Noninvasive imaging of the foveal avascular zone with high-speed, phase-variance optical coherence tomography

Investigative Ophthalmology and Visual Science

Volumn 53, Issue 1, 2012, Pages 85-92

  Kim, Dae Yu ^a,b   Fingler, Jeff ^c   Zawadzki, Robert J ^a   Park, Susanna S ^a   Morse, Lawrence S ^a   Schwartz, Daniel M ^d   Fraser, Scott E ^c   Werner, John S ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of California   (United States)

^c CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC RETINOPATHY; EYE FUNDUS; FEMALE; HUMAN; MALE; MICROCIRCULATION; MORPHOLOGY; OPTICAL COHERENCE TOMOGRAPHY; PRIORITY JOURNAL; RETINA BLOOD VESSEL; RETINA FLUORESCEIN ANGIOGRAPHY; RETINA FOVEA; VASCULARIZATION; CAPILLARY; FLUORESCENCE ANGIOGRAPHY; FOURIER ANALYSIS; MIDDLE AGED; PATHOLOGY; THREE DIMENSIONAL IMAGING;

ADULT; AGED; CAPILLARIES; DIABETIC RETINOPATHY; FEMALE; FLUORESCEIN ANGIOGRAPHY; FOURIER ANALYSIS; FOVEA CENTRALIS; HUMANS; IMAGING, THREE-DIMENSIONAL; MALE; MICROCIRCULATION; MIDDLE AGED; RETINAL VESSELS; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 84857962348     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-8249     Document Type: Article

References (34)

1. Fruttiger M. Development of the retinal vasculature. Angiogenesis. 2007;10:77-88.
2. Tick S, Rossant F, Ghorbel I, et al. Foveal shape and structure in a normal population. Invest Ophthalmol Vis Sci. 2011;52:5105-5110.
3. Bird AC, Weale RA. On the retinal vasculature of the human fovea. Exp Eye Res. 1974;19:409-417.
4. Yap M, Gilchrist J, Weatherill J. Psychophysical measurement of the foveal avascular zone. Ophthal Physiol Opt. 1987;7:405-410.
5. Bradley A, Applegate RA, Zeffren BS, van Heuven WAJ. Psychophysical measurement of the size and shape of the human foveal avascular zone. Ophthal Physiol Opt. 1992;12:18-23.
6. Bresnick GH, Condit R, Syrjala S, Palta M, Groo A, Korth K. Abnormalities of the foveal avascular zone in diabetic retinopathy. Arch Ophthalmol. 1984;102:1286-1293.
7. Arend O, Wolf S, Jung F, et al. Retinal microcirculation in patients with diabetes mellitus: dynamic and morphological analysis of perifoveal capillary network. Br J Ophthalmol. 1991;75:514-518.
8. Conrath J, Giorgi R, Raccah D, Ridings B. Foveal avascular zone in diabetic retinopathy: quantitative vs qualitative assessment. Eye. 2005;19:322-326.
9. Gray DC, Merigan W, Wolfing JI, et al. In vivo fluorescence imaging of primate retinal ganglion cells and retinal pigment epithelial cells. Opt Express. 2006;14:7144-7158.
10. Tam J, Martin JA, Roorda A. Noninvasive visualization and analysis of parafoveal capillaries in humans. Invest Ophthalmol Vis Sci. 2010;51:1691-1698.
11. Popovic Z, Knutsson P, Thaung J, Owner-Petersen M, Sjöstrand J. Noninvasive imaging of human foveal capillary network using dual-conjugate adaptive optics. Invest Ophthalmol Vis Sci. 2011: 52;2649-2655.
12. Wang Q, Kocaoglu OP, Cense B, et al. Imaging retinal capillaries using ultrahigh-resolution optical coherence tomography and adaptive optics. Invest Ophthalmol Vis Sci. 2011;52:6292-6299.
13. Makita S, Jaillon F, Yamanari M, Miura M, Yasuno Y. Comprehensive in vivo micro-vascular imaging of the human eye by dualbeam-scan Doppler optical coherence angiography. Opt Express. 2011;19:1271-1283.
14. Zotter S, Pircher M, Torzicky T, et al. Visualization of microvasculature by dual-beam phase-resolved Doppler optical coherence tomography. Opt Express. 2011;19:1217-1227.
15. Kim D, Fingler J, Werner JS, Schwartz DM, Fraser SE, Zawadzki RJ. In vivo volumetric imaging of human retinal circulation with phase-variance optical coherence tomography. Biomed Opt Express. 2011;2:1504-1513.
16. Fingler J, Schwartz D, Yang C, Fraser SE. Mobility and transverse flow visualization using phase variance contrast with spectral domain optical coherence tomography. Opt Express. 2007;15: 12636-12653.
17. Fingler J, Readhead C, Schwartz DM, Fraser SE. Phase-contrast OCT imaging of transverse flows in the mouse retina and choroid. Invest Ophthalmol Vis Sci. 2008;49:5055-5059.
18. Huang D, Swanson EA, Lin CP, et al. Optical coherence tomography. Science. 1991;254:1178-1181.
19. Delori FC, Webb RH, Sliney DH. Maximum permissible exposures for ocular safety (ANSI 2000), with emphasis on ophthalmic devices. J Opt Soc Am A. 2007;24:1250-1265.
20. Kim D, Werner JS, Zawadzki RJ. Comparison of phase-shifting techniques for in vivo full-range, high-speed Fourier-domain optical coherence tomography. J Biomed Opt. 2010;15:056011.
21. Nassif N, Cense B, Park B, et al. In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve. Opt Express. 2004;12:367-376.
22. Zawadzki RJ, Jones SM, Olivier SS, et al. Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging. Opt Express. 2005;13:8532-8546.
23. Wojtkowski M, Srinivasan V, Ko T, Fujimoto J, Kowalczyk A, Duker J. Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation. Opt Express. 2004;12:2404-2422.
24. Fingler J, Zawadzki RJ, Werner JS, Schwartz D, Fraser SE. Volumetric microvascular imaging of human retina using optical coherence tomography with a novel motion contrast technique. Opt Express. 2009;17:22190-22200.
25. White B, Pierce M, Nassif N, et al. In vivo dynamic human retinal blood flow imaging using ultra-high-speed spectral domain optical coherence tomography. Opt Express. 2003;11:3490-3497.
26. Andrey P, Boudier T. Adaptive active contours. ImageJ Conference; May 18-29, 2006; Luxembourg, Belgium.
27. Arend O, Remky A, Harris A, Bertram B, Reim M, Wolf S. Macular microcirculation in cystoid maculopathy of diabetic patients. Br J Ophthalmol. 1995;79:628-632.
28. Wilkinson CP, Ferris FL III, Klein RE, et al. Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology. 2003;110:1677-1682.
29. Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986;i:307-310.
30. Zheng Y, Gandhi JS, Stangos AN, et al. Automated segmentation of foveal avascular zone in fundus fluorescein angiography. Invest Ophthalmol Vis Sci. 2010;51:3653-3659.
31. Chylack LT, Leske MC, McCarthy D, et al. Lens opacities classification system II (LOCS II): the longitudinal study of cataract study group. Arch Ophthalmol. 1989;107:991-997.
32. Povazay B, Hofer B, Torti C, et al. Impact of enhanced resolution, speed and penetration on three-dimensional retinal optical coherence tomography. Opt Express. 2009;17:4134-4150.
33. Bennett AG, Rudnicka AR, Edgar DF. Improvements on Littmann's method of determining the size of retinal features by fundus photography. Graefes Arch Clin Exp Ophthalmol. 1994;232:361-367.
34. Foreman DM, Bagley S, Moore J, Ireland GW, McLeod D, Boulton ME. Three-dimensional analysis of the retinal vasculature using immunofluorescent staining and confocal laser scanning microscopy. Br J Ophthalmol. 1996;80:246-251.