REACTION; REPRODUCIBILITY OF RESULTS; TELOMERE;

EID: 84930230940     PISSN: 03005771     EISSN: 14643685     Source Type: Journal    
DOI: 10.1093/ije/dyu191     Document Type: Article

References (30)

1. von Zglinicki T, Serra V, Lorenz M et al. Short telomeres in patients with vascular dementia: an indicator of low antioxidative capacity and a possible risk factor? Lab Invest 2000;80:1739-47.
2. Cawthon RM, Smith KR, O'Brien E, Sivatchenko A, Kerber RA. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 2003;361:393-95.
3. Fitzpatrick AL, Kronmal RA, Gardner JP et al. Leukocyte telomere length and cardiovascular disease in the cardiovascular health study. Am J Epidemiol 2007;165:14-21.
4. Kimura M, Hjelmborg JV, Gardner JP et al. Telomere length and mortality: a study of leukocytes in elderly Danish twins. Am J Epidemiol 2008;167:799-806.
5. Epel ES, Merkin SS, Cawthon R et al. The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men. Aging (Albany NY) 2009;1:81-88.
6. Ehrlenbach S, Willeit P, Kiechl S et al. Raising the bar on telomere epidemiology. Int J Epidemiol 2010;39:308-17.
7. Watfa G, Dragonas C, Brosche T et al. Study of telomere length and different markers of oxidative stress in patients with Parkinson's disease. J Nutr Health Aging 2011;15:277-81.
8. Honig LS, Kang MS, Schupf N, Lee JH, Mayeux R. Association of shorter leukocyte telomere repeat length with dementia and mortality. Arch Neurol 2012;69:1332-39.
9. Lee J, Sandford AJ, Connett JE et al. The relationship between telomere length and mortality in chronic obstructive pulmonary disease (COPD). PLoS One 2012;7:e35567.
10. Weischer M, Bojesen SE, Cawthon RM, Freiberg JJ, Tybjaerg-Hansen A, Nordestgaard BG. Short telomere length, myocardial infarction, ischemic heart disease, and early death. Arterioscler Thromb Vasc Biol 2012;32:822-29.
11. Hoffmann J, Spyridopoulos I. Telomere length in cardiovascular disease: new challenges in measuring this marker of cardiovascular aging. Future Cardiol 2011;7:789-803.
12. Mather KA, Jorm AF, Parslow RA, Christensen H. Is telomere length a biomarker of aging? A review. J Gerontol A Biol Sci Med Sci 2011;66A:202-13.
13. von Zglinicki T. Will your telomeres tell your future? BMJ 2012; 344:e1727.
14. Aviv A, Hunt SC, Lin J, Cao X, Kimura M, Blackburn E. Impartial comparative analysis of measurement of leukocyte telomere length/DNA content by Southern blots and qPCR. Nucleic Acids Res 2011;39:e134.
15. Elbers CC, Garcia ME, Kimura M et al. Comparison between Southern blots and qPCR analysis of leukocyte telomere length in the Health ABC Study. J Gerontol A Biol Sci Med Sci 2014; 69:527-31.
16. Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature 1990;345:458-60.
17. Okuda K, Bardeguez A, Gardner JP et al. Telomere length in the newborn. Pediatr Res 2002;52:377-81.
18. Baird DM, Rowson J, Wynford-Thomas D, Kipling D. Extensive allelic variation and ultrashort telomeres in senescent human cells. Nat Genet 2003;33:203-07.
19. Rufer N, Dragowska W, Thornbury G, Roosnek E, Lansdorp PM. Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry. Nat Biotechnol 1998;16: 743-47.
20. Baerlocher GM, Mak J, Tien T, Lansdorp PM. Telomere length measurement by fluorescence in situ hybridization and flow cytometry: tips and pitfalls. Cytometry 2002;47: 89-99.
21. O'Sullivan JN, Finley JC, Risques RA, Shen WT, Gollahon KA, Rabinovitch PS. Quantitative fluorescence in situ hybridization (QFISH) of telomere lengths in tissue and cells. Curr Protoc Cytom 2005;Chapter 12:Unit 12 6.
22. Cawthon RM. Telomere measurement by quantitative PCR. Nucleic Acids Res 2002;30:e47.
23. Cawthon RM. Telomere length measurement by a novel monochrome multiplex quantitative PCR method. Nucleic Acids Res 2009;37:e21.
24. Cunningham JM, Johnson RA, Litzelman K et al. Telomere length varies by DNA extraction method: implications for epidemiologic research. Cancer Epidemiol Biomarkers Prev 2013;22: 2047-54.
25. Kimura M, Stone RC, Hunt SC et al. Measurement of telomere length by the Southern blot analysis of terminal restriction fragment lengths. Nat Protoc 2010;5:1596-607.
26. Sanders JL, Newman AB. Telomere length in epidemiology: a biomarker of aging, age-related disease, both, or neither? Epidemiol Rev 2013;35:112-31.
27. Aviv A. The epidemiology of human telomeres: faults and promises. J Gerontol A Biol Sci Med Sci 2008;63:979-83.
28. Shiels PG. Improving precision in investigating aging: why telomeres can cause problems. J Gerontol A Biol Sci Med Sci 2010;65A:789-91.
29. Lorenz M, Saretzki G, Sitte N, Metzkow S, von Zglinicki T. BJ fibroblasts display high antioxidant capacity and slow telomere shortening independent of hTERT transfection. Free Radic Biol Med 2001;31:824-31.
30. Bodnar AG, Ouellette M, Frolkis M et al. Extension of life-span by introduction of telomerase into normal human cells. Science 1998;279:349-52.