EGFR oligomerization organizes kinase-active dimers into competent signalling platforms

Nature Communications

Volumn 7, Issue , 2016, Pages

  Needham, Sarah R ^a   Roberts, Selene K ^a   Arkhipov, Anton ^b   Mysore, Venkatesh P ^b   Tynan, Christopher J ^a   Zanetti Domingues, Laura C ^a   Kim, Eric T ^b   Losasso, Valeria ^c   Korovesis, Dimitrios ^a   Hirsch, Michael ^a   Rolfe, Daniel J ^a   Clarke, David T ^a   Winn, Martyn D ^c   Lajevardipour, Alireza ^d   Clayton, Andrew H A ^d   Pike, Linda J ^e   Perani, Michela ^f   Parker, Peter J ^f,g   Shan, Yibing ^b   Shaw, David E ^b,h   Martin Fernandez, Marisa L ^a   more..

^a Science and Technology Facilities Council   (United Kingdom)

^b D E SHAW RESEARCH   (United States)

^c DARESBURY LABORATORY   (United Kingdom)

^d SWINBURNE UNIVERSITY OF TECHNOLOGY   (Australia)

^e WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f KING'S COLLEGE LONDON   (United Kingdom)

^g THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^h Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIMER; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; LIGAND; OLIGOMER; PHOSPHOTRANSFERASE; PROTEIN KINASE C;

CHEMICAL BINDING; CONCENTRATION (COMPOSITION); ENZYME ACTIVITY; GENE EXPRESSION; LIGAND; MOLECULAR ANALYSIS;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; BINDING SITE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIMERIZATION; FEMALE; FLUORESCENCE RESONANCE ENERGY TRANSFER; FLUOROMETRY; FLUOROPHORE LOCALIZATION IMAGING WITH PHOTOBLEACHING; LIGAND BINDING; MOLECULAR DYNAMICS; NONHUMAN; OLIGOMERIZATION; PREDICTION; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RECEPTOR BINDING; RECEPTOR DOWN REGULATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STRUCTURAL MODEL; ANIMAL; ARTIFACT; CHEMISTRY; CHO CELL LINE; CRICETULUS; HAMSTER; METABOLISM; PHOSPHORYLATION; PROTEIN DOMAIN; PROTEIN MULTIMERIZATION;

ANIMALS; ARTIFACTS; BINDING SITES; CHO CELLS; CRICETINAE; CRICETULUS; EPIDERMAL GROWTH FACTOR; FLUORESCENCE RESONANCE ENERGY TRANSFER; LIGANDS; MOLECULAR DYNAMICS SIMULATION; PHOSPHORYLATION; PROTEIN DOMAINS; PROTEIN MULTIMERIZATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION;

EID: 84994036884     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms13307     Document Type: Article

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