Urinary kidney injury molecule-1 levels as a marker of early kidney injury in hypertensive patients

Minerva Urologica e Nefrologica

Volumn 68, Issue 5, 2016, Pages 456-461

  Kadioglu, Tulay ^a   Uzunlulu, Mehmet ^a   Yigit Kaya, Sureyya ^a   Oguz, Aytekin ^a   Gonenli, Gokhan ^a   Isbilen, Banu ^a   Isman, Ferruh ^a  

^a GOZTEPE TRAINING AND RESEARCH HOSPITAL   (Turkey)

Author keywords

Biomarkers; Hypertension; Hypertensive nephropathy

Indexed keywords

ALANINE AMINOTRANSFERASE; ANGIOTENSIN RECEPTOR ANTAGONIST; ASPARTATE AMINOTRANSFERASE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CREATININE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; FIBRIC ACID DERIVATIVE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; KIDNEY INJURY MOLECULE 1; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; UREA; BIOLOGICAL MARKER; HAVCR1 PROTEIN, HUMAN;

ADULT; ANTHROPOMETRIC PARAMETERS; ARTICLE; BIOCHEMICAL ANALYSIS; BODY MASS; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE DURATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GLOMERULUS FILTRATION RATE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERTENSION; KIDNEY INJURY; MALE; MICROALBUMINURIA; SYSTOLIC BLOOD PRESSURE; ACUTE KIDNEY INJURY; CASE CONTROL STUDY; COMPLICATION; EARLY DIAGNOSIS; MIDDLE AGED; URINE;

ACUTE KIDNEY INJURY; BIOMARKERS; CASE-CONTROL STUDIES; EARLY DIAGNOSIS; FEMALE; HEPATITIS A VIRUS CELLULAR RECEPTOR 1; HUMANS; HYPERTENSION; MALE; MIDDLE AGED;

EID: 84992336037     PISSN: 03932249     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Zhang Z, Humphreys BD, Bonventre JV. Shedding of the urinary biomarker kidney injury molecule-1 (KIM-1) is regulated by MAP kinases and juxtamembrane region. J Am Soc Nephrol 2007;18:2704-14.
2. Lisowska-Myjak B. Serum and urinary biomarkers of acute kidney injury. Blood Purif 2010;29:357-65.
3. Han WK, Bailly V, Abichandani R, Thadhani R, Bonventre JV. Kidney injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury. Kidney Int 2002;62:237-44.
4. Koyner JL, Vaidya VS, Bennet VR, Ma Q, Worcester EM, Akhter SA, et al. Urinary biomarkers in the clinical prognosis and early detection of acute kidney injury. Clin J Am Soc Nephrol 2010;5:2154-65.
5. van Timmeren MM, Vaidya VS, Van Ree RM, Oterdoom LH, De Vries APJ, Gans ROB, et al. High urinary excretion of kidney injury molecule-1 is an independent predictor of graft loss in renal transplant recipients. Transplantation 2007;84:1625-30.
6. Walker WG. Hypertension-related renal injury: a major contributor to end-stage renal disease. Am J Kidney Dis 1993;22:164-73.
7. Pontremoli R, Nicolella C, Viazzi F, Ravera M, Sofia A, Berruti v, et al. Microalbuminuria is an early marker of target organ damage in essential hypertension. Am J Hypertens 1998;11:430-8.
8. Middleton RJ, Foley RN, Hegarty J, Cheung CM, McElduff P, Gibson JM, et al. The unrecognized prevalence of chronic kidney disease in diabetes. Nephrol Dial Transplant 2006;21:88-92.
9. Ruggenenti P, Gaspari F, Perna A, Remuzzi G. Cross sectional longitudinal study of spot morning urine protein: creatinine ratio, 24 hour urine protein excretion rate, glomerular filtration rate, and end stage renal failure in chronic renal disease in patients without diabetes. BMJ 1998;316:504-9.
10. Matsushita K, Tonelli M, Lloyd A, Levey AS, Coresh J, Hemmelgarn BR; alberta Kidney Disease network. clinical risk implications of the CKD epidemiology collaboration (CKD-EPI) equation compared with the Modi-fication of Diet in Renal Disease (MDRD) Study equation for estimated GFR. Am J Kidney Dis 2012;60:241-9.
11. Liangos O, Perianayagam MC, Vaidya VS, Han WK, Wald R, Tighiouart H, et al. Urinary N-acetyl-β-(D)- glucosaminidase activity and kidney injury molecule-1 level are associated with adverse outcomes in acute renal failure. J Am Soc Nephrol. 2007;18:904-12
12. Waanders F, van Timmeren MM, Stegeman CA, Bakker SJ, Van Goor H. Kidney injury molecule-1 in renal disease. J Pathol 2010;220:7-16.
13. Nangaku M. Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure. J Am Soc Nephrol 2006;17:17-25.
14. Haase M, Mertens PR. Biomarkers: more than just markers! Nephrol Dial Transplant 2015;30:33-8
15. Nielsen SE, Schjoedt KJ, Astrup AS, Tarnow L, Lajer M, Hansen PR, et al. Neutrophil gelatinase-associated lipocalin (NGAL) and Kidney injury Molecule 1 (KIM1) in patients with diabetic nephropathy: a cross sectional study and the effects of lisinopril. Diabet Med 2010;27:1144-50.
16. Sabbisetti VS, Waikar SS, Antoine DJ, Smiles A, Wang C, Ravisankar A, et al. Blood kidney injury molecule-1 is a biomarker of acute and chronic kidney injury and predicts progression to ESRD in type I diabetes. J Am Soc Nephrol 2014;25:2177-86.
17. Peralta CA, Katz R, Bonventre JV, Sabbisetti VS, Siscovick D, Sarnak M, et al. Associations of urinary levels of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) with kidney function decline in the Multi-ethnic Study of atherosclerosis (MESA). Am J Kidney Dis 2012;60:904-11.
18. Heijnen BF, van Essen H, Schalkwijk CG, Janssen BJ, Struijker-Boudier HA. Renal inflammatory markers during the onset of hypertension in spontaneously hypertensive rats. Hypertens Res 2014;37:100-9.
19. Waanders F, Vaidya VS, Van Goor H, Leuvenink H, Damman K, Hamming I, et al. Effect of renin-angiotensin-aldosterone system inhibition, dietary sodium restriction, and/or diuretics on urinary kidney injury molecule 1 excretion in nondiabetic proteinuric kidney disease: a post hoc analysis of a randomized controlled trial. Am J Kidney Dis 2009;53:16-25.