Endothelial nitric oxide synthase gene polymorphisms are associated with cardiovascular risks in prehypertensives

Journal of the American Society of Hypertension

Volumn 10, Issue 11, 2016, Pages 865-872

  Pal, Gopal Krushna ^a   Adithan, Chandrasekaran ^a   Umamaheswaran, Gurusamy ^a   Pal, Pravati ^a   Nanda, Nivedita ^a   Indumathy, Jagadeeswaran ^a   Syamsunder, Avupati Naga ^a  

^a JAWAHARLAL INSTITUTE OF POSTGRADUATE MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

Autonomic imbalance; baroreflex sensitivity; heart rate variability; prehypertension

Indexed keywords

C REACTIVE PROTEIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; LIPID; RENIN; TUMOR NECROSIS FACTOR; BIOLOGICAL MARKER; NOS3 PROTEIN, HUMAN;

ADULT; ARTICLE; BLOOD PRESSURE VARIABILITY; CARDIOVASCULAR PARAMETERS; CARDIOVASCULAR RISK; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; HEART OUTPUT; HEART RATE VARIABILITY; HEART STROKE VOLUME; HOMEOSTATIC MODEL FOR ASSESSMENT OF INSULIN RESISTANCE; HUMAN; INFLAMMATION; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; METABOLISM; MOLECULAR PATHOLOGY; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; PREDICTION; PREHYPERTENSION; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SYMPATHOVAGAL IMBALANCE; VASCULAR RESISTANCE; YOUNG ADULT; ADOLESCENT; ADRENERGIC SYSTEM; BLOOD; BLOOD PRESSURE; BODY MASS; CARDIOVASCULAR DISEASE; GENETIC PREDISPOSITION; GENETICS; HEART RATE; INDIA; PATHOPHYSIOLOGY; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ADULT; BAROREFLEX; BIOMARKERS; BLOOD PRESSURE; BODY MASS INDEX; CARDIOVASCULAR DISEASES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HEART RATE; HUMANS; INDIA; INSULIN RESISTANCE; MALE; NITRIC OXIDE SYNTHASE TYPE III; POLYMORPHISM, SINGLE NUCLEOTIDE; PREHYPERTENSION; RENIN; RISK FACTORS; SYMPATHETIC NERVOUS SYSTEM; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 84994418119     PISSN: 19331711     EISSN: 18787436     Source Type: Journal    
DOI: 10.1016/j.jash.2016.09.001     Document Type: Article

References (37)

1. 1 Lewington, S., Clarke, R., Qizilbash, N., Peto, R., Collins, R., Prospective Studies collaboration. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet 360 (2002), 1903–1913.
2. 2 Nery, A.B., Mesquita, E.T., Lugon, J.R., Kang, H.C., de Miranda, V.A., de Souza, B.G., et al. Prehypertension and cardiovascular risk factors in adults enrolled in a primary care programme. Eur J Cardiovasc Prev Rehabil 18 (2011), 233–239.
3. 3 Pal, G.K., Pal, P., Nanda, N., Amudharaj, D., Adithan, C., Cardiovascular dysfunctions and sympathovagal imbalance in hypertension and prehypertension: physiological perspectives. Future Cardiol 9 (2013), 53–69.
4. 4 Pal, G.K., Pal, P., Nanda, N., Lalitha, V., Dutta, T.K., Adithan, C., Sympathovagal imbalance in young prehypertensives: importance of male-female difference. Am J Med Sci 345 (2013), 10–17.
5. 5 Pal, G.K., Adithan, C., Ananthanarayanan, P.H., Dutta, T.K., Pal, P., Nanda, N., et al. Body mass index contributes to sympathovagal imbalance in prehypertensives. BMC Cardiovasc Disord, 12, 2012, 54.
6. 6 Pal, G.K., Adithan, C., Ananthanarayanan, P.H., Pal, P., Nanda, N., Thiyagarajan, D., et al. Association of sympathovagal imbalance with cardiovascular risks in young prehypertensives. Am J Cardiol 112 (2013), 1757–1762.
7. 7 Thiyagarajan, R., Pal, P., Pal, G.K., Subramanian, S.K., Bobby, Z., Das, A.K., et al. Cardiovagal modulation, oxidative stress, and cardiovascular risk factors in prehypertensive subjects: cross-sectional study. Am J Hypertens 26 (2013), 850–857.
8. 8 Garcia, E.A., Newhouse, S., Caulfield, M.J., Munroe, P.B., Genes and hypertension. Curr Pharm Des 9 (2003), 1679–1689.
9. 9 Seo, D., Ginsburg, G.S., Goldschmidt-Clermont, P.J., Gene expression analysis of cardiovascular diseases: novel insights into biology and clinical applications. J Am Coll Cardiol 48 (2006), 227–235.
10. 10 Fung, M.M., Rao, F., Poddar, S., Mahata, M., Khandrika, S., Mahata, S.K., et al. Early inflammatory and metabolic changes in association with AGTR1 polymorphisms in prehypertensive subjects. Am J Hypertens 24 (2011), 225–233.
11. 11 Hall, J.E., Granger, J.P., do Carmo, J.M., da Silva, A.A., Dubinion, J., George, E., et al. Hypertension: physiology and pathophysiology. Compr Physiol 2 (2012), 2393–2442.
12. 12 Cooke, J.P., Dzau, V.J., Nitric oxide synthase: role in the genesis of vascular disease. Annu Rev Med 48 (1997), 489–509.
13. 13 Sander, M., Chavoshan, B., Victor, R.G., A large blood pressure rising effect of nitric oxide synthase inhibition in humans. Hypertension 33 (1999), 937–942.
14. 14 Gilani, M., Kaiser, D.R., Bratteli, C.W., Alinder, C., Rajala, S., Bank, A.J., et al. Role of nitric oxide deficiency and its detection as a risk factor in pre-hypertension. J Am Soc Hypertens 1 (2007), 45–55.
15. 15 Niu, W., Qi, Y., An updated meta-analysis of endothelial nitric oxide synthase gene: three well-characterized polymorphisms with hypertension. PLoS One, 6, 2011, e24266.
16. 16 Shesely, E.G., Maeda, N., Kim, H.S., Desai, K.M., Krege, J.H., Laubach, V.E., et al. Elevated blood pressure in mice lacking endothelial nitric oxide synthase. Proc Natl Acad Sci U S A 93 (1996), 13176–13181.
17. 17 Bruno, R.M., Ghiadoni, L., Seravalle, G., Dell'oro, R., Taddei, S., Grassi, G., Sympathetic regulation of vascular function in health and disease. Front Physiol, 3, 2012, 284.
18. 18 Zanzinger, J., Role of nitric oxide in the neural control of cardiovascular function. Cardiovasc Res 43 (1999), 639–649.
19. 19 Binkley, P.F., Nunziatta, E., Liu-Stratton, Y., Cooke, G., A polymorphism of the endothelial nitric oxide synthase promoter is associated with an increase in autonomic imbalance in patients with congestive heart failure. Am Heart J 149 (2005), 342–348.
20. 20 Rossi, G.P., Maiolino, G., Zanchetta, M., Sticchi, D., Pedon, L., Cesari, M., et al. The T(-786)C endothelial nitric oxide synthase genotype predicts cardiovascular mortality in high-risk patients. J Am Coll Cardiol 48 (2006), 1166–1174.
21. 21 Classification of blood pressure. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure, 2004, National Heart, Lung and Blood Institute; National High Blood Pressure Education Program; NIH Publication, USA, 12.
22. 22 Jensen-Urstad, K., Saltin, B., Ericson, M., Storck, N., Jensen-Urstad, M., Pronounced resting bradycardia in male elite runners is associated with high heart rate variability. Scand J Med Sci Sports 7 (1997), 274–278.
23. 23 Imholz, B.P.M., Wieling, W., van Montfrans, G.A., Wesseling, K.H., Fifteen years experience with finger arterial pressure monitoring: assessment of the technology. Cardiovasc Res 38 (1998), 605–616.
24. 24 Task force of the European Society of Cardiology and the North American society of pacing and electrophysiology: heart rate variability. Standard and measurement, physiological interpretation and clinical use. Circulation 93 (1996), 1043–1065.
25. 25 Periaswamy, R., Gurusamy, U., Shewade, D.G., Cherian, A., Swaminathan, R.P., Dutta, T.K., et al. Genders specific association of endothelial nitric oxide synthase gene (Glu298Asp) polymorphism with essential hypertension in a south Indian population. Clin Chim Acta 395 (2008), 134–136.
26. 26 Lewis, C.M., Knight, J., Introduction To genetic association studies. Cold Spring Harb Protoc 2012 (2012), 297–306.
27. 27 Milliani, A., Heart rate variability: from bench to bedside. Eur J Intern Med 16 (2005), 12–20.
28. 28 Jensen, M.T., Suadicani, P., Hein, H.O., Gyntelberg, F., Elevated resting heart rate, physical fitness and all-cause mortality: a 16-year follow-up in the Copenhagen Male Study. Heart 99 (2013), 882–887.
29. 29 White, W.B., Heart rate and the rate-pressure product as determinants of cardiovascular risk in patients with hypertension. Am J Hypertens 12 (1999), 50S–55S.
30. 30 Rovere, M.T.L., Maestri, R., Pinna, G.D., Baroreflex sensitivity assessment: latest advances and strategies. Eur Cardiol 7 (2011), 89–92.
31. 31 Lieb, D.C., Parson, H.K., Mamikunian, G., Vinik, A.I., Cardiac autonomic imbalance in newly diagnosed and established diabetes is associated with markers of adipose tissue inflammation. Exp Diabetes Res, 2012, 2012, 878760.
32. 32 Leon-Cabrera, S., Solís-Lozano, L., Suárez-Álvarez, K., González-Chávez, A., Béjar, Y.L., Robles-Díaz, G., et al. Hyperleptinemia is associated with parameters of low-grade systemic inflammation and metabolic dysfunction in obese human beings. Front Integr Neurosci 7 (2013), 62–68.
33. 33 Marsden, P.A., Heng, H.H., Scherer, S.W., Stewart, R.J., Hall, A.V., Shi, X.M., et al. Structure and chromosomal localization of the endothelial nitric oxide synthase gene. J Biol Chem 268 (1993), 17478–17488.
34. 34 Miyamoto, Y., Satio, Y., Kajiyama, N., Yoshimura, M., Shimasaki, Y., Nakayama, M., et al. Endothelial nitric oxide synthase gene is positively associated with essential hypertension. Hypertension 32 (1998), 3–8.
35. 35 Hingorani, A.D., Liang, C.F., Fatibene, J., Monteith, S., Parsons, A., Haydock, S., et al. A common variant of the endothelial nitric oxide synthase (Glu298Asp) is a major risk factor for coronary artery disease in the UK. Circulation 100 (1999), 1515–1520.
36. 36 Honzíková, N., Fiser, B., Baroreflex sensitivity and essential hypertension in adolescents. Physiol Res 58 (2009), 605–612.
37. 37 Shankarishan, P., Borah, P.K., Ahmed, G., Mahanta, J., Prevalence of endothelial nitric oxide synthase (eNOS) gene exon 7 Glu298Asp variant in North Eastern India. Indian J Med Res 133 (2011), 487–491.