Moderate Exercise Improves Immunity and Decreases Illness Rates

American Journal of Lifestyle Medicine

Volumn 5, Issue 4, 2011, Pages 338-345

  Nieman, David C ^a  

^a APPALACHIAN STATE UNIVERSITY   (United States)

Author keywords

inflammation; natural killer cells; neutrophils; physical activity; upper respiratory tract infection

Indexed keywords

EID: 84993682682     PISSN: 15598276     EISSN: None     Source Type: Journal    
DOI: 10.1177/1559827610392876     Document Type: Review

References (65)

1. National Institute of Allergy and Infectious Diseases. The common cold fact sheet. http://www.3.niaid.nih.gov/topics/commonCold. Accessed November 9, 2009.
2. Fendrick AM, Monto AS, Nightengale B., Sarnes M. The economic burden of non-influenza-related viral respiratory tract infection in the United States. Arch Intern Med 2003;163: 487-494.
3. Monto AS Epidemiology of viral respiratory infections. Am J Med. 2002; 112(6A):4S-12S.
4. Cohen S. Keynote Presentation at the Eight International Congress of Behavioral Medicine: the Pittsburgh common cold studies: psychosocial predictors of susceptibility to respiratory infectious illness. Int J Behav Med. 2005; 12: 123-131.
5. Spiegel K., Sheridan JF, Van Cauter E. Effect of sleep deprivation on response to immunization. JAMA. 2002; 288: 1471-1472.
6. Cohen S., Doyle WJ, Alper CM, Janicki-Deverts D., Turner RB Sleep habits and susceptibility to the common cold. Arch Intern Med. 2009; 169: 62-67.
7. Wolvers DA, van Herpen-Broekmans WM, Logman MH, van der Wielen RP, Albers R. Effect of a mixture of micronutrients, but not of bovine colostrum concentrate, on immune function parameters in healthy volunteers: a randomized placebo-controlled study. Nutr J. 2006; 5: 28.
8. Nieman DC Immune function responses to ultramarathon race competition. Med Sportiva 2009; 13: 189-96.
9. Shephard RJ, Kavanagh T., Mertens DJ, Qureshi S., Clark M. Personal health benefits of Masters athletics competition. Br J Sports Med. 1995; 29: 35-40.
10. Davis JM, Kohut ML, Colbert LH, Jackson DA, Ghaffar A., Mayer EP Exercise, alveolar macrophage function, and susceptibility to respiratory infection. J Appl Physiol. 1997; 83: 1461-1466.
11. Matthews CE, Ockene IS, Freedson PS, Rosal MC, Merriam PA, Hebert JR Moderate to vigorous physical activity and risk of upper-respiratory tract infection. Med Sci Sports Exerc. 2002; 34: 1242-1248.
12. Kostka T., Praczko K. Interrelationship between physical activity, symptomatology of upper respiratory tract infections, and depression in elderly people. Gerontology. 2007; 53: 187-193.
13. Kostka T., Drygas W., Jegier A., Praczko K. Physical activity and upper respiratory tract infections. Int J Sports Med. 2008; 29: 158-162.
14. Strasner A., Barlow CE, Kampert JB, Dunn AL Impact of physical activity on URTI symptoms in Project PRIME participants. Med Sci Sports Exerc. 2001; 33(suppl):S304.
15. Nieman DC, Henson DA, Austin MD, Sha W. Upper respiratory tract infection is reduced in physically fit and active adults. Br J Sports Med. In press.
16. Barrett B., Brown R., Mundt M., et al. The Wisconsin Upper Respiratory Symptom Survey is responsive, reliable, and valid. J Clin Epidemiol. 2005;58: 609-617.
17. Neuman MI, Willett WC, Curhan GC Physical activity and the risk of community-acquired pneumonia in US women. Am J Med. 2010; 123: 281.e7-281.e11.
18. Nieman DC, Nehlsen-Cannarella SL, Markoff PA, et al. The effects of moderate exercise training on natural killer cells and acute upper respiratory tract infections. Int J Sports Med. 1990; 11: 467-473.
19. Nieman DC, Nehlsen-Cannarella SL, Henson DA, et al. Immune response to exercise training and/or energy restriction in obese women. Med Sci Sports Exerc. 1998;30: 679-686.
20. Chubak J., McTiernan A., Sorensen B., et al. Moderate-intensity exercise reduces the incidence of colds among postmenopausal women. Am J Med. 2006; 119: 937-942.
21. Nehlsen-Cannarella SL, Nieman DC, Jessen J., et al. The effects of acute moderate exercise on lymphocyte function and serum immunoglobulins. Int J Sports Med. 1991; 12: 391-398.
22. Nieman DC Exercise effects on systemic immunity. Immunol Cell Biol. 2000; 78: 496-501.
23. Nieman DC, Nehlsen-Cannarella SL The immune response to exercise. Semin Hematol. 1994; 31: 166-179.
24. Nieman DC, Henson DA, Austin MD, Brown VA The immune response to a 30-minute walk. Med Sci Sports Exerc. 2005; 37: 57-62.
25. Murphy DA, Davis JM, Brown AS, et al. Role of lung macrophages on susceptibility to respiratory infection following short-term moderate exercise training. Am J Physiol Regul Integr Comp Physiol. 2004; 287: R1354-R1358.
26. Edwards DM, Burns VE, Reynolds T., Carroll D., Drayson M., Ring C. Acute stress exposure prior to influenza vaccination enhances antibody response in women. Brain Behav Immun. 2006;20: 159-168.
27. Kohut ML, Arntson BA, Lee W., et al. Moderate exercise improves antibody response to influenza immunization in older adults. Vaccine. 2004; 22: 2298-2306.
28. Kohut ML, Lee W., Martin A., et al. The exercise-induced enhancement of influenza immunity is mediated in part by improvements in psychosocial factors in older adults. Brain Behav Immun. 2005; 19: 357-366.
29. Lowder T., Padgett DA, Woods JA Moderate exercise early after influenza virus infection reduces the Th1 inflammatory response in lungs of mice. Exerc Immunol Rev. 2006; 12: 97-111.
30. Weinberger B., Herndler-Brandstetter D., Schwanninger A., et al. Biology of immune response to vaccines in elderly persons. Clin Infect Dis. 2008; 46: 1078-1084.
31. Pawelec G., Larbi A. Immunity and aging in man: annual review 2006/2007. Exp Gerontol. 2008; 43: 34-38.
32. Targonski PV, Jacobson RM Immunosenescence: role and measurement in influenza vaccine response among the elderly. Vaccine. 2007; 25: 3066-3069.
33. Gruver AL, Hudson LL, Sempowski GD Immunosenescence of aging. J Pathol. 2007; 211: 144-156.
34. Chakravarti B., Abraham GM Aging and T-cell-mediated immunity. Mech Ageing Dev. 1999; 108: 183-206.
35. Vitetta L., Anton B. Lifestyle and nutrition, caloric restriction, mitochondrial health and hormones: scientific interventions for anti-aging. Clin Interv Aging. 2007; 2: 537-543.
36. Aw D., Silva AB, Palmer DB Immunosenescence: emerging challenges for an aging population. Immunology. 2007; 120: 435-446.
37. Haase H., Mocchegiani E., Rink L. Correlation between zinc status and immune function in the elderly. Biogerontology. 2006; 7: 421-428.
38. Meydani SN, Han SN, Wu D. Vitamin E and immune response in the aged: molecular mechanisms and clinical implications. Immunol Rev. 2005; 205: 269-284.
39. Nieman DC, Henson DA Role of endurance exercise in immune senescence. Med Sci Sports Exerc. 1994; 26: 172-181.
40. Henson DA, Nieman DC, Pistilli EE, et al. Influence of carbohydrate and age on lymphocyte function following a marathon. Int J Sport Nutr Exerc Metab. 2004; 14: 308-322.
41. Kohut ML, Senchina DA Reversing age-associated immunosenescence via exercise. Exerc Immunol Rev. 2004; 10: 6-41.
42. Shinkai S., Kohno H., Kimura K., et al. Physical activity and immune senescence in men. Med Sci Sports Exerc. 1995; 27: 1516-1526.
43. Keylock KT, Lowder T., Leifheit KA, et al. Higher antibody, but not cell-mediated, responses to vaccination in high physically fit elderly. J Appl Physiol. 2007; 102: 1090-1098.
44. Nieman DC, Henson DA, Gusewitch G., et al. Physical activity and immune function in elderly women. Med Sci Sports Exerc. 1993; 25: 823-831.
45. Nieman DC Immune function. In: Gisolfi CV, Lamb DR, Nadel E, eds. Exercise in Older Adults. Carmel, IN: Cooper Publishing Group; 1995: 435-461. Perspectives in Exercise Science and Sports Medicine; vol 8.
46. Kohut ML, McCann DA, Russell DW, et al. Aerobic exercise, but not flexibility/resistance exercise, reduces serum IL-18, CRP, and IL-6 independent of beta-blockers, BMI, and psychosocial factors in older adults. Brain Behav Immun. 2006; 20: 201-209.
47. Senchina DA, Kohut ML Immunological outcomes of exercise in older adults. Clin Interv Aging. 2007; 2: 3-16.
48. Flynn MG, Fahlman M., Braun WA, et al. Effects of resistance training on selected indexes of immune function in elderly women. J Appl Physiol. 1999; 86: 1905-1913.
49. Woods JA, Ceddia MA, Wolters BW, Evans JK, Lu Q., McAuley E. Effects of 6 months of moderate aerobic exercise training on immune function in the elderly. Mech Ageing Dev. 1999; 109: 1-19.
50. Bruunsgaard H., Jensen MS, Schjerling P., et al. Exercise induces recruitment of lymphocytes with an activated phenotype and short telomeres in young and elderly humans. Life Sci. 1999;65: 2623-2633.
51. Ceddia MA, Price EA, Kohlmeier CK, et al. Differential leukocytosis and lymphocyte mitogenic response to acute maximal exercise in the young and old. Med Sci Sports Exerc. 1999; 31: 829-836.
52. Fiatarone MA, Morley JE, Bloom ET, Benton D., Solomon GF, Makinodan T. The effect of exercise on natural killer cell activity in young and old subjects. J Gerontol. 1989; 44: M37-M45.
53. Khansari N., Shakiba Y., Mahmoudi M. Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer. Recent Pat Inflamm Allergy Drug Discov. 2009; 3: 73-80.
54. Devaraj S., Valleggi S., Siegel D., Jialal I. Role of C-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome. Curr Atheroscler Rep. 2010; 12: 110-118.
55. Pearson TA, Mensah GA, Alexander RW, et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation. 2003; 107: 499-511.
56. Hsu FC, Kritchevsky SB, Liu Y., et al. Association between inflammatory components and physical function in the health, aging, and body composition study: a principal component analysis approach. J Gerontol A Biol Sci Med Sci. 2009;64: 581-589.
57. Lavoie ME, Rabasa-Lhoret R., Doucet E., et al. Association between physical activity energy expenditure and inflammatory markers in sedentary overweight and obese women. Int J Obes (Lond). 2010; 34: 1387-1395.
58. Beavers KM, Brinkley TE, Nicklas BJ Effect of exercise training on chronic inflammation. Clin Chim Acta. 2010; 411: 785-793.
59. Ford ES Does exercise reduce inflammation? Physical activity and C-reactive protein among U.S. adults. Epidemiology. 2002;13: 561-568.
60. Borodulin K., Laatikainen T., Salomaa V., Jousilahti P. Associations of leisure time physical activity, self-rated physical fitness, and estimated aerobic fitness with serum C-reactive protein among 3,803 adults. Atherosclerosis. 2006; 185: 381-387.
61. Shanely RA, Jin F., Henson DA, Knab AM, Sha W., Nieman DA Self-reported physical fitness and activity are predictive of decreased inflammation and oxidative stress. Med Sci Sports Exerc. In press.
62. Dekker MJ, Lee S., Hudson R., et al. An exercise intervention without weight loss decreases circulating interleukin-6 in lean and obese men with and without type 2 diabetes mellitus. Metabolism. 2007; 56: 332-338.
63. Petersen AM, Pedersen BK The anti-inflammatory effect of exercise. J Appl Physiol. 2005; 98: 1154-1162.
64. Ryan AS, Nicklas BJ Reductions in plasma cytokine levels with weight loss improve insulin sensitivity in overweight and obese postmenopausal women. Diabetes Care. 2004; 27: 1699-1705.
65. Ferrier KE, Nestel P., Taylor A., Drew BC, Kingwell BA Diet but not aerobic exercise training reduces skeletal muscle TNFalpha in overweight humans. Diabetologia. 2004; 47: 630-637.