The basic biology of HER2

Annals of Oncology

Volumn 12, Issue SUPPL. 1, 2001, Pages

  Rubin, I ^a   Yarden, Y ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Breast cancer; HER2 (erbB 2, neu); Network; Signal transduction; Tumor growth; Tyrosine phosphorylation

Indexed keywords

CELL SURFACE RECEPTOR; DIMER; EPIDERMAL GROWTH FACTOR RECEPTOR; HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 1; HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 3; HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 4; LIGAND; MONOCLONAL ANTIBODY; MONOMER; TRASTUZUMAB; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOLOGY; BREAST CANCER; BREAST TUMOR; CANCER THERAPY; CARCINOGENICITY; CELL DIFFERENTIATION; CELL GROWTH; CELL SURFACE; CONTROLLED STUDY; DIMERIZATION; GENE OVEREXPRESSION; LIGAND BINDING; NONHUMAN; ONCOGENE NEU; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; SIGNAL TRANSDUCTION;

EID: 0034869825     PISSN: 09237534     EISSN: None     Source Type: Journal    
DOI: 10.1093/annonc/12.suppl_1.S3     Document Type: Article

References (40)

1. Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts
2. Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene
3. Amplification of a novel v-erb B-related gene in a human mammary carcinoma
4. The biology of erb B-2/neu/HER-2 and its role in cancer
5. Biochemical and clinical implications of the ErbB/HER signaling network of growth factor receptors
6. Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
7. The HER-2/neu oncogene in breast cancer: Prognostic factor, predictive factor, and target for therapy
8. The ErbB-2/HER2 oncogenic receptor of adenocarcinomas: From orphanhood to multiple stromal ligands
9. Receptor protein-kinases and their signal transduction pathways
10. The ErbB signaling network in embryogenesis and oncogenesis: Signal diversification through combinatorial ligand-receptor interactions
11. ErbB tyrosine kinases and the two neuregulin families constitute a ligand-receptor network
12. Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions
13. Differential expression of NDF/neuregulin receptors ErbB-3 and ErbB-4 and involvement in inhibition of neuronal differentiation
14. Development and characterization of a rhuMAb HER2 antibody assay for clinical evaluation of cytotoxic potency
15. Neuregulins and their receptors: A versatile signaling module in organogenesis and oncogenesis
16. A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor
17. Pathogenic poxviruses reveal viral strategies to exploit the ErbB signaling network
18. The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors
19. Bivalence of EGF-like ligands drives the ErbB signaling network
20. ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: Implications for breast cancer
21. Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin
22. All ErbB receptors other than the epidermal growth factor receptor are endocytosis impaired
23. Insect cell-expressed p180ErbB3 possesses an impaired tyrosine kinase activity
24. The carboxyl terminus of the kinase-defective neuregulin receptor ErbB-3 confers mitogenic superiority and dictates endocytic routing
25. Down-modulation of an oncogene protein product and reversion of the transformed phenotype by monoclonal antibodies
26. Mechanistic aspects of the opposing effects of monoclonal antibodies to the ERBB2 receptor on tumor growth
27. Suppression and promotion of tumor growth by monoclonal antibodies to ErbB-2 differentially correlate with cellular uptake
28. Therapy of an animal model of human gastric cancer using a combination of anti-erbB-2 monoclonal antibodies
29. c-Cb1: A regulator of T-cell receptor-mediated signaling
30. c-Cb1/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor
31. Coupling of the c-Cb1 protooncogene product to ErbB-1/EGF-receptor but not to other ErbB proteins
32. Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cb1/Sli-1
33. Alternative intracellular routing of ErbB receptors may determine signaling potency
34. Detection and quantitation of HER-2/neu gene amplification in human breast cancer archival material using fluorescence in situ hybridization
35. Overexpression of the c-erbB-2 oncoprotein in human breast carcinomas: Immunohistological assessment correlates with gene amplification
36. Studies of the HER-2/neu protooncogene in human breast and ovarian cancer
37. Neu overexpression correlates with extent of disease in large-cell ductal in situ carcinoma of the breast
38. HER2 antibody for human cancer therapy
39. Recombinant humanized anti-HER2 antibody (Herceptin™) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts
40. Antibody to HER-2/neu receptor blocks DNA repair after cisplatin in human breast and ovarian cancer cells