Effect of a mixture of micronutrients, but not of bovine colostrum concentrate, on immune function parameters in healthy volunteers: A randomized placebo-controlled study

Nutrition Journal

Volumn 5, Issue 1, 2006, Pages

  Wolvers, Danielle A W ^a   Van Herpen Broekmans, Wendy M R ^a   Logman, Margot H G M ^a   Van Der Wielen, Reggy P J ^a   Albers, Ruud ^a  

^a UNILEVER RESEARCH VLAARDINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; BETA CAROTENE; PLACEBO; TYPHUS VACCINE; ZINC;

ADULT; AGED; ARTICLE; CATTLE; CELLULAR IMMUNITY; CLINICAL TRIAL; COLOSTRUM; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; IMMUNE RESPONSE; IMMUNITY; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MALE; NUTRITIONAL STATUS; OXIDATIVE STRESS; PARAMETER; PHAGOCYTOSIS; RANDOMIZED CONTROLLED TRIAL; TETANUS; TYPHOID FEVER; VACCINATION;

ADULT; AGED; AGED, 80 AND OVER; AGING; ANIMALS; ASCORBIC ACID; BETA CAROTENE; CATTLE; CELL PROLIFERATION; COLOSTRUM; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYPERSENSITIVITY, DELAYED; IMMUNITY; LEUKOCYTE COUNT; LYMPHOCYTES; MALE; MICRONUTRIENTS; MIDDLE AGED; PHAGOCYTOSIS; TETANUS TOXOID; TYPHOID-PARATYPHOID VACCINES; VACCINATION; VITAMIN E;

BOS TAURUS;

EID: 33845510496     PISSN: None     EISSN: 14752891     Source Type: Journal    
DOI: 10.1186/1475-2891-5-28     Document Type: Article

References (45)

1. Field CJ, Johnson IR, Schley PD: Nutrients and their role in host resistance to infection. J Leukoc Biol 2002, 71:16-32.
2. de la Fuente M, Ferrandez MD, Burgos MS, Soler A, Prieto A, Miquel J: Immune function in aged women is improved by ingestion of vitamins C and E. Can J Physiol Pharmacol 1998, 76:373-380.
3. Jayachandran M, Rani PJA, Arivazhagan P, Panneerselvam C: Neutrophil phagocytic function and humoral immune response with reference to ascorbate supplementation in aging humans. JOURNAL OF ANTI-AGING MEDICINE 2000, 3:37.
4. Anderson R, Oosthuizen R, Maritz R, Theron A, Van Rensburg AJ: The effects of increasing weekly doses of ascorbate on certain cellular and humoral immune functions in normal volunteers. Am J Clin Nutr 1980, 33:71-76.
5. Nieman DC, Henson DA, Butterworth DE, Warren BJ, Davis JM, Fagoaga OR, Nehlsen-Cannarella SL: Vitamin C supplementation does not alter the immune response to 2.5 hours of running. International Journal Of Sport Nutrition 1997, 7:173-184.
6. Delafuente JC, Prendergast JM, Modigh A: Immunologic modulation by vitamin C in the elderly. Int J Immunopharmacol 1986, 8:205-211.
7. Nieman DC, Henson DA, McAnulty SR, McAnulty L, Swick NS, Utter AC, Vinci DM, Opiela SJ, Morrow JD: Influence of vitamin C supplementation on oxidative and immune changes after an ultramarathon. J Appl Physiol 2002, 92:1970-1977.
8. Meydani SN, Meydani M, Blumberg JB, Leka LS, Siber G, Loszewski R, Thompson C, Pedrosa MC, Diamond RD, Stollar BD: Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trial. JAMA 1997, 277:1380-1386.
9. Pallast EG, Schouten EG, De Waart FG, Fonk HC, Doekes G, von Blomberg BM, Kok FJ: Effect of 50- and 100-mg vitamin E supplements on cellular immune function in noninstitutionalized elderly persons. Am J Clin Nutr 1999, 69:1273-1281.
10. Chew BP, Park JS: Carotenoid action on the immune response. J Nutr 2004, 134:257S-261S.
11. Santos MS, Meydani SN, Leka L, Wu D, Fotouhi N, Meydani M, Hennekens CH, Gaziano JM: Natural killer cell activity in elderly men is enhanced by beta- carotene supplementation. Am J Clin Nutr 1996, 64:772-777.
12. Santos MS, Gaziano JM, Leka LS, Beharka AA, Hennekens CH, Meydani SN: Beta-carotene-induced enhancement of natural killer cell activity in elderly men: an investigation of the role of cytokines. Am J Clin Nutr 1998, 68:164-170.
13. Santos MS, Leka LS, Ribaya-Mercado JD, Russell RM, Meydani M, Hennekens CH, Gaziano JM, Meydani SN: Short- and long-term beta-carotene supplementation do not influence T cell-mediated immunity in healthy elderly persons. Am J Clin Nutr 1997, 66:917-924.
14. Bogden JD, Oleske JM, Lavenhar MA, Munves EM, Kemp FW, Bruening KS, Holding KJ, Denny TN, Guarino MA, Krieger LM: Zinc and immunocompetence in elderly people: effects of zinc supplementation for 3 months. Am J Clin Nutr 1988, 48:655-663.
15. Bogden JD, Oleske JM, Lavenhar MA, Munves EM, Kemp FW, Bruening KS, Holding KJ, Denny TN, Guarino MA, Holland BK: Effects of one year of supplementation with zinc and other micronutrients on cellular immunity in the elderly. J Am Coll Nutr 1990, 9:214-225.
16. Fortes C, Forastiere F, Agabiti N, Fano V, Pacifici R, Virgili F, Piras G, Guidi L, Bartoloni C, Tricerri A, Zuccaro P, Ebrahim S, Perucci CA: The effect of zinc and vitamin A supplementation on immune response in an older population. J Am Geriatr Soc 1998, 46:19-26.
17. Duchateau J, Delepesse G, Vrijens R, Collet H: Beneficial effects of oral zinc supplementation on the immune response of old people. Am J Med 1981, 70:1001-1004.
18. Provinciali M, Montenovo A, Di Stefano G, Colombo M, Daghetta L, Cairati M, Veroni C, Cassino R, Della TF, Fabris N: Effect of zinc or zinc plus arginine supplementation on antibody titre and lymphocyte subsets after influenza vaccination in elderly subjects: a randomized controlled trial. Age Ageing 1998, 27:715-722.
19. Playford RJ, Macdonald CE, Johnson WS: Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders. Am J Clin Nutr 2000, 72:5-14.
20. Gill HS, Doull F, Rutherfurd KJ, Cross ML: Immunoregulatory peptides in bovine milk. Br J Nutr 2000, 84 Suppl 1:S111-S117.
21. Korhonen H, Marnila P, Pihlanto LA, Ryhanen EL: Bioactive components of milk: natural ingredients for health promotion. Innovations-in-Food-Technology; 2001, 10:23-27.
22. Sugisawa H, Itou T, Sakai T: Promoting effect of colostrum on the phagocytic activity of bovine polymorphonuclear leukocytes in vitro. BIOLOGY OF THE NEONATE 2001, 79:140.
23. Loimaranta V, Nuutila J, Marnila P, Tenovuo J, Korhonen H, Lilius EM: Colostral proteins from cows immunised with Streptococcus mutans/S. sobrinus support the phagocytosis and killing of mutans streptococci by human leucocytes. J Med Microbiol 1999, 48:917-926.
24. He F, Tuomola E, Arvilommi H, Salminen S: Modulation of human humoral immune response through orally administered bovine colostrum. FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY 2001, 31:93.
25. Albers R, Antoine JM, Bourdet-Sicard R, Calder PC, Gleeson M, Lesourd B, Samartin S, Sanderson IR, Van Loo J, Vas Dias FW, Watzl B: Markers to measure immunomodulation in human nutrition intervention studies. Br J Nutr 2005, 94:452-481.
26. Viret JF, Favre D, Wegmuller B, Herzog C, Que JU, Cryz SJ Jr., Lang AB: Mucosal and systemic immune responses in humans after primary and booster immunizations with orally administered invasive and noninvasive live attenuated bacteria. Infect Immun 1999, 67:3680-3685.
27. Herraiz LA, Hsieh WC, Parker RS, Swanson JE, Bendich A, Roe DA: Effect of UV exposure and beta-carotene supplementation on delayed-type hypersensitivity response in healthy older men. J Am Coll Nutr 1998, 17:617-624.
28. Shell-Duncan B, Wood JW: The evaluation of delayed-type hypersensitivity responsiveness and nutritional status as predictors of gastro-intestinal and acute respiratory infection: a prospective field study among traditional nomadic Kenyan children. J Trop Pediatr 1997, 43:25-32.
29. Christou NV, Tellado-Rodriguez J, Chartrand L, Giannas B, Kapadia B, Meakins J, Rode H, Gordon J: Estimating mortality risk in preoperative patients using immunologic, nutritional, and acute-phase response variables. Ann Surg 1989, 210:69-77.
30. Nakayama K, Monma M, Fukushima T, Ohrui T, Sasaki H: Tuberculin responses and risk of pneumonia in immobile elderly patients. Thorax 2000, 55:867-869.
31. Blatt SP, Hendrix CW, Butzin CA, Freeman TM, Ward WW, Hensley RE, Melcher GP, Donovan DJ, Boswell RN: Delayed-type hypersensitivity skin testing predicts progression to AIDS in HIV-infected patients. Ann Intern Med 1993, 119:177-184.
32. Graat JM, Schouten EG, Kok FJ: Effect of daily vitamin e and multivitamin-mineral supplementation on acute respiratory tract infections in elderly persons: a randomized controlled trial. JAMA 2002, 288:715-721.
33. Meydani SN, Leka LS, Fine BC, Dallal GE, Keusch GT, Singh MF, Hamer DH: Vitamin E and respiratory tract infections in elderly nursing home residents: a randomized controlled trial. JAMA 2004, 292:828-836.
34. Hamer M, Wolvers D, Albers R: Using stress models to evaluate immuno-modulating effects of nutritional intervention in healthy individuals. J Am Coll Nutr 2004, 23:637-646.
35. Ahluwalia N, Mastro AM, Ball R, Miles MP, Rajendra R, Handte G: Cytokine production by stimulated mononuclear cells did not change with aging in apparently healthy, well-nourished women. Mech Ageing Dev 2001, 122:1269-1279.
36. Krause D, Mastro AM, Handte G, Smiciklas-Wright H, Miles MP, Ahluwalia N: Immune function did not decline with aging in apparently healthy, well-nourished women. Mech Ageing Dev 1999, 112:43-57.
37. Daudu PA, Kelley DS, Taylor PC, Burri BJ, Wu MM: Effect of a low beta-carotene diet on the immune functions of adult women. Am J Clin Nutr 1994, 60:969-972.
38. Hughes DA, Wright AJ, Finglas PM, Peerless AC, Bailey AL, Astley SB, Pinder AC, Southon S: The effect of beta-carotene supplementation on the immune function of blood monocytes from healthy male nonsmokers. J Lab Clin Med 1997, 129:309-317.
39. A.J. H, W.N. C: Lipi-based vehicles for the oral delivery of poorly water soluble drugs. Advanced Drug Delivery Reviews 1997, 25:103-128.
40. MacGregor KJ, Embleton JK, Lacy JE: Influence of lipolysis on drug absorption from the gastrointestinal tract. Advanced Drug Delivery Reviews 1997, 25:33-46.
41. O'Driscoll CM: Lipid-based formulations for intestinal lymphatic delivery. Eur J Pharm Sci 2002, 15:405-415.
42. Pouton CW: Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems. Eur J Pharm Sci 2000, 11 Suppl 2:S93-S98.
43. Sugisawa H, Itou T, Ichimura Y, Sakai T: Bovine milk enhances the oxidative burst activity of polymorphonuclear leukocytes in low concentrations. J Vet Med Sci 2002, 64:1113-1116.
44. Brinkworth GD, Buckley JD: Concentrated bovine colostrum protein supplementation reduces the incidence of self-reported symptoms of upper respiratory tract infection in adult males. Eur J Nutr 2003, 42:228-232.
45. Mero A, Miikkulainen H, Riski J, Pakkanen R, Aalto J, Takala T: Effects of bovine colostrum supplementation on serum IGF-I, IgG, hormone, and saliva IgA during training. J Appl Physiol 1997, 83:1144-1151.