메뉴 건너뛰기




Volumn 8, Issue 42, 2016, Pages 28437-28447

Assessing the Immunosafety of Engineered Nanoparticles with a Novel in Vitro Model Based on Human Primary Monocytes

Author keywords

gold and silver nanoparticles; human primary monocytes; in vitro model; nanoimmunosafety; proteomics

Indexed keywords

BODY FLUIDS; CURRICULA; GOLD; METAL NANOPARTICLES; MOLECULAR BIOLOGY; NANOPARTICLES; NANOSTRUCTURED MATERIALS; PATHOLOGY; PHYSIOLOGICAL MODELS;

EID: 84994027728     PISSN: 19448244     EISSN: 19448252     Source Type: Journal    
DOI: 10.1021/acsami.6b06278     Document Type: Article
Times cited : (41)

References (62)
  • 2
    • 84876800337 scopus 로고    scopus 로고
    • Macrophage Biology in Development, Homeostasis and Disease
    • Wynn, T. A.; Chawla, A.; Pollard, J. W. Macrophage Biology in Development, Homeostasis and Disease Nature 2013, 496, 445-455 10.1038/nature12034
    • (2013) Nature , vol.496 , pp. 445-455
    • Wynn, T.A.1    Chawla, A.2    Pollard, J.W.3
  • 3
    • 80055109585 scopus 로고    scopus 로고
    • The Triggering of Apoptosis in Macrophages by Pristine Graphene through the MAPK and TGF-beta Signaling Pathways
    • Li, Y.; Liu, Y.; Fu, Y.; Wei, T.; Le Guyader, L.; Gao, G.; Liu, R. S.; Chang, Y. Z.; Chen, C. The Triggering of Apoptosis in Macrophages by Pristine Graphene through the MAPK and TGF-beta Signaling Pathways Biomaterials 2012, 33, 402-411 10.1016/j.biomaterials.2011.09.091
    • (2012) Biomaterials , vol.33 , pp. 402-411
    • Li, Y.1    Liu, Y.2    Fu, Y.3    Wei, T.4    Le Guyader, L.5    Gao, G.6    Liu, R.S.7    Chang, Y.Z.8    Chen, C.9
  • 4
    • 84555197147 scopus 로고    scopus 로고
    • Interaction of Nanoparticles with Immunocompetent Cells: Nanosafety Considerations
    • Boraschi, D.; Costantino, L.; Italiani, P. Interaction of Nanoparticles with Immunocompetent Cells: Nanosafety Considerations Nanomedicine 2012, 7, 121-131 10.2217/nnm.11.169
    • (2012) Nanomedicine , vol.7 , pp. 121-131
    • Boraschi, D.1    Costantino, L.2    Italiani, P.3
  • 7
    • 19944401541 scopus 로고    scopus 로고
    • Surface Plasmon Resonance Scattering and Absorption of Anti-EGFR Antibody Conjugated Gold Nanoparticles in Cancer Diagnostics: Applications in Oral Cancer
    • El-Sayed, I. H.; Huang, X.; El-Sayed, M. A. Surface Plasmon Resonance Scattering and Absorption of Anti-EGFR Antibody Conjugated Gold Nanoparticles in Cancer Diagnostics: Applications in Oral Cancer Nano Lett. 2005, 5, 829-834 10.1021/nl050074e
    • (2005) Nano Lett. , vol.5 , pp. 829-834
    • El-Sayed, I.H.1    Huang, X.2    El-Sayed, M.A.3
  • 12
    • 84863338085 scopus 로고    scopus 로고
    • Mesoporous Silica-Coated Gold Nanorods as a Light-Mediated Multifunctional Theranostic Platform for Cancer Treatment
    • Zhang, Z.; Wang, L.; Wang, J.; Jiang, X.; Li, X.; Hu, Z.; Ji, Y.; Wu, X.; Chen, C. Mesoporous Silica-Coated Gold Nanorods as a Light-Mediated Multifunctional Theranostic Platform for Cancer Treatment Adv. Mater. 2012, 24, 1418-1423 10.1002/adma.201104714
    • (2012) Adv. Mater. , vol.24 , pp. 1418-1423
    • Zhang, Z.1    Wang, L.2    Wang, J.3    Jiang, X.4    Li, X.5    Hu, Z.6    Ji, Y.7    Wu, X.8    Chen, C.9
  • 13
    • 50649113474 scopus 로고    scopus 로고
    • Biodistribution of Colloidal Gold Nanoparticles after Intravenous Administration: Effect of Particle Size
    • Sonavane, G.; Tomoda, K.; Makino, K. Biodistribution of Colloidal Gold Nanoparticles after Intravenous Administration: Effect of Particle Size Colloids Surf., B 2008, 66, 274-280 10.1016/j.colsurfb.2008.07.004
    • (2008) Colloids Surf., B , vol.66 , pp. 274-280
    • Sonavane, G.1    Tomoda, K.2    Makino, K.3
  • 14
    • 79960132035 scopus 로고    scopus 로고
    • The Effect of Sedimentation and Diffusion on Cellular Uptake of Gold Nanoparticles
    • Cho, E. C.; Zhang, Q.; Xia, Y. The Effect of Sedimentation and Diffusion on Cellular Uptake of Gold Nanoparticles Nat. Nanotechnol. 2011, 6, 385-391 10.1038/nnano.2011.58
    • (2011) Nat. Nanotechnol. , vol.6 , pp. 385-391
    • Cho, E.C.1    Zhang, Q.2    Xia, Y.3
  • 15
    • 77955769029 scopus 로고    scopus 로고
    • Surface Chemistry and Aspect Ratio Mediated Cellular Uptake of Au Nanorods
    • Qiu, Y.; Liu, Y.; Wang, L.; Xu, L.; Bai, R.; Ji, Y.; Wu, X.; Zhao, Y.; Li, Y.; Chen, C. Surface Chemistry and Aspect Ratio Mediated Cellular Uptake of Au Nanorods Biomaterials 2010, 31, 7606-7619 10.1016/j.biomaterials.2010.06.051
    • (2010) Biomaterials , vol.31 , pp. 7606-7619
    • Qiu, Y.1    Liu, Y.2    Wang, L.3    Xu, L.4    Bai, R.5    Ji, Y.6    Wu, X.7    Zhao, Y.8    Li, Y.9    Chen, C.10
  • 16
    • 67749137301 scopus 로고    scopus 로고
    • Cytotoxicity and Immunological Response of Gold and Silver Nanoparticles of Different Sizes
    • Yen, H. J.; Hsu, S. h.; Tsai, C. L. Cytotoxicity and Immunological Response of Gold and Silver Nanoparticles of Different Sizes Small 2009, 5, 1553-1561 10.1002/smll.200900126
    • (2009) Small , vol.5 , pp. 1553-1561
    • Yen, H.J.1    Hsu, S.H.2    Tsai, C.L.3
  • 19
    • 77956274546 scopus 로고    scopus 로고
    • Toxicity and Cellular Uptake of Gold Nanoparticles: What We Have Learned so Far?
    • Alkilany, A. M.; Murphy, C. J. Toxicity and Cellular Uptake of Gold Nanoparticles: What We Have Learned So Far? J. Nanopart. Res. 2010, 12, 2313-2333 10.1007/s11051-010-9911-8
    • (2010) J. Nanopart. Res. , vol.12 , pp. 2313-2333
    • Alkilany, A.M.1    Murphy, C.J.2
  • 21
    • 57249095780 scopus 로고    scopus 로고
    • Silver Nanoparticles as a New Generation of Antimicrobials
    • Rai, M.; Yadav, A.; Gade, A. Silver Nanoparticles as a New Generation of Antimicrobials Biotechnol. Adv. 2009, 27, 76-83 10.1016/j.biotechadv.2008.09.002
    • (2009) Biotechnol. Adv. , vol.27 , pp. 76-83
    • Rai, M.1    Yadav, A.2    Gade, A.3
  • 23
    • 63449105617 scopus 로고    scopus 로고
    • Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells
    • AshaRani, P.; Low Kah Mun, G.; Hande, M. P.; Valiyaveettil, S. Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells ACS Nano 2009, 3, 279-290 10.1021/nn800596w
    • (2009) ACS Nano , vol.3 , pp. 279-290
    • AshaRani, P.1    Low Kah Mun, G.2    Hande, M.P.3    Valiyaveettil, S.4
  • 24
    • 67749088047 scopus 로고    scopus 로고
    • Studies on the Biocompatibility and the Interaction of Silver Nanoparticles with Human Mesenchymal Stem Cells (hMSCs)
    • Greulich, C.; Kittler, S.; Epple, M.; Muhr, G.; Köller, M. Studies on the Biocompatibility and the Interaction of Silver Nanoparticles with Human Mesenchymal Stem Cells (hMSCs) Langenbeck. Arch. Surg. 2009, 394, 495-502 10.1007/s00423-009-0472-1
    • (2009) Langenbeck. Arch. Surg. , vol.394 , pp. 495-502
    • Greulich, C.1    Kittler, S.2    Epple, M.3    Muhr, G.4    Köller, M.5
  • 25
    • 77955697820 scopus 로고    scopus 로고
    • Toxicity of Silver Nanoparticles Increases during Storage because of Slow Dissolution under Release of Silver Ions
    • Kittler, S.; Greulich, C.; Diendorf, J.; Koller, M.; Epple, M. Toxicity of Silver Nanoparticles Increases During Storage Because of Slow Dissolution under Release of Silver Ions Chem. Mater. 2010, 22, 4548-4554 10.1021/cm100023p
    • (2010) Chem. Mater. , vol.22 , pp. 4548-4554
    • Kittler, S.1    Greulich, C.2    Diendorf, J.3    Koller, M.4    Epple, M.5
  • 26
    • 68049090816 scopus 로고    scopus 로고
    • Oxidative Stress-Dependent Toxicity of Silver Nanoparticles in Human Hepatoma Cells
    • Kim, S.; Choi, J. E.; Choi, J.; Chung, K.-H.; Park, K.; Yi, J.; Ryu, D.-Y. Oxidative Stress-Dependent Toxicity of Silver Nanoparticles in Human Hepatoma Cells Toxicol. In Vitro 2009, 23, 1076-1084 10.1016/j.tiv.2009.06.001
    • (2009) Toxicol. in Vitro , vol.23 , pp. 1076-1084
    • Kim, S.1    Choi, J.E.2    Choi, J.3    Chung, K.-H.4    Park, K.5    Yi, J.6    Ryu, D.-Y.7
  • 27
    • 77649338980 scopus 로고    scopus 로고
    • Silver Nanoparticles Induce Cytotoxicity by a Trojan-Horse Type Mechanism
    • Park, E.-J.; Yi, J.; Kim, Y.; Choi, K.; Park, K. Silver Nanoparticles Induce Cytotoxicity by a Trojan-Horse Type Mechanism Toxicol. In Vitro 2010, 24, 872-878 10.1016/j.tiv.2009.12.001
    • (2010) Toxicol. in Vitro , vol.24 , pp. 872-878
    • Park, E.-J.1    Yi, J.2    Kim, Y.3    Choi, K.4    Park, K.5
  • 28
    • 84944097618 scopus 로고    scopus 로고
    • Impact of Storage Conditions and Storage Time on Silver Nanoparticles' Physicochemical Properties and Implications for Their Biological Effects
    • Izak-Nau, E.; Huk, A.; Reidy, B.; Uggerud, H.; Vadset, M.; Eiden, S.; Voetz, M.; Himly, M.; Duschl, A.; Dusinska, M.; Lynch, I. Impact of Storage Conditions and Storage Time on Silver Nanoparticles' Physicochemical Properties and Implications for Their Biological Effects RSC Adv. 2015, 5, 84172-84185 10.1039/C5RA10187E
    • (2015) RSC Adv. , vol.5 , pp. 84172-84185
    • Izak-Nau, E.1    Huk, A.2    Reidy, B.3    Uggerud, H.4    Vadset, M.5    Eiden, S.6    Voetz, M.7    Himly, M.8    Duschl, A.9    Dusinska, M.10    Lynch, I.11
  • 29
    • 84956907526 scopus 로고    scopus 로고
    • Endotoxin Contamination: A Key Element in the Interpretation of Nanosafety Studies
    • Li, Y.; Boraschi, D. Endotoxin Contamination: A Key Element in the Interpretation of Nanosafety Studies Nanomedicine 2016, 11, 269-287 10.2217/nnm.15.196
    • (2016) Nanomedicine , vol.11 , pp. 269-287
    • Li, Y.1    Boraschi, D.2
  • 33
    • 77955532199 scopus 로고    scopus 로고
    • Time Evolution of the Nanoparticle Protein Corona
    • Casals, E.; Pfaller, T.; Duschl, A.; Oostingh, G. J.; Puntes, V. Time Evolution of the Nanoparticle Protein Corona ACS Nano 2010, 4, 3623-3632 10.1021/nn901372t
    • (2010) ACS Nano , vol.4 , pp. 3623-3632
    • Casals, E.1    Pfaller, T.2    Duschl, A.3    Oostingh, G.J.4    Puntes, V.5
  • 34
    • 62649139025 scopus 로고    scopus 로고
    • Immunological and Inflammatory Functions of the Interleukin-1 Family
    • Dinarello, C. A. Immunological and Inflammatory Functions of the Interleukin-1 Family Annu. Rev. Immunol. 2009, 27, 519-550 10.1146/annurev.immunol.021908.132612
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 519-550
    • Dinarello, C.A.1
  • 35
    • 79960610118 scopus 로고    scopus 로고
    • Revigo Summarizes and Visualizes Long Lists of Gene Ontology Terms
    • Supek, F.; Bošnjak, M.; Škunca, N.; Šmuc, T. Revigo Summarizes and Visualizes Long Lists of Gene Ontology Terms PLoS One 2011, 6, e21800 10.1371/journal.pone.0021800
    • (2011) PLoS One , vol.6 , pp. e21800
    • Supek, F.1    Bošnjak, M.2    Škunca, N.3    Šmuc, T.4
  • 36
    • 79651474507 scopus 로고    scopus 로고
    • Problems and Challenges in the Development and Validation of Human Cell-Based Assays to Determine Nanoparticle-Induced Immunomodulatory Effects
    • Oostingh, G. J.; Casals, E.; Italiani, P.; Colognato, R.; Stritzinger, R.; Ponti, J.; Pfaller, T.; Kohl, Y.; Ooms, D.; Favilli, F. et al. Problems and Challenges in the Development and Validation of Human Cell-Based Assays to Determine Nanoparticle-Induced Immunomodulatory Effects Part. Fibre Toxicol. 2011, 8, 8 10.1186/1743-8977-8-8
    • (2011) Part. Fibre Toxicol. , vol.8 , pp. 8
    • Oostingh, G.J.1    Casals, E.2    Italiani, P.3    Colognato, R.4    Stritzinger, R.5    Ponti, J.6    Pfaller, T.7    Kohl, Y.8    Ooms, D.9    Favilli, F.10
  • 37
    • 64449083462 scopus 로고    scopus 로고
    • In Vitro Investigation of Immunomodulatory Effects Caused by Engineered Inorganic Nanoparticles-the Impact of Experimental Design and Cell Choice
    • Pfaller, T.; Puntes, V.; Casals, E.; Duschl, A.; Oostingh, G. J. In Vitro Investigation of Immunomodulatory Effects Caused by Engineered Inorganic Nanoparticles-the Impact of Experimental Design and Cell Choice Nanotoxicology 2009, 3, 46-59 10.1080/17435390802546071
    • (2009) Nanotoxicology , vol.3 , pp. 46-59
    • Pfaller, T.1    Puntes, V.2    Casals, E.3    Duschl, A.4    Oostingh, G.J.5
  • 38
    • 84894377473 scopus 로고    scopus 로고
    • Size-Dependent Cytotoxicity of Silver Nanoparticles in Human Lung Cells: The Role of Cellular Uptake, Agglomeration and Ag Release
    • Gliga, A. R.; Skoglund, S.; Odnevall Wallinder, I.; Fadeel, B.; Karlsson, H. L. Size-Dependent Cytotoxicity of Silver Nanoparticles in Human Lung Cells: The Role of Cellular Uptake, Agglomeration and Ag Release Part. Fibre Toxicol. 2014, 11, 11 10.1186/1743-8977-11-11
    • (2014) Part. Fibre Toxicol. , vol.11 , pp. 11
    • Gliga, A.R.1    Skoglund, S.2    Odnevall Wallinder, I.3    Fadeel, B.4    Karlsson, H.L.5
  • 39
    • 84864435661 scopus 로고    scopus 로고
    • Cellular Uptake, Intracellular Trafficking and Cytotoxicity of Silver Nanoparticles
    • Singh, R. P.; Ramarao, P. Cellular Uptake, Intracellular Trafficking and Cytotoxicity of Silver Nanoparticles Toxicol. Lett. 2012, 213, 249-259 10.1016/j.toxlet.2012.07.009
    • (2012) Toxicol. Lett. , vol.213 , pp. 249-259
    • Singh, R.P.1    Ramarao, P.2
  • 40
    • 31944451232 scopus 로고    scopus 로고
    • Toxic Potential of Materials at the Nanolevel
    • Nel, A.; Xia, T.; Mädler, L.; Li, N. Toxic Potential of Materials at the Nanolevel Science 2006, 311, 622-627 10.1126/science.1114397
    • (2006) Science , vol.311 , pp. 622-627
    • Nel, A.1    Xia, T.2    Mädler, L.3    Li, N.4
  • 41
    • 84864684976 scopus 로고    scopus 로고
    • Blood-Nanoparticle Interactions and in Vivo Biodistribution: Impact of Surface PEG and Ligand Properties
    • Shah, N. B.; Vercellotti, G. M.; White, J. G.; Fegan, A.; Wagner, C. R.; Bischof, J. C. Blood-Nanoparticle Interactions and in Vivo Biodistribution: Impact of Surface PEG and Ligand Properties Mol. Pharmaceutics 2012, 9, 2146-2155 10.1021/mp200626j
    • (2012) Mol. Pharmaceutics , vol.9 , pp. 2146-2155
    • Shah, N.B.1    Vercellotti, G.M.2    White, J.G.3    Fegan, A.4    Wagner, C.R.5    Bischof, J.C.6
  • 43
    • 43849098061 scopus 로고    scopus 로고
    • Cytokine Induction by Pyrogens: Comparison of Whole Blood, Mononuclear Cells, and TLR-Transfectants
    • Kikkert, R.; De Groot, E. R.; Aarden, L. A. Cytokine Induction by Pyrogens: Comparison of Whole Blood, Mononuclear Cells, and TLR-Transfectants J. Immunol. Methods 2008, 336, 45-55 10.1016/j.jim.2008.03.010
    • (2008) J. Immunol. Methods , vol.336 , pp. 45-55
    • Kikkert, R.1    De Groot, E.R.2    Aarden, L.A.3
  • 44
    • 84994007841 scopus 로고    scopus 로고
    • Bacterial Endotoxin Binds to the Surface of Gold Nanoparticles and Triggers Inflammation
    • Antalya, Turkey, Apr. 23-26, 2014; International Nanotoxicology Congress
    • Li, Y.; Tran, N.; Puntes, V. F.; Boraschi, D. Bacterial Endotoxin Binds to the Surface of Gold Nanoparticles and Triggers Inflammation. 7th International Nanotoxicology Congress-NanoTox 2014, Antalya, Turkey, Apr. 23-26, 2014; International Nanotoxicology Congress, 2014; p 142.
    • (2014) 7th International Nanotoxicology Congress - NanoTox 2014 , pp. 142
    • Li, Y.1    Tran, N.2    Puntes, V.F.3    Boraschi, D.4
  • 45
    • 0034659784 scopus 로고    scopus 로고
    • M-1/M-2 Macrophages and the Th1/Th2 Paradigm
    • Mills, C. D.; Kincaid, K.; Alt, J. M.; Heilman, M. J.; Hill, A. M. M-1/M-2 Macrophages and the Th1/Th2 Paradigm J. Immunol. 2000, 164, 6166-6173 10.4049/jimmunol.164.12.6166
    • (2000) J. Immunol. , vol.164 , pp. 6166-6173
    • Mills, C.D.1    Kincaid, K.2    Alt, J.M.3    Heilman, M.J.4    Hill, A.M.5
  • 47
    • 85191983349 scopus 로고    scopus 로고
    • From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation
    • Italiani, P.; Boraschi, D. From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation Front. Immunol. 2014, 5, 514 10.3389/fimmu.2014.00514
    • (2014) Front. Immunol. , vol.5 , pp. 514
    • Italiani, P.1    Boraschi, D.2
  • 48
    • 84941742533 scopus 로고    scopus 로고
    • The Interleukin (IL)-1 Cytokine Family-Balance between Agonists and Antagonists in Inflammatory Diseases
    • Palomo, J.; Dietrich, D.; Martin, P.; Palmer, G.; Gabay, C. The Interleukin (IL)-1 Cytokine Family-Balance between Agonists and Antagonists in Inflammatory Diseases Cytokine 2015, 76, 25-37 10.1016/j.cyto.2015.06.017
    • (2015) Cytokine , vol.76 , pp. 25-37
    • Palomo, J.1    Dietrich, D.2    Martin, P.3    Palmer, G.4    Gabay, C.5
  • 49
    • 77949780454 scopus 로고    scopus 로고
    • A Review of the in Vivo and in Vitro Toxicity of Silver and Gold Particulates: Particle Attributes and Biological Mechanisms Responsible for the Observed Toxicity
    • Johnston, H. J.; Hutchison, G.; Christensen, F. M.; Peters, S.; Hankin, S.; Stone, V. A Review of the in Vivo and in Vitro Toxicity of Silver and Gold Particulates: Particle Attributes and Biological Mechanisms Responsible for the Observed Toxicity Crit. Rev. Toxicol. 2010, 40, 328-346 10.3109/10408440903453074
    • (2010) Crit. Rev. Toxicol. , vol.40 , pp. 328-346
    • Johnston, H.J.1    Hutchison, G.2    Christensen, F.M.3    Peters, S.4    Hankin, S.5    Stone, V.6
  • 50
    • 79951921750 scopus 로고    scopus 로고
    • Biodistribution and Toxicity of Engineered Gold Nanoparticles: A Review of in Vitro and in Vivo Studies
    • Khlebtsov, N.; Dykman, L. Biodistribution and Toxicity of Engineered Gold Nanoparticles: A Review of in Vitro and in Vivo Studies Chem. Soc. Rev. 2011, 40, 1647-1671 10.1039/C0CS00018C
    • (2011) Chem. Soc. Rev. , vol.40 , pp. 1647-1671
    • Khlebtsov, N.1    Dykman, L.2
  • 51
    • 77958088616 scopus 로고    scopus 로고
    • Unexpected Toxicity of Monolayer Protected Gold Clusters Eliminated by PEG-Thiol Place Exchange Reactions
    • Simpson, C. A.; Huffman, B. J.; Gerdon, A. E.; Cliffel, D. E. Unexpected Toxicity of Monolayer Protected Gold Clusters Eliminated by PEG-Thiol Place Exchange Reactions Chem. Res. Toxicol. 2010, 23, 1608-1616 10.1021/tx100209t
    • (2010) Chem. Res. Toxicol. , vol.23 , pp. 1608-1616
    • Simpson, C.A.1    Huffman, B.J.2    Gerdon, A.E.3    Cliffel, D.E.4
  • 52
    • 84873720901 scopus 로고    scopus 로고
    • In Vivo Toxicity, Biodistribution, and Clearance of Glutathione-Coated Gold Nanoparticles
    • Simpson, C. A.; Salleng, K. J.; Cliffel, D. E.; Feldheim, D. L. In Vivo Toxicity, Biodistribution, and Clearance of Glutathione-Coated Gold Nanoparticles Nanomedicine (N. Y., NY, U. S.) 2013, 9, 257-263 10.1016/j.nano.2012.06.002
    • (2013) Nanomedicine (N. Y., NY, U. S.) , vol.9 , pp. 257-263
    • Simpson, C.A.1    Salleng, K.J.2    Cliffel, D.E.3    Feldheim, D.L.4
  • 53
    • 80655145977 scopus 로고    scopus 로고
    • Biodistribution and Acute Toxicity of Naked Gold Nanoparticles in a Rabbit Hepatic Tumor Model
    • Glazer, E. S.; Zhu, C.; Hamir, A. N.; Borne, A.; Thompson, C. S.; Curley, S. A. Biodistribution and Acute Toxicity of Naked Gold Nanoparticles in a Rabbit Hepatic Tumor Model Nanotoxicology 2011, 5, 459-468 10.3109/17435390.2010.516026
    • (2011) Nanotoxicology , vol.5 , pp. 459-468
    • Glazer, E.S.1    Zhu, C.2    Hamir, A.N.3    Borne, A.4    Thompson, C.S.5    Curley, S.A.6
  • 54
    • 77953958484 scopus 로고    scopus 로고
    • Biodistribution of PEG-Modified Gold Nanoparticles Following Intratracheal Instillation and Intravenous Injection
    • Lipka, J.; Semmler-Behnke, M.; Sperling, R. A.; Wenk, A.; Takenaka, S.; Schleh, C.; Kissel, T.; Parak, W. J.; Kreyling, W. G. Biodistribution of PEG-Modified Gold Nanoparticles Following Intratracheal Instillation and Intravenous Injection Biomaterials 2010, 31, 6574-6581 10.1016/j.biomaterials.2010.05.009
    • (2010) Biomaterials , vol.31 , pp. 6574-6581
    • Lipka, J.1    Semmler-Behnke, M.2    Sperling, R.A.3    Wenk, A.4    Takenaka, S.5    Schleh, C.6    Kissel, T.7    Parak, W.J.8    Kreyling, W.G.9
  • 57
    • 84858317747 scopus 로고    scopus 로고
    • In Vivo Genotoxicity of Silver Nanoparticles after 90-Day Silver Nanoparticle Inhalation Exposure
    • Kim, J. S.; Sung, J. H.; Ji, J. H.; Song, K. S.; Lee, J. H.; Kang, C. S.; Yu, I. J. In Vivo Genotoxicity of Silver Nanoparticles after 90-Day Silver Nanoparticle Inhalation Exposure SH W 2011, 2, 34-38 10.5491/SHAW.2011.2.1.34
    • (2011) SH W , vol.2 , pp. 34-38
    • Kim, J.S.1    Sung, J.H.2    Ji, J.H.3    Song, K.S.4    Lee, J.H.5    Kang, C.S.6    Yu, I.J.7
  • 58
    • 84929742910 scopus 로고    scopus 로고
    • Optimising the Use of Commercial Lal Assays for the Analysis of Endotoxin Contamination in Metal Colloids and Metal Oxide Nanoparticles
    • Li, Y.; Italiani, P.; Casals, E.; Tran, N.; Puntes, V. F.; Boraschi, D. Optimising the Use of Commercial Lal Assays for the Analysis of Endotoxin Contamination in Metal Colloids and Metal Oxide Nanoparticles Nanotoxicology 2015, 9, 462-473 10.3109/17435390.2014.948090
    • (2015) Nanotoxicology , vol.9 , pp. 462-473
    • Li, Y.1    Italiani, P.2    Casals, E.3    Tran, N.4    Puntes, V.F.5    Boraschi, D.6
  • 59
    • 17344392308 scopus 로고    scopus 로고
    • A New Mathematical Model for Relative Quantification in Real-Time RT-PCR
    • Pfaffl, M. W. A New Mathematical Model for Relative Quantification in Real-Time RT-PCR Nucleic Acids Res. 2001, 29, e45 10.1093/nar/29.9.e45
    • (2001) Nucleic Acids Res. , vol.29 , pp. e45
    • Pfaffl, M.W.1
  • 60
    • 0003126516 scopus 로고    scopus 로고
    • Fast Optimal Leaf Ordering for Hierarchical Clustering
    • Bar-Joseph, Z.; Gifford, D. K.; Jaakkola, T. S. Fast Optimal Leaf Ordering for Hierarchical Clustering Bioinformatics 2001, 17, S22-S29 10.1093/bioinformatics/17.suppl-1.S22
    • (2001) Bioinformatics , vol.17 , pp. S22-S29
    • Bar-Joseph, Z.1    Gifford, D.K.2    Jaakkola, T.S.3
  • 61
    • 0030669030 scopus 로고    scopus 로고
    • Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale
    • DeRisi, J. L.; Iyer, V. R.; Brown, P. O. Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale Science 1997, 278, 680-686 10.1126/science.278.5338.680
    • (1997) Science , vol.278 , pp. 680-686
    • DeRisi, J.L.1    Iyer, V.R.2    Brown, P.O.3
  • 62
    • 79960366540 scopus 로고    scopus 로고
    • Prediction of Metabolic Pathways from Genome-Scale Metabolic Networks
    • Faust, K.; Croes, D.; van Helden, J. Prediction of Metabolic Pathways from Genome-Scale Metabolic Networks BioSystems 2011, 105, 109-121 10.1016/j.biosystems.2011.05.004
    • (2011) BioSystems , vol.105 , pp. 109-121
    • Faust, K.1    Croes, D.2    Van Helden, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.