Rapamycin inhibition of polyposis and progression to dysplasia in a mouse model

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Hardiman, Karin M ^a   Liu, Jianhua ^a   Feng, Ying ^a   Greenson, Joel K ^a   Fearon, Eric R ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; BETA CATENIN; MAMMALIAN TARGET OF RAPAMYCIN; RAPAMYCIN; TRANSCRIPTION FACTOR SOX9; WNT PROTEIN; ANTINEOPLASTIC ANTIBIOTIC;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APC GENE; ARTICLE; CANCER INHIBITION; CELL DIFFERENTIATION; CELL PROLIFERATION; COLON MALFORMATION; COLON POLYPOSIS; CONTROLLED STUDY; DISEASE CLASSIFICATION; DISEASE COURSE; DISEASE MODEL; DRUG POTENCY; GENE EXPRESSION REGULATION; GENE MUTATION; GOBLET CELL; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SURVIVAL; WNT SIGNALING PATHWAY; ADENOMATOUS POLYPOSIS COLI; ANIMAL; CELL LINE; COLON; COLONIC POLYPS; CYTOLOGY; DRUG EFFECTS; EPITHELIUM CELL; GENETICS; INTESTINE MUCOSA; METABOLISM; PATHOLOGY; TRANSGENIC ANIMAL;

ADENOMATOUS POLYPOSIS COLI; ADENOMATOUS POLYPOSIS COLI PROTEIN; ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIBIOTICS, ANTINEOPLASTIC; BETA CATENIN; CELL DIFFERENTIATION; CELL LINE; COLON; COLONIC POLYPS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; EPITHELIAL CELLS; HUMANS; INTESTINAL MUCOSA; MICE; SIROLIMUS; SOX9 TRANSCRIPTION FACTOR; WNT SIGNALING PATHWAY;

EID: 84899723618     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0096023     Document Type: Article

References (18)

1. Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, et al. (2013) The way Wnt works: components and mechanism. Growth Factors 31: 1-31.
2. Fujishita T, Aoki K, Lane HA, Aoki M, Taketo MM (2008) Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice. Proc Natl Acad Sci U S A 105: 13544-13549.
3. Tuech JJ, Pessaux P, Regenet N, Ziani M, Ollier JC, et al. (2004) Endoscopic transanal resection using the urological resectoscope in the management of patients with rectal villous adenomas. Int J Colorectal Dis 19: 569-573. (Pubitemid 39445413)
4. Nozawa H, Watanabe T, Nagawa H (2007) Phosphorylation of ribosomal p70 S6 kinase and rapamycin sensitivity in human colorectal cancer. Cancer Lett 251: 105-113. (Pubitemid 46589769)
5. Easton JB, Houghton PJ (2006) mTOR and cancer therapy. Oncogene 25: 6436-6446. (Pubitemid 44582287)
6. Alayev A, Holz MK (2013) mTOR signaling for biological control and cancer. J Cell Physiol.
7. Roig AI, Eskiocak U, Hight SK, Kim SB, Delgado O, et al. (2010) Immortalized epithelial cells derived from human colon biopsies express stem cell markers and differentiate in vitro. Gastroenterology 138: 1012-1021 e1011-1015.
8. Piso P, Dahlke MH, Mirena P, Schmidt U, Aselmann H, et al. (2004) Total mesorectal excision for middle and lower rectal cancer: a single institution experience with 337 consecutive patients. J Surg Oncol 86: 115-121. (Pubitemid 38720760)
9. Buunen M, Veldkamp R, Hop WC, Kuhry E, Jeekel J, et al. (2009) Survival after laparoscopic surgery versus open surgery for colon cancer: long-term outcome of a randomised clinical trial. Lancet Oncol 10: 44-52.
10. Knaus J (1999) Functional results of total mesorectal excision for rectal cancer. Int J Surg Investig 1: 263-267.
11. Staal FJ, Noort Mv M, Strous GJ, Clevers HC (2002) Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin. EMBO Rep 3: 63-68. (Pubitemid 34144817)
12. Hildebrandt W, Hamann A, Krakowski-Roosen H, Kinscherf R, Dugi K, et al. (2004) Effect of thiol antioxidant on body fat and insulin reactivity. J Mol Med (Berl) 82: 336-344. (Pubitemid 38680291)
13. Ponnurangam S, Standing D, Rangarajan P, Subramaniam D (2013) Tandutinib inhibits the Akt/mTOR signaling pathway to inhibit colon cancer growth. Mol Cancer Ther.
14. Koehl GE, Spitzner M, Ousingsawat J, Schreiber R, Geissler EK, et al. (2010) Rapamycin inhibits oncogenic intestinal ion channels and neoplasia in APC(Min/+) mice. Oncogene 29: 1553-1560.
15. Miller SJ, Heist KA, Feng Y, Galban CJ, Rehemtulla A, et al. (2012) Multimodal imaging of growth and rapamycin-induced regression of colonic adenomas in apc mutation-dependent mouse. Transl Oncol 5: 313-320.
16. Hinoi T, Akyol A, Theisen BK, Ferguson DO, Greenson JK, et al. (2007) Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation. Cancer Res 67: 9721-9730. (Pubitemid 47621219)
17. Rodel F, Schaller U, Schultze-Mosgau S, Beuscher HU, Keilholz L, et al. (2004) The induction of TGF-beta(1) and NF-kappaB parallels a biphasic time course of leukocyte/endothelial cell adhesion following low-dose X-irradiation. Strahlenther Onkol 180: 194-200. (Pubitemid 38461543)
18. Kenniston JA, Burton RE, Siddiqui SM, Baker TA, Sauer RT (2004) Effects of local protein stability and the geometric position of the substrate degradation tag on the efficiency of ClpXP denaturation and degradation. J Struct Biol 146: 130-140. (Pubitemid 38372184)