Endothelin A receptor activation on mesangial cells initiates Alport glomerular disease

Kidney International

Volumn 90, Issue 2, 2016, Pages 300-310

  Dufek, Brianna ^a   Meehan, Daniel T ^a   Delimont, Duane ^a   Cheung, Linda ^a   Gratton, Michael Anne ^b   Phillips, Grady ^b   Song, Wenping ^c   Liu, Shiguang ^c   Cosgrove, Dominic ^a  

^a BOYS TOWN NATIONAL RESEARCH HOSPITAL   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c SANOFI   (France)

Author keywords

actin dynamics; Alport syndrome; endothelin; glomerulonephritis

Indexed keywords

ACTIN; CYTOKINE; DREBRIN; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; MESSENGER RNA; METALLOPROTEINASE; SITAXSENTAN; SMALL INTERFERING RNA; ENDOTHELIN RECEPTOR ANTAGONIST; ISOXAZOLE DERIVATIVE; LAMININ; THIOPHENE DERIVATIVE;

ALPORT SYNDROME; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; FILOPODIUM; GENE SILENCING; GLOMERULOPATHY; GLOMERULOSCLEROSIS; GLOMERULUS BASEMENT MEMBRANE; GLOMERULUS CAPILLARY; HYPERTENSION; KIDNEY FIBROSIS; LIFESPAN; MEMBRANE STRUCTURE; MESANGIUM CELL; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; UPREGULATION; ANIMAL; BIOMECHANICS; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; METABOLISM; NEPHRITIS; PHYSIOLOGY; PODOCYTE; PSEUDOPODIUM; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

ANIMALS; BIOMECHANICAL PHENOMENA; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; ENDOTHELIN RECEPTOR ANTAGONISTS; ENDOTHELIN-1; FLUORESCENT ANTIBODY TECHNIQUE; GENE KNOCKDOWN TECHNIQUES; GLOMERULAR BASEMENT MEMBRANE; HYPERTENSION; ISOXAZOLES; LAMININ; MESANGIAL CELLS; MICE; MICE, INBRED C57BL; NEPHRITIS, HEREDITARY; PODOCYTES; PROTEINURIA; PSEUDOPODIA; RECEPTOR, ENDOTHELIN A; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; THIOPHENES; UP-REGULATION;

EID: 84992524298     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1016/j.kint.2016.02.018     Document Type: Article

References (32)

1. 1 Kleppel, M.M., Fan, W., Cheong, H.I., Michael, A.F., Evidence for separate networks of classical and novel basement membrane collagen: characterization of alpha 3(IV)-Alport antigen heterodimer. J Biol Chem 267 (1992), 4137–4142.
2. 2 Gunwar, S., Ballester, F., Noelken, M.E., et al. Glomerular basement membrane: identification of a novel disulfide-cross-linked network of alpha3, alpha4, and alpha5 chains of type IV collagen and its implications for the pathogenesis of Alport syndrome. J Biol Chem 273 (1998), 8767–8775.
3. 3 LeBleu, V., Sund, M., Sugimoto, H., et al. Identification of the NC1 domain of α3 chain as critical for α3α4α5 type IV collagen network assembly. J Biol Chem 285 (2010), 41874–41885.
4. 4 Meehan, D.T., Delimont, D., Cheung, L., et al. Biomechanical strain causes maladaptive gene regulation, contributing to Alport glomerular disease. Kidney Int 76 (2009), 968–976.
5. 5 Zallocchi, M., Johnson, B., Meehan, D.T., et al. α1β1 integrin/Rac1-dependent mesangial invasion of glomerular capillaries in Alport syndrome. Am J Pathol 183 (2013), 1269–1280.
6. 6 Cosgrove, D., Rodgers, K., Meehan, D., et al. Integrin alpha1beta1 and transforming growth factor-beta1 play distinct roles in Alport glomerular pathogenesis and serve as dual targets for metabolic therapy. Am J Pathol 157 (2000), 1649–1659.
7. 7 Kashtan, C.E., Kim, Y., Lees, G.E., et al. Abnormal glomerular basement membrane laminins in murine, canine, and human Alport syndrome: aberrant laminin alpha2 deposition is species independent. J Am Soc Nephrol 12 (2001), 252–260.
8. 8 Delimont, D., Dufek, B.M., Meehan, D.T., et al. Laminin alpha2-mediated focal adhesion kinase activation triggers Alport glomerular pathogenesis. PLoS One, 9, 2014, e99083.
9. 9 Gross, O., Beirowski, B., Koepke, M.L., et al. Preemptive ramipril therapy delays renal failure and reduces renal fibrosis in COL4A3-knockout mice with Alport syndrome. Kidney Int 63 (2003), 438–446.
10. 10 Grenda, R., Wuhl, E., Litwin, M., et al., for the ESCAPE Trial Group. Urinary excretion of endothelin-1 (ET-1), transforming growth factor-beta1 (TGF-beta1) and vascular endothelial growth factor (VEGF165) in paedeatric chronic kidney diseases: results from ESCAPE trial. Nephrol Dial Transplant 22 (2007), 3487–3494.
11. B in the rat kidney. J Histochem Cytochem 54 (2006), 1193–1203.
12. 12 Chahdi, A., Sorokin, A., Endothelin 1 stimulates beta1Pix-dependent activation of Cdc42 through the G(salpha) pathway. Exp Biol Med (Maywood) 231 (2006), 761–765.
13. 13 Chahdi, A., Miller, B., Sorokin, A., Endothelin 1 induces beta 1Pix translocation and Cdc42 activation via protein kinase A-dependent pathway. J Biol Chem 280 (2005), 578–584.
14. 14 Sakai, T., Kriz, W., The structural relationship between mesangial cells and basement membrane of the renal glomerulus. Anat Embryol (Berl) 176 (1987), 373–386.
15. 15 Fukuda, R., Suico, M.A., Kai, Y., et al. Podocyte p53 limits the severity of experimental Alport syndrome. J Am Soc Nephrol 27 (2016), 144–157.
16. 16 Webster, G.A., Perkins, N.D., Transcriptional cross talk between NF-kappaB and p53. Mol Cell Biol 19 (1999), 3485–3495.
17. 17 Eddy, A.A., Proteinuria and interstitial injury. Nephrol Dial Transplant 19 (2004), 277–281.
18. 18 Suleiman, H., Zhang, L., Roth, R., et al. Nanoscale protein architecture of the kidney glomerular basement membrane. Elife, 2, 2013, e01149.
19. 19 Gross, O., Girgert, R., Beirowski, B., et al. Loss of collagen-receptor DDR1 delays renal fibrosis in hereditary type IV collagen disease. Matrix Biol 29 (2010), 346–356.
20. 20 Durvasula, R.V., Shankland, S.J., Mechanical strain increases SPARC levels in podocytes: implications for glomerulosclerosis. Am J Physiol Renal Physiol 289 (2005), F577–F584.
21. 21 Durvasula, R.V., Petermann, A.T., Hiromura, K., et al. Activation of a local tissue angiotensin system in podocytes by mechanical strain. Kidney Int 65 (2004), 30–39.
22. 22 Daehn, I., Casalena, G., Zhang, T., et al. Endothelial mitochondrial oxidative stress determines podocyte depletion in segmental glomerulosclerosis. J Clin Invest 124 (2014), 1608–1621.
23. 23 Sayers, R., Kalluri, R., Rodgers, K.D., et al. Role for transforming growth factor-beta1 in Alport renal disease progression. Kidney Int 56 (1999), 1662–1673.
24. 24 Ryu, M., Mulay, S.R., Miosge, N., et al. Tumour necrosis factor-α drives Alport glomerulosclerosis in mice by promoting podocyte apoptosis. J Pathol 226 (2012), 120–131.
25. 25 Rodriguez-Pascual, F., Reimunde, F.M., Redondo-Horcajo, M., Lamas, S., Transforming growth factor-beta induces endothelin-1 expression through activation of the Smad signaling pathway. J Cardiovasc Pharmacol 44:suppl 1 (2004), S39–S42.
26. 26 Marsden, P.A., Brenner, B.M., Transcriptional regulation of the endothelin-1 gene by TNF-alpha. Am J Physiol 262 (1992), C854–C861.
27. 27 Pohl, M., Danz, K., Gross, O., et al. Diagnosis of Alport syndrome–search for proteomic biomarkers in body fluids. Pediatric Nephrol 28 (2013), 2117–2123.
28. 28 Cosgrove, D., Meehan, D.T., Grunkemeyer, J.A., et al. Collagen 4A3 knockout: a mouse model for autosomal Alport syndrome. Genes Dev 10 (1996), 2981–2992.
29. 29 Rheault, M.N., Kren, S.M., Thielen, B.K., et al. Mouse model of X-linked Alport syndrome. J Am Soc Nephrol 15 (2004), 1466–1474.
30. 30 Cosgrove, D., Meehan, D.T., Delimont, D., et al. Integrin alpha1beta1 regulates matrix metalloproteinases via p38 mitogen-activated protein kinase in mesangial cells: implications for Alport syndrome. Am J Pathol 172 (2008), 761–773.
31. 31 Rao, V.H., Meehan, D., Delimont, D., et al. Role for macrophage metalloelastase in glomerular basement membrane damage associated with Alport syndrome. Am J Pathol 169 (2006), 32–46.
32. 32 Takemoto, M., Asker, N., Gerhardt, H., et al. A new method for large scale isolation of kidney glomeruli from mice. Am J Pathol 161 (2002), 799–805.