Growth inhibitory effect of paratocarpin E, a prenylated chalcone isolated from Euphorbia humifusa Wild., by induction of autophagy and apoptosis in human breast cancer cells

Bioorganic Chemistry

Volumn 69, Issue , 2016, Pages 121-128

  Gao, Suyu ^a   Sun, Dejuan ^a   Wang, Guan ^a   Zhang, Jin ^a   Jiang, Yingnan ^a   Li, Guoyu ^b   Zhang, Ke ^b   Wang, Lei ^a   Huang, Jian ^a   Chen, Lixia ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b SHIHEZI UNIVERSITY   (China)

Author keywords

Apoptosis; Autophagy; Breast cancer; Euphorbia humifusa Wild.; Paratocarpin E

Indexed keywords

ANTINEOPLASTIC AGENT; APIGENIN; BECLIN 1; CASPASE 8; CASPASE 9; CYTOCHROME C; FAS ANTIGEN; FLUOROURACIL; HYPOLAETIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KAEMPFEROL; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PARATOCARPIN E; PROTEIN BAX; PROTEIN BCL 2; QUERCETIN; UNCLASSIFIED DRUG; CHALCONE DERIVATIVE;

769 P CELL LINE; 786 O CELL LINE; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; BREAST CANCER; CANCER INHIBITION; CONTROLLED STUDY; DRUG MECHANISM; EUPHORBIA; EUPHORBIA HUMIFUSA; HL 60 CELL LINE; HUMAN; HUMAN CELL; KIDNEY CELL; MCF 7 CELL LINE; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; U937 CELL LINE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; ISOLATION AND PURIFICATION; STRUCTURE ACTIVITY RELATION; TUMOR CELL CULTURE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; AUTOPHAGY; CELL PROLIFERATION; CHALCONES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; EUPHORBIA; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84994034545     PISSN: 00452068     EISSN: 10902120     Source Type: Journal    
DOI: 10.1016/j.bioorg.2016.10.005     Document Type: Article

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