-
1
-
-
84880932230
-
Disease duration and the integrity of the nigrostriatal system in Parkinson's disease
-
Kordower JH, Olanow CW, Dodiya HB, Chu Y, Beach TG, Adler CH, Halliday GM, &Bartus RT (2013) Disease duration and the integrity of the nigrostriatal system in Parkinson's disease. Brain, 136, 2419-2431.
-
(2013)
Brain
, vol.136
, pp. 2419-2431
-
-
Kordower, J.H.1
Olanow, C.W.2
Dodiya, H.B.3
Chu, Y.4
Beach, T.G.5
Adler, C.H.6
Halliday, G.M.7
Bartus, R.T.8
-
2
-
-
79951476995
-
Bioactivity of AAV2-neurturin gene therapy (CERE-120): Differences between Parkinson's disease and nonhuman primate brains
-
Bartus RT, Herzog CD, Chu Y, Wilson A, Brown L, Siffert J, Johnson EM, Olanow CW, Mufson EJ, &Kordower JH (2011) Bioactivity of AAV2-neurturin gene therapy (CERE-120): Differences between Parkinson's disease and nonhuman primate brains. Mov Disord, 26, 27-36.
-
(2011)
Mov Disord
, vol.26
, pp. 27-36
-
-
Bartus, R.T.1
Herzog, C.D.2
Chu, Y.3
Wilson, A.4
Brown, L.5
Siffert, J.6
Johnson, E.M.7
Olanow, C.W.8
Mufson, E.J.9
Kordower, J.H.10
-
3
-
-
0033773237
-
Preservation of a functional nigrostriatal dopamine pathway by GDNF in the intrastriatal 6-OHDA lesion model depends on the site of administration of the trophic factor
-
Kirik D, Rosenblad C, &Björklund A (2000) Preservation of a functional nigrostriatal dopamine pathway by GDNF in the intrastriatal 6-OHDA lesion model depends on the site of administration of the trophic factor. Eur J Neurosci, 12, 3871-3882.
-
(2000)
Eur J Neurosci
, vol.12
, pp. 3871-3882
-
-
Kirik, D.1
Rosenblad, C.2
Björklund, A.3
-
4
-
-
3843057052
-
Changes of dopamine turnover in the progression of Parkinson's disease as measured by positron emission tomography: Their relation to diseasecompensatory mechanisms
-
Sossi V, de la Fuente-Fernández R, Holden JE, Schulzer M, Ruth TJ, &Stoessl J (2004) Changes of dopamine turnover in the progression of Parkinson's disease as measured by positron emission tomography: Their relation to diseasecompensatory mechanisms. J Cereb Blood Flow Metab, 24, 869-876.
-
(2004)
J Cereb Blood Flow Metab
, vol.24
, pp. 869-876
-
-
Sossi, V.1
De La Fuente-Fernández, R.2
Holden, J.E.3
Schulzer, M.4
Ruth, T.J.5
Stoessl, J.6
-
5
-
-
78650209340
-
Dopamine turnover increases in asymptomatic LRRK2 mutations carriers
-
Sossi V, de la Fuente-Fernández R, Nandhagopal R, Schulzer M, McKenzie J, Ruth TJ, Aasly JO, Farrer MJ, Wszolek ZK, &Stoessl JA (2010) Dopamine turnover increases in asymptomatic LRRK2 mutations carriers. Mov Disord, 25, 2717-2723.
-
(2010)
Mov Disord
, vol.25
, pp. 2717-2723
-
-
Sossi, V.1
De La Fuente-Fernández, R.2
Nandhagopal, R.3
Schulzer, M.4
McKenzie, J.5
Ruth, T.J.6
Aasly, J.O.7
Farrer, M.J.8
Wszolek, Z.K.9
Stoessl, J.A.10
-
6
-
-
79955466566
-
Age-specific progression of nigrostriatal dysfunction in Parkinson's disease
-
de la Fuente-Fernández R, Schulzer M, Kuramoto L, Cragg J, Ramachandiran N, Au WL, Mak E, McKenzie J, McCormick S, Sossi V, Ruth TJ, Lee CS, Calne DB, &Stoessl AJ (2011) Age-specific progression of nigrostriatal dysfunction in Parkinson's disease. Ann Neurol, 69, 803-810.
-
(2011)
Ann Neurol
, vol.69
, pp. 803-810
-
-
De La Fuente-Fernández, R.1
Schulzer, M.2
Kuramoto, L.3
Cragg, J.4
Ramachandiran, N.5
Au, W.L.6
Mak, E.7
McKenzie, J.8
McCormick, S.9
Sossi, V.10
Ruth, T.J.11
Lee, C.S.12
Calne, D.B.13
Stoessl, A.J.14
-
7
-
-
18844471416
-
In vivo positron emission tomographic evidence for compensatory changes in presynaptic dopaminergic nerve terminals in Parkinson's disease
-
Lee CS, Samii A, Sossi V, Ruth TJ, Schulzer M, Holden JE, Wudel J, Pal PK, de la Fuente-Fernandez R, Calne DB, &Stoessl AJ (2000) In vivo positron emission tomographic evidence for compensatory changes in presynaptic dopaminergic nerve terminals in Parkinson's disease. Ann Neurol, 47, 493-503.
-
(2000)
Ann Neurol
, vol.47
, pp. 493-503
-
-
Lee, C.S.1
Samii, A.2
Sossi, V.3
Ruth, T.J.4
Schulzer, M.5
Holden, J.E.6
Wudel, J.7
Pal, P.K.8
De La Fuente-Fernandez, R.9
Calne, D.B.10
Stoessl, A.J.11
-
8
-
-
0025954066
-
Ageing and Parkinson's disease: Substantia nigra regional selectivity
-
Fearnley JM, &Lees AJ (1991) Ageing and Parkinson's disease: Substantia nigra regional selectivity. Brain, 114(Pt 5), 2283-2301.
-
(1991)
Brain
, vol.114
, pp. 2283-2301
-
-
Fearnley, J.M.1
Lees, A.J.2
-
9
-
-
84963758311
-
Retrograde axonal degeneration in Parkinson disease
-
Tagliaferro P,& Burke RE (2016) Retrograde axonal degeneration in Parkinson disease. J Parkinsons Dis, 6, 1-15.
-
(2016)
J Parkinsons Dis
, vol.6
, pp. 1-15
-
-
Tagliaferro, P.1
Burke, R.E.2
-
10
-
-
63849332293
-
Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alphasynucleinopathy
-
Chung CY, Koprich JB, Siddiqi H, &Isacson O (2009) Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alphasynucleinopathy. J Neurosci, 29, 3365-3373.
-
(2009)
J Neurosci
, vol.29
, pp. 3365-3373
-
-
Chung, C.Y.1
Koprich, J.B.2
Siddiqi, H.3
Isacson, O.4
-
11
-
-
84856570373
-
Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of --synuclein in midbrain dopamine neurons
-
Decressac M, Mattsson B, Lundblad M, Weikop P, &Björklund A (2012) Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of --synuclein in midbrain dopamine neurons. Neurobiol Dis, 45, 939-953.
-
(2012)
Neurobiol Dis
, vol.45
, pp. 939-953
-
-
Decressac, M.1
Mattsson, B.2
Lundblad, M.3
Weikop, P.4
Björklund, A.5
-
12
-
-
84938081340
-
An early axonopathy in a hLRRK2(R1441G) transgenic model of Parkinson disease
-
Tagliaferro P, Kareva T, Oo TF, Yarygina O, Kholodilov N, &Burke RE (2015) An early axonopathy in a hLRRK2(R1441G) transgenic model of Parkinson disease. Neurobiol Dis, 82, 359-371.
-
(2015)
Neurobiol Dis
, vol.82
, pp. 359-371
-
-
Tagliaferro, P.1
Kareva, T.2
Oo, T.F.3
Yarygina, O.4
Kholodilov, N.5
Burke, R.E.6
-
13
-
-
67649813448
-
Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease
-
Li Y, Liu W, Oo TF, Wang L, Tang Y, Jackson-Lewis V, Zhou C, Geghman K, BogdanovM, Przedborski S, BealMF, Burke RE, &Li C (2009) Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nat Neurosci, 12, 826-828.
-
(2009)
Nat Neurosci
, vol.12
, pp. 826-828
-
-
Li, Y.1
Liu, W.2
Oo, T.F.3
Wang, L.4
Tang, Y.5
Jackson-Lewis, V.6
Zhou, C.7
Geghman, K.8
Bogdanov, M.9
Przedborski, S.10
Beal, M.F.11
Burke, R.E.12
Li, C.13
-
14
-
-
84873423314
-
Transcription factor Nurr1 maintains fiber integrity and nuclear-encoded mitochondrial gene expression in dopamine neurons
-
Kadkhodaei B, Alvarsson A, Schintu N, Ramsköld D, Volakakis N, Joodmardi E, Yoshitake T, Kehr J, Decressac M, Björklund A, Sandberg R, Svenningsson P, &Perlmann T (2013) Transcription factor Nurr1 maintains fiber integrity and nuclear-encoded mitochondrial gene expression in dopamine neurons. Proc Natl Acad Sci U S A, 110, 2360-2365.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 2360-2365
-
-
Kadkhodaei, B.1
Alvarsson, A.2
Schintu, N.3
Ramsköld, D.4
Volakakis, N.5
Joodmardi, E.6
Yoshitake, T.7
Kehr, J.8
Decressac, M.9
Björklund, A.10
Sandberg, R.11
Svenningsson, P.12
Perlmann, T.13
-
15
-
-
84908409010
-
Progressive nigrostriatal terminal dysfunction and degeneration in the engrailed1 heterozygous mouse model of Parkinson's disease
-
Nordström U, Beauvais G, Ghosh A, Pulikkaparambil Sasidharan BC, Lundblad M, Fuchs J, Joshi RL, Lipton JW, Roholt A, Medicetty S, Feinstein TN, Steiner JA, Escobar Galvis ML, Prochiantz A, &Brundin P (2015) Progressive nigrostriatal terminal dysfunction and degeneration in the engrailed1 heterozygous mouse model of Parkinson's disease. Neurobiol Dis, 73, 70-82.
-
(2015)
Neurobiol Dis
, vol.73
, pp. 70-82
-
-
Nordström, U.1
Beauvais, G.2
Ghosh, A.3
Pulikkaparambil, S.B.C.4
Lundblad, M.5
Fuchs, J.6
Joshi, R.L.7
Lipton, J.W.8
Roholt, A.9
Medicetty, S.10
Feinstein, T.N.11
Steiner, J.A.12
Escobar, G.M.L.13
Prochiantz, A.14
Brundin, P.15
-
16
-
-
33846804054
-
Progressive loss of dopaminergic neurons in the ventral midbrain of adult mice heterozygote for Engrailed1
-
Sonnier L, Le Pen G, Hartmann A, Bizot J-C, Trovero F, Krebs M-O, &Prochiantz A (2007) Progressive loss of dopaminergic neurons in the ventral midbrain of adult mice heterozygote for Engrailed1. J Neurosci, 27, 1063-1071.
-
(2007)
J Neurosci
, vol.27
, pp. 1063-1071
-
-
Sonnier, L.1
Le Pen, G.2
Hartmann, A.3
Bizot, J.-C.4
Trovero, F.5
Krebs, M.-O.6
Prochiantz, A.7
-
17
-
-
84929880464
-
Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease
-
Laguna A, Schintu N, Nobre A, Alvarsson A, Volakakis N, Jacobsen JK, Gómez-Galán M, Sopova E, Joodmardi E, Yoshitake T, Deng Q, Kehr J, Ericson J, Svenningsson P, Shupliakov O, &Perlmann T (2015) Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease. Nat Neurosci, 18, 826-835.
-
(2015)
Nat Neurosci
, vol.18
, pp. 826-835
-
-
Laguna, A.1
Schintu, N.2
Nobre, A.3
Alvarsson, A.4
Volakakis, N.5
Jacobsen, J.K.6
Gómez-Galán, M.7
Sopova, E.8
Joodmardi, E.9
Yoshitake, T.10
Deng, Q.11
Kehr, J.12
Ericson, J.13
Svenningsson, P.14
Shupliakov, O.15
Perlmann, T.16
-
18
-
-
0033539664
-
Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein
-
Galvin JE, Uryu K, Lee VM, &Trojanowski JQ (1999) Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein. Proc Natl Acad Sci U S A, 96, 13450-13455.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 13450-13455
-
-
Galvin, J.E.1
Uryu, K.2
Lee, V.M.3
Trojanowski, J.Q.4
-
19
-
-
0036322266
-
Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases
-
Duda JE, Giasson BI, Mabon ME, Lee VM-Y, &Trojanowski JQ (2002) Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases. Ann Neurol, 52, 205-210.
-
(2002)
Ann Neurol
, vol.52
, pp. 205-210
-
-
Duda, J.E.1
Giasson, B.I.2
Mabon, M.E.3
Lee, V.M.-Y.4
Trojanowski, J.Q.5
-
20
-
-
84994107542
-
3D-EM characterization of "axonal swellings" in the Engrailed-1 heterozygous mouse model of Parkinson's disease
-
San Diego
-
Kurowska Z, Kidd G, Benson E, Brundin P, Medicetty S, &Trapp B (2015) 3D-EM characterization of "axonal swellings" in the Engrailed-1 heterozygous mouse model of Parkinson's disease. In Movement Disorders Suppl. 1 (poster), San Diego, p. 1:94.
-
(2015)
Movement Disorders Suppl. 1 (Poster)
, pp. 1-94
-
-
Kurowska, Z.1
Kidd, G.2
Benson, E.3
Brundin, P.4
Medicetty, S.5
Trapp, B.6
-
21
-
-
84944030529
-
Engrailed homeoprotein protects mesencephalic dopaminergic neurons from oxidative stress
-
Rekaik H, Blaudin de Thé F-X, Fuchs J, Massiani-Beaudoin O, Prochiantz A, &Joshi RL (2015) Engrailed homeoprotein protects mesencephalic dopaminergic neurons from oxidative stress. Cell Rep, 13, 242-250.
-
(2015)
Cell Rep
, vol.13
, pp. 242-250
-
-
Rekaik, H.1
De Thé, F.-X.B.2
Fuchs, J.3
Massiani-Beaudoin, O.4
Prochiantz, A.5
Joshi, R.L.6
-
22
-
-
80053220669
-
Engrailed protects mouse midbrain dopaminergic neurons against mitochondrial complex i insults
-
Alvarez-Fischer D, Fuchs J, Castagner F, Stettler O, Massiani-Beaudoin O, Moya KL, Bouillot C, Oertel WH, Lombes A, FaigleW, Joshi RL, Hartmann A, &Prochiantz A (2011) Engrailed protects mouse midbrain dopaminergic neurons against mitochondrial complex I insults. Nat Neurosci, 14, 1260-1266.
-
(2011)
Nat Neurosci
, vol.14
, pp. 1260-1266
-
-
Alvarez-Fischer, D.1
Fuchs, J.2
Castagner, F.3
Stettler, O.4
Massiani-Beaudoin, O.5
Moya, K.L.6
Bouillot, C.7
Oertel, W.H.8
Lombes, A.9
Faigle, W.10
Joshi, R.L.11
Hartmann, A.12
Prochiantz, A.13
-
23
-
-
82855167148
-
Engrailed homeoprotein recruits the adenosine A1 receptor to potentiate ephrin A5 function in retinal growth cones
-
Stettler O, Joshi RL, Wizenmann A, Reingruber J, Holcman D, Bouillot C, Castagner F, Prochiantz A,& MoyaKL (2012) Engrailed homeoprotein recruits the adenosine A1 receptor to potentiate ephrin A5 function in retinal growth cones. Development, 139, 215-224.
-
(2012)
Development
, vol.139
, pp. 215-224
-
-
Stettler, O.1
Joshi, R.L.2
Wizenmann, A.3
Reingruber, J.4
Holcman, D.5
Bouillot, C.6
Castagner, F.7
Prochiantz, A.8
Moya, K.L.9
-
24
-
-
33847770318
-
1-Methyl-4-phenylpyridinium affects fast axonal transport by activation of caspase and protein kinase C
-
Morfini G, Pigino G, Opalach K, Serulle Y, Moreira JE, Sugimori M, Llinás RR, &Brady ST (2007) 1-Methyl-4-phenylpyridinium affects fast axonal transport by activation of caspase and protein kinase C. Proc Natl Acad Sci U S A, 104, 2442-2447.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 2442-2447
-
-
Morfini, G.1
Pigino, G.2
Opalach, K.3
Serulle, Y.4
Moreira, J.E.5
Sugimori, M.6
Llinás, R.R.7
Brady, S.T.8
-
25
-
-
33847784020
-
1-Methyl-4-phenylpyridinium induces synaptic dysfunction through a pathway involving caspase and PKCdelta enzymatic activities
-
Serulle Y, Morfini G, Pigino G, Moreira JE, Sugimori M, Brady ST, &Llinás RR (2007) 1-Methyl-4-phenylpyridinium induces synaptic dysfunction through a pathway involving caspase and PKCdelta enzymatic activities. Proc Natl Acad Sci U S A, 104, 2437-2441.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 2437-2441
-
-
Serulle, Y.1
Morfini, G.2
Pigino, G.3
Moreira, J.E.4
Sugimori, M.5
Brady, S.T.6
Llinás, R.R.7
-
26
-
-
84863188413
-
Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease
-
Chu Y, Morfini GA, Langhamer LB, He Y, Brady ST, &Kordower JH (2012) Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease. Brain, 135, 2058-2073.
-
(2012)
Brain
, vol.135
, pp. 2058-2073
-
-
Chu, Y.1
Morfini, G.A.2
Langhamer, L.B.3
He, Y.4
Brady, S.T.5
Kordower, J.H.6
-
27
-
-
84861595545
-
Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of --synuclein and LRRK2 in the brain
-
Friedman LG, Lachenmayer ML, Wang J, He L, Poulose SM, Komatsu M, Holstein GR, &Yue Z (2012) Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of --synuclein and LRRK2 in the brain. J Neurosci, 32, 7585-7593.
-
(2012)
J Neurosci
, vol.32
, pp. 7585-7593
-
-
Friedman, L.G.1
Lachenmayer, M.L.2
Wang, J.3
He, L.4
Poulose, S.M.5
Komatsu, M.6
Holstein, G.R.7
Yue, Z.8
-
28
-
-
84959314882
-
Axon self-destruction: New links among SARM1, MAPKs, and NAD+ metabolism
-
Gerdts J, SummersDW, Milbrandt J,& DiAntonioA(2016) Axon self-destruction: New links among SARM1, MAPKs, and NAD+ metabolism. Neuron, 89, 449-460.
-
(2016)
Neuron
, vol.89
, pp. 449-460
-
-
Gerdts, J.1
Summers, D.W.2
Milbrandt, J.3
DiAntonio, A.4
-
29
-
-
84928411460
-
SARM1 activation triggers axon degeneration locally via NAD+ destruction
-
Gerdts J, Brace EJ, Sasaki Y, DiAntonio A, &Milbrandt J (2015) SARM1 activation triggers axon degeneration locally via NAD+ destruction. Science, 348, 453-457.
-
(2015)
Science
, vol.348
, pp. 453-457
-
-
Gerdts, J.1
Brace, E.J.2
Sasaki, Y.3
DiAntonio, A.4
Milbrandt, J.5
-
30
-
-
48249139449
-
Multiple sclerosis: An immune or neurodegenerative disorder
-
Trapp BD, &Nave K-A (2008) Multiple sclerosis: An immune or neurodegenerative disorder? Annu Rev Neurosci, 31, 247-269.
-
(2008)
Annu Rev Neurosci
, vol.31
, pp. 247-269
-
-
Trapp, B.D.1
Nave, K.-A.2
|