-
1
-
-
84892153139
-
Clinical development success rates for investigational drugs
-
Hay M, Thomas DW, Craighead JL, Economides C, Rosenthal J (2014) Clinical development success rates for investigational drugs. Nat Biotechnol 32:40-51
-
(2014)
Nat Biotechnol
, vol.32
, pp. 40-51
-
-
Hay, M.1
Thomas, D.W.2
Craighead, J.L.3
Economides, C.4
Rosenthal, J.5
-
2
-
-
84901946024
-
Lessons learned from the fate of AstraZeneca’s drug pipeline: A five-dimensional framework
-
Cook D, Brown D, Alexander R et al (2014) Lessons learned from the fate of AstraZeneca’s drug pipeline: a five-dimensional framework. Nat Rev Drug Discov 13:419-431
-
(2014)
Nat Rev Drug Discov
, vol.13
, pp. 419-431
-
-
Cook, D.1
Brown, D.2
Alexander, R.3
-
3
-
-
40749111022
-
Genomic changes and gene expression profiles reveal that established glioma cell lines are poorly representative of primary human gliomas
-
Li A, Walling J, Kotliarov Y et al (2008) Genomic changes and gene expression profiles reveal that established glioma cell lines are poorly representative of primary human gliomas. Mol Cancer Res 6:21-30
-
(2008)
Mol Cancer Res
, vol.6
, pp. 21-30
-
-
Li, A.1
Walling, J.2
Kotliarov, Y.3
-
4
-
-
84880291315
-
Evaluating cell lines as tumour models by comparison of genomic profiles
-
Domcke S, Sinha R, Levine DA et al (2013) Evaluating cell lines as tumour models by comparison of genomic profiles. Nat Commun 4:2126
-
(2013)
Nat Commun
, vol.4
, pp. 2126
-
-
Domcke, S.1
Sinha, R.2
Levine, D.A.3
-
5
-
-
13844312493
-
Assessment of tumor characteristic gene expression in cell lines using a tissue similarity index (TSI)
-
Sandberg R, Ernberg I (2005) Assessment of tumor characteristic gene expression in cell lines using a tissue similarity index (TSI). Proc Natl Acad Sci U S A 102:2052-2057
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 2052-2057
-
-
Sandberg, R.1
Ernberg, I.2
-
6
-
-
0024097759
-
Regulation of milk protein and basement membrane gene expression: The influence of the extracellular matrix
-
Aggeler J, Park CS, Bissell MJ (1988) Regulation of milk protein and basement membrane gene expression: the influence of the extracellular matrix. J Dairy Sci 71:2830-2842
-
(1988)
J Dairy Sci
, vol.71
, pp. 2830-2842
-
-
Aggeler, J.1
Park, C.S.2
Bissell, M.J.3
-
7
-
-
84893868500
-
Of plasticity and specificity: Dialectics of the micro-and macro-environment and the organ phenotype
-
Bhat R, Bissell MJ (2014) Of plasticity and specificity: dialectics of the micro-and macro-environment and the organ phenotype. Wiley Interdiscip Rev Membr Transp Signal 3:147-163
-
(2014)
Wiley Interdiscip Rev Membr Transp Signal
, vol.3
, pp. 147-163
-
-
Bhat, R.1
Bissell, M.J.2
-
8
-
-
0020456385
-
How does the extracellular matrix direct gene expression?
-
Bissell MJ, Hall HG, Parry G (1982) How does the extracellular matrix direct gene expression? J Theor Biol 99:31-68
-
(1982)
J Theor Biol
, vol.99
, pp. 31-68
-
-
Bissell, M.J.1
Hall, H.G.2
Parry, G.3
-
9
-
-
84929353122
-
Ex vivo maintenance of primary human multiple myeloma cells through the optimization of the osteoblastic niche
-
Zhang W, Gu Y, Sun Q et al (2015) Ex vivo maintenance of primary human multiple myeloma cells through the optimization of the osteoblastic niche. PLoS One 10:e0125995.doi:10.1371/journal.pone.0125995
-
(2015)
Plos One
, vol.10
-
-
Zhang, W.1
Gu, Y.2
Sun, Q.3
-
10
-
-
84905179282
-
Patient-specific 3D microfluidic tissue model for multiple myeloma
-
Zhang W, Lee WY, Siegel DS et al (2014) Patient-specific 3D microfluidic tissue model for multiple myeloma. Tissue Eng Part C Methods 20:663-670
-
(2014)
Tissue Eng Part C Methods
, vol.20
, pp. 663-670
-
-
Zhang, W.1
Lee, W.Y.2
Siegel, D.S.3
-
11
-
-
84891404742
-
Organoid cultures for the analysis of cancer phenotypes
-
Sachs N, Clevers H (2014) Organoid cultures for the analysis of cancer phenotypes. Curr Opin Genet Dev 24:68-73
-
(2014)
Curr Opin Genet Dev
, vol.24
, pp. 68-73
-
-
Sachs, N.1
Clevers, H.2
-
12
-
-
84865978356
-
On the biomechanics of stem cell niche formation in the gut—modelling growing organoids
-
Buske P, Przybilla J, Loeffler M et al (2012) On the biomechanics of stem cell niche formation in the gut—modelling growing organoids. FEBS J 279:3475-3487
-
(2012)
FEBS J
, vol.279
, pp. 3475-3487
-
-
Buske, P.1
Przybilla, J.2
Loeffler, M.3
-
13
-
-
84928494312
-
Microbead-guided reconstruction of the 3D osteocyte network during microfluidic perfusion culture
-
Gu Y, Zhang W, Qiaoling S et al (2015) Microbead-guided reconstruction of the 3D osteocyte network during microfluidic perfusion culture. J Mater Chem B 3:3625-3633
-
(2015)
J Mater Chem B
, vol.3
, pp. 3625-3633
-
-
Gu, Y.1
Zhang, W.2
Qiaoling, S.3
-
14
-
-
0036280046
-
Integrins as novel drug targets for overcoming innate drug resistance
-
Damiano JS (2002) Integrins as novel drug targets for overcoming innate drug resistance. Curr Cancer Drug Targets 2:37-43
-
(2002)
Curr Cancer Drug Targets
, vol.2
, pp. 37-43
-
-
Damiano, J.S.1
-
15
-
-
33750631842
-
Tumor microenvironment and drug resistance in hematologic malignancies
-
Li ZW, Dalton WS (2006) Tumor microenvironment and drug resistance in hematologic malignancies. Blood Rev 20:333-342
-
(2006)
Blood Rev
, vol.20
, pp. 333-342
-
-
Li, Z.W.1
Dalton, W.S.2
-
16
-
-
84894437581
-
Overexpression of fibronectin confers cell adhesion-mediated drug resistance (CAM-DR) against 5-FU in oral squamous cell carcinoma cells
-
Nakagawa Y, Nakayama H, Nagata M et al (2014) Overexpression of fibronectin confers cell adhesion-mediated drug resistance (CAM-DR) against 5-FU in oral squamous cell carcinoma cells. Int J Oncol 44:1376-1384
-
(2014)
Int J Oncol
, vol.44
, pp. 1376-1384
-
-
Nakagawa, Y.1
Nakayama, H.2
Nagata, M.3
-
17
-
-
44349130354
-
ANTI-ADHESION evolves to a promising therapeutic concept in oncology
-
Schmidmaier R, Baumann P (2008) ANTI-ADHESION evolves to a promising therapeutic concept in oncology. Curr Med Chem 15:978-990
-
(2008)
Curr Med Chem
, vol.15
, pp. 978-990
-
-
Schmidmaier, R.1
Baumann, P.2
-
20
-
-
84903143269
-
3D tumor models: History, advances and future perspectives
-
Benien P, Swami A (2014) 3D tumor models: history, advances and future perspectives. Future Oncol 10:1311-1327
-
(2014)
Future Oncol
, vol.10
, pp. 1311-1327
-
-
Benien, P.1
Swami, A.2
-
21
-
-
84899513546
-
Three-dimensional in vitro cancer models: A short review
-
Wang C, Tang Z, Zhao Y et al (2014) Three-dimensional in vitro cancer models: a short review. Biofabrication 6:022001
-
(2014)
Biofabrication
, vol.6
-
-
Wang, C.1
Tang, Z.2
Zhao, Y.3
-
22
-
-
84906816780
-
Three-dimensional models of cancer for pharmacology and cancer cell biology: Capturing tumor complexity in vitro/ex vivo
-
Hickman JA, Graeser R, de Hoogt R et al (2014) Three-dimensional models of cancer for pharmacology and cancer cell biology: capturing tumor complexity in vitro/ex vivo. Biotechnol J 9:1115-1128
-
(2014)
Biotechnol J
, vol.9
, pp. 1115-1128
-
-
Hickman, J.A.1
Graeser, R.2
De Hoogt, R.3
-
23
-
-
84926188062
-
Mechanical stimulation of bone marrow in situ induces bone formation in trabecular explants
-
Birmingham E, Kreipke TC, Dolan EB et al (2015) Mechanical stimulation of bone marrow in situ induces bone formation in trabecular explants. Ann Biomed Eng 43:1036-1050
-
(2015)
Ann Biomed Eng
, vol.43
, pp. 1036-1050
-
-
Birmingham, E.1
Kreipke, T.C.2
Dolan, E.B.3
-
24
-
-
38749097368
-
Design and validation of a dynamic flow perfusion bioreactor for use with compliant tissue engineering scaffolds
-
Jaasma MJ, Plunkett NA, O'Brien FJ (2008) Design and validation of a dynamic flow perfusion bioreactor for use with compliant tissue engineering scaffolds. J Biotechnol 133:490-496
-
(2008)
J Biotechnol
, vol.133
, pp. 490-496
-
-
Jaasma, M.J.1
Plunkett, N.A.2
O'brien, F.J.3
-
26
-
-
84883190440
-
Ex-vivo dynamic 3-D culture of human tissues in the RCCS bioreactor allows the study of multiple myeloma biology and response to therapy
-
Ferrarini M, Steimberg N, Ponzoni M et al (2013) Ex-vivo dynamic 3-D culture of human tissues in the RCCS bioreactor allows the study of multiple myeloma biology and response to therapy. PLoS One 8:e71613
-
(2013)
Plos One
, vol.8
-
-
Ferrarini, M.1
Steimberg, N.2
Ponzoni, M.3
-
27
-
-
84901067389
-
A microfluidic-based platform for tumour spheroid culture, monitoring and drug screening
-
Kwapiszewska K, Michalczuk A, Rybka M et al (2014) A microfluidic-based platform for tumour spheroid culture, monitoring and drug screening. Lab Chip 14:2096-2104
-
(2014)
Lab Chip
, vol.14
, pp. 2096-2104
-
-
Kwapiszewska, K.1
Michalczuk, A.2
Rybka, M.3
-
28
-
-
81355122671
-
Microfluidic 3D bone tissue model for high-throughput evaluation of wound-healing and infection-preventing biomaterials
-
Lee JH, Gu Y, Wang H, Lee WY (2012) Microfluidic 3D bone tissue model for high-throughput evaluation of wound-healing and infection-preventing biomaterials. Biomaterials 33:999-1006
-
(2012)
Biomaterials
, vol.33
, pp. 999-1006
-
-
Lee, J.H.1
Gu, Y.2
Wang, H.3
Lee, W.Y.4
-
29
-
-
84881247617
-
Real-time and non-invasive impedimetric monitoring of cell proliferation and chemosensitiv-ity in a perfusion 3D cell culture microfluidic chip
-
Lei KF, Wu MH, Hsu CW, Chen YD (2014) Real-time and non-invasive impedimetric monitoring of cell proliferation and chemosensitiv-ity in a perfusion 3D cell culture microfluidic chip. Biosens Bioelectron 51:16-21
-
(2014)
Biosens Bioelectron
, vol.51
, pp. 16-21
-
-
Lei, K.F.1
Wu, M.H.2
Hsu, C.W.3
Chen, Y.D.4
-
31
-
-
84895784261
-
New drugs and novel mechanisms of action in multiple myeloma in 2013: A report from the International Myeloma Working Group (IMWG)
-
Ocio EM, Richardson PG, Rajkumar SV et al (2014) New drugs and novel mechanisms of action in multiple myeloma in 2013: a report from the International Myeloma Working Group (IMWG). Leukemia 28:525-542
-
(2014)
Leukemia
, vol.28
, pp. 525-542
-
-
Ocio, E.M.1
Richardson, P.G.2
Rajkumar, S.V.3
-
32
-
-
84893724480
-
Association of response endpoints with survival outcomes in multiple myeloma
-
Lonial S, Anderson KC (2014) Association of response endpoints with survival outcomes in multiple myeloma. Leukemia 28:258-268
-
(2014)
Leukemia
, vol.28
, pp. 258-268
-
-
Lonial, S.1
Erson, K.C.2
-
33
-
-
84866373814
-
Targeting of adhesion molecules as a therapeutic strategy in multiple myeloma
-
Neri P, Bahlis NJ (2012) Targeting of adhesion molecules as a therapeutic strategy in multiple myeloma. Curr Cancer Drug Targets 12:776-796
-
(2012)
Curr Cancer Drug Targets
, vol.12
, pp. 776-796
-
-
Neri, P.1
Bahlis, N.J.2
-
34
-
-
79959417349
-
Integrin beta7-mediated regulation of multiple myeloma cell adhesion, migration, and invasion
-
Neri P, Ren L, Azab AK et al (2011) Integrin beta7-mediated regulation of multiple myeloma cell adhesion, migration, and invasion. Blood 117:6202-6213
-
(2011)
Blood
, vol.117
, pp. 6202-6213
-
-
Neri, P.1
Ren, L.2
Azab, A.K.3
-
35
-
-
0034009920
-
Integrin-mediated drug resistance in multiple myeloma
-
Damiano JS, Dalton WS (2000) Integrin-mediated drug resistance in multiple myeloma. Leuk Lymphoma 38:71-81
-
(2000)
Leuk Lymphoma
, vol.38
, pp. 71-81
-
-
Damiano, J.S.1
Dalton, W.S.2
-
36
-
-
84891909864
-
Drug resistance in multiple myeloma: Latest findings and new concepts on molecular mechanisms
-
Abdi J, Chen G, Chang H (2013) Drug resistance in multiple myeloma: latest findings and new concepts on molecular mechanisms. Oncotarget 4:2186-2207
-
(2013)
Oncotarget
, vol.4
, pp. 2186-2207
-
-
Abdi, J.1
Chen, G.2
Chang, H.3
-
37
-
-
0033570946
-
The proliferative potential of myeloma plasma cells manifest in the SCID-hu host
-
Yaccoby S, Epstein J (1999) The proliferative potential of myeloma plasma cells manifest in the SCID-hu host. Blood 94:3576-3582
-
(1999)
Blood
, vol.94
, pp. 3576-3582
-
-
Yaccoby, S.1
Epstein, J.2
-
38
-
-
0032532608
-
Primary myeloma cells growing in SCID-hu mice: a model for studying the biology and treatment of myeloma and its manifestations
-
Yaccoby S, Barlogie B, Epstein J (1998) Primary myeloma cells growing in SCID-hu mice: a model for studying the biology and treatment of myeloma and its manifestations. Blood 92:2908-2913
-
(1998)
Blood
, vol.92
, pp. 2908-2913
-
-
Yaccoby, S.1
Barlogie, B.2
Epstein, J.3
-
39
-
-
84928325529
-
NOD/SCID-GAMMA mice are an ideal strain to assess the efficacy of therapeutic agents used in the treatment of myeloma bone disease
-
Lawson MA, Paton-Hough JM, Evans HR et al (2015) NOD/SCID-GAMMA mice are an ideal strain to assess the efficacy of therapeutic agents used in the treatment of myeloma bone disease. PLoS One 10:e0119546
-
(2015)
Plos One
, vol.10
-
-
Lawson, M.A.1
Paton-Hough, J.M.2
Evans, H.R.3
-
40
-
-
84911486061
-
Investigating osteogenic differentiation in multiple myeloma using a novel 3D bone marrow niche model
-
Reagan MR, Mishima Y, Glavey SV et al (2014) Investigating osteogenic differentiation in multiple myeloma using a novel 3D bone marrow niche model. Blood 124:3250-3259
-
(2014)
Blood
, vol.124
, pp. 3250-3259
-
-
Reagan, M.R.1
Mishima, Y.2
Glavey, S.V.3
-
41
-
-
53449085087
-
A unique three-dimensional model for evaluating the impact of therapy on multiple myeloma
-
Kirshner J, Thulien KJ, Martin LD et al (2008) A unique three-dimensional model for evaluating the impact of therapy on multiple myeloma. Blood 112:2935-2945
-
(2008)
Blood
, vol.112
, pp. 2935-2945
-
-
Kirshner, J.1
Thulien, K.J.2
Martin, L.D.3
-
42
-
-
84934911468
-
Well plate-based perfusion culture device for tissue and tumor microenvironment replication
-
Zhang W, Gu Y, Hao Y et al (2015) Well plate-based perfusion culture device for tissue and tumor microenvironment replication. Lab Chip 15:2854-2863
-
(2015)
Lab Chip
, vol.15
, pp. 2854-2863
-
-
Zhang, W.1
Gu, Y.2
Hao, Y.3
-
43
-
-
65449168376
-
Multifunctional nanofibrous scaffold for tissue engineering
-
Yang X, Ogbolu KR, Wang H (2008) Multifunctional nanofibrous scaffold for tissue engineering. J Exp Nanosci 3:329-345
-
(2008)
J Exp Nanosci
, vol.3
, pp. 329-345
-
-
Yang, X.1
Ogbolu, K.R.2
Wang, H.3
|