Swept-source OCT angiography imaging of the foveal avascular zone and macular capillary network density in diabetic retinopathy

Investigative Ophthalmology and Visual Science

Volumn 57, Issue 8, 2016, Pages 3907-3913

  Al Sheikh, Mayss ^a,b   Akil, Handan ^a   Pfau, Maximilian ^a,c   Sadda, Srinivas R ^b  

^a DOHENY EYE INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF BONN   (Germany)

Author keywords

Angiography; Diabetic retinopathy; Foveal avascular zone; Optical coherence tomography; Vessel density

Indexed keywords

ADULT; AGED; ANGIOGRAPHY; ARTICLE; CAPILLARY NETWORK DENSITY; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC RETINOPATHY; FEMALE; FOVEAL AVASCULAR ZONE AREA; HUMAN; MALE; OPTICAL COHERENCE TOMOGRAPHY; PRIORITY JOURNAL; SENSORY SYSTEM PARAMETERS; VESSEL DENSITY; CAPILLARY; CASE CONTROL STUDY; DIAGNOSTIC IMAGING; FLUORESCENCE ANGIOGRAPHY; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; PROSPECTIVE STUDY; RETINA FOVEA; RETINA MACULA LUTEA; VASCULARIZATION; VERY ELDERLY;

AGED; AGED, 80 AND OVER; CAPILLARIES; CASE-CONTROL STUDIES; DIABETIC RETINOPATHY; FEMALE; FLUORESCEIN ANGIOGRAPHY; FOVEA CENTRALIS; HUMANS; MACULA LUTEA; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 84992366215     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.16-19570     Document Type: Article

References (29)

1. Klein R. The epidemiology of diabetic retinopathy: findings from the Wisconsin epidemiologic study of diabetic retinopathy. Int Ophthalmol Clin. 1987;27:230–238.
2. Stefansson E, Bek T, Porta M, Larsen N, Kristinsson JK, Agardh E. Screening and prevention of diabetic blindness. Acta Ophthalmol Scand. 2000;78:374–385.
3. Saaddine JB, Honeycutt AA, Narayan KM, Zhang X, Klein R, Boyle JP. Projection of diabetic retinopathy and other major eye diseases among people with diabetes mellitus: United States, 2005–2050. Arch Ophthalmol. 2008;126:1740–1747.
4. Wu L, Fernandez-Loaiza P, Sauma J, Hernandez-Bogantes E, Masis M. Classification of diabetic retinopathy and diabetic macular edema. World J Diabetes. 2013;4:290–294.
5. Schoenfeld ER, Greene JM, Wu SY, Leske MC. Patterns of adherence to diabetes vision care guidelines: baseline findings from the diabetic retinopathy awareness program. Ophthalmology. 2001;108:563–571.
6. Davis MD, Fisher MR, Gangnon RE, et al. Risk factors for highrisk proliferative diabetic retinopathy and severe visual loss: early treatment diabetic retinopathy study report #18. Invest Ophthalmol Vis Sci. 1998;39:233–252.
7. Snodderly DM, Weinhaus RS. Retinal vasculature of the fovea of the squirrel monkey, saimiri sciureus: three-dimensional architecture, visual screening, and relationships to the neuronal layers. J Comp Neurol. 1990;297:145–163.
8. Linsenmeier RA, Braun RD. Oxygen distribution and consumption in the cat retina during normoxia and hypoxemia. J Gen Physiol. 1992;99:177–197.
9. Nagaoka T, Sato E, Takahashi A, Yokota H, Sogawa K, Yoshida A. Impaired retinal circulation in patients with type 2 diabetes mellitus: retinal laser Doppler velocimetry study. Invest Ophthalmol Vis Sci. 2010;51:6729–6734.
10. Durham JT, Herman IM. Microvascular modifications in diabetic retinopathy. Curr Diab Rep. 2011;11:253–264.
11. Wiley H, Ferris F. Nonproliferative diabetic retinopathy and diabetic macular edema. In: Ryan S, Sadda S, Hinton D, eds. Retina. London, UK: Elsevier Saunders; 2013:940–968.
12. Arend O, Wolf S, Jung F, et al. Retinal microcirculation in patients with diabetes mellitus: dynamic and morphological analysis of perifoveal capillary network. Br J Ophthalmol. 1991;75:514–518.
13. Kwiterovich K, Maguire M, Murphy R. Frequency of adverse systemic reactions after fluorescein angiography. Ophthalmology. 1998;98:1139–1142.
14. Sohn EH, van Dijk HW, Jiao C, et al. Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitus. Proc Natl Acad Sci U S A. 2016;113:E2655–E2664.
15. Yi J, Liu W, Chen S, et al. Visible light optical coherence tomography measures retinal oxygen metabolic response to systemic oxygenation. Light Sci Appl. 2015;4:e334.
16. Spaide RF, Klancnik JM Jr, Cooney MJ. Retinal vascular layers imaged by fluorescein angiography and optical coherence tomography angiography. JAMA Ophthalmol. 2015;133:45–50.
17. Jia Y, Tan O, Tokayer J, et al. Split-spectrum amplitudedecorrelation angiography with optical coherence tomography. Opt Express. 2012;20:4710–4725.
18. Kuehlewein L, Tepelus TC, An L, Durbin MK, Srinivas S, Sadda SR. Noninvasive visualization and analysis of the human parafoveal capillary network using swept source OCT optical microangiography. Invest Ophthalmol Vis Sci. 2015;56:3984-3988.
19. Chidambara L, Gadde SG, Yadav NK, et al. Characteristics and quantification of vascular changes in macular telangiectasia type 2 on optical coherence tomography angiography [published online ahead of print January 28, 2016]. Br J Ophthalmol. doi:10.1136/bjophthalmol-2015-307941.
20. Gadde SG, Anegondi N, Bhanushali D, et al. Quantification of vessel density in retinal optical coherence tomography angiography images using local fractal dimension. Invest Ophthalmol Vis Sci. 2016;57:246–252.
21. Ishibazawa A, Nagaoka T, Takahashi A, et al. Optical coherence tomography angiography in diabetic retinopathy: a prospective pilot study. Am J Ophthalmol. 2015;160:35–44.
22. de Carlo TE, Chin AT, Bonini Filho MA, et al. Detection of microvascular changes in eyes of patients with diabetes but not clinical diabetic retinopathy using optical coherence tomography angiography. Retina. 2015;35:2364–2370.
23. Bresnick GH, Condit R, Syrjala S, Palta M, Groo A, Korth K. Abnormalities of the foveal avascular zone in diabetic retinopathy. Arch Ophthalmol. 1984;102:1286–1293.
24. Mansour AM, Schachat A, Bodiford G, Haymond R. Foveal avascular zone in diabetes mellitus. Retina. 1993;13:125–128.
25. Kim DY, Fingler J, Zawadzki RJ, et al. Noninvasive imaging of the foveal avascular zone with high-speed, phase-variance optical coherence tomography. Invest Ophthalmol Vis Sci. 2012;53:85–92.
26. Takase N, Nozaki M, Kato A, Ozeki H, Yoshida M, Ogura Y. Enlargement of foveal avascular zone in diabetic eyes evaluated by en face optical coherence tomography angiography. Retina. 2015;35:2377–2383.
27. Hwang TS, Jia Y, Gao SS, et al. Optical coherence tomography angiography features of diabetic retinopathy. Retina. 2015;35: 2371–2376.
28. de Carlo TE, Chin AT, Joseph T, et al. Distinguishing diabetic macular edema from capillary nonperfusion using optical coherence tomography angiography. Ophthalmic Surg Lasers Imaging Retina. 2016;47:108–114.
29. Curtis TM, Gardiner TA, Stitt AW. Microvascular lesions of diabetic retinopathy: clues towards understanding pathogenesis? Eye (Lond). 2009;23:1496–1508.