Inhibition of Aberrant MicroRNA-133a Expression in Endothelial Cells by Statin Prevents Endothelial Dysfunction by Targeting GTP Cyclohydrolase 1 in Vivo

Circulation

Volumn 134, Issue 22, 2016, Pages 1752-1765

  Li, Peng ^a   Yin, Ya Ling ^a   Guo, Tao ^b   Sun, Xue Ying ^c   Ma, Hui ^b   Zhu, Mo Li ^a   Zhao, Fan Rong ^a   Xu, Ping ^a   Chen, Yuan ^b   Wan, Guang Rui ^a   Jiang, Fan ^b   Peng, Qi Sheng ^d   Liu, Chao ^e   Liu, Li Ying ^c   Wang, Shuang Xi ^a,b  

^a XINXIANG MEDICAL UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

^c CENTRAL SOUTH UNIVERSITY   (China)

^d JILIN UNIVERSITY   (China)

^e HUBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

endothelial cells; GTP cyclohydrolase; hydroxymethylglutaryl CoA reductase inhibitors; mic; MIRN133; nitric oxide synthase; roRNA, rat; type III

Indexed keywords

ACETYLCHOLINE; ALPHA SMOOTH MUSCLE ACTIN; ANTAGOMIR; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; INTERLEUKIN 6; MALONALDEHYDE; MEVINOLIN; MICRORNA; MICRORNA 1; MICRORNA 133A; MICRORNA 133B; MICRORNA 206; MICRORNA 613; OXIDIZED LOW DENSITY LIPOPROTEIN; REACTIVE OXYGEN METABOLITE; SHORT HAIRPIN RNA; SUPEROXIDE DISMUTASE; TETRAHYDROBIOPTERIN; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR; GCH1 PROTEIN, MOUSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MESSENGER RNA; MIRN133 MICRORNA, RAT; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOVASCULAR RISK; CLINICAL ASSESSMENT; CONTROLLED STUDY; DRUG EFFECT; DRUG TARGETING; DYSLIPIDEMIA; ECTOPIC EXPRESSION; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME INHIBITION; FLUORESCENCE IN SITU HYBRIDIZATION; GENE OVEREXPRESSION; HYPERGLYCEMIA; HYPERHOMOCYSTEINEMIA; HYPERLIPIDEMIA; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RISK FACTOR; UPREGULATION; VASCULAR ENDOTHELIUM; VASODILATATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; UMBILICAL VEIN ENDOTHELIAL CELL;

ANIMALS; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; GTP CYCLOHYDROLASE; HEK293 CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LOVASTATIN; MICE; MICRORNAS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; RATS; RISK FACTORS; RNA, MESSENGER; UP-REGULATION;

EID: 84992736409     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.116.017949     Document Type: Article

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