Hepatoprotective effect of Cichorium intybus L., a traditional Uighur medicine, against carbon tetrachloride-induced hepatic fibrosis in rats

World Journal of Gastroenterology

Volumn 20, Issue 16, 2014, Pages 4753-4760

  Li, Guo Yu ^a,b   Gao, Hong Ying ^c   Huang, Jian ^c   Lu, Jin ^c   Gu, Jing Kai ^a   Wang, Jin Hui ^b,c  

^a JILIN UNIVERSITY   (China)

^b SHIHEZI UNIVERSITY   (China)

^c SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Carbon tetrachloride; Cichorium intybus l. extract; Hepatic fibrosis; Traditional uighur medicine

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CARBON TETRACHLORIDE; CICHORIUM INTYBUS EXTRACT; FU FANG BIE JIA RUAN GAN PIAN; GLUTATHIONE; HERBACEOUS AGENT; HYDROXYPROLINE; LAMININ; MALONALDEHYDE; PLANT EXTRACT; SUPEROXIDE DISMUTASE; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; ANTIOXIDANT; BIOLOGICAL MARKER;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHICORY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; LIVER FIBROSIS; LIVER FUNCTION; LIVER PROTECTION; NONHUMAN; RAT; TRADITIONAL MEDICINE; ULTRAVIOLET SPECTROPHOTOMETRY; ANIMAL; BLOOD; CELL PROTECTION; CHEMICALLY INDUCED; DOSE RESPONSE; DRUG EFFECTS; LIVER; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; MEDICINAL PLANT; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; PHYTOTHERAPY; TIME; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; BIOLOGICAL MARKERS; CARBON TETRACHLORIDE; CHICORY; CYTOPROTECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; LIVER; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; OXIDATIVE STRESS; PHYTOTHERAPY; PLANTS, MEDICINAL; RATS, WISTAR; TIME FACTORS;

EID: 84899647604     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v20.i16.4753     Document Type: Article

References (27)

1. Alloush GA, Belesky DP, Clapham WM, Forage Chicory: A Plant Resource for Nutrient-Rich Sites. J Agron Crop Sci 2003; 189: 96-104 [DOI: 10.1046/j.1439-037X.2003.00014.x]
2. Xu YM, Hu TM, Zhang CL, Wu HX, Yang YL. Anti-microbial Activities of the Extracts from Cichorium intybus L. Roots. Acta Bot Borea1 Occident Sin 2006; 26: 615-619
3. Mares D, Romagnoli C, Tosi B, Andreotti E, Chillemi G, Poli F. Chicory extracts from Cichorium intybus L. as potential antifungals. Mycopathologia 2005; 160: 85-91 [PMID: 16160773 DOI: 10.1007/s11046-004-6635-2]
4. Liu H, Wang Q, Liu Y, Chen G, Cui J. Antimicrobial and antioxidant activities of Cichorium intybus root extract using orthogonal matrix design. J Food Sci 2013; 78: M258-M263 [PMID: 23387896 DOI: 10.1111/1750-3841.12040]
5. Bischoff TA, Kelley CJ, Karchesy Y, Laurantos M, Nguyen- Dinh P, Arefi AG. Antimalarial activity of lactucin and lactucopicrin: sesquiterpene lactones isolated from Cichorium intybus L. J Ethnopharmacol 2004; 95: 455-457 [PMID: 15507374 DOI: 10.1016/j.jep.2004.06.031]
6. Heimler D, Isolani L, Vignolini P, Romani A. Polyphenol content and antiradical activity of Cichorium intybus L. from biodynamic and conventional farming. Food Chem 2009; 114: 765-770 [DOI: 10.1016/j.foodchem.2008.10.010]
7. Rasmussen MK, Klausen CL, Ekstrand B. Regulation of cytochrome P450 mRNA expression in primary porcine hepatocytes by selected secondary plant metabolites from chicory (Cichorium intybus L.). Food Chem 2014; 146: 255-263 [DOI: 10.1016/j.foodchem.2013.09.068]
8. Petrovic J, Stanojkovic A, Comic Lj, Curcic S. Antibacterial activity of Cichorium intybus. Fitoterapia 2004; 75: 737-739 [PMID: 15567253 DOI: 10.1016/j.fitote.2004.05.001]
9. Pushparaj PN, Low HK, Manikandan J, Tan BK, Tan CH. Anti-diabetic effects of Cichorium intybus in streptozotocininduced diabetic rats. J Ethnopharmacol 2007; 111: 430-434 [PMID: 17197141 DOI: 10.1016/j.jep.2006.11.028]
10. Kim JH, Mun YJ, Woo WH, Jeon KS, An NH, Park JS. Effects of the ethanol extract of Cichorium intybus on the immunotoxicity by ethanol in mice. Int Immunopharmacol 2002; 2: 733-744 [PMID: 12095163 DOI: 10.1016/S1567-5769(02)00008-5]
11. Gilani AH, Janbaz KH. Evaluation of the liver protective potential of Cichorium intybus seed extract on Acetaminophen and CCl(4)-induced damage. Phytomedicine 1994; 1: 193-197 [PMID: 23195938 DOI: 10.1016/S0944-7113(11)80064-4]
12. Hassan HA, Yousef MI. Ameliorating effect of chicory (Cichorium intybus L.)-supplemented diet against nitrosamine precursors-induced liver injury and oxidative stress in male rats. Food Chem Toxicol 2010; 48: 2163-2169 [PMID: 20478349 DOI: 10.1016/j.fct.2010.05.023]
13. Ahmed B, Al-Howiriny TA, Siddiqui AB. Antihepatotoxic activity of seeds of Cichorium intybus. J Ethnopharmacol 2003; 87: 237-240 [PMID: 12860315 DOI: 10.1016/S0378-8741(03)00145-4]
14. Kong Y, Liu XQ, Zhang B. Effects of the Extract of Chicory on Serum Uric Acid and Lipid in the Quail with Hyperuricemia /Hypertriglyceridemia. Beijing Zhongyiyao Daxue Xuebao 2004; 27: 29-31
15. Azay-Milhau J, Ferrare K, Leroy J, Aubaterre J, Tournier M, Lajoix AD, Tousch D. Antihyperglycemic effect of a natural chicoric acid extract of chicory (Cichorium intybus L.): a comparative in vitro study with the effects of caffeic and ferulic acids. J Ethnopharmacol 2013; 150: 755-760 [PMID: 24126061 DOI: 10.1016/j.jep.2013.09.046]
16. Bais HP, Ravishankar GA. Cichorium intybus L.-cultivation, processing, utility, value addition and biotechnology, with an emphasis on current status and future prospects. J Sci Food Agric 2001; 81: 467-484 [DOI: 10.1002/jsfa.817]
17. Figueira GM, Park KJ, Brod FPR, Honorio SL. Evaluation of desorption isotherms, drying rates and inulin concentration of chicory roots (Cichorium intybus L.) with and without enzymatic inactivation. J Food Eng 2004; 63: 273-280 [DOI: 10.1016/j.jfoodeng.2003.06.001]
18. Kim TW, Yang KS. Antioxidative effects of cichorium intybus root extract on LDL (low density lipoprotein) oxidation. Arch Pharm Res 2001; 24: 431-436 [PMID: 11693546 DOI: 10.1007/BF02975190]
19. Cavin C, Delannoy M, Malnoe A, Debefve E, Touché A, Courtois D, Schilter B. Inhibition of the expression and activity of cyclooxygenase-2 by chicory extract. Biochem Biophys Res Commun 2005; 327: 742-749 [PMID: 15649409 DOI: 10.1016/j.bbrc.2004.12.061]
20. Gadgoli C, Mishra SH. Antihepatotoxic activity of Cichorium intybus. J Ethnopharmacol 1997; 58: 131-134 [PMID: 9406902 DOI: 10.1016/S0378-8741(97)00090-1]
21. Friedman SL. Mechanisms of disease: Mechanisms of hepatic fibrosis and therapeutic implications. Nat Clin Pract Gastroenterol Hepatol 2004; 1: 98-105 [PMID: 16265071 DOI: 10.1038/ncpgasthep0055]
22. Friedman SL, Roll FJ, Boyles J, Bissell DM. Hepatic lipocytes: the principal collagen-producing cells of normal rat liver. Proc Natl Acad Sci USA 1985; 82: 8681-8685 [PMID: 3909149 DOI: 10.1073/pnas.82.24.8681]
23. Friedman SL, Bansal MB. Reversal of hepatic fibrosis-fact or fantasy? Hepatology 2006; 43: S82-S88 [PMID: 16447275 DOI: 10.1002/hep.20974]
24. Ahmad A, Ahmad R. Understanding the mechanism of hepatic fibrosis and potential therapeutic approaches. Saudi J Gastroenterol 2012; 18: 155-167 [PMID: 22626794 DOI: 10.4103/1319-3767.96445]
25. Tsai CF, Hsu YW, Chen WK, Chang WH, Yen CC, Ho YC, Lu FJ. Hepatoprotective effect of electrolyzed reduced water against carbon tetrachloride-induced liver damage in mice. Food Chem Toxicol 2009; 47: 2031-2036 [PMID: 19477216 DOI: 10.1016/j.fct.2009.05.021]
26. Gao HY, Li GY, Lou MM, Li XY, Wei XY, Wang JH. Hepatoprotective effect of Matrine salvianolic acid B salt on Carbon Tetrachloride-Induced Hepatic Fibrosis. J Inflamm (Lond) 2012; 9: 16 [PMID: 22559721]
27. Zafar R, Mujahid Ali S. Anti-hepatotoxic effects of root and root callus extracts of Cichorium intybus L. J Ethnopharmacol 1998; 63: 227-231 [PMID: 10030727 DOI: 10.1016/S0378-8741(98)00087-7]