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Volumn , Issue , 2008, Pages 228-247

Serotonin Receptor Modulators

Author keywords

Agonists; Functional dyspepsia; Gut motor disorders; Myenteric ganglia; Serotonin receptor modulators

Indexed keywords


EID: 84992738200     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470760307.ch18     Document Type: Chapter
Times cited : (1)

References (138)
  • 1
    • 4644251659 scopus 로고
    • Ricerche sul secreto delle cellule ente-rocromaffini. IX. Intorno alla natura chimica della sostanza specifica
    • Vialli M, Erspamer V. Ricerche sul secreto delle cellule ente-rocromaffini. IX. Intorno alla natura chimica della sostanza specifica. Boll Soc Med Chir Pavia 1937; 51:1111-30.
    • (1937) Boll Soc Med Chir Pavia , vol.51 , pp. 1111-1130
    • Vialli, M.1    Erspamer, V.2
  • 2
    • 0001894877 scopus 로고
    • Serotonin modulation of gastrointestinal motility
    • Gaginella TS, Galligan JJ, eds, Boca Raton: CRC Press
    • Tonini M, De Ponti F. Serotonin modulation of gastrointestinal motility. In: Gaginella TS, Galligan JJ, eds. Serotonin and Gastrointestinal Function. Boca Raton: CRC Press, 1995: 53-84.
    • (1995) Serotonin and Gastrointestinal Function. , pp. 53-84
    • Tonini, M.1    De Ponti, F.2
  • 3
    • 0001471321 scopus 로고
    • The effect of intraluminal application of 5-hydroxytryptamine and 5-hydroxytryptophan on peristalsis: the local production of 5-HT and its release in relation to intraluminal pressure and propulsive activity
    • Biilbring E, Lin RCY. The effect of intraluminal application of 5-hydroxytryptamine and 5-hydroxytryptophan on peristalsis: the local production of 5-HT and its release in relation to intraluminal pressure and propulsive activity. J Physiol (Land) 1958; 140: 381-98.
    • (1958) J Physiol (Land) , vol.140 , pp. 381-398
    • Biilbring, E.1    Lin, R.C.Y.2
  • 4
    • 0002716935 scopus 로고
    • The release of 5-hydroxytryptamine in relation to pressure exerted on the intestinal mucosa
    • Biilbring E, Crema A. The release of 5-hydroxytryptamine in relation to pressure exerted on the intestinal mucosa. J Physiol (Lond) 1959; 146: 18-28.
    • (1959) J Physiol (Lond) , vol.146 , pp. 18-28
    • Biilbring, E.1    Crema, A.2
  • 5
    • 0014136866 scopus 로고
    • 5-hydroxytryptamine participation in the vagal inhibitory innervation of the stomach
    • Biilbring E, Gershon MD. 5-hydroxytryptamine participation in the vagal inhibitory innervation of the stomach. J Physiol (Lond) 1967; 192: 23-6.
    • (1967) J Physiol (Lond) , vol.192 , pp. 23-26
    • Biilbring, E.1    Gershon, M.D.2
  • 6
    • 0346732962 scopus 로고    scopus 로고
    • Re-screening serotonin receptors for genetic variants identifies population and molecular genetic complexity
    • Glatt CE, Tampilic M, Christie C, DeYoung J, Freimer NB. Re-screening serotonin receptors for genetic variants identifies population and molecular genetic complexity. Am J Med Genet 2004; 124B: 92-100.
    • (2004) Am J Med Genet , vol.124 B , pp. 92-100
    • Glatt, C.E.1    Tampilic, M.2    Christie, C.3    DeYoung, J.4    Freimer, N.B.5
  • 7
    • 0038339428 scopus 로고    scopus 로고
    • Serotonin availability is increased in mucosa of guinea pigs with TNBS-induced colitis
    • Linden DR, Chen JX, Gershon MD, Sharkey KA, Mawe GM. Serotonin availability is increased in mucosa of guinea pigs with TNBS-induced colitis. Am] Physiol 2003; 285: G207-16.
    • (2003) Am] Physiol , vol.285 , pp. G207-16
    • Linden, D.R.1    Chen, J.X.2    Gershon, M.D.3    Sharkey, K.A.4    Mawe, G.M.5
  • 8
    • 2942525747 scopus 로고    scopus 로고
    • Molecular de-fects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and IBS
    • Coates MD, Mahoney CR, Linden DR et al. Molecular de-fects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and IBS. Gastroenterology 2004; 126: 1657-64.
    • (2004) Gastroenterology , vol.126 , pp. 1657-1664
    • Coates, M.D.1    Mahoney, C.R.2    Linden, D.R.3
  • 9
    • 0036325415 scopus 로고    scopus 로고
    • Serotonin-transporter polymorphism pharmacogenetics in diarrhea-predominant irritable bowel syndrome
    • Camilleri M, Atanasova E, Carlson PJ et al. Serotonin-transporter polymorphism pharmacogenetics in diarrhea-predominant irritable bowel syndrome. Gastroenterology 2002;123:425-32.
    • (2002) Gastroenterology , vol.123 , pp. 425-432
    • Camilleri, M.1    Atanasova, E.2    Carlson, P.J.3
  • 10
    • 0029619510 scopus 로고
    • Gastrointestinal prokinetic benzamides: the pharmacology underlying stimulation of motility
    • Lo Briejer MR, Akkermans LM, Schuurkes JA. Gastrointestinal prokinetic benzamides: the pharmacology underlying stimulation of motility. Pharmacol Rev 1995; 47: 631-51.
    • (1995) Pharmacol Rev , vol.47 , pp. 631-651
    • Lo Briejer, M.R.1    Akkermans, L.M.2    Schuurkes, J.A.3
  • 11
    • 0028048885 scopus 로고
    • The importance of 5-hydroxytryptamine receptors in the gut
    • Read NW, Gwee KA. The importance of 5-hydroxytryptamine receptors in the gut. Pharmacol Ther 1994; 62: 159-73.
    • (1994) Pharmacol Ther , vol.62 , pp. 159-173
    • Read, N.W.1    Gwee, K.A.2
  • 12
    • 0000388842 scopus 로고
    • Electrophysiological studies of 5-hydroxytryptamine receptors on enteric neurons
    • Gaginella TS, Galligan JJ, eds, Boca Raton: CRC Press
    • Galligan J J. Electrophysiological studies of 5-hydroxytryptamine receptors on enteric neurons. In: Gaginella TS, Galligan JJ, eds. Serotonin and Gastrointestinal Function. Boca Raton: CRC Press, 1995: 109-26.
    • (1995) Serotonin and Gastrointestinal Function. , pp. 109-126
    • Galligan, J.J.1
  • 14
    • 0012245089 scopus 로고
    • Peripheral neural serotonin receptors: identification and characterization with specific antagonists and agonists
    • Mawe GM, Branchek TA, Gershon MD. Peripheral neural serotonin receptors: identification and characterization with specific antagonists and agonists. Proc Natl Acad Sci USA 1986; 83: 9799-803.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 9799-9803
    • Mawe, G.M.1    Branchek, T.A.2    Gershon, M.D.3
  • 15
    • 0028183017 scopus 로고
    • International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin)
    • Hoyer D, Clarke DE, Fozard JR et al. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol Rev 1994; 46: 157-203.
    • (1994) Pharmacol Rev , vol.46 , pp. 157-203
    • Hoyer, D.1    Clarke, D.E.2    Fozard, J.R.3
  • 16
    • 0029665567 scopus 로고    scopus 로고
    • 5-HT1A receptor-mediated inhibition of acetylcholine release from guinea pig myenteric plexus: potential mechanisms
    • Dietrich C, Kilbinger H. 5-HT1A receptor-mediated inhibition of acetylcholine release from guinea pig myenteric plexus: potential mechanisms. Neuropharmacology 1996; 35: 483-8.
    • (1996) Neuropharmacology , vol.35 , pp. 483-488
    • Dietrich, C.1    Kilbinger, H.2
  • 17
    • 0028973068 scopus 로고
    • Coexpression of 5-HT2A and 5-HT4 receptors coupled to distinct signaling pathways in human intestinal muscle cells
    • Kuemmerle JF, Murthy KS, Grider JR, Martin DC, Ma-khlouf GM. Coexpression of 5-HT2A and 5-HT4 receptors coupled to distinct signaling pathways in human intestinal muscle cells. Gastroenterology 1995; 109: 1791-800.
    • (1995) Gastroenterology , vol.109 , pp. 1791-1800
    • Kuemmerle, J.F.1    Murthy, K.S.2    Grider, J.R.3    Martin, D.C.4    Ma-khlouf, G.M.5
  • 18
    • 0032918751 scopus 로고    scopus 로고
    • Review article: clinical pharmacology models of irritable bowel syndrome
    • Malagelada JR. Review article: clinical pharmacology models of irritable bowel syndrome. Aliment Pharmacol Ther 1999; 13(Suppl.2): 57-64.
    • (1999) Aliment Pharmacol Ther , vol.13 , pp. 57-64
    • Malagelada, J.R.1
  • 19
    • 0031769521 scopus 로고    scopus 로고
    • Functional gut disorders: from motility to sensitivity disorders. A review of current and investigational drugs for their management
    • De Ponti F, Malagelada JR. Functional gut disorders: from motility to sensitivity disorders. A review of current and investigational drugs for their management. Pharmacol Ther 1998; 80: 49-88.
    • (1998) Pharmacol Ther , vol.80 , pp. 49-88
    • De Ponti, F.1    Malagelada, J.R.2
  • 20
    • 0030608788 scopus 로고    scopus 로고
    • Evidence for a 5-HT3 receptor involvement in the facilitation of peristalsis on mucosal application of 5-HT in the guinea pig isolated ileum
    • Tuladhar BR, Kaisar M, Naylor RJ. Evidence for a 5-HT3 receptor involvement in the facilitation of peristalsis on mucosal application of 5-HT in the guinea pig isolated ileum. Br J Pharmacol 1997; 122: 1174-8.
    • (1997) Br J Pharmacol , vol.122 , pp. 1174-1178
    • Tuladhar, B.R.1    Kaisar, M.2    Naylor, R.J.3
  • 21
    • 0032909949 scopus 로고    scopus 로고
    • Propulsion in guinea pig colon induced by 5-hydroxytryptamine (HT) via 5-HT4 and 5-HT3 receptors
    • Jin JG, Foxx-Orenstein AE, Grider JR. Propulsion in guinea pig colon induced by 5-hydroxytryptamine (HT) via 5-HT4 and 5-HT3 receptors. J Pharmacol Exp Ther 1999; 288: 93-7.
    • (1999) J Pharmacol Exp Ther , vol.288 , pp. 93-97
    • Jin, J.G.1    Foxx-Orenstein, A.E.2    Grider, J.R.3
  • 22
    • 0025786509 scopus 로고
    • Pharmacologic profile of (R)-5-[(l-methyl-3-indolyl)carbonyl]-4,5,6,7-tetrahy-dro-lH-benzimidazole hydrochloride (YM060), a potent and selective 5-hydroxytryptamine3 receptor antagonist, and its enantiomer in the isolated tissue
    • Miyata K, Kamato T, Nishida A et al. Pharmacologic profile of (R)-5-[(l-methyl-3-indolyl)carbonyl]-4,5,6,7-tetrahy-dro-lH-benzimidazole hydrochloride (YM060), a potent and selective 5-hydroxytryptamine3 receptor antagonist, and its enantiomer in the isolated tissue. J Pharmacol Exp Ther 1991; 259: 15-21.
    • (1991) J Pharmacol Exp Ther , vol.259 , pp. 15-21
    • Miyata, K.1    Kamato, T.2    Nishida, A.3
  • 23
    • 0028971429 scopus 로고
    • 5-HT3 receptor involvement in descending reflex relaxation in the rabbit isolated distal colon
    • Messori E, Candura SM, Coccini T, Balestra B, Tonini M. 5-HT3 receptor involvement in descending reflex relaxation in the rabbit isolated distal colon. Eur J Pharmacol 1995; 286: 205-8.
    • (1995) Eur J Pharmacol , vol.286 , pp. 205-208
    • Messori, E.1    Candura, S.M.2    Coccini, T.3    Balestra, B.4    Tonini, M.5
  • 24
    • 0026612742 scopus 로고
    • Role of serotonin 3 receptor in stress-induced defecation
    • Miyata K, Kamato T, Nishida A et al. Role of serotonin 3 receptor in stress-induced defecation. J Pharmacol Exp Ther 1992;261:297-303.
    • (1992) J Pharmacol Exp Ther , vol.261 , pp. 297-303
    • Miyata, K.1    Kamato, T.2    Nishida, A.3
  • 25
    • 0027488957 scopus 로고
    • Effect of FK1052, a potent 5-hydroxytryptamine 3 and 5-hydroxytryptamine 4 receptor dual antagonist, on colonic function in vivo
    • Kadowaki M, Nagakura Y, Tomoi M, Mori J, Kohsaka M. Effect of FK1052, a potent 5-hydroxytryptamine 3 and 5-hydroxytryptamine 4 receptor dual antagonist, on colonic function in vivo. J Pharmacol Exp Ther 1993; 266: 74-80.
    • (1993) J Pharmacol Exp Ther , vol.266 , pp. 74-80
    • Kadowaki, M.1    Nagakura, Y.2    Tomoi, M.3    Mori, J.4    Kohsaka, M.5
  • 26
    • 0033607370 scopus 로고    scopus 로고
    • Differential localization of 5-hydroxytryptamine 3 and 5-hydroxytryptamine 4 receptors in the human rectum
    • Sakurai-Yamashita Y, Yamashita K, Yoshimura M, Taniyama K. Differential localization of 5-hydroxytryptamine 3 and 5-hydroxytryptamine 4 receptors in the human rectum. Life Sci 2000; 66:31-1.
    • (2000) Life Sci , vol.66 , pp. 31-31
    • Sakurai-Yamashita, Y.1    Yamashita, K.2    Yoshimura, M.3    Taniyama, K.4
  • 27
    • 0032835003 scopus 로고    scopus 로고
    • Differential distribution of 5-hydroxytryptamine 3 receptor in the colon between human and guinea pig
    • Sakurai-Yamashita Y, Yamashita K et al. Differential distribution of 5-hydroxytryptamine 3 receptor in the colon between human and guinea pig. Chin J Physiol 1999; 42: 195-8.
    • (1999) Chin J Physiol , vol.42 , pp. 195-198
    • Sakurai-Yamashita, Y.1    Yamashita, K.2
  • 28
    • 0024474193 scopus 로고
    • Effect of selective 5HT3 antagonist (GR 38032F) on small intestinal transit and release of gastrointestinal peptides
    • Talley NT, Phillips SF, Haddad A et al. Effect of selective 5HT3 antagonist (GR 38032F) on small intestinal transit and release of gastrointestinal peptides. Dig Dis Sci 1989; 34:1511-15.
    • (1989) Dig Dis Sci , vol.34 , pp. 1511-1515
    • Talley, N.T.1    Phillips, S.F.2    Haddad, A.3
  • 29
    • 0026741853 scopus 로고
    • Selective 5-hydroxytryptamine type 3 receptor antagonism with ondansetron as treatment for diarrhea-predominant irritable bowel syndrome: a pilot study
    • Steadman CJ, Talley NJ, Phillips SF, Zinsmeister AR. Selective 5-hydroxytryptamine type 3 receptor antagonism with ondansetron as treatment for diarrhea-predominant irritable bowel syndrome: a pilot study. Mayo Clin Proc 1992; 67: 732-8.
    • (1992) Mayo Clin Proc , vol.67 , pp. 732-738
    • Steadman, C.J.1    Talley, N.J.2    Phillips, S.F.3    Zinsmeister, A.R.4
  • 30
    • 0025219706 scopus 로고
    • GR 38032F (ondansetron), a selective 5-HT3 receptor antagonist, slows colonic transit in healthy man
    • Talley NJ, Phillips SF, Haddad A et al. GR 38032F (ondansetron), a selective 5-HT3 receptor antagonist, slows colonic transit in healthy man. Dig Dis Sci 1990; 35: 477-80.
    • (1990) Dig Dis Sci , vol.35 , pp. 477-480
    • Talley, N.J.1    Phillips, S.F.2    Haddad, A.3
  • 31
    • 0024999306 scopus 로고
    • Colonic transit in man is slowed by ondansetron (GR38032F), a selective 5-hydroxytryptamine receptor (type 3) antagonist
    • Gore S, Gilmore IT, Haigh CG, Brownless SM, Stockdale H, Morris Al. Colonic transit in man is slowed by ondansetron (GR38032F), a selective 5-hydroxytryptamine receptor (type 3) antagonist. Alim Pharmacol Ther 1990; 4: 139-44.
    • (1990) Alim Pharmacol Ther , vol.4 , pp. 139-144
    • Gore, S.1    Gilmore, I.T.2    Haigh, C.G.3    Brownless, S.M.4    Stockdale, H.5    Al, M.6
  • 32
    • 0028295092 scopus 로고
    • Serotonergic me- 1 diation of postprandial colonic tonic and phasic responses in humans
    • von der Ohe M, Hanson RB, Camilleri M. Serotonergic me- 1 diation of postprandial colonic tonic and phasic responses in humans. Gut 1994; 35: 536-11.
    • (1994) Gut , vol.35 , pp. 536-511
    • von der Ohe, M.1    Hanson, R.B.2    Camilleri, M.3
  • 33
    • 0030036160 scopus 로고    scopus 로고
    • Selective 5-hydroxytryptamine antagonism: a role in irritable bowel syn-A drome and functional dyspepsia?
    • Maxton DG, Morris J, Whorwell PJ. Selective 5-hydroxytryptamine antagonism: a role in irritable bowel syn-A drome and functional dyspepsia? Alim Pharmacol Ther 1996; 10: 595-9.
    • (1996) Alim Pharmacol Ther , vol.10 , pp. 595-599
    • Maxton, D.G.1    Morris, J.2    Whorwell, P.J.3
  • 34
    • 0027469647 scopus 로고
    • Reduction of rectal sensitivity and post-prandial motility by granisetron, a 5 HT3-receptor A antagonist, in patients with irritable bowel syndrome
    • Prior A, Read NW. Reduction of rectal sensitivity and post-prandial motility by granisetron, a 5 HT3-receptor A antagonist, in patients with irritable bowel syndrome. Alim Pharmacol Ther 1993; 7: 175-80.
    • (1993) Alim Pharmacol Ther , vol.7 , pp. 175-180
    • Prior, A.1    Read, N.W.2
  • 35
    • 0028182404 scopus 로고
    • A 5-HT3 antagonist corrects the postprandial colonic hypertonic response in carcinoid diarrhea
    • von der Ohe MR, Camilleri M, Kvols LK. A 5-HT3 antagonist corrects the postprandial colonic hypertonic response in carcinoid diarrhea. Gastroenterology 1994; 106: 1184-9.
    • (1994) Gastroenterology , vol.106 , pp. 1184-1189
    • von der Ohe, M.R.1    Camilleri, M.2    Kvols, L.K.3
  • 37
    • 0032928638 scopus 로고    scopus 로고
    • Ability of mosapride to bind to 5-HT4 receptor in the human stomach
    • Sakurai-Yamashita Y, Takada K, Takemura K et al. Ability of mosapride to bind to 5-HT4 receptor in the human stomach. Jpn J Pharmacol 1999; 79:493-6.
    • (1999) Jpn J Pharmacol , vol.79 , pp. 493-496
    • Sakurai-Yamashita, Y.1    Takada, K.2    Takemura, K.3
  • 38
    • 0022340452 scopus 로고
    • Evidence against an acetylcholine releasing action of cisapride in the human colon
    • Burleigh DE, Trout SJ. Evidence against an acetylcholine releasing action of cisapride in the human colon. Br] Clin Pharmacol 1985; 20: 475-8.
    • (1985) Br] Clin Pharmacol , vol.20 , pp. 475-478
    • Burleigh, D.E.1    Trout, S.J.2
  • 39
    • 0027131630 scopus 로고
    • Evidence for the involvement of a 5-HT4 receptor in the secretory response of human small intestine to 5-HT
    • Borman RA, Burleigh DE. Evidence for the involvement of a 5-HT4 receptor in the secretory response of human small intestine to 5-HT. Br] Pharmacol 1993; 110:927-8.
    • (1993) Br] Pharmacol , vol.110 , pp. 927-928
    • Borman, R.A.1    Burleigh, D.E.2
  • 40
    • 0027212330 scopus 로고
    • Cisapride and a structural analogue, R 76,186, are 5-hydroxytryptamine 4 (5-HT4) receptor agonists on the guinea-pig colon ascendens
    • Briejer MR, Akkermans LM, Meulemans AL, Lefebvre RA, Schuurkes JA. Cisapride and a structural analogue, R 76,186, are 5-hydroxytryptamine 4 (5-HT4) receptor agonists on the guinea-pig colon ascendens. Naunyn Schmiedebergs Arch Pharmacol 1993; 347:464-70.
    • (1993) Naunyn Schmiedebergs Arch Pharmacol , vol.347 , pp. 464-470
    • Briejer, M.R.1    Akkermans, L.M.2    Meulemans, A.L.3    Lefebvre, R.A.4    Schuurkes, J.A.5
  • 41
    • 0027376397 scopus 로고
    • The guinea-pig distal colon - a sensitive preparation for the investigation of 5-HT4 receptor-mediated contractions
    • Wardle KA, Sanger GJ. The guinea-pig distal colon - a sensitive preparation for the investigation of 5-HT4 receptor-mediated contractions. Br J Pharmacol 1993; 110: 1593-9.
    • (1993) Br J Pharmacol , vol.110 , pp. 1593-1599
    • Wardle, K.A.1    Sanger, G.J.2
  • 42
    • 0028989385 scopus 로고
    • Differences in response to 5-HT4 receptor agonists and antagonists of the 5-HT4-like receptor in human colon circular smooth muscle
    • Tarn FS, Hillier K, Bunce KT, Grossman C. Differences in response to 5-HT4 receptor agonists and antagonists of the 5-HT4-like receptor in human colon circular smooth muscle. Br J Pharmacol 1995; 115: 172-6.
    • (1995) Br J Pharmacol , vol.115 , pp. 172-176
    • Tarn, F.S.1    Hillier, K.2    Bunce, K.T.3    Grossman, C.4
  • 43
    • 0030034178 scopus 로고    scopus 로고
    • Stimulation of cyclic AMP formation in the circular smooth muscle of human colon by activation of 5-HT4-like receptors
    • McLean PG, Coupar IM. Stimulation of cyclic AMP formation in the circular smooth muscle of human colon by activation of 5-HT4-like receptors. Br J Pharmacol 1996; 117: 238-9.
    • (1996) Br J Pharmacol , vol.117 , pp. 238-239
    • McLean, P.G.1    Coupar, I.M.2
  • 44
    • 4644305021 scopus 로고    scopus 로고
    • Cholinergic 5-HT4 receptor stimulation enhances canine and human colon longitudinal muscle contractility [abstract]
    • Prins NH, Akkermans LMA, Lefebvre RA, Cheyns P, Schuurkes JAJ. Cholinergic 5-HT4 receptor stimulation enhances canine and human colon longitudinal muscle contractility [abstract]. Neurogastroenterol Motil 2000; 12: 267.
    • (2000) Neurogastroenterol Motil , vol.12 , pp. 267
    • Prins, N.H.1    Akkermans, L.M.A.2    Lefebvre, R.A.3    Cheyns, P.4    Schuurkes, J.A.J.5
  • 45
    • 0029976793 scopus 로고    scopus 로고
    • 5-HT released by mucosal stimuli initiate peristalsis by activating 5-HT4/5-HTlp receptors on sensory CGRP neurons
    • Grider JR, Kuemmerle JF, Jin JG. 5-HT released by mucosal stimuli initiate peristalsis by activating 5-HT4/5-HTlp receptors on sensory CGRP neurons. Am J Physiol 1996; 270: 778-82.
    • (1996) Am J Physiol , vol.270 , pp. 778-782
    • Grider, J.R.1    Kuemmerle, J.F.2    Jin, J.G.3
  • 46
    • 0029830522 scopus 로고    scopus 로고
    • Distinct 5-HT receptors mediate the peristaltic reflex induced by mucosal stimuli in human and guinea-pig intestine
    • Foxx-Orenstein AE, Kuemmerle JF, Grider JR. Distinct 5-HT receptors mediate the peristaltic reflex induced by mucosal stimuli in human and guinea-pig intestine. Gastroenterology 1996; 111: 1281-90.
    • (1996) Gastroenterology , vol.111 , pp. 1281-1290
    • Foxx-Orenstein, A.E.1    Kuemmerle, J.F.2    Grider, J.R.3
  • 47
    • 0031595212 scopus 로고    scopus 로고
    • 5-Hydroxytryp-tamine 4 receptor agonists initiate the peristaltic reflex in human, rat, and guinea pig intestine
    • Grider JR, Foxx-Orenstein AE, Jin JG. 5-Hydroxytryp-tamine 4 receptor agonists initiate the peristaltic reflex in human, rat, and guinea pig intestine. Gastroenterology 1998; 115: 370-80.
    • (1998) Gastroenterology , vol.115 , pp. 370-380
    • Grider, J.R.1    Foxx-Orenstein, A.E.2    Jin, J.G.3
  • 48
    • 0031876343 scopus 로고    scopus 로고
    • The influence of cisapride on gastric tone and the perception of gastric distension
    • Tack J, Broeckaert D, Coulie B, Janssens J. The influence of cisapride on gastric tone and the perception of gastric distension. Aliment Pharmacol Ther 1998; 12: 761-6.
    • (1998) Aliment Pharmacol Ther , vol.12 , pp. 761-766
    • Tack, J.1    Broeckaert, D.2    Coulie, B.3    Janssens, J.4
  • 49
    • 0034912728 scopus 로고    scopus 로고
    • Effect of cisapride on gastric sensitivity to distension, gastric compliance and duodeno-gastric reflexes in healthy humans
    • Manes G, Dominguez-Munoz JE, Leodolter A, Malferthein-er P. Effect of cisapride on gastric sensitivity to distension, gastric compliance and duodeno-gastric reflexes in healthy humans. Dig Liver Dis 2001; 33:407-13.
    • (2001) Dig Liver Dis , vol.33 , pp. 407-413
    • Manes, G.1    Dominguez-Munoz, J.E.2    Leodolter, A.3    Malferthein-er, P.4
  • 50
    • 0000924339 scopus 로고    scopus 로고
    • Antinociceptive properties of HTF919 (tegaserod), a 5-HT4 receptor partial agonist, on colorectal distension in rats [abstract]
    • Coelho AM, Rovira P, Fioramonti J, Buéno L. Antinociceptive properties of HTF919 (tegaserod), a 5-HT4 receptor partial agonist, on colorectal distension in rats [abstract]. Gastroenterology 2000; 118 (Suppl. 2): A835.
    • (2000) Gastroenterology , vol.118 , pp. A835
    • Coelho, A.M.1    Rovira, P.2    Fioramonti, J.3    Buéno, L.4
  • 51
    • 0037441307 scopus 로고    scopus 로고
    • Tegaserod, a 5-HT4 receptor partial agonist, decreases sensitivity to rectal distension in healthy subjects
    • Coffin B, Farmachidi JP, Rueegg P, Bastie A, Bouhassira D. Tegaserod, a 5-HT4 receptor partial agonist, decreases sensitivity to rectal distension in healthy subjects. Aliment Pharmacol Ther 2003; 17: 577-85.
    • (2003) Aliment Pharmacol Ther , vol.17 , pp. 577-585
    • Coffin, B.1    Farmachidi, J.P.2    Rueegg, P.3    Bastie, A.4    Bouhassira, D.5
  • 52
    • 0033129381 scopus 로고    scopus 로고
    • Review article: clinical pharmacology of alos-etron
    • Gunput MD. Review article: clinical pharmacology of alos-etron. Aliment Pharmacol Ther 1999; 13 (Suppl. 2): 70-6.
    • (1999) Aliment Pharmacol Ther , vol.13 , pp. 70-76
    • Gunput, M.D.1
  • 53
    • 0032919392 scopus 로고    scopus 로고
    • Review article: the therapeutic potential of 5-HT3 receptor antagonists in the treatment of irritable bowel syndrome
    • Humphrey PP, Bountra C, Clayton N, Kozlowski K. Review article: the therapeutic potential of 5-HT3 receptor antagonists in the treatment of irritable bowel syndrome. Aliment Pharmacol Ther 1999; 13 (Suppl. 2): 31-8.
    • (1999) Aliment Pharmacol Ther , vol.13 , pp. 31-38
    • Humphrey, P.P.1    Bountra, C.2    Clayton, N.3    Kozlowski, K.4
  • 54
    • 0034090555 scopus 로고    scopus 로고
    • Alosetron [see Guest Commentaries]
    • Balfour JA, Goa KL, Perry CM. Alosetron [see Guest Commentaries]. Drugs 2000; 59: 511-18.
    • (2000) Drugs , vol.59 , pp. 511-518
    • Balfour, J.A.1    Goa, K.L.2    Perry, C.M.3
  • 55
    • 0034066325 scopus 로고    scopus 로고
    • The 5-HT3 receptor antagonist alosetron inhibits the colorectal distention induced depressor response and spinal c-fos expression in the anaesthetised rat
    • Kozlowski CM, Green A, Grundy D, Boissonade FM, Bountra C. The 5-HT3 receptor antagonist alosetron inhibits the colorectal distention induced depressor response and spinal c-fos expression in the anaesthetised rat. Gut 2000; 46:474-80.
    • (2000) Gut , vol.46 , pp. 474-480
    • Kozlowski, C.M.1    Green, A.2    Grundy, D.3    Boissonade, F.M.4    Bountra, C.5
  • 56
    • 0031658491 scopus 로고    scopus 로고
    • Effect of alosetron on responses to colonic distension in patients with irritable bowel syndrome
    • Delvaux M, Louvel D, Mamet JP, Campos-Oriola R, Frexi-nos J. Effect of alosetron on responses to colonic distension in patients with irritable bowel syndrome. Aliment Pharmacol Ther 1998; 12: 849-55.
    • (1998) Aliment Pharmacol Ther , vol.12 , pp. 849-855
    • Delvaux, M.1    Louvel, D.2    Mamet, J.P.3    Campos-Oriola, R.4    Frexi-nos, J.5
  • 57
    • 0033938748 scopus 로고    scopus 로고
    • Effects of alosetron on gastrointestinal transit time and rectal sensation in patients with irritable bowel syndrome
    • Thumshirn M, Coulie B, Camilleri M, Zinsmeister AR, Burton DD, Van Dyke C. Effects of alosetron on gastrointestinal transit time and rectal sensation in patients with irritable bowel syndrome. Aliment Pharmacol Ther 2000; 14: 869-78.
    • (2000) Aliment Pharmacol Ther , vol.14 , pp. 869-878
    • Thumshirn, M.1    Coulie, B.2    Camilleri, M.3    Zinsmeister, A.R.4    Burton, D.D.5    Van Dyke, C.6
  • 58
    • 0025369550 scopus 로고
    • The effects of granisetron, ICS 205930 and ondansetron on the visceral pain reflex induced by duodenal distension
    • Moss HE, Sanger GJ. The effects of granisetron, ICS 205930 and ondansetron on the visceral pain reflex induced by duodenal distension. Br J Pharmacol 1990; 100:497-501.
    • (1990) Br J Pharmacol , vol.100 , pp. 497-501
    • Moss, H.E.1    Sanger, G.J.2
  • 59
    • 0032894361 scopus 로고    scopus 로고
    • Central modulation of rectal distension-induced blood pressure changes by alosetron, a 5-HT3 receptor antagonist
    • Miura M, Lawson DC, Clary EM, Mangel AW, Pappas TN. Central modulation of rectal distension-induced blood pressure changes by alosetron, a 5-HT3 receptor antagonist. Dig Dis Sci 1999; 44: 20-4.
    • (1999) Dig Dis Sci , vol.44 , pp. 20-24
    • Miura, M.1    Lawson, D.C.2    Clary, E.M.3    Mangel, A.W.4    Pappas, T.N.5
  • 60
    • 0029848204 scopus 로고    scopus 로고
    • Modification of visceral sensitivity and pain in irritable bowel syndrome by 5-HT3 antagonism (ondansetron)
    • Goldberg PA, Kamm MA, Setti-Carraro P, van der Sijp JR, Roth C. Modification of visceral sensitivity and pain in irritable bowel syndrome by 5-HT3 antagonism (ondansetron). Digestion 1996; 57: 478-83.
    • (1996) Digestion , vol.57 , pp. 478-483
    • Goldberg, P.A.1    Kamm, M.A.2    Setti-Carraro, P.3    van der Sijp, J.R.4    Roth, C.5
  • 61
    • 0029958673 scopus 로고    scopus 로고
    • Ondansetron reduces nausea induced by gastroduodenal stimulation without changing gastric motility
    • Feinle C, Read NW. Ondansetron reduces nausea induced by gastroduodenal stimulation without changing gastric motility. Am J Physiol 1996; 261: G591-7.
    • (1996) Am J Physiol , vol.261 , pp. G591-7
    • Feinle, C.1    Read, N.W.2
  • 62
    • 0035074588 scopus 로고    scopus 로고
    • A dose-ranging, pla- cebo-controlled, randomized trial of alosetron in patients with functional dyspepsia
    • Talley NJ, Van Zanten SV, Saez LR et al. A dose-ranging, pla- cebo-controlled, randomized trial of alosetron in patients with functional dyspepsia. Aliment Pharmacol Ther 2001; 15: 525-37.
    • (2001) Aliment Pharmacol Ther , vol.15 , pp. 525-537
    • Talley, N.J.1    Van Zanten, S.V.2    Saez, L.R.3
  • 63
    • 0036169076 scopus 로고    scopus 로고
    • Effects of 5-HT3 antagonism on postprandial gastric volume and symptoms in humans
    • Kuo B, Camilleri M, Burton D, Viramontes B et al. Effects of 5-HT3 antagonism on postprandial gastric volume and symptoms in humans. Aliment Pharmacol Ther 2002; 16: 225-33.
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 225-233
    • Kuo, B.1    Camilleri, M.2    Burton, D.3    Viramontes, B.4
  • 65
    • 0033963225 scopus 로고    scopus 로고
    • A double-blind, randomized, placebo-controlled dose-ranging study to evaluate the efficacy of alosetron in the treatment of irritable bowel syndrome
    • Bardhan KD, Bodemar G, Geldof H et al. A double-blind, randomized, placebo-controlled dose-ranging study to evaluate the efficacy of alosetron in the treatment of irritable bowel syndrome. Aliment Pharmacol Ther 2000; 14: 23-34.
    • (2000) Aliment Pharmacol Ther , vol.14 , pp. 23-34
    • Bardhan, K.D.1    Bodemar, G.2    Geldof, H.3
  • 66
    • 0032749795 scopus 로고    scopus 로고
    • Alosetron relieves pain and improves bowel function compared with mebev-erine in female nonconstipated irritable bowel syndrome patients
    • Jones RH, Holtmann G, Rodrigo L et al. Alosetron relieves pain and improves bowel function compared with mebev-erine in female nonconstipated irritable bowel syndrome patients. Aliment Pharmacol Ther 1999; 13: 1419-27.
    • (1999) Aliment Pharmacol Ther , vol.13 , pp. 1419-1427
    • Jones, R.H.1    Holtmann, G.2    Rodrigo, L.3
  • 67
    • 0034712539 scopus 로고    scopus 로고
    • Efficacy and safety of alosetron in women with irritable bowel syndrome: a randomised, placebo-controlled trial
    • Camilleri M, Northcutt AR, Kong S, Dukes GE, McSorley D, Mangel AW. Efficacy and safety of alosetron in women with irritable bowel syndrome: a randomised, placebo-controlled trial. Lancet 2000; 355: 1035-40.
    • (2000) Lancet , vol.355 , pp. 1035-1040
    • Camilleri, M.1    Northcutt, A.R.2    Kong, S.3    Dukes, G.E.4    McSorley, D.5    Mangel, A.W.6
  • 68
    • 0037295146 scopus 로고    scopus 로고
    • Efficacy of alosetron in irritable bowel syndrome: a meta-analysis of randomized controlled trials
    • Cremonini F, Delgado-Aros S, CamilJeri M. Efficacy of alosetron in irritable bowel syndrome: a meta-analysis of randomized controlled trials. Neurogastroenterol Motil 2003; 15: 79-86.
    • (2003) Neurogastroenterol Motil , vol.15 , pp. 79-86
    • Cremonini, F.1    Delgado-Aros, S.2    CamilJeri, M.3
  • 70
    • 0033624746 scopus 로고    scopus 로고
    • Effects of the 5-HT3 antagonist cilansetron vs placebo on phasic sigmoid colonic motility in healthy man: a double-blind crossover trial
    • Stacher G, Weber U, Stacher-Janotta G et al. Effects of the 5-HT3 antagonist cilansetron vs placebo on phasic sigmoid colonic motility in healthy man: a double-blind crossover trial. Br J Clin Pharmacol 2000; 49:429-36.
    • (2000) Br J Clin Pharmacol , vol.49 , pp. 429-436
    • Stacher, G.1    Weber, U.2    Stacher-Janotta, G.3
  • 71
    • 15544364013 scopus 로고    scopus 로고
    • Cilansetron is efficacious for relief of urgency in patients with irritable bowel syndrome with diarrhea predominance (IBS-D)
    • Clouse R.E., Caras S., Cataldi F., et al. Cilansetron is efficacious for relief of urgency in patients with irritable bowel syndrome with diarrhea predominance (IBS-D). JPGN 2004; 39 (Suppl. 3): S777.
    • (2004) JPGN , vol.39 , pp. S777
    • Clouse, R.E.1    Caras, S.2    Cataldi, F.3
  • 72
    • 10744222165 scopus 로고    scopus 로고
    • Effect of a novel 5-HT3 receptor agonist MKC-733 on upper gastrointestinal motility in humans
    • Coleman NS, Marciani L, Blackshaw E et al. Effect of a novel 5-HT3 receptor agonist MKC-733 on upper gastrointestinal motility in humans. Aliment Pharmacol Ther 2003; 18: 1039-48.
    • (2003) Aliment Pharmacol Ther , vol.18 , pp. 1039-1048
    • Coleman, N.S.1    Marciani, L.2    Blackshaw, E.3
  • 73
    • 0033258353 scopus 로고    scopus 로고
    • Review article: cardiac adverse effects of gastrointestinal prokinetics
    • Tonini M, De Ponti F, Di Nucci A, Crema F. Review article: cardiac adverse effects of gastrointestinal prokinetics. Alim Pharmacol Ther 1999; 13: 1585-91.
    • (1999) Alim Pharmacol Ther , vol.13 , pp. 1585-1591
    • Tonini, M.1    De Ponti, F.2    Di Nucci, A.3    Crema, F.4
  • 74
    • 0035123099 scopus 로고    scopus 로고
    • Review article: tegaserod
    • Camilleri M. Review article: tegaserod. Aliment Pharmacol Ther 2001; 15: 277-89.
    • (2001) Aliment Pharmacol Ther , vol.15 , pp. 277-289
    • Camilleri, M.1
  • 75
    • 0038509016 scopus 로고    scopus 로고
    • Tegaserod: a review of its use in the management of irritable bowel syndrome with constipation in women
    • Wagstaff AJ, Frampton JE, Croom KF. Tegaserod: a review of its use in the management of irritable bowel syndrome with constipation in women. Drugs 2003; 63: 1101-20.
    • (2003) Drugs , vol.63 , pp. 1101-1120
    • Wagstaff, A.J.1    Frampton, J.E.2    Croom, K.F.3
  • 76
    • 0032589966 scopus 로고    scopus 로고
    • Effect of prucalopride, a new enterokinetic agent, on gastrointestinal transit and anorectal function in healthy volunteers
    • Poen AC, Felt-Bersma RJ, Van Dongen PA, Meuwissen SG. Effect of prucalopride, a new enterokinetic agent, on gastrointestinal transit and anorectal function in healthy volunteers. Aliment Pharmacol Ther 1999; 13: 1493-7.
    • (1999) Aliment Pharmacol Ther , vol.13 , pp. 1493-1497
    • Poen, A.C.1    Felt-Bersma, R.J.2    Van Dongen, P.A.3    Meuwissen, S.G.4
  • 77
    • 0001300175 scopus 로고    scopus 로고
    • Prucalopride accelerates small bowel and colonic transit in patients with chronic functional constipation (FC) or constipation-predominant irritable bowel syndrome (C-IBS) [abstract]
    • Camilleri M, McKinzie S, Burton D, Thomforde GM, Zinsmeister A, Bouras EP. Prucalopride accelerates small bowel and colonic transit in patients with chronic functional constipation (FC) or constipation-predominant irritable bowel syndrome (C-IBS) [abstract]. Gastroenterology 2000; 118(Suppl.2):A845.
    • (2000) Gastroenterology , vol.118 , pp. A845
    • Camilleri, M.1    McKinzie, S.2    Burton, D.3    Thomforde, G.M.4    Zinsmeister, A.5    Bouras, E.P.6
  • 78
    • 0035057423 scopus 로고    scopus 로고
    • Irritable bowel syndrome: new agents targeting serotonin receptor subtypes
    • De Ponti F, Tonini M. Irritable bowel syndrome: new agents targeting serotonin receptor subtypes. Drugs 2001; 61: 317-32.
    • (2001) Drugs , vol.61 , pp. 317-332
    • De Ponti, F.1    Tonini, M.2
  • 79
    • 0030801806 scopus 로고    scopus 로고
    • Electrophysiological characterization of the prokinetic agents cisapride and mosapride in vivo and in vitro: implications for proarrhythmic pptential?
    • Carlsson L, Amos GJ, Andersson B, Drews L, Duker G, Wadstedt G. Electrophysiological characterization of the prokinetic agents cisapride and mosapride in vivo and in vitro: implications for proarrhythmic pptential? J Pharmacol Exp Ther 1997; 282: 220-7.
    • (1997) J Pharmacol Exp Ther , vol.282 , pp. 220-227
    • Carlsson, L.1    Amos, G.J.2    Andersson, B.3    Drews, L.4    Duker, G.5    Wadstedt, G.6
  • 80
    • 0033033084 scopus 로고    scopus 로고
    • Comparison of tegaserod (HTF 919) and its main human metabolite with cisapride and erythromycin on cardiac repolarization in the isolated rabbit heart
    • Drici MD, Ebert SN, Wang WX et al. Comparison of tegaserod (HTF 919) and its main human metabolite with cisapride and erythromycin on cardiac repolarization in the isolated rabbit heart. J Cardiovasc Pharmacol 1999; 34: 82-8.
    • (1999) J Cardiovasc Pharmacol , vol.34 , pp. 82-88
    • Drici, M.D.1    Ebert, S.N.2    Wang, W.X.3
  • 81
    • 0000382890 scopus 로고    scopus 로고
    • Tegaserod has a favorable safety and tolerability profile in patients with constipation predominant and alternating forms of irritable bowel syndrome (IBS) [abstract]
    • Whorwell PJ, Krumholz S, Muller-Lissner S, Schmitt C, Dunger-Baldauf C, Rueegg PC. Tegaserod has a favorable safety and tolerability profile in patients with constipation predominant and alternating forms of irritable bowel syndrome (IBS) [abstract]. Gastroenterology 2000; 118 (Suppl. 2):A1204.
    • (2000) Gastroenterology , vol.118 , pp. A1204
    • Whorwell, P.J.1    Krumholz, S.2    Muller-Lissner, S.3    Schmitt, C.4    Dunger-Baldauf, C.5    Rueegg, P.C.6
  • 82
    • 0030972047 scopus 로고    scopus 로고
    • SDZ HTF 919 stimulates canine colonic motility and transit in vivo
    • Nguyen A, Camilleri M, Kost LJ et al. SDZ HTF 919 stimulates canine colonic motility and transit in vivo. J Pharmacol Exp Ther 1997; 280: 1270-6.
    • (1997) J Pharmacol Exp Ther , vol.280 , pp. 1270-1276
    • Nguyen, A.1    Camilleri, M.2    Kost, L.J.3
  • 83
    • 0033005188 scopus 로고    scopus 로고
    • Selective stimulation of colonic transit by the benzofuran 5HT4 agonist, prucalopride, in healthy humans
    • Bouras EP, Camilleri M, Burton DD, McKinzie S. Selective stimulation of colonic transit by the benzofuran 5HT4 agonist, prucalopride, in healthy humans. Gut 1999; 44: 682-6.
    • (1999) Gut , vol.44 , pp. 682-686
    • Bouras, E.P.1    Camilleri, M.2    Burton, D.D.3    McKinzie, S.4
  • 84
    • 4243385591 scopus 로고    scopus 로고
    • Prucalopride (PRU) improves colonic transit and stool frequency in patients (pts) with slow and normal transit constipation [abstract]
    • Emmanuel AV, Nicholls T, Roy AJ, Antonelli K, Kamm MA. Prucalopride (PRU) improves colonic transit and stool frequency in patients (pts) with slow and normal transit constipation [abstract]. Gastroenterology 2000; 118 (Suppl. 2): A846.
    • (2000) Gastroenterology , vol.118 , pp. A846
    • Emmanuel, A.V.1    Nicholls, T.2    Roy, A.J.3    Antonelli, K.4    Kamm, M.A.5
  • 85
    • 0027508263 scopus 로고
    • Pharmacological effects of the new gastroprokinetic agent mosapride citrate and its metabolites in experimental animals [abstract!
    • Yoshida N, Omoya H, Kato S, Ito T. Pharmacological effects of the new gastroprokinetic agent mosapride citrate and its metabolites in experimental animals [abstract!. Arzneimittelforschung 1993; 43: 1078-83.
    • (1993) Arzneimittelforschung , vol.43 , pp. 1078-1083
    • Yoshida, N.1    Omoya, H.2    Kato, S.3    Ito, T.4
  • 86
    • 0031457583 scopus 로고    scopus 로고
    • Comparison of effect of mosapride citrate and existing 5-HT4 receptor agonists on gastrointestinal motility in vivo and in vitro
    • Mine Y, Yoshikawa T, Oku S, Nagai R, Yoshida N, Hosoki K. Comparison of effect of mosapride citrate and existing 5-HT4 receptor agonists on gastrointestinal motility in vivo and in vitro. J Pharmacol Exp Ther 1997; 283: 1000-8.
    • (1997) J Pharmacol Exp Ther , vol.283 , pp. 1000-1008
    • Mine, Y.1    Yoshikawa, T.2    Oku, S.3    Nagai, R.4    Yoshida, N.5    Hosoki, K.6
  • 87
    • 0031963781 scopus 로고    scopus 로고
    • The effect of mosapride, a novel prokinetic, on acid reflux variables in patients with gastro-oesophageal reflux disease
    • Ruth M, Hamelin B, Rôhss K, Lundell L. The effect of mosapride, a novel prokinetic, on acid reflux variables in patients with gastro-oesophageal reflux disease. Alim Phar-macol Ther 1998; 12: 35-10.
    • (1998) Alim Phar-macol Ther , vol.12 , pp. 35-10
    • Ruth, M.1    Hamelin, B.2    Rôhss, K.3    Lundell, L.4
  • 88
    • 0036234667 scopus 로고    scopus 로고
    • Dose finding study of mosapride in functional dyspepsia: a placebo-controlled, randomized study
    • Hallerback BI, Bommelaer G, Bredberg E et al. Dose finding study of mosapride in functional dyspepsia: a placebo-controlled, randomized study. Aliment Pharmacol Ther 2002; 16: 959-67.
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 959-967
    • Hallerback, B.I.1    Bommelaer, G.2    Bredberg, E.3
  • 89
    • 0001300174 scopus 로고    scopus 로고
    • Tegaserod (HTF919), a 5-HT4 receptor partial agonist, accelerates gastrointestinal transit
    • Degen L, Matzinger D, Merz M. Tegaserod (HTF919), a 5-HT4 receptor partial agonist, accelerates gastrointestinal transit. Gastroenterology 2000; 118: A845.
    • (2000) Gastroenterology , vol.118 , pp. A845
    • Degen, L.1    Matzinger, D.2    Merz, M.3
  • 91
    • 0034089045 scopus 로고    scopus 로고
    • Tegaserod accelerates orocecal transit in patients with constipation-predominant irritable bowel syndrome
    • Prather CM, Camilleri M, Zinsmeister AR, McKinzie S, Thomforde G. Tegaserod accelerates orocecal transit in patients with constipation-predominant irritable bowel syndrome. Gastroenterology 2000; 118: 463-8.
    • (2000) Gastroenterology , vol.118 , pp. 463-468
    • Prather, C.M.1    Camilleri, M.2    Zinsmeister, A.R.3    McKinzie, S.4    Thomforde, G.5
  • 92
    • 0034794595 scopus 로고    scopus 로고
    • Tegaserod, a 5-HT(4) receptor partial agonist, relieves symptoms in irritable bowel syndrome patients with abdominal pain, bloating and constipation
    • Muller-Lissner SA, Fumagalli I, Bardhan KD et al. Tegaserod, a 5-HT(4) receptor partial agonist, relieves symptoms in irritable bowel syndrome patients with abdominal pain, bloating and constipation. Aliment Pharmacol Ther 2001; 15: 1655-66.
    • (2001) Aliment Pharmacol Ther , vol.15 , pp. 1655-1666
    • Muller-Lissner, S.A.1    Fumagalli, I.2    Bardhan, K.D.3
  • 93
    • 0036829638 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of tegaserod in female patients suffering from irritable bowel syndrome with constipation
    • Novick J, Miner P, Krause R et al. A randomized, double-blind, placebo-controlled trial of tegaserod in female patients suffering from irritable bowel syndrome with constipation. Aliment Pharmacol Ther 2002; 16: 1877-88.
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 1877-1888
    • Novick, J.1    Miner, P.2    Krause, R.3
  • 94
    • 0037799916 scopus 로고    scopus 로고
    • An Asia-Pacific, double blind, placebo controlled, randomised study to evaluate the efficacy, safety, and tolerability of tegaserod in patients with irritable bowel syndrome
    • Kellow J, Lee OY, Chang FY et al. An Asia-Pacific, double blind, placebo controlled, randomised study to evaluate the efficacy, safety, and tolerability of tegaserod in patients with irritable bowel syndrome. Gut 2003; 52: 671-6.
    • (2003) Gut , vol.52 , pp. 671-676
    • Kellow, J.1    Lee, O.Y.2    Chang, F.Y.3
  • 95
    • 0036792345 scopus 로고    scopus 로고
    • Long-term safety of tegaserod in patients with constipation-predominant irritable bowel syndrome
    • Tougas G, Snape WJ Jr, Otten MH et al. Long-term safety of tegaserod in patients with constipation-predominant irritable bowel syndrome. Aliment Pharmacol Ther 2002; 16: 1701-8.
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 1701-1708
    • Tougas, G.1    Snape, W.J.2    Otten, M.H.3
  • 96
    • 0031950380 scopus 로고    scopus 로고
    • Effect of a novel prokinetic drug, R093877, on gastrointestinal transit in healthy volunteers
    • Emmanuel AV, Kamm MA, Roy AJ, Antonelli K. Effect of a novel prokinetic drug, R093877, on gastrointestinal transit in healthy volunteers. Gut 1998; 42: 511-16.
    • (1998) Gut , vol.42 , pp. 511-516
    • Emmanuel, A.V.1    Kamm, M.A.2    Roy, A.J.3    Antonelli, K.4
  • 97
    • 0000833619 scopus 로고    scopus 로고
    • A double-blind, placebo controlled evaluation of safety and efficacy of 12-week, twice-daily treatment with prucaloprid in patients with chronic constipation
    • Otten M, Schneider H, Wurzer H et al. A double-blind, placebo controlled evaluation of safety and efficacy of 12-week, twice-daily treatment with prucaloprid in patients with chronic constipation. Gastroenterology 1999; 116: 1055.
    • (1999) Gastroenterology , vol.116 , pp. 1055
    • Otten, M.1    Schneider, H.2    Wurzer, H.3
  • 98
    • 0031815458 scopus 로고    scopus 로고
    • SB-207266: 5-HT4 receptor antagonism in human isolated gut and prevention of 5-HT-evoked sensitization of peristalsis and increased defaecation in animal models
    • Sanger GJ, Banner SE, Smith MI, Wardle KA. SB-207266: 5-HT4 receptor antagonism in human isolated gut and prevention of 5-HT-evoked sensitization of peristalsis and increased defaecation in animal models. Neurogastroenterol Motil 1998; 10: 271-9.
    • (1998) Neurogastroenterol Motil , vol.10 , pp. 271-279
    • Sanger, G.J.1    Banner, S.E.2    Smith, M.I.3    Wardle, K.A.4
  • 99
    • 4243567328 scopus 로고    scopus 로고
    • Effects of a serotonin (5-HT4) receptor antagonist on gastrointestinal (GI) transit, colonic motor and sensory function in health
    • Bharucha AE, Camilleri M, Ferber I, Zinsmeister AR. Effects of a serotonin (5-HT4) receptor antagonist on gastrointestinal (GI) transit, colonic motor and sensory function in health. Gastroenterology 1999; 116: A958.
    • (1999) Gastroenterology , vol.116 , pp. A958
    • Bharucha, A.E.1    Camilleri, M.2    Ferber, I.3    Zinsmeister, A.R.4
  • 100
    • 0029826824 scopus 로고    scopus 로고
    • 5-Hydroxytryptamine and functional bowel disorders
    • Sanger GJ. 5-Hydroxytryptamine and functional bowel disorders. Neurogastroenterol Motil 1996; 8: 319-31.
    • (1996) Neurogastroenterol Motil , vol.8 , pp. 319-331
    • Sanger, G.J.1
  • 101
    • 0034037433 scopus 로고    scopus 로고
    • Increased defecation during stress or after 5-hydroxytryptophan: selective inhibition by the 5-HT4 receptor antagonist, SB-207266
    • Sanger GJ, Yoshida M, Yahyah M, Kitazumi K. Increased defecation during stress or after 5-hydroxytryptophan: selective inhibition by the 5-HT4 receptor antagonist, SB-207266. Br J Pharmacol 2000; 130: 706-12.
    • (2000) Br J Pharmacol , vol.130 , pp. 706-712
    • Sanger, G.J.1    Yoshida, M.2    Yahyah, M.3    Kitazumi, K.4
  • 102
    • 4243462608 scopus 로고    scopus 로고
    • A pharmacodynamic model of 5-HT4 receptor activation in man: antagonism by the 5-HT4 receptor antagonist SB-207266
    • Cooper SM, Haydock SF, Tompson DJ, Higgins RG, Fitzpatrick KL. A pharmacodynamic model of 5-HT4 receptor activation in man: antagonism by the 5-HT4 receptor antagonist SB-207266. Gastroenterology 1999; 116: A598.
    • (1999) Gastroenterology , vol.116 , pp. A598
    • Cooper, S.M.1    Haydock, S.F.2    Tompson, D.J.3    Higgins, R.G.4    Fitzpatrick, K.L.5
  • 103
    • 0032589965 scopus 로고    scopus 로고
    • 5-HT4 receptor antagonism in irritable bowel syndrome: effect of SB-207266-A on rectal sensitivity and small bowel transit
    • Houghton LA, Jackson NA, Whorwell PJ, Cooper SM. 5-HT4 receptor antagonism in irritable bowel syndrome: effect of SB-207266-A on rectal sensitivity and small bowel transit. Aliment Pharmacol Ther 1999; 13: 1437-44.
    • (1999) Aliment Pharmacol Ther , vol.13 , pp. 1437-1444
    • Houghton, L.A.1    Jackson, N.A.2    Whorwell, P.J.3    Cooper, S.M.4
  • 104
    • 0032863410 scopus 로고    scopus 로고
    • Hypersensitivity and hyperreactivity in the irritable bowel syndrome: an opportunity for drug discovery
    • Sanger GJ. Hypersensitivity and hyperreactivity in the irritable bowel syndrome: an opportunity for drug discovery. Dig Dis 1999; 17: 90-9.
    • (1999) Dig Dis , vol.17 , pp. 90-99
    • Sanger, G.J.1
  • 105
    • 0033551606 scopus 로고    scopus 로고
    • 5-HT4 receptor antagonism potentiates inhibition of intestinal allodynia by 5-HT3 receptor antagonism in conscious rats
    • Smith MI, Banner SE, Sanger GJ. 5-HT4 receptor antagonism potentiates inhibition of intestinal allodynia by 5-HT3 receptor antagonism in conscious rats. Neurosci Lett 1999;271:61-4.
    • (1999) Neurosci Lett , vol.271 , pp. 61-64
    • Smith, M.I.1    Banner, S.E.2    Sanger, G.J.3
  • 106
    • 0032914788 scopus 로고    scopus 로고
    • Role of nitric oxide in fasting gastric fundus tone and in 5-HT1 receptor-mediated relaxation of gastric fundus
    • Coulie B, Tack J, Sifrim D, Andrioli A, Janssens J. Role of nitric oxide in fasting gastric fundus tone and in 5-HT1 receptor-mediated relaxation of gastric fundus. Am J Physiol 1999; 276: G373-7.
    • (1999) Am J Physiol , vol.276 , pp. G373-7
    • Coulie, B.1    Tack, J.2    Sifrim, D.3    Andrioli, A.4    Janssens, J.5
  • 107
    • 0030976871 scopus 로고    scopus 로고
    • Sumatriptan, a selective 5-HT1 receptor agonist, induces a lag phase for gastric emptying of liquids in humans
    • Coulie B, Tack J, Maes B, Geypens B, De Roo M, Janssens J. Sumatriptan, a selective 5-HT1 receptor agonist, induces a lag phase for gastric emptying of liquids in humans. Am J Physiol 1997; 272: G902-8.
    • (1997) Am J Physiol , vol.272 , pp. G902-8
    • Coulie, B.1    Tack, J.2    Maes, B.3    Geypens, B.4    De Roo, M.5    Janssens, J.6
  • 108
    • 0034070874 scopus 로고    scopus 로고
    • Influence of sumatriptan on gastric fundus tone and on the perception of gastric distension in man
    • Tack J, Coulie B, Wilmer A, Andrioli A, Janssens J. Influence of sumatriptan on gastric fundus tone and on the perception of gastric distension in man. Gut 2000; 46:468-73.
    • (2000) Gut , vol.46 , pp. 468-473
    • Tack, J.1    Coulie, B.2    Wilmer, A.3    Andrioli, A.4    Janssens, J.5
  • 109
    • 0026736886 scopus 로고
    • Effect of sumatriptan, a new selective 5HTl-like agonist, on liquid gastric emptying in man
    • Houghton LA, Fowler P, Keene ON, Read NW. Effect of sumatriptan, a new selective 5HTl-like agonist, on liquid gastric emptying in man. Aliment Pharmacol Ther 1992; 6: 685-91.
    • (1992) Aliment Pharmacol Ther , vol.6 , pp. 685-691
    • Houghton, L.A.1    Fowler, P.2    Keene, O.N.3    Read, N.W.4
  • 110
  • 111
    • 0036826919 scopus 로고    scopus 로고
    • 5-HT 1-receptor agonist sumatriptan modifies gastric size after 500 ml of water in dyspeptic patients and normal subjects
    • Malatesta MG, Fascetti E, Ciccaglione AF et al. 5-HT 1-receptor agonist sumatriptan modifies gastric size after 500 ml of water in dyspeptic patients and normal subjects. Dig Dis Sci 2002; 47: 2591-5.
    • (2002) Dig Dis Sci , vol.47 , pp. 2591-2595
    • Malatesta, M.G.1    Fascetti, E.2    Ciccaglione, A.F.3
  • 112
    • 0032589715 scopus 로고    scopus 로고
    • Effect of sumatriptan, a 5HT1 agonist, on the frequency of transient lower esophageal sphincter relaxations and gastroesophageal reflux in healthy subjects
    • Sifrim D, Holloway RH, Tack J et al. Effect of sumatriptan, a 5HT1 agonist, on the frequency of transient lower esophageal sphincter relaxations and gastroesophageal reflux in healthy subjects. Am J Gastroenterol 1999; 94: 3158-64.
    • (1999) Am J Gastroenterol , vol.94 , pp. 3158-3164
    • Sifrim, D.1    Holloway, R.H.2    Tack, J.3
  • 114
    • 0038001495 scopus 로고    scopus 로고
    • Role of 5-HT1B/D receptors in canine gastric accommodation: effect of sumatriptan and 5-HT1B/D receptor antagonists
    • De Ponti F, Crema F, Moro E, Nardelli G, Frigo G, Crema A. Role of 5-HT1B/D receptors in canine gastric accommodation: effect of sumatriptan and 5-HT1B/D receptor antagonists. Am J Physiol 2003; 285: G96-104.
    • (2003) Am J Physiol , vol.285 , pp. G96-104
    • De Ponti, F.1    Crema, F.2    Moro, E.3    Nardelli, G.4    Frigo, G.5    Crema, A.6
  • 115
    • 2142815173 scopus 로고    scopus 로고
    • Triptans and gastric accommodation: pharmacological and therapeutic aspects
    • Moro E, Crema F, De Ponti F, Frigo G. Triptans and gastric accommodation: pharmacological and therapeutic aspects. Dig Liver Dis 2004; 36: 85-92.
    • (2004) Dig Liver Dis , vol.36 , pp. 85-92
    • Moro, E.1    Crema, F.2    De Ponti, F.3    Frigo, G.4
  • 117
    • 0031671842 scopus 로고    scopus 로고
    • Decrease in gastric sensitivity to distension by 5-HT1A receptor agonists in rats
    • Rouzade ML, Fioramonti J, Bueno L. Decrease in gastric sensitivity to distension by 5-HT1A receptor agonists in rats. Dig Dis Sci 1998; 43: 2048-54.
    • (1998) Dig Dis Sci , vol.43 , pp. 2048-2054
    • Rouzade, M.L.1    Fioramonti, J.2    Bueno, L.3
  • 119
    • 0344010046 scopus 로고    scopus 로고
    • In vivo characterization of 5-HT1A receptor-mediated gastric relaxation in conscious dogs
    • Janssen P, Prins NH, Moreaux B, Meulemans AL, Lefebvre RA. In vivo characterization of 5-HT1A receptor-mediated gastric relaxation in conscious dogs. Br J Pharmacol 2003; 140: 913-20.
    • (2003) Br J Pharmacol , vol.140 , pp. 913-920
    • Janssen, P.1    Prins, N.H.2    Moreaux, B.3    Meulemans, A.L.4    Lefebvre, R.A.5
  • 120
    • 0000628975 scopus 로고    scopus 로고
    • Placebo controlled trial of buspirone, a fundus relaxing drug, in functional dyspepsia: effect on symptoms and gastric sensory and motor function
    • Tack J, Piessevaux H, Coulie B, Fischler B, DeGucht VA. Placebo controlled trial of buspirone, a fundus relaxing drug, in functional dyspepsia: effect on symptoms and gastric sensory and motor function. Gastroenterology 1999; 116: G1423.
    • (1999) Gastroenterology , vol.116 , pp. G1423
    • Tack, J.1    Piessevaux, H.2    Coulie, B.3    Fischler, B.4    DeGucht, V.A.5
  • 122
    • 0029024923 scopus 로고
    • Characterization of a postjunctional 5-HT receptor mediating relaxation of guinea-pig isolated ileum
    • Carter D, Champney M, Hwang B, Eglen RM. Characterization of a postjunctional 5-HT receptor mediating relaxation of guinea-pig isolated ileum. Eur] Pharmacol 1995; 280: 243-50.
    • (1995) Eur] Pharmacol , vol.280 , pp. 243-250
    • Carter, D.1    Champney, M.2    Hwang, B.3    Eglen, R.M.4
  • 124
    • 0036267564 scopus 로고    scopus 로고
    • Pharmacological characterization of the 5-HT receptors mediating contraction and relaxation of canine isolated proximal stomach smooth muscle
    • Janssen P, Prins NH, Meulemans AL, Lefebvre RA. Pharmacological characterization of the 5-HT receptors mediating contraction and relaxation of canine isolated proximal stomach smooth muscle. Br J Pharmacol 2002; 136: 321-9.
    • (2002) Br J Pharmacol , vol.136 , pp. 321-329
    • Janssen, P.1    Prins, N.H.2    Meulemans, A.L.3    Lefebvre, R.A.4
  • 125
    • 0037739827 scopus 로고    scopus 로고
    • 5-HT7 receptors mediate the inhibitory effect of 5-HT on peristalsis in the isolated guinea-pig ileum
    • Tuladhar BR, Ge L, Naylor RJ. 5-HT7 receptors mediate the inhibitory effect of 5-HT on peristalsis in the isolated guinea-pig ileum. Br J Pharmacol 2003; 138: 1210-14.
    • (2003) Br J Pharmacol , vol.138 , pp. 1210-1214
    • Tuladhar, B.R.1    Ge, L.2    Naylor, R.J.3
  • 126
    • 0037183764 scopus 로고    scopus 로고
    • 5-HT7 receptors are involved in mediating 5-HT-induced activation of rat primary afferent neurons
    • Meuser T, Pietruck C, Gabriel A, Xie GX, Lim KJ, Pierce PP. 5-HT7 receptors are involved in mediating 5-HT-induced activation of rat primary afferent neurons. Life Sci 2002; 71: 2279-89.
    • (2002) Life Sci , vol.71 , pp. 2279-2289
    • Meuser, T.1    Pietruck, C.2    Gabriel, A.3    Xie, G.X.4    Lim, K.J.5    Pierce, P.P.6
  • 127
    • 0033978273 scopus 로고    scopus 로고
    • Treatment of functional gastrointestinal disorders with antidepressant medications: a meta-analysis
    • Jackson JL, O'Malley PG, Tomkins G, Balden E, Santero J, Kroenke K. Treatment of functional gastrointestinal disorders with antidepressant medications: a meta-analysis. Am J Med 2000; 108: 65-72.
    • (2000) Am J Med , vol.108 , pp. 65-72
    • Jackson, J.L.1    O'Malley, P.G.2    Tomkins, G.3    Balden, E.4    Santero, J.5    Kroenke, K.6
  • 128
    • 0028301413 scopus 로고
    • Influence of antidepressants on whole gut and orocaecal transit times in health and irritable bowel syndrome
    • Gorard DA, Libby GW, Farthing MJ. Influence of antidepressants on whole gut and orocaecal transit times in health and irritable bowel syndrome. Aliment Pharmacol Ther 1994; 8: 159-66.
    • (1994) Aliment Pharmacol Ther , vol.8 , pp. 159-166
    • Gorard, D.A.1    Libby, G.W.2    Farthing, M.J.3
  • 129
    • 0028842127 scopus 로고
    • Effect of a tricyclic antidepressant on small intestinal motility in health and 1 diarrhea-predominant irritable bowel syndrome
    • Gorard DA, Libby GW, Farthing MJ. Effect of a tricyclic antidepressant on small intestinal motility in health and 1 diarrhea-predominant irritable bowel syndrome. Dig Dis Sci 1995; 40: 86-95.
    • (1995) Dig Dis Sci , vol.40 , pp. 86-95
    • Gorard, D.A.1    Libby, G.W.2    Farthing, M.J.3
  • 130
    • 0031862833 scopus 로고    scopus 로고
    • Imipramine decreases oesophageal pain perception in human male volunteers
    • Peghini PL, Katz PO, Castell DO. Imipramine decreases oesophageal pain perception in human male volunteers. J. Gut 1998;42:807-13.
    • (1998) J. Gut , vol.42 , pp. 807-813
    • Peghini, P.L.1    Katz, P.O.2    Castell, D.O.3
  • 131
    • 0030900827 scopus 로고    scopus 로고
    • Irritable bowel syndrome: a technical review for practice guideline development
    • Drossman DA, Whitehead WE, Camilleri M. Irritable bowel syndrome: a technical review for practice guideline development. Gastroenterology 1997; 112: 2120-37.
    • (1997) Gastroenterology , vol.112 , pp. 2120-2137
    • Drossman, D.A.1    Whitehead, W.E.2    Camilleri, M.3
  • 132
    • 0026506296 scopus 로고
    • Antidepressant-induced analgesia in chronic non-malignant pain: a meta-analysis of 39 placebo-controlled studies
    • Onghena P, Van Houdenhove B. Antidepressant-induced analgesia in chronic non-malignant pain: a meta-analysis of 39 placebo-controlled studies. Pain 1992; 49: 205-19.
    • (1992) Pain , vol.49 , pp. 205-219
    • Onghena, P.1    Van Houdenhove, B.2
  • 133
    • 0037441297 scopus 로고    scopus 로고
    • Influence of the selective serotonin re-uptake inhibitor, paroxet- 1 ine, on gastric sensorimotor function in humans
    • Tack J, Broekaert D, Coulie B, Fischler B, Janssens J. Influence of the selective serotonin re-uptake inhibitor, paroxet- 1 ine, on gastric sensorimotor function in humans. Aliment Pharmacol Ther 2003; 17: 603-8.
    • (2003) Aliment Pharmacol Ther , vol.17 , pp. 603-608
    • Tack, J.1    Broekaert, D.2    Coulie, B.3    Fischler, B.4    Janssens, J.5
  • 134
    • 0037229534 scopus 로고    scopus 로고
    • Selective effects of serotonergic psychoactive agents on gastrointestinal functions in health
    • Chial HJ, Camilleri M, Burton D, Thomforde G, Olden KW, Stephens D. Selective effects of serotonergic psychoactive agents on gastrointestinal functions in health. Am J Physiol 2003; 284: G130-7.
    • (2003) Am J Physiol , vol.284 , pp. G130-7
    • Chial, H.J.1    Camilleri, M.2    Burton, D.3    Thomforde, G.4    Olden, K.W.5    Stephens, D.6
  • 135
    • 0036050129 scopus 로고    scopus 로고
    • Effect of the selective serotonin reuptake inhibitor sertraline on gastric sensitivity and compliance in healthy humans
    • Ladabaum U, Glidden D. Effect of the selective serotonin reuptake inhibitor sertraline on gastric sensitivity and compliance in healthy humans. Neurogastroenterol Motil 2002; 14: 395-102.
    • (2002) Neurogastroenterol Motil , vol.14 , pp. 395-102
    • Ladabaum, U.1    Glidden, D.2
  • 136
    • 0031987329 scopus 로고    scopus 로고
    • Effect of amitriptyline on symptoms, sleep, and visceral perception in patients with functional dyspepsia
    • Mertz H, Fass R, Kodner A, Yan-Go F, Fullerton S, Mayer EA. Effect of amitriptyline on symptoms, sleep, and visceral perception in patients with functional dyspepsia. Am J Gastroenterol 1998; 93: 160-5.
    • (1998) Am J Gastroenterol , vol.93 , pp. 160-165
    • Mertz, H.1    Fass, R.2    Kodner, A.3    Yan-Go, F.4    Fullerton, S.5    Mayer, E.A.6
  • 137
    • 0038418617 scopus 로고    scopus 로고
    • The selective serotonin reuptake inhibitor fluoxetine does not change rectal sensitivity and symptoms in patients with irritable bowel syndrome: a double blind, randomized, placebo-controlled study
    • Kuiken SD, Tytgat GNJ, Boeckxstaens GEE. The selective serotonin reuptake inhibitor fluoxetine does not change rectal sensitivity and symptoms in patients with irritable bowel syndrome: a double blind, randomized, placebo-controlled study. Clin Gastroenterol Hepatol 2003; 1: 219-28.
    • (2003) Clin Gastroenterol Hepatol , vol.1 , pp. 219-228
    • Kuiken, S.D.1    Tytgat, G.N.J.2    Boeckxstaens, G.E.E.3
  • 138
    • 0141892613 scopus 로고    scopus 로고
    • Effects of venlafaxine, buspirone, and placebo on colonic sensorimotor functions in healthy humans
    • Chial HJ, Camilleri M, Ferber I et al. Effects of venlafaxine, buspirone, and placebo on colonic sensorimotor functions in healthy humans. Clin Gastroenterol Hepatol 2003; 1: 211-18.
    • (2003) Clin Gastroenterol Hepatol , vol.1 , pp. 211-218
    • Chial, H.J.1    Camilleri, M.2    Ferber, I.3


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