Large-scale detection of antigen-specific T cells using peptide-MHC-I multimers labeled with DNA barcodes

Nature Biotechnology

Volumn 34, Issue 10, 2016, Pages 1037-1045

  Bentzen, Amalie Kai ^a   Marquard, Andrea Marion ^a   Lyngaa, Rikke ^a   Saini, Sunil Kumar ^a   Ramskov, Sofie ^a   Donia, Marco ^b   Such, Lina ^a   Furness, Andrew J S ^c   McGranahan, Nicholas ^c,d   Rosenthal, Rachel ^c,d   Straten, Per Thor ^b   Szallasi, Zoltan ^a   Svane, Inge Marie ^b   Swanton, Charles ^c,d   Quezada, Sergio A ^c   Jakobsen, Søren Nyboe ^a,e   Eklund, Aron Charles ^a   Hadrup, Sine Reker ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^e Immudex   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; BAR CODES; CELL CULTURE; CELL PROLIFERATION; CELLS; CYTOLOGY; DERMATOLOGY; DIAGNOSIS; DISEASES; EPITOPES; ONCOLOGY; PATIENT TREATMENT; PEPTIDES; SCREENING; VIRUSES;

CELL POPULATIONS; CLINICAL SAMPLES; LOW-FREQUENCY; MAJOR HISTOCOMPATIBILITY COMPLEX; NON SMALL CELL LUNG CANCER; PERIPHERAL BLOOD; SINGLE SAMPLE; T CELL RECOGNITION;

T-CELLS;

CD8 ANTIGEN; EPITOPE; MELANOMA ANTIGEN; PEPTIDE; POLYMER; ANTIGEN;

ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; CD8+ T LYMPHOCYTE; CELL EXPANSION; CELL FUNCTION; CELL POPULATION; CELL SPECIFICITY; COMPARATIVE STUDY; DNA BARCODING; EPITOPE MAPPING; FLOW CYTOMETRY; HLA SYSTEM; HUMAN; HUMAN CELL; HUMAN TISSUE; LIMIT OF DETECTION; MAJOR HISTOCOMPATIBILITY COMPLEX; NEOPLASM; NON SMALL CELL LUNG CANCER; PRIORITY JOURNAL; T LYMPHOCYTE; TUMOR ASSOCIATED LEUKOCYTE; TUMOR GROWTH; CELL CULTURE; GENE; GENETICS; HIGH THROUGHPUT SCREENING; IMMUNOASSAY; IMMUNOLOGY; PROCEDURES; PROTEIN MULTIMERIZATION; STAINING;

ANTIGENS; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; DNA BARCODING, TAXONOMIC; GENES, MHC CLASS I; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; IMMUNOASSAY; PEPTIDES; PROTEIN MULTIMERIZATION; STAINING AND LABELING;

EID: 84992109841     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.3662     Document Type: Article

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