The human IgM pentamer is a mushroom-shaped molecule with a flexural bias

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 35, 2009, Pages 14960-14965

  Czajkowsky, Daniel M ^a   Shao, Zhifeng ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b Chinese National Human Genome Center at Shanghai   (China)

Author keywords

AFM; Homology modeling; Immunoglobulin; Single molecule

Indexed keywords

COMPLEMENT COMPONENT C1Q; CYSTEINE; DISULFIDE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN M; MEMBRANE ANTIGEN; MONOMER;

ARTICLE; ATOMIC FORCE MICROSCOPY; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELL SURFACE; COMPLEMENT ACTIVATION; CRYSTAL STRUCTURE; GENE MUTATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; CRYSTALLOGRAPHY, X-RAY; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN M; MICROSCOPY, ATOMIC FORCE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURAL HOMOLOGY, PROTEIN;

BASIDIOMYCOTA;

EID: 70349284531     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0903805106     Document Type: Article

References (47)

1. Boes M, Prodeus AP, Schmidt T, Carroll MC, Chen J (1998) A critical role of natural immunoglobulinMin immediate defense against systemic bacterial infection. J Exp Med 188:2381-2386. (Pubitemid 29028511)
2. Ochsenbein AF, et al. (1999) Control of early viral and bacterial distribution and disease by natural antibodies. Science 286:2156-2159.
3. Vollmers HP, Brandlein S (2006) Natural IgM antibodies: The orphaned molecules in immune surveillance. Adv Drug Deliv Rev 58:755-765.
4. BeutnerU, et al. (2008) Neoadjuvant therapy of gastric cancer with the human monoclonal IgM antibody SC-1: Impact on the immune system. Oncol Rep 19:761-769.
5. Illert B, et al. (2005) Human antibody SC-1 reduces disseminated tumor cells in nude mice with human gastric cancer. Oncol Rep 13:765-770.
6. Vollmers HP, et al. (1998) Tumor-specific apoptosis induced by the human monoclonal antibody SC-1: A new therapeutical approach for stomach cancer. Oncol Rep 5:35-40.
7. Vollmers HP, et al. (1998) Adjuvant therapy for gastric adenocarcinoma with the apoptosis-inducing human monoclonal antibody SC-1: First clinical and histopathological results. Oncol Rep 5:549-552.
8. Fleming SD (2006) Natural antibodies, autoantibodies and complement activation in tissue injury. Autoimmunity 39:379-386. (Pubitemid 44269615)
9. Stahl D, et al. (2001) Altered antibody repertoires of plasma IgM and IgG toward nonself antigens in patients with warm autoimmune hemolytic anemia. Hum Immunol 62:348-361. (Pubitemid 32298977)
10. Baudino L, et al. (2007) IgM and IgA anti-erythrocyte autoantibodies induce anemia in a mouse model through multivalency-dependent hemagglutination but not through complement activation. Blood 109:5355-5362. (Pubitemid 46890557)
11. Feldmann M, Brennan FM, Maini RN (1996) Rheumatoid arthritis. Cell 85:307-310.
12. Murphy KP, Travers P, Walport M (2008) in Janeway's immunobiology (Garland Science, New York) 7th Ed.
13. Feinstein A, Munn EA (1969) Conformation of the free and antigen-bound IgM antibody molecules. Nature 224:1307-1309.
14. Feinstein A, Richardson N, Taussig MJ (1986) Immunoglobulin flexibility in complement activation. Immunol Today 7:169-174.
15. Feinstein A, Richardson NE (1981) Tertiary structure of the constant regions of immunoglobins in relation to their function. Monogr Allergy 17:28-47.
16. Munn EA, Bachmann L, Feinstein A (1980) Structure of hydrated immunoglobulins and antigen-antibody complexes. Electron microscopy of spray-freeze-etched specimens. Biochim Biophys Acta 625:1-9. (Pubitemid 11242485)
17. Perkins SJ, Nealis AS, Sutton BJ, Feinstein A (1991) Solution structure of human and mouse immunoglobulin M by synchrotron X-ray scattering and molecular graphics modelling. A possible mechanism for complement activation. J Mol Biol 221:1345-1366.
18. Zheng Y, Shopes B, Holowka D, Baird B (1991) Conformations of IgE bound to its receptor Fc epsilon RI and in solution. Biochemistry 30:9125-9132.
19. Wan T, et al. (2002) The crystal structure of IgE Fc reveals an asymmetrically bent conformation. Nat Immunol 3:681-686. (Pubitemid 34752478)
20. Wiersma EJ, Shulman MJ (1995) Assembly of IgM. Role of disulfide bonding and noncovalent interactions. J Immunol 154:5265-5272.
21. Han W, Mou J, Sheng J, Yang J, Shao Z (1995) Cryo atomic force microscopy: A new approach for biological imaging at high resolution. Biochemistry 34:8215-8220.
22. Altschul SF, et al. (1997) Gapped BLAST and PSI-BLAST: A new generation of protein database search programs. Nucleic Acids Res 25:3389-3402.
23. Frutiger S, Hughes GJ, Paquet N, Luthy R, Jaton JC (1992) Disulfide bond assignment in human J chain and its covalent pairing with immunoglobulin M. Biochemistry 31:12643-12647. (Pubitemid 23016531)
24. Fazel S, Wiersma EJ, Shulman MJ (1997) Interplay of J chain and disulfide bonding in assembly of polymeric IgM. Int Immunol 9:1149-1158. (Pubitemid 27361758)
25. Volkov VV, et al. (2003) Low-resolution structure of immunoglobulins IgG, IgM and rheumatoid factor IgM-RF from solution X-ray scattering data. J Appl Cryst 36:503-508.
26. Volkov VV, Svergun DI (2003) Uniqueness of ab initio shape determination in small-angle scattering. J Appl Cryst 36:860-864.
27. Sheng S, Shao Z (2002) Cryo-atomic force microscopy. Methods Cell Biol 68:243-256.
28. Shao Z, Zhang Y (1996) Biological cryo atomic force microscopy: A brief review. Ultramicroscopy 66:141-152. (Pubitemid 27272651)
29. Zhang Y, Sheng S, Shao Z (1996) Imaging biological structures with the cryo atomic force microscope. Biophys J 71:2168-2176. (Pubitemid 26325997)
30. Zhang Y, Shao Z, Somlyo AP, Somlyo AV (1997) Cryo-atomic force microscopy of smooth muscle myosin. Biophys J 72:1308-1318. (Pubitemid 27113653)
31. Sheng S, Czajkowsky DM, Shao Z (2006) Localization of linker histone in chromatosomes by cryo-atomic force microscopy. Biophys J 91:L35-37. (Pubitemid 44174236)
32. Sheng S, et al. (2003) Cryo-atomic force microscopy of unphosphorylated and thiophosphorylated single smooth muscle myosin molecules. J Biol Chem 278:39892-39896. (Pubitemid 37248552)
33. Shao Z, Shi D, Somlyo AV (2000) Cryoatomic force microscopy offilamentousactin. Biophys J 78:950-958.
34. Arya S, et al. (1994) Mapping of amino acid residues in the C mu 3 domain of mouse IgM important in macromolecular assembly and complement-dependent cytolysis. J Immunol 152:1206-1212. (Pubitemid 24134347)
35. Taylor B, et al. (1994) C1q binding properties of monomer and polymer forms of mouse IgM mu-chain variants. Pro544Gly and Pro434Ala. J Immunol 153:5303-5313. (Pubitemid 24983930)
36. Wright JF, Shulman MJ, Isenman DE, Painter RH (1988) C1 binding by murine IgM. The effect of a Pro-to-Ser exchange at residue 436 of the mu-chain. J Biol Chem 263:11221-11226.
37. Ghumra A, et al. (2008) Identification of residues in the Cmu4 domain of polymeric IgM essential for interaction with Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1). J Immunol 181:1988-2000.
38. Shibuya A, et al. (2000) Fc alpha/mu receptor mediates endocytosis of IgM-coated microbes. Nat Immunol 1:441-446.
39. Feinstein A, Munn EA, Richardson NE (1971) The three-dimensional conformation of M and A globulin molecules. Ann N Y Acad Sci 190:104-121.
40. Zlatarova AS, et al. (2006) Existence of different but overlapping IgG- and IgM-binding sites on the globular domain of human C1q. Biochemistry 45:9979-9988.
41. Gaboriaud C, et al. (2004) Structure and activation of the C1 complex of complement: Unraveling the puzzle. Trends Immunol 25:368-373. (Pubitemid 38780953)
42. Guex N, Peitsch MC (1997) SWISS-MODEL and the Swiss-PdbViewer: An environment for comparative protein modeling. Electrophoresis 18:2714-2723. (Pubitemid 28059943)
43. Graille M, et al. (2000) Crystal structure of a Staphylococcus aureus protein A domain complexed with the Fab fragment of a human IgM antibody: Structural basis for recognition of B-cell receptors and superantigen activity. Proc Natl Acad Sci USA 97:5399-5404. (Pubitemid 30313730)
44. Sorensen V, Sundvold V, Michaelsen TE, Sandlie I (1999) Polymerization of IgA and IgM: Roles of Cys309/Cys414 and the secretory tailpiece. J Immunol 162:3448-3455.
45. Humphrey W, Dalke A, Schulten K (1996) VMD: Visual molecular dynamics. J Mol Graphics 14:33-38, 27-38.
46. Phillips JC, et al. (2005) Scalable molecular dynamics with NAMD. J Comput Chem26:1781-1802.
47. Pettersen EF, et al. (2004) UCSF Chimera-a visualization system for exploratory research and analysis. J Comput Chem 25:1605-1612.