Exploring the Catalytic Mechanism of Human Glutamine Synthetase by Computer Simulations

Biochemistry

Volumn 55, Issue 42, 2016, Pages 5907-5916

  Issoglio, Federico M ^a   Campolo, Nicolas ^b   Zeida, Ari ^a   Grune, Tilman ^b,c   Radi, Rafael ^b   Estrin, Dario A ^a   Bartesaghi, Silvina ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b DEPARTAMENTO DE BIOQUÍMICA   (Uruguay)

^c GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; AMMONIA; CATALYSIS; ENERGY BARRIERS; MOLECULAR DYNAMICS; MOLECULAR MODELING; QUANTUM THEORY; REACTION INTERMEDIATES; REACTION KINETICS; THERMODYNAMICS;

ACID-BASE EQUILIBRIA; CATALYTIC MECHANISMS; CLASSICAL MOLECULAR DYNAMICS; GLUTAMINE SYNTHETASE; POST-TRANSLATIONAL MODIFICATIONS; QUANTUM MECHANICS/MOLECULAR MECHANICS; REACTION FREE ENERGY; THERMODYNAMICS AND KINETICS;

FREE ENERGY;

AMMONIA; ENZYME; GAMMA GLUTAMYL PHOSPHATE; GLUTAMATE AMMONIA LIGASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; COMPUTER SIMULATION; ENZYME STRUCTURE; HUMAN; MOLECULAR DYNAMICS; NITROGEN METABOLISM; NUCLEOPHILICITY; PRIORITY JOURNAL; QUANTUM MECHANICS; REACTION ANALYSIS;

EID: 84993953607     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.6b00822     Document Type: Article

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