The T-786C Endothelial Nitric Oxide Synthase Genotype Predicts Cardiovascular Mortality in High-Risk Patients

Journal of the American College of Cardiology

Volumn 48, Issue 6, 2006, Pages 1166-1174

  Rossi, Gian Paolo ^a   Maiolino, Giuseppe ^a   Zanchetta, Mario ^a   Sticchi, Daniele ^a   Pedon, Luigi ^a   Cesari, Maurizio ^a   Montemurro, Domenico ^a   De Toni, Renzo ^a   Zavattiero, Silvia ^a   Pessina, Achille C ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; CYTOSINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; MYELOPEROXIDASE; NITRATE; NITRITE; THYMINE;

ADULT; AGED; AMPLICON; ANGIOCARDIOGRAPHY; ARTICLE; CARDIOVASCULAR DISEASE; CAUCASIAN; COHORT ANALYSIS; CORONARY ARTERY DISEASE; ENZYME BLOOD LEVEL; EVENT FREE SURVIVAL; EXON; FEMALE; FLUORESCENCE RESONANCE ENERGY TRANSFER; FOLLOW UP; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HIGH RISK PATIENT; HUMAN; HYPERTENSION; KAPLAN MEIER METHOD; MAJOR CLINICAL STUDY; MALE; MELTING POINT; MORTALITY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROGNOSIS; PROMOTER REGION; PROPORTIONAL HAZARDS MODEL; SINGLE NUCLEOTIDE POLYMORPHISM; SURVIVAL; VASCULAR ENDOTHELIUM; VASODILATATION;

AGED; BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; CHEST PAIN; COHORT STUDIES; CORONARY DISEASE; CYTOSINE; FEMALE; FOLLOW-UP STUDIES; GENOTYPE; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; NITRIC OXIDE SYNTHASE TYPE III; POLYMORPHISM, SINGLE NUCLEOTIDE; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; RISK FACTORS; THYMINE;

EID: 33748424868     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2006.05.046     Document Type: Article

References (55)

1. American Heart Association. Heart Disease and Stroke Statistics-2004 Update. Available at: http://www.americanheart.org/downloadable/heart/1079736729696HDSStats2004UpdateREV3-19-04.pdf. Accessed January 9, 2006.
2. Wang Q., Rao S., Shen G.Q., et al. Premature myocardial infarction novel susceptibility locus on chromosome 1P34-36 identified by genomewide linkage analysis. Am J Hum Genet 74 (2004) 262-271
3. Wang L., Fan C., Topol S.E., Topol E.J., and Wang Q. Mutation of MEF2A in an inherited disorder with features of coronary artery disease. Science 302 (2003) 1578-1581
4. Helgadottir A., Manolescu A., Thorleifsson G., et al. The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nat Genet 36 (2004) 233-239
5. Winkelmann B.R., Hager J., Kraus W.E., et al. Genetics of coronary heart disease: current knowledge and research principles. Am Heart J 140 (2000) S11-S26
6. Al Suwaidi J., Hamasaki S., Higano S.T., et al. Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction. Circulation 101 (2000) 948-954
7. Targonski P.V., Bonetti P.O., Pumper G.M., et al. Coronary endothelial dysfunction is associated with an increased risk of cerebrovascular events. Circulation 107 (2003) 2805-2809
8. Schachinger V., Britten M.B., and Zeiher A.M. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 101 (2000) 1899-1906
9. Halcox J.P., Schenke W.H., Zalos G., et al. Prognostic value of coronary vascular endothelial dysfunction. Circulation 106 (2002) 653-658
10. Hingorani A.D. Polymorphisms in endothelial nitric oxide synthase and atherogenesis: John French Lecture 2000. Atherosclerosis 154 (2001) 521-527
11. Tesauro M., Thompson W.C., Rogliani P., et al. Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: cleavage of proteins with aspartate vs. glutamate at position 298. Proc Natl Acad Sci USA 97 (2000) 2832-2835
12. Fairchild T.A., Fulton D., Fontana J.T., et al. Acidic hydrolysis as a mechanism for the cleavage of the Glu(298)→Asp variant of human endothelial nitric-oxide synthase. J Biol Chem 276 (2001) 26674-26679
13. Rossi G.P., Taddei S., Virdis A., et al. The T-786C and Glu298Asp polymorphisms of the endothelial nitric oxide gene affect the forearm blood flow responses of Caucasian hypertensive patients. J Am Coll Cardiol 41 (2003) 938-945
14. Rossi G.P., Cesari M., Zanchetta M., et al. The T-786C endothelial nitric oxide synthase genotype is a novel risk factor for coronary artery disease in Caucasian patients of the GENICA study. J Am Coll Cardiol 41 (2003) 930-937
15. Cattaruzza M., Guzik T.J., Slodowski W., et al. Shear stress insensitivity of endothelial nitric oxide synthase expression as a genetic risk factor for coronary heart disease. Circ Res 95 (2004) 841-847
16. Hirashiki A., Yamada Y., Murase Y., et al. Association of gene polymorphisms with coronary artery disease in low- or high-risk subjects defined by conventional risk factors. J Am Coll Cardiol 42 (2003) 1429-1437
17. Celermajer D.S., Sorensen K.E., Spiegelhalter D.J., et al. Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women. J Am Coll Cardiol 24 (1994) 471-476
18. Luscher T.F., Tanner F.C., Tschudi M.R., and Noll G. Endothelial dysfunction in coronary artery disease. Ann Rev Med 44 (1993) 395-418
19. Casas J.P., Bautista L.E., Humphries S.E., and Hingorani A.D. Endothelial nitric oxide synthase genotype and ischemic heart disease: meta-analysis of 26 studies involving 23028 subjects. Circulation 109 (2004) 1359-1365
20. Rossi G.P., Cesari M., De Toni R., et al. Antibodies to oxidized low-density lipoproteins and angiographically assessed coronary artery disease in white patients. Circulation 108 (2003) 2467-2472
21. Cesari M., Maiolino G., Colonna S., et al. Under treatment with lipid-lowering drugs of high-risk coronary heart disease patients of the GENICA study. J Cardiovasc Pharmacol 42 (2003) 484-490
22. 2003 European Society of Hypertension-European Society of Cardiology guidelines for the management of arterial hypertension. J Hypertens 21 (2003) 1011-1053
23. Cesari M., Zanchetta M., Burlina A., et al. Hyperhomocysteinemia is inversely related with left ventricular ejection fraction and predicts cardiovascular mortality in high-risk coronary artery disease hypertensives. Arterioscler Thromb Vasc Biol 25 (2005) 115-121
24. Smith L.R., Harrell Jr. F.E., Rankin J.S., et al. Determinants of early versus late cardiac death in patients undergoing coronary artery bypass graft surgery. Circulation 84 (1991) III245-III253
25. Mark D.B., Nelson C.L., Califf R.M., et al. Continuing evolution of therapy for coronary artery disease. Initial results from the era of coronary angioplasty. Circulation 89 (1994) 2015-2025
26. Califf R.M., Armstrong P.W., Carver J.R., D'Agostino R.B., and Strauss W.E. 27th Bethesda Conference: matching the intensity of risk factor management with the hazard for coronary disease events. Task Force 5. Stratification of patients into high, medium and low risk subgroups for purposes of risk factor management. J Am Coll Cardiol 27 (1996) 1007-1019
27. Staessen J.A., Fagard R., Thijs L., et al. Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Lancet 350 (1997) 757-764
28. Tabachnick B.G., and Fidell L.S. Multiple regression. In: Tabachnick B.G., and Fidell L.S. (Eds). Using Multivariate Statistics (2001), Allyn and Bacon, Boston, MA 133-139
29. GeneCanvas. Thesias. Available at: http://ecgene.net/genecanvas/news.php. Accessed March 6, 2006.
30. Tregouet D.A., Escolano S., Tiret L., Mallet A., and Golmard J.L. A new algorithm for haplotype-based association analysis: the Stochastic-EM algorithm. Ann Hum Genet 68 (2004) 165-177
31. Jeerooburkhan N., Jones L.C., Bujac S., et al. Genetic and environmental determinants of plasma nitrogen oxides and risk of ischemic heart disease. Hypertension 38 (2001) 1054-1061
32. Tregouet D.A., and Tiret L. Cox proportional hazards survival regression in haplotype-based association analysis using the Stochastic-EM algorithm. Eur J Hum Genet 12 (2004) 971-974
33. Wang X.L., Mahaney M.C., Sim A.S., et al. Genetic contribution of the endothelial constitutive nitric oxide synthase gene to plasma nitric oxide levels. Arterioscler Thromb Vasc Biol 17 (1997) 3147-3153
34. Koh K.K., Ahn J.Y., Choi Y.M., et al. Vascular effects of step I diet in hypercholesterolemic patients with coronary artery disease. Am J Cardiol 92 (2003) 708-710
35. Wang X.L., Rainwater D.L., Leone A., and Mahaney M.C. Effects of diabetes on plasma nitrotyrosine levels. Diabet Med 21 (2004) 577-580
36. Shimasaki Y., Yasue H., Yoshimura M., et al. Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with myocardial infarction. J Am Coll Cardiol 31 (1998) 1506-1510
37. Hingorani A.D., Liang C.F., Fatibene J., et al. A common variant of the endothelial nitric oxide synthase (Glu298→Asp) is a major risk factor for coronary artery disease in the UK. Circulation 100 (1999) 1515-1520
38. Asakimori Y., Yorioka N., Tanaka J., et al. Association between ENOS gene polymorphism and cardiovascular events in nondiabetic hemodialysis patients: a prospective study. Am J Kidney Dis 44 (2004) 112-120
39. Hibi K., Ishigami T., Tamura K., et al. Endothelial nitric oxide synthase gene polymorphism and acute myocardial infarction. Hypertension 32 (1998) 521-526
40. Poirier O., Mao C., Mallet C., et al. Polymorphisms of the endothelial nitric oxide synthase gene-no consistent association with myocardial infarction in the ECTIM study. Eur J Clin Invest 29 (1999) 284-290
41. Gardemann A., Lohre J., Cayci S., et al. The T allele of the missense Glu(298)Asp endothelial nitric oxide synthase gene polymorphism is associated with coronary heart disease in younger individuals with high atherosclerotic risk profile. Atherosclerosis 160 (2002) 167-175
42. Nakayama M., Yasue H., Yoshimura M., et al. T-786→C mutation in the 5′-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm. Circulation 99 (1999) 2864-2870
43. Miyamoto Y., Saito Y., Nakayama M., et al. Replication protein A1 reduces transcription of the endothelial nitric oxide synthase gene containing a -786T→C mutation associated with coronary spastic angina. Hum Mol Genet 9 (2000) 2629-2637
44. Luscher T.F., and Corti R. Flow: the signal of life. Circ Res 95 (2004) 749-751
45. Vallance P., Leone A., Calver A., Collier J., and Moncada S. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 339 (1992) 572-575
46. Agema W.R., DeMaat M.P., Zwinderman A.H., et al. An integrated evaluation of endothelial constitutive nitric oxide synthase polymorphisms and coronary artery disease in men. Clin Sci (Lond) 107 (2004) 255-261
47. Hingorani A. Resolving inconsistency in the results of genetic association studies of cardiovascular disease. Clin Sci (Lond) 107 (2004) 251-253
48. Okamoto T., Akaike T., Sawa T., et al. Activation of matrix metalloproteinases by peroxynitrite-induced protein S-glutathiolation via disulfide S-oxide formation. J Biol Chem 276 (2001) 29596-29602
49. Siwik D.A., Pagano P.J., and Colucci W.S. Oxidative stress regulates collagen synthesis and matrix metalloproteinase activity in cardiac fibroblasts. Am J Physiol Cell Physiol 280 (2001) C53-C60
50. Siwik D.A., and Colucci W.S. Regulation of matrix metalloproteinases by cytokines and reactive oxygen/nitrogen species in the myocardium. Heart Fail Rev 9 (2004) 43-51
51. Fleming I., Mohamed A., Galle J., et al. Oxidized low-density lipoprotein increases superoxide production by endothelial nitric oxide synthase by inhibiting PKCalpha. Cardiovasc Res 65 (2005) 897-906
52. Adachi T., Weisbrod R.M., Pimentel D.R., et al. S-Glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide. Nat Med 10 (2004) 1200-1207
53. Zhang R., Brennan M.L., Fu X., et al. Association between myeloperoxidase levels and risk of coronary artery disease. JAMA 286 (2001) 2136-2142
54. Baldus S., Heeschen C., Meinertz T., et al. Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes. Circulation 108 (2003) 1440-1445
55. Rossi G.P., and Maiolino G. Do meta-analyses of association studies of endothelial nitric oxide synthase variants and ischemic heart disease provide conclusive answers?. Circulation 110 (2004) e305-e306