Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System

Cell Reports

Volumn 17, Issue 4, 2016, Pages 1071-1086

  Murdoch, John D ^a,b   Rostosky, Christine M ^a   Gowrisankaran, Sindhuja ^a   Arora, Amandeep S ^a   Soukup, Sandra Fausia ^c,d   Vidal, Ramon ^e   Capece, Vincenzo ^e   Freytag, Siona ^a   Fischer, Andre ^b,e   Verstreken, Patrik ^c,d   Bonn, Stefan ^e   Raimundo, Nuno ^b   Milosevic, Ira ^a  

^a EUROPEAN NEUROSCIENCE INSTITUTE   (Germany)

^b UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^c DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^d UNIVERSITY OF LEUVEN   (Belgium)

^e GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

Author keywords

ataxia; autophagy; endocytosis; endophilin; FBXO32; neurodegeneration; next generation sequencing; Parkinson's disease; protein homeostasis; ubiquitin proteasome system

Indexed keywords

ATROGIN 1; ENDOPHILIN; GLIAL FIBRILLARY ACIDIC PROTEIN; PROTEASOME; TRANSCRIPTION FACTOR FKHRL1; UBIQUITIN; UBIQUITIN PROTEIN LIGASE E3; 2-ACYLGLYCEROPHOSPHATE ACYLTRANSFERASE; ACYLTRANSFERASE; FBXO32 PROTEIN, HUMAN; FBXO32 PROTEIN, MOUSE; FOXO3 PROTEIN, MOUSE; MUSCLE PROTEIN; PROTEIN BINDING; UBIQUITIN PROTEIN LIGASE;

ARTICLE; ATAXIA; AUTOPHAGOSOME; AUTOPHAGY; ENDOCYTOSIS; ENDOPHILIN A DEFICIENCY; MOUSE; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN DEGRADATION; PROTEIN HOMEOSTASIS; AGING; ANIMAL; APOPTOSIS; BRAIN; COMPLICATION; DEFICIENCY; GENETIC TRANSCRIPTION; GENETICS; HELA CELL LINE; HIPPOCAMPUS; HOMEOSTASIS; HUMAN; KNOCKOUT MOUSE; MALE; METABOLISM; MOTOR DYSFUNCTION; MUTATION; PARKINSON DISEASE; PATHOLOGY; UPREGULATION;

ACYLTRANSFERASES; AGING; ANIMALS; APOPTOSIS; ATAXIA; AUTOPHAGOSOMES; AUTOPHAGY; BRAIN; FORKHEAD BOX PROTEIN O3; HELA CELLS; HIPPOCAMPUS; HOMEOSTASIS; HUMANS; MALE; MICE; MICE, KNOCKOUT; MOVEMENT DISORDERS; MUSCLE PROTEINS; MUTATION; NERVE DEGENERATION; PARKINSON DISEASE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; SKP CULLIN F-BOX PROTEIN LIGASES; TRANSCRIPTION, GENETIC; UBIQUITIN; UP-REGULATION;

EID: 84992049086     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.09.058     Document Type: Article

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