The ω-3 polyunsaturated fatty acids prevented colitis-associated carcinogenesis through blocking dissociation of β-catenin complex, inhibiting COX-2 through repressing NF-κB, and inducing 15-prostaglandin dehydrogenase

Oncotarget

Volumn 7, Issue 39, 2016, Pages 63583-63595

  Han, Young Min ^a   Jeong, Migyeung ^a   Park, Jong Min ^a   Kim, Mi Young ^a,d   Go, Eun Jin ^a   Cha, Ji Young ^b   Kim, Kyung Jo ^c   Hahm, Ki Baik ^a,d  

^a CHA University   (South Korea)

^b Gachon University   (South Korea)

^c University of Ulsan   (South Korea)

^d CHA Bundang Medical Center   (South Korea)

Author keywords

15 PGDH; Colitic cancer; COX 2; Fat 1 transgenic mice; catenin complex; 3 PUFAs

Indexed keywords

15 HYDROXYPROSTAGLANDIN DEHYDROGENASE; BETA CATENIN; CYCLINE; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OMEGA 3 FATTY ACID; PROSTAGLANDIN E2; PROTEIN BAX; PROTEIN BCL 2; SURVIVIN; 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CANCER PREVENTION; COLITIS; COLITIS ASSOCIATED CANCER; COLON CANCER; COLON CARCINOGENESIS; COMPLEX FORMATION; CONTROLLED STUDY; DISSOCIATION; DOSE RESPONSE; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG DOSE COMPARISON; ENZYME INHIBITION; GENE EXPRESSION REGULATION; IN VITRO STUDY; LIPID ANALYSIS; MOUSE; NONHUMAN; TRANSCRIPTION INITIATION; TRANSGENIC MOUSE; UPREGULATION; WILD TYPE MOUSE; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CARCINOGENESIS; CELL PROLIFERATION; CHEMISTRY; COLON TUMOR; COMPLICATION; DRUG EFFECTS; HUMAN; METABOLISM; PATHOLOGY; TUMOR CELL CULTURE;

ANIMALS; BETA CATENIN; CARCINOGENESIS; CELL PROLIFERATION; COLITIS; COLONIC NEOPLASMS; CYCLOOXYGENASE 2; FATTY ACIDS, OMEGA-3; GENE EXPRESSION REGULATION; HUMANS; HYDROXYPROSTAGLANDIN DEHYDROGENASES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NF-KAPPA B; TUMOR CELLS, CULTURED;

EID: 84994056098     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.11544     Document Type: Article

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