Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses

Journal of Molecular Cell Biology

Volumn 8, Issue 5, 2016, Pages 426-438

  Mora, Javier ^a,b   Schlemmer, Andrea ^a   Wittig, Ilka ^a   Richter, Florian ^a   Putyrski, Mateusz ^a,c   Frank, Ann Christin ^a   Han, Yingying ^a,d   Jung, Michaela ^a   Ernst, Andreas ^a,c   Weigert, Andreas ^a   Brüne, Bernhard ^a  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSIDAD DE COSTA RICA   (Costa Rica)

^c FRAUNHOFER INSTITUTE FOR MOLECULAR BIOLOGY AND APPLIED ECOLOGY IME   (Germany)

^d JILIN UNIVERSITY   (China)

Author keywords

apoptosis; cancer; IL 1 family; inflammation

Indexed keywords

INTERLEUKIN 1; INTERLEUKIN 38; INTERLEUKIN 6; INTERLEUKIN 8; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; AUTOIMMUNITY; CELL DEATH; CELL EXPANSION; COCULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HUMAN; HUMAN CELL; IMMUNOREGULATION; INFLAMMATION; MACROPHAGE ACTIVATION; MACROPHAGE CULTURE; NEOPLASM; PYROPTOSIS; T CELL CULTURE; TH17 CELL;

EID: 84992365616     PISSN: 16742788     EISSN: 17594685     Source Type: Journal    
DOI: 10.1093/jmcb/mjw006     Document Type: Article

References (42)

1. Abdulahad, W.H., Boots, A.M., and Kallenberg, C.G. (2011). FoxP3+ CD4+ T cells in systemic autoimmune diseases: the delicate balance between true regulatory T cells, and effector Th-17 cells. Rheumatology 50, 646-656
2. Afonina, I.S., Muller, C., Martin, S.J., et al. (2015). Proteolytic processing of interleukin-1 family cytokines: variations on a common theme. Immunity 42, 991-1004
3. Arthur, J.S., and Ley, S.C. (2013). Mitogen-activated protein kinases in innate immunity. Nat. Rev. Immunol. 13, 679-692
4. Bensen, J.T., Dawson, P.A., Mychaleckyj, J.C., et al. (2001). Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14. J. Interferon Cytokine Res. 21, 899-904
5. Born, T.L., Smith, D.E., Garka, K.E., et al. (2000). Identification, and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of anewclass of IL-1R-related proteins based on signaling. J. Biol. Chem. 275, 29946-29954
6. Carrie, A., Jun, L., Bienvenu, T., et al. (1999). A new member of the IL-1 receptor family highly expressed in hippocampus, and involved in X-linked mental retardation. Nat. Genet. 23, 25-31
7. Chiyomaru, T., Yamamura, S., Zaman, M.S., et al. (2012). Genistein suppresses prostate cancer growth through inhibition of oncogenic microRNA-151. PLoS One 7, e43812
8. Chou, C.T., Timms, A.E., Wei, J.C., et al. (2006). Replication of association of IL1 gene complex members with ankylosing spondylitis in Taiwanese Chinese. Ann. Rheum. Dis. 65, 1106-1109
9. Debets, R., Timans, J.C., Homey, B., et al. (2001). Two novel IL-1 family members, IL-1d, and IL-1z, function as an antagonist, and agonist of NF-kB activation through the orphan IL-1 receptor-related protein 2. J. Immunol. 167, 1440-1446
10. Dehghan, A., Dupuis, J., Barbalic, M., et al. (2011). Meta-analysis of genomewide association studies in .80000 subjects identifies multiple loci for C-reactive protein levels. Circulation 123, 731-738
11. Dinarello, C.A. (2009). Immunological, and inflammatory functions of the interleukin-1 family. Annu. Rev. Immunol. 27, 519-550
12. Dinarello, C.A. (2013). Overview of the interleukin-1 family of ligands, and receptors. Semin. Immunol. 25, 389-393
13. Eisenstein, E.M., and Williams, C.B. (2009). The T(reg)/Th17 cell balance: a new paradigm for autoimmunity. Pediatr. Res. 65, 26R-31R
14. Galindo, R.C., Ayllon, N., Smrdel, K.S., et al. (2012). Gene expression profile suggests that pigs (Sus scrofa) are susceptible to Anaplasma phagocytophilum but control infection. Parasit. Vectors 5, 181
15. Gambino, F., Kneib, M., Pavlowsky, A., etal. (2009). IL1RAPL1controls inhibitory networks during cerebellar development in mice. Eur. J. Neurosci. 30, 1476-1486
16. Garlanda, C., Dinarello, C.A., and Mantovani, A. (2013). The interleukin-1 family: back to the future. Immunity 39, 1003-1018
17. Gregory, C.D., and Pound, J.D. (2011). Cell death in the neighbourhood: direct microenvironmental effects of apoptosis in normal, and neoplastic tissues. J. Pathol. 223, 177-194
18. Guo, Z.S., Li, C., Lin, Z.M., et al. (2010). Association of IL-1 gene complex members with ankylosing spondylitis in Chinese Han population. Int. J. Immunogenet. 37, 33-37
19. Heinecke, J.L., Ridnour, L.A., Cheng, R.Y., et al. (2014). Tumormicroenvironmentbased feed-forward regulation of NOS2 in breast cancer progression. Proc. Natl Acad. Sci. USA 111, 6323-6328
20. Jung, M.Y., Kang, S.W., Kim, S.K., et al. (2010). The interleukin-1family genepolymorphisms in Korean patients with rheumatoid arthritis. Scand. J. Rheumatol. 39, 190-196
21. Khan, J.A., Brint, E.K., O'Neill, L.A., et al. (2004). Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL. J. Biol. Chem. 279, 31664-31670
22. Laurence, A., and O'Shea, J.J. (2007). T(H)-17 differentiation: of mice, and men. Nat. Immunol. 8, 903-905
23. Ley, S., Weigert, A., Heriche, J.K., et al. (2013a). RNAi screen in apoptotic cancer cell-stimulated human macrophages reveals co-regulation of IL-6/IL-10 expression. Immunobiology 218, 40-51
24. Ley, S., Weigert, A., Weichand, B., et al. (2013b). The role of TRKA signaling in IL-10 production by apoptotic tumor cell-activated macrophages. Oncogene 32, 631-640
25. Lin, H., Ho, A.S., Haley-Vicente, D., et al. (2001). Cloning, and characterization of IL-1HY2, a novel interleukin-1 family member. J. Biol. Chem. 276, 20597-20602
26. Mehrotra, S., Pecaut, M.J., and Gridley, D.S. (2014). Minocycline modulates cytokine, and gene expression profiles in the brain after whole-body exposure to radiation. In Vivo 28, 21-32
27. Monnet, D., Kadi, A., Izac, B., et al. (2012). Association between the IL-1 family gene cluster, and spondyloarthritis. Ann. Rheum. Dis. 71, 885-890
28. Mutamba, S., Allison, A., Mahida, Y., et al. (2012). Expression of IL-1Rrp2 by human myelomonocytic cells is unique to DCs, and facilitates DC maturation by IL-1F8, and IL-1F9. Eur. J. Immunol. 42, 607-617
29. Pasparakis, M., and Vandenabeele, P. (2015). Necroptosis, and its role in inflammation. Nature 517, 311-320
30. Pavlowsky, A., Zanchi, A., Pallotto, M., et al. (2010). Neuronal JNK pathway activation by IL-1 is mediated through IL1RAPL1, a protein required for development of cognitive functions. Commun. Integr. Biol. 3, 245-247
31. Rahman, P., Sun, S., Peddle, L., et al. (2006). Association between the interleukin-1 family gene cluster, and psoriatic arthritis. Arthritis Rheum. 54, 2321-2325
32. Sims, J.E., and Smith, D.E. (2010). The IL-1 family: regulators of immunity. Nat. Rev. Immunol. 10, 89-102
33. Towne, J.E., Garka, K.E., Renshaw, B.R., et al. (2004). Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2, and IL-1RAcP to activate the pathway leading to NF-kB, and MAPKs. J. Biol. Chem. 279, 13677-13688
34. Towne, J.E., Renshaw, B.R., Douangpanya, J., et al. (2011). Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36a, IL-36b, and IL-36g) or antagonist (IL-36Ra) activity. J. Biol. Chem. 286, 42594-42602
35. van de Veerdonk, F.L., and Netea, M.G. (2013). New insights in the immunobiology of IL-1 family members. Front. Immunol. 4, 167
36. van de Veerdonk, F.L., Stoeckman, A.K., Wu, G., et al. (2012). IL-38 binds to the IL-36 receptor, and has biological effects on immune cells similar to IL-36 receptor antagonist. Proc. Natl Acad. Sci. USA 109, 3001-3005
37. Vanden Berghe, T., Linkermann, A., Jouan-Lanhouet, S., et al. (2014). Regulated necrosis: the expanding network of non-apoptotic cell death pathways. Nat. Rev. Mol. Cell Biol. 15, 135-147
38. Weigert, A., Johann, A.M., von Knethen, A., et al. (2006). Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate. Blood 108, 1635-1642
39. Weigert, A., Tzieply, N., von Knethen, A., et al. (2007). Tumor cell apoptosis polarizes macrophages role of sphingosine-1-phosphate. Mol. Biol. Cell 18, 3810-3819
40. Xiao, W., Hodge, D.R., Wang, L., et al. (2004). Co-operative functions between nuclear factors NFkB, and CCAT/enhancer-binding protein-b (C/EBP-b) regulate the IL-6 promoter in autocrine human prostate cancer cells. Prostate 61, 354-370
41. Xu, H., Zhu, X., Hu, Y., et al. (2014).DNAmethylomein spleen of avian pathogenic Escherichia coli-challenged broilers, and integration with mRNA expression. Sci. Rep. 4, 4299
42. Zitvogel, L., Kepp, O., and Kroemer, G. (2010). Decoding cell death signals in inflammation, and immunity. Cell 140, 798-804