A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme

Journal of Structural Biology

Volumn 196, Issue 3, 2016, Pages 437-447

  Dharadhar, Shreya ^a   Clerici, Marcello ^a,b   van Dijk, Willem J ^a   Fish, Alexander ^a   Sixma, Titia K ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Allosteric regulation; Deubiquitinating enzyme; Enzyme catalysis; Protein structure; Small angle X ray scattering (SAXS); Surface Plasmon Resonance (SPR)

Indexed keywords

CARRIER PROTEINS AND BINDING PROTEINS; DEUBIQUITINASE; UBIQUITIN SPECIFIC PROTEASE 12; UNCLASSIFIED DRUG; USP1 ASSOCIATED FACTOR; NUCLEAR PROTEIN; PROTEIN BINDING; UBIQUITIN; UBIQUITIN THIOLESTERASE; USP1 ASSOCIATED FACTOR 1, HUMAN; USP12 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; INSECT CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; CATALYSIS; CHEMISTRY; HUMAN; SMALL ANGLE SCATTERING; SURFACE PLASMON RESONANCE; ULTRASTRUCTURE; X RAY; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; DEUBIQUITINATING ENZYMES; HUMANS; NUCLEAR PROTEINS; PROTEIN BINDING; SCATTERING, SMALL ANGLE; SURFACE PLASMON RESONANCE; UBIQUITIN; UBIQUITIN THIOLESTERASE; X-RAYS;

EID: 84994481846     PISSN: 10478477     EISSN: 10958657     Source Type: Journal    
DOI: 10.1016/j.jsb.2016.09.011     Document Type: Article

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