Effect of Renin-Angiotensin-Aldosterone System Inhibition, Dietary Sodium Restriction, and/or Diuretics on Urinary Kidney Injury Molecule 1 Excretion in Nondiabetic Proteinuric Kidney Disease: A Post Hoc Analysis of a Randomized Controlled Trial

American Journal of Kidney Diseases

Volumn 53, Issue 1, 2009, Pages 16-25

  Waanders, Femke ^a   Vaidya, Vishal S ^b   van Goor, Harry ^a   Leuvenink, Henri ^a   Damman, Kevin ^a   Hamming, Inge ^a   Bonventre, Joseph V ^b   Vogt, Liffert ^a   Navis, Gerjan ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

angiotensin II type 1 receptor blockade; biomarker; interstitial renal damage; kidney injury molecule 1; losartan; N acetyl d glucosaminidase; proteinuria; Renin angiotensin aldosterone system; tubular damage marker

Indexed keywords

HYDROCHLOROTHIAZIDE PLUS LOSARTAN; KIDNEY INJURY MOLECULE 1; LOSARTAN; N ACETYL BETA GLUCOSAMINIDASE; PLACEBO;

ADULT; AGED; ARTICLE; BLOOD PRESSURE; CLINICAL ARTICLE; CONTROLLED STUDY; DEMOGRAPHY; FEMALE; HIGH SODIUM INTAKE; HUMAN; KIDNEY FUNCTION; KIDNEY TUBULE DISORDER; MALE; POST HOC ANALYSIS; PROTEIN URINE LEVEL; PROTEINURIA; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SODIUM RESTRICTION; TREATMENT OUTCOME; URINARY EXCRETION;

ACETYLGLUCOSAMINIDASE; ADULT; AGED; ANTIHYPERTENSIVE AGENTS; BIOLOGICAL MARKERS; CHRONIC DISEASE; COMBINED MODALITY THERAPY; CROSS-OVER STUDIES; DIURETICS; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; HYDROCHLOROTHIAZIDE; KIDNEY DISEASES; LOSARTAN; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; PROTEINURIA; RECEPTORS, VIRUS; RENIN-ANGIOTENSIN SYSTEM; SODIUM, DIETARY; TREATMENT OUTCOME;

EID: 57649144008     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.ajkd.2008.07.021     Document Type: Article

References (36)

1. Wang Y., Rangan G.K., Tay Y.C., et al. Induction of monocyte chemoattractant protein-1 by albumin is mediated by nuclear factor kappaB in proximal tubule cells. J Am Soc Nephrol 10 (1999) 1204-1213
2. Morigi M., Macconi D., Zoja C., et al. Protein overload-induced NF-kappaB activation in proximal tubular cells requires H(2)O(2) through a PKC-dependent pathway. J Am Soc Nephrol 13 (2002) 1179-1189
3. Zoja C., Donadelli R., Colleoni S., et al. Protein overload stimulates RANTES production by proximal tubular cells depending on NF-kappaB activation. Kidney Int 53 (1998) 1608-1615
4. Tang S., Leung J.C., Abe K., et al. Albumin stimulates interleukin-8 expression in proximal tubular epithelial cells in vitro and in vivo. J Clin Invest 111 (2003) 515-527
5. Eddy A.A. Interstitial nephritis induced by protein-overload proteinuria. Am J Pathol 135 (1989) 719-733
6. Ruggenenti P., Schieppati A., and Remuzzi G. Progression, remission, regression of chronic renal diseases. Lancet 357 (2001) 1601-1608
7. Ruggenenti P., Perna A., and Remuzzi G. Retarding progression of chronic renal disease: The neglected issue of residual proteinuria. Kidney Int 63 (2003) 2254-2261
8. Remuzzi G., Perico N., Macia M., et al. The role of renin-angiotensin-aldosterone system in the progression of chronic kidney disease. Kidney Int Suppl 99 (2005) S57-S65
9. Vaidya V.S., Ramirez V., Ichimura T., et al. Urinary kidney injury molecule-1: A sensitive quantitative biomarker for early detection of kidney tubular injury. Am J Physiol Renal Physiol 290 (2006) F517-F529
10. van Timmeren M.M., van den Heuvel M.C., Bailly V., et al. Tubular kidney injury molecule-1 (KIM-1) in human renal disease. J Pathol 212 (2007) 209-217
11. van Timmeren M.M., Bakker S.J., Vaidya V.S., et al. Tubular kidney injury molecule-1 in protein-overload nephropathy. Am J Physiol Renal Physiol 291 (2006) F456-F464
12. van Timmeren M.M., Vaidya V.S., van Ree R.M., et al. High urinary excretion of kidney injury molecule-1 is an independent predictor of graft loss in renal transplant recipients. Transplantation 84 (2007) 1625-1630
13. Vogt L., Waanders F., Boomsma F., et al. Effects of dietary sodium and hydrochlorothiazide on the antiproteinuric efficacy of losartan. J Am Soc Nephrol 19 (2008) 999-1007
14. Liangos O., Perianayagam M.C., Vaidya V.S., et al. Urinary N-acetyl-β-d-glucosaminidase activity and kidney injury molecule-1 level are associated with adverse outcomes in acute renal failure. J Am Soc Nephrol 18 (2007) 904-912
15. Han W.K., Bailly V., Abichandani R., et al. Kidney injury molecule-1 (KIM-1): A novel biomarker for human renal proximal tubule injury. Kidney Int 62 (2002) 237-244
16. Lockwood T.D., and Bosmann H.B. The use of urinary N-acetyl-beta-glucosaminidase in human renal toxicology. I. Partial biochemical characterization and excretion in humans and release from the isolated perfused rat kidney. Toxicol Appl Pharmacol 49 (1979) 323-336
17. Kramer AB, van Timmeren MM, Schuurs TA, et al: De novo induction of kidney injury molecule-1 (KIM-1) in proteinuria-induced renal damage is reduced by RAAS blockade. Am J Physiol (in press)
18. de Borst M.H., van Timmeren M.M., Vaidya V.S., et al. Induction of kidney injury molecule-1 in homozygous Ren2 rats is attenuated by blockade of the renin-angiotensin system or p38 MAP kinase. Am J Physiol Renal Physiol 292 (2007) F313-F320
19. Nakao N., Yoshimura A., Morita H., et al. Combination treatment of angiotensin-II receptor blocker and angiotensin-converting-enzyme inhibitor in non-diabetic renal disease (COOPERATE): A randomised controlled trial. Lancet 361 (2003) 117-124
20. Lysaght M.J. Maintenance dialysis population dynamics: Current trends and long-term implications. J Am Soc Nephrol 13 suppl 1 (2002) S37-S40
21. Coresh J., Astor B.C., Greene T., et al. Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey. Am J Kidney Dis 41 (2003) 1-12
22. Wehrmann M., Bohle A., Bogenschutz O., et al. Long-term prognosis of chronic idiopathic membranous glomerulonephritis. An analysis of 334 cases with particular regard to tubulo-interstitial changes. Clin Nephrol 31 (1989) 67-76
23. Wehrmann M., Bohle A., Held H., et al. Long-term prognosis of focal sclerosing glomerulonephritis. An analysis of 250 cases with particular regard to tubulointerstitial changes. Clin Nephrol 33 (1990) 115-122
24. Bazzi C., Petrini C., Rizza V., et al. Characterization of proteinuria in primary glomerulonephritides. SDS-PAGE patterns: Clinical significance and prognostic value of low molecular weight ("tubular") proteins. Am J Kidney Dis 29 (1997) 27-35
25. Bazzi C., Petrini C., Rizza V., et al. A modern approach to selectivity of proteinuria and tubulointerstitial damage in nephrotic syndrome. Kidney Int 58 (2000) 1732-1741
26. Bazzi C., Petrini C., Rizza V., et al. Urinary N-acetyl-beta-glucosaminidase excretion is a marker of tubular cell dysfunction and a predictor of outcome in primary glomerulonephritis. Nephrol Dial Transplant 17 (2002) 1890-1896
27. Hamming I., Navis G., Kocks M.J., et al. ACE inhibition has adverse renal effects during dietary sodium restriction in proteinuric and healthy rats. J Pathol 209 (2006) 129-139
28. Zhou Y., Vaidya V.S., Brown R.P., et al. Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium. Toxicol Sci 101 (2008) 159-170
29. Vaidya V.S., Shankar K., Lock E.A., et al. Renal injury and repair following S-1, 2 dichlorovinyl-l-cysteine administration to mice. Toxicol Appl Pharmacol 188 (2003) 110-121
30. Wiley R.A., Choo H.Y., and Traiger G.J. The effect of nephrotoxic furans on urinary N-acetylglucosaminidase levels in mice. Toxicol Lett 14 (1982) 93-96
31. Tylicki L., Rutkowski P., Renke M., et al. Addition of aldosterone receptor blocker to dual renin-angiotensin-aldosterone blockade leads to limitation of tubulointerstitial injury of kidney. Kidney Int 72 (2007) 1164-1165
32. Yang Y., Ohta K., Shimizu M., et al. Treatment with low-dose angiotensin-converting enzyme inhibitor (ACEI) plus angiotensin II receptor blocker (ARB) in pediatric patients with IgA nephropathy. Clin Nephrol 64 (2005) 35-40
33. Bailly V., Zhang Z., Meier W., et al. Shedding of kidney injury molecule-1, a putative adhesion protein involved in renal regeneration. J Biol Chem 277 (2002) 39739-39748
34. Liu B.C., Zhang L., Lv L.L., et al. Application of antibody array technology in the analysis of urinary cytokine profiles in patients with chronic kidney disease. Am J Nephrol 26 (2006) 483-490
35. Sanders J.S., Huitema M.G., Hanemaaijer R., et al. Urinary matrix metalloproteinases reflect renal damage in anti-neutrophil cytoplasm autoantibody-associated vasculitis. Am J Physiol Renal Physiol 293 (2007) F1927-F1934
36. Thrailkill K.M., Bunn R.C., Moreau C.S., et al. Matrix metalloproteinase-2 dysregulation in type 1 diabetes. Diabetes Care 30 (2007) 2321-2326