Mechanisms of resistance and sensitivity to anti-HER2 therapies in HER2+ breast cancer

Oncotarget

Volumn 7, Issue 39, 2016, Pages 64431-64446

  Gagliato, Debora de Melo ^a   Jardim, Denis Leonardo Fontes ^a   Marchesi, Mario Sergio Pereira ^b   Hortobagyi, Gabriel N ^c  

^a Instituto de Oncologia do Paraná   (Brazil)

^b Roche Pharmaceuticals SA   (Brazil)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Anti HER2 therapy; Breast cancer; HER2 disease; Resistance to treatment; Trastuzumab

Indexed keywords

8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; ALPELISIB; BUPARLISIB; CANERTINIB; CAPECITABINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERLOTINIB; EVEROLIMUS; FORETINIB; LAPATINIB; LETROZOLE; MAMMALIAN TARGET OF RAPAMYCIN; NAVELBINE; NERATINIB; PACLITAXEL; PERTUZUMAB; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PILARALISIB; PLACEBO; PROTEIN KINASE B; RAS PROTEIN; SARACATINIB; SCATTER FACTOR RECEPTOR; SOMATOMEDIN C RECEPTOR; TRASTUZUMAB; TRASTUZUMAB EMTANSINE; UNINDEXED DRUG; ANTINEOPLASTIC AGENT; ERBB2 PROTEIN, HUMAN; IGF1R PROTEIN, HUMAN; MET PROTEIN, HUMAN; MTOR PROTEIN, HUMAN; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PIK3CA PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE; SOMATOMEDIN RECEPTOR; TARGET OF RAPAMYCIN KINASE; TUMOR MARKER;

BREAST CANCER; CANCER ADJUVANT THERAPY; CANCER PROGNOSIS; CANCER RESISTANCE; CANCER STAGING; CANCER SURVIVAL; CARDIOPULMONARY INSUFFICIENCY; CLINICAL EFFECTIVENESS; DISEASE FREE SURVIVAL; DRUG PROTEIN BINDING; EPIDERMAL GROWTH FACTOR RECEPTOR 2 POSITIVE BREAST CANCER; GENE AMPLIFICATION; HUMAN; IMMUNE RESPONSE; LUNG EDEMA; LUNG EMBOLISM; NONHUMAN; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PNEUMONIA; PROGRESSION FREE SURVIVAL; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; RESPIRATORY FAILURE; REVIEW; TREATMENT DURATION; TREATMENT RESPONSE; ANIMAL; ANTAGONISTS AND INHIBITORS; BREAST TUMOR; DRUG RESISTANCE; ENZYMOLOGY; FEMALE; GENETICS; METABOLISM; MOLECULARLY TARGETED THERAPY; MORTALITY; TREATMENT OUTCOME;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BIOMARKERS, TUMOR; BREAST NEOPLASMS; CLASS I PHOSPHATIDYLINOSITOL 3-KINASES; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; MOLECULAR TARGETED THERAPY; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-MET; RECEPTOR, ERBB-2; RECEPTORS, SOMATOMEDIN; SRC-FAMILY KINASES; TOR SERINE-THREONINE KINASES; TREATMENT OUTCOME;

EID: 84994045501     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.7043     Document Type: Review

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