Identification of genes that elicit disuse muscle atrophy via the transcription factors p50 and Bcl-3

PLoS ONE

Volumn 6, Issue 1, 2011, Pages

  Wu, Chia Ling ^a   Kandarian, Susan C ^a   Jackman, Robert W ^a  

^a BOSTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATROGIN 1; CYTOKINE RECEPTOR; GAMMA INTERFERON INDUCIBLE PROTEIN 10; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INITIATION FACTOR 4B; MUSCLE RING FINGER 1 PROTEIN; PROTEASOME; PROTEIN BCL 3; PROTEIN P50; TRANSCRIPTION FACTOR FKHRL1; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTOR RUNX1; TUMOR NECROSIS FACTOR RELATED WEAK INDUCER OF APOPTOSIS RECEPTOR; UNCLASSIFIED DRUG; NFKB1 PROTEIN, MOUSE; ONCOPROTEIN; PROTEIN KINASE R; PROTO ONCOGENE PROTEIN BCL 3; PROTO-ONCOGENE PROTEIN BCL-3; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENE TARGETING; GENETIC TRANSCRIPTION; MALE; MOUSE; MUSCLE ATROPHY; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TRANSLATION INITIATION; UPREGULATION; WILD TYPE; ANIMAL; GENETICS; METABOLISM; MOUSE MUTANT;

MUS;

ANIMALS; BINDING SITES; EIF-2 KINASE; GENE EXPRESSION PROFILING; MICE; MICE, KNOCKOUT; MUSCULAR ATROPHY; MUSCULAR DISORDERS, ATROPHIC; NF-KAPPA B P50 SUBUNIT; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; TRANSCRIPTION FACTORS;

EID: 79251553157     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0016171     Document Type: Article

References (44)

1. Kandarian SC, Jackman RW (2006) Intracellular signaling during skeletal muscle atrophy. Muscle Nerve 33: 155-165.
2. Sandri M (2008) Signaling in muscle atrophy and hypertrophy. Physiology (Bethesda) 23: 160-170.
3. Bar-Shai M, Carmeli E, Ljubuncic P, Reznick AZ (2008) Exercise and immobilization in aging animals: the involvement of oxidative stress and NFkappaB activation. Free Radic Biol Med 44: 202-214.
4. Salminen A, Kaarniranta K (2010) Genetics vs. entropy: longevity factors suppress the NF-kappaB-driven entropic aging process. Ageing Res Rev 9: 298-314.
5. Judge AR, Koncarevic A, Hunter RB, Liou HC, Jackman RW, et al. (2007) Role for I{kappa}B{alpha}, but not c-Rel, in skeletal muscle atrophy. Am J Physiol Cell Physiol 292: C372-382.
6. Van Gammeren D, Damrauer JS, Jackman RW, Kandarian SC (2009) The IkappaB kinases IKKalpha and IKKbeta are necessary and sufficient for skeletal muscle atrophy. Faseb J 23: 362-370.
7. Hunter RB, Kandarian SC (2004) Disruption of either the Nfkb1 or the Bcl3 gene inhibits skeletal muscle atrophy. J Clin Invest 114: 1504-1511.
8. Hunter RB, Stevenson E, Koncarevic A, Mitchell-Felton H, Essig DA, et al. (2002) Activation of an alternative NF-kappaB pathway in skeletal muscle during disuse atrophy. Faseb J 16: 529-538.
9. Mourkioti F, Kratsios P, Luedde T, Song YH, Delafontaine P, et al. (2006) Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration. J Clin Invest 116: 2945-2954.
10. Cai D, Frantz JD, Tawa NE, Jr., Melendez PA, Oh BC, et al. (2004) IKKbeta/NF-kappaB activation causes severe muscle wasting in mice. Cell 119: 285-298.
11. Kumar A, Boriek AM (2003) Mechanical stress activates the nuclear factorkappaB pathway in skeletal muscle fibers: a possible role in Duchenne muscular dystrophy. FASEB J 17: 386-396.
12. Acharyya S, Villalta SA, Bakkar N, Bupha-Intr T, Janssen PM, et al. (2007) Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy. J Clin Invest 117: 889-901.
13. Acharyya S, Butchbach ME, Sahenk Z, Wang H, Saji M, et al. (2005) Dystrophin glycoprotein complex dysfunction: a regulatory link between muscular dystrophy and cancer cachexia. Cancer Cell 8: 421-432.
14. Rhoads MG, Kandarian SC, Pacelli F, Doglietto GB, Bossola M (2010) Expression of NF-kappaB and IkappaB proteins in skeletal muscle of gastric cancer patients. Eur J Cancer.
15. Gilmore TD (2006) Introduction to NF-kappaB: players, pathways, perspectives. Oncogene 25: 6680-6684.
16. Hayden MS, Ghosh S (2008) Shared principles in NF-kappaB signaling. Cell 132: 344-362.
17. Perkins ND (2007) Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol 8: 49-62.
18. Stevenson EJ, Giresi PG, Koncarevic A, Kandarian SC (2003) Global analysis of gene expression patterns during disuse atrophy in rat skeletal muscle. J Physiol 551: 33-48.
19. Frenette J, Cai B, Tidball JG (2000) Complement activation promotes muscle inflammation during modified muscle use. Am J Pathol 156: 2103-2110.
20. Peterson JM, Guttridge DC (2008) Skeletal muscle diseases, inflammation, and NF-kappaB signaling: insights and opportunities for therapeutic intervention. Int Rev Immunol 27: 375-387.
21. Heissmeyer V, Krappmann D, Wulczyn FG, Scheidereit C (1999) NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes. Embo J 18: 4766-4778.
22. Caamano JH, Perez P, Lira SA, Bravo R (1996) Constitutive expression of Bc1-3 in thymocytes increases the DNA binding of NF-kappaB1 (p50) homodimers in vivo. Mol Cell Biol 16: 1342-1348.
23. Fujita T, Nolan GP, Liou HC, Scott ML, Baltimore D (1993) The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimers. Genes Dev 7: 1354-1363.
24. Sacheck JM, Hyatt JP, Raffaello A, Jagoe RT, Roy RR, et al. (2007) Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases. Faseb J 21: 140-155.
25. Cohen S, Brault JJ, Gygi SP, Glass DJ, Valenzuela DM, et al. (2009) During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation. J Cell Biol 185: 1083-1095.
26. Witt SH, Granzier H, Witt CC, Labeit S (2005) MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination. J Mol Biol 350: 713-722.
27. Clarke BA, Drujan D, Willis MS, Murphy LO, Corpina RA, et al. (2007) The E3 Ligase MuRF1 degrades myosin heavy chain protein in dexamethasonetreated skeletal muscle. Cell Metab 6: 376-385.
28. Bodine SC, Latres E, Baumhueter S, Lai VK, Nunez L, et al. (2001) Identification of ubiquitin ligases required for skeletal muscle atrophy. Science 294: 1704-1708.
29. Leung TH, Hoffmann A, Baltimore D (2004) One nucleotide in a kappaB site can determine cofactor specificity for NF-kappaB dimers. Cell 118: 453-464.
30. Frith MC, Fu Y, Yu L, Chen JF, Hansen U, et al. (2004) Detection of functional DNA motifs via statistical over-representation. Nucleic Acids Res 32: 1372-1381.
31. Gomes MD, Lecker SH, Jagoe RT, Navon A, Goldberg AL (2001) Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy. Proc Natl Acad Sci U S A 98: 14440-14445.
32. Taillandier D, Aurousseau E, Meynial-Denis D, Bechet D, Ferrara M, et al. (1996) Coordinate activation of lysosomal, Ca 2+-activated and ATP-ubiquitindependent proteinases in the unweighted rat soleus muscle. Biochem J 316: 65-72.
33. Yamazaki Y, Kamei Y, Sugita S, Akaike F, Kanai S, et al. (2010) The cathepsin L gene is a direct target of FOXO1 in skeletal muscle. Biochem J 427: 171-178.
34. Sandri M, Sandri C, Gilbert A, Skurk C, Calabria E, et al. (2004) Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell 117: 399-412.
35. Wang X, Blagden C, Fan J, Nowak SJ, Taniuchi I, et al. (2005) Runx1 prevents wasting, myofibrillar disorganization, and autophagy of skeletal muscle. Genes Dev 19: 1715-1722.
36. Mittal A, Bhatnagar S, Kumar A, Lach-Trifilieff E, Wauters S, et al. (2010) The TWEAK-Fn14 system is a critical regulator of denervation-induced skeletal muscle atrophy in mice. J Cell Biol 188: 833-849.
37. Dogra C, Changotra H, Wedhas N, Qin X, Wergedal JE, et al. (2007) TNFrelated weak inducer of apoptosis (TWEAK) is a potent skeletal muscle-wasting cytokine. Faseb J 21: 1857-1869.
38. Ohmori Y, Hamilton TA (1993) Cooperative interaction between interferon (IFN) stimulus response element and kappa B sequence motifs controls IFN gamma- and lipopolysaccharide-stimulated transcription from the murine IP-10 promoter. J Biol Chem 268: 6677-6688.
39. Schulte LM, Navarro J, Kandarian SC (1993) Regulation of sarcoplasmic reticulum calcium pump gene expression by hindlimb unweighting. Am J Physiol 264: C1308-C1315.
40. Koncarevic A, Jackman RW, Kandarian SC (2007) The ubiquitin-protein ligase Nedd4 targets Notch1 in skeletal muscle and distinguishes the subset of atrophies caused by reduced muscle tension. Faseb J 21: 427-437.
41. Kuehn H, Liberzon A, Reich M, Mesirov JP (2008) Using GenePattern for gene expression analysis. Curr Protoc Bioinformatics Chapter 7: Unit 7 12.
42. Storey JD, Tibshirani R (2003) Statistical significance for genomewide studies. Proc Natl Acad Sci U S A 100: 9440-9445.
43. Andrews JL, Zhang X, McCarthy JJ, McDearmon EL, Hornberger TA, et al. (2010) CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function. Proc Natl Acad Sci U S A 107: 19090-19095.
44. Tachibana K, Kobayashi Y, Tanaka T, Tagami M, Sugiyama A, et al. (2005) Gene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoforms. Nucl Recept 3: 3.