Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy

Cell

Volumn 167, Issue 3, 2016, Pages 739-749.e11

  Furness, Sebastian George Barton ^a   Liang, Yi Lynn ^a   Nowell, Cameron James ^a   Halls, Michelle Louise ^a   Wookey, Peter John ^b   Dal Maso, Emma ^a   Inoue, Asuka ^c,d   Christopoulos, Arthur ^a   Wootten, Denise ^a   Sexton, Patrick Michael ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c TOHOKU UNIVERSITY   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

BRET; calcitonin; calcitonin receptor; CTR; efficacy; FRET; G protein coupled receptor; GPCR; native PAGE; TIRF

Indexed keywords

CALCITONIN RECEPTOR; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATE; LIGAND; ADENOSINE DIPHOSPHATE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL SURFACE; COMPLEX FORMATION; CONTROLLED STUDY; CORRELATION ANALYSIS; COS 7 CELL LINE; DRUG EFFICACY; DRUG POTENCY; HUMAN; LIGAND BINDING; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; AGONISTS; ANIMAL; BIOSYNTHESIS; CHEMISTRY; CHLOROCEBUS AETHIOPS; COS CELL LINE; METABOLISM; PROTEIN MULTIMERIZATION;

ADENOSINE DIPHOSPHATE; ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; GTP-BINDING PROTEINS; GUANOSINE TRIPHOSPHATE; HUMANS; LIGANDS; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; RECEPTORS, CALCITONIN;

EID: 84992121103     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2016.09.021     Document Type: Article

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