Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 10, 2007, Pages 2817-2822

  Wang, Gary T ^a   Mantei, Robert A ^a   Kawai, Megumi ^a   Tedrow, Jason S ^a   Barnes, David M ^a   Wang, Jieyi ^a   Zhang, Qian ^a   Lou, Pingping ^a   Garcia, Lora A ^a   Bouska, Jennifer ^a   Yates, Melinda ^a   Park, Chang ^a   Judge, Russell A ^a   Lesniewski, Richard ^a   Sheppard, George S ^a   Bell, Randy L ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Methionine aminopeptidase 2 (MetAP2) inhibitors; Sulfonamides of 5,6 disubstituted anthranilic acids

Indexed keywords

ANTHRANILIC ACID; ENZYME INHIBITOR; MANGANESE; METHIONYL AMINOPEPTIDASE 2 INHIBITOR; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CELL ACTIVITY; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG STRUCTURE; HUMAN; HUMAN CELL; PROTEIN BINDING;

AMINOPEPTIDASES; ANTHRANILIC ACIDS; LEAD; METALLOENDOPEPTIDASES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 34247353336     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.02.062     Document Type: Article

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