Metformin Activates AMPK through the Lysosomal Pathway

Cell Metabolism

Volumn 24, Issue 4, 2016, Pages 521-522

  Zhang, Chen Song ^a   Li, Mengqi ^a   Ma, Teng ^a   Zong, Yue ^a   Cui, Jiwen ^a   Feng, Jin Wei ^a   Wu, Yu Qing ^a   Lin, Shu Yong ^a   Lin, Sheng Cai ^a  

^a XIAMEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; AXIN; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LAMTOR1 PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; METFORMIN; PROTEIN; RAPTOR PROTEIN; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CLINICAL TRIAL (TOPIC); COMPLEX FORMATION; CONCENTRATION PROCESS; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IMMUNOPRECIPITATION; IN VITRO STUDY; KNOCKOUT MOUSE; LETTER; LIVER CELL; LIVER DISEASE; LIVER HOMOGENATE; LYSOSOME; MOUSE; NONHUMAN; NUTRIENT SUPPLY; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN INTERACTION; SINGLE DRUG DOSE; ANIMAL; DRUG EFFECTS; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; SIGNAL TRANSDUCTION;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; DIABETES MELLITUS, TYPE 2; ENZYME ACTIVATION; HEPATOCYTES; HUMANS; HYPOGLYCEMIC AGENTS; LYSOSOMES; METFORMIN; SIGNAL TRANSDUCTION;

EID: 84992363334     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2016.09.003     Document Type: Letter

References (10)

1. Barzilai, N., Crandall, J.P., Kritchevsky, S.B., Espeland, M.A., Cell Metab. 23 (2016), 1060–1065.
2. Burkewitz, K., Zhang, Y., Mair, W.B., Cell Metab. 20 (2014), 10–25.
3. Foretz, M., Guigas, B., Bertrand, L., Pollak, M., Viollet, B., Cell Metab. 20 (2014), 953–966.
4. Fullerton, M.D., Galic, S., Marcinko, K., Sikkema, S., Pulinilkunnil, T., Chen, Z.P., O'Neill, H.M., Ford, R.J., Palanivel, R., O'Brien, M., et al. Nat. Med. 19 (2013), 1649–1654.
5. Hardie, D.G., Cell Metab. 20 (2014), 939–952.
6. He, L., Wondisford, F.E., Cell Metab. 21 (2015), 159–162.
7. Li, Y., Xu, S., Mihaylova, M.M., Zheng, B., Hou, X., Jiang, B., Park, O., Luo, Z., Lefai, E., Shyy, J.Y., et al. Cell Metab. 13 (2011), 376–388.
8. Shaw, R.J., Lamia, K.A., Vasquez, D., Koo, S.H., Bardeesy, N., Depinho, R.A., Montminy, M., Cantley, L.C., Science 310 (2005), 1642–1646.
9. Zhang, Y.L., Guo, H., Zhang, C.S., Lin, S.Y., Yin, Z., Peng, Y., Luo, H., Shi, Y., Lian, G., Zhang, C., et al. Cell Metab. 18 (2013), 546–555.
10. Zhang, C.S., Jiang, B., Li, M., Zhu, M., Peng, Y., Zhang, Y.L., Wu, Y.Q., Li, T.Y., Liang, Y., Lu, Z., et al. Cell Metab. 20 (2014), 526–540.