Molecular Mechanisms of Glutamine Synthetase Mutations that Lead to Clinically Relevant Pathologies

PLoS Computational Biology

Volumn 12, Issue 2, 2016, Pages

  Frieg, Benedikt ^a   Görg, Boris ^a   Homeyer, Nadine ^a   Keitel, Verena ^a   Häussinger, Dieter ^a   Gohlke, Holger ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANTIBODIES; BINDING ENERGY; FREE ENERGY; MOLECULAR DYNAMICS; STABILITY;

ATP-BINDING; BRAIN MALFORMATION; CATALYSE; CATALYTIC CYCLES; DIRECT INTERACTIONS; DYNAMICS SIMULATION; FREE-ENERGY CALCULATIONS; GLUTAMINE SYNTHETASE; MEDIATED INTERACTION; MOLECULAR MECHANISM;

CATALYST ACTIVITY;

ADENOSINE TRIPHOSPHATE; AMINO ACID DERIVATIVE; ARGININE; CYSTEINE; EPITOPE; GLUTAMATE AMMONIA LIGASE; GLUTAMATE AMMONIA LIGASE ANTIBODY; GLUTAMIC ACID; METHIONINE SULFOXIMINE; MONOCLONAL ANTIBODY; MUTANT PROTEIN; SERINE; UNCLASSIFIED DRUG; PROTEIN BINDING;

APO GENE; ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME STRUCTURE; GENE MUTATION; GENETIC DISORDER; GENETIC TRANSFECTION; HEK293 CELL LINE; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; MOLECULAR MODEL; MOLECULAR PATHOLOGY; MUTATIONAL ANALYSIS; PREDICTION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SIMULATION; CHEMISTRY; DEFICIENCY; DISORDERS OF AMINO ACID AND PROTEIN METABOLISM; GENETICS; METABOLISM; MOLECULAR DYNAMICS; MUTATION;

ADENOSINE TRIPHOSPHATE; AMINO ACID METABOLISM, INBORN ERRORS; GLUTAMATE-AMMONIA LIGASE; HEK293 CELLS; HUMANS; MOLECULAR DYNAMICS SIMULATION; MUTATION; PROTEIN BINDING;

EID: 84959467438     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1004693     Document Type: Article

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