Hyperammonemia in gene-targeted mice lacking functional hepatic glutamine synthetase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 17, 2015, Pages 5521-5526

  Qvartskhava, Natalia ^a   Lang, Philipp A ^a   Görg, Boris ^a   Pozdeev, Vitaly I ^a   Ortiz, Marina Pascual ^a   Lang, Karl S ^b   Bidmon, Hans J ^a   Lang, Elisabeth ^a   Leibrock, Christina B ^c   Herebian, Diran ^a   Bode, Johannes G ^a   Lang, Florian ^c   Häussinger, Dieter ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Glutamine; Hepatic encephalopathy; Metabolic zonation; Oxidative stress; RNA oxidation

Indexed keywords

AMMONIA; GLUTAMATE AMMONIA LIGASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN TISSUE; CEREBELLUM; CONTROLLED STUDY; GENE DELETION; HEPATIC ENCEPHALOPATHY; HIPPOCAMPUS; HOMEOSTASIS; HYPERAMMONEMIA; IN VIVO STUDY; LIFESPAN; LIVER CELL; LIVER METABOLISM; LOCOMOTION; LOXP SITE; MICROGLIA; MOUSE; NITRATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PYRIFORM CORTEX; SOMATOSENSORY CORTEX; UREA CYCLE; UREA CYCLE DISORDER; UREA NITROGEN BLOOD LEVEL; ANIMAL; ANIMAL BEHAVIOR; BRAIN; DISEASE MODEL; ENZYMOLOGY; GENE TARGETING; GENETICS; KNOCKOUT MOUSE; LIVER; MEMORY; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY;

MUS;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN; DISEASE MODELS, ANIMAL; GENE TARGETING; GLUTAMATE-AMMONIA LIGASE; HYPERAMMONEMIA; LIVER; LOCOMOTION; MEMORY; MICE; MICE, KNOCKOUT; OXIDATIVE STRESS;

EID: 84928536699     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1423968112     Document Type: Article

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