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Volumn 11, Issue , 2015, Pages 9-15

Stimulating immune responses to fight cancer: Basic biology and mechanisms

Author keywords

bioactive lipids; cancer; cytokines; hypoxia; immune response; immunotherapy

Indexed keywords

CANCER VACCINE; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 RECEPTOR;

EID: 84991539367     PISSN: 17437555     EISSN: 17437563     Source Type: Journal    
DOI: 10.1111/AJCO.12410     Document Type: Review
Times cited : (8)

References (58)
  • 1
    • 84907969859 scopus 로고    scopus 로고
    • Oncogene-triggered suppression of DNA repair leads to DNA instability in cancer
    • Yaglom JA, McFarland C, Mirny L, Sherman MY. Oncogene-triggered suppression of DNA repair leads to DNA instability in cancer. Oncotarget 2014; 5: 8367–78.
    • (2014) Oncotarget , vol.5 , pp. 8367-8378
    • Yaglom, J.A.1    McFarland, C.2    Mirny, L.3    Sherman, M.Y.4
  • 2
    • 40449120350 scopus 로고    scopus 로고
    • An oncogene-induced DNA damage model for cancer development
    • Halazonetis TD, Gorgoulis VG, Bartek J. An oncogene-induced DNA damage model for cancer development. Science 2008; 319: 1352–5.
    • (2008) Science , vol.319 , pp. 1352-1355
    • Halazonetis, T.D.1    Gorgoulis, V.G.2    Bartek, J.3
  • 3
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646–74.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 4
    • 85027946414 scopus 로고    scopus 로고
    • Interleukin 6 downregulates p53 expression and activity by stimulating ribosome biogenesis: A new pathway connecting inflammation to cancer
    • Brighenti E, Calabrese C, Liguori G et al. Interleukin 6 downregulates p53 expression and activity by stimulating ribosome biogenesis: a new pathway connecting inflammation to cancer. Oncogene 2014; 33: 4396–406.
    • (2014) Oncogene , vol.33 , pp. 4396-4406
    • Brighenti, E.1    Calabrese, C.2    Liguori, G.3
  • 5
    • 84898880402 scopus 로고    scopus 로고
    • Inflammation to cancer: The molecular biology in the pancreas (Review)
    • Ling S, Feng T, Jia K, Tian Y, Li Y. Inflammation to cancer: the molecular biology in the pancreas (Review). Oncol Lett 2014; 7: 1747–54.
    • (2014) Oncol Lett , vol.7 , pp. 1747-1754
    • Ling, S.1    Feng, T.2    Jia, K.3    Tian, Y.4    Li, Y.5
  • 6
    • 0035902802 scopus 로고    scopus 로고
    • Chronic immune activation and inflammation as the cause of malignancy
    • O’Byrne KJ, Dalgleish AG. Chronic immune activation and inflammation as the cause of malignancy. Br J Cancer 2001; 85: 473–83.
    • (2001) Br J Cancer , vol.85 , pp. 473-483
    • O’Byrne, K.J.1    Dalgleish, A.G.2
  • 7
    • 84895751725 scopus 로고    scopus 로고
    • Thromboxane synthase expression and correlation with VEGF and angio-genesis in non-small cell lung cancer
    • Cathcart MC, Gately K, Cummins R et al. Thromboxane synthase expression and correlation with VEGF and angio-genesis in non-small cell lung cancer. Biochim Biophys Acta 2014; 1842: 747–55.
    • (2014) Biochim Biophys Acta , vol.1842 , pp. 747-755
    • Cathcart, M.C.1    Gately, K.2    Cummins, R.3
  • 8
    • 33748358343 scopus 로고    scopus 로고
    • Inhibition of cyclooxygenase-2 decreases breast cancer cell motility, invasion and matrix metalloproteinase expression
    • Larkins TL, Nowell M, Singh S, Sanford GL. Inhibition of cyclooxygenase-2 decreases breast cancer cell motility, invasion and matrix metalloproteinase expression. BMC Cancer 2006; 6: 181.
    • (2006) BMC Cancer , vol.6
    • Larkins, T.L.1    Nowell, M.2    Singh, S.3    Sanford, G.L.4
  • 9
    • 36149000163 scopus 로고    scopus 로고
    • Lipoxy-genase metabolism: Roles in tumor progression and sur-vival
    • Pidgeon GP, Lysaght J, Krishnamoorthy S et al. Lipoxy-genase metabolism: roles in tumor progression and sur-vival. Cancer Metastasis Rev 2007; 26: 503–24.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 503-524
    • Pidgeon, G.P.1    Lysaght, J.2    Krishnamoorthy, S.3
  • 10
    • 84858604500 scopus 로고    scopus 로고
    • 2 inhibitors: A review of their structure-activity relationships
    • Zarghi A, Arfaei S, Selective COX. 2 inhibitors: a review of their structure-activity relationships. Iran J Pharm Res 2011; 10: 655–83.
    • (2011) Iran J Pharm Res , vol.10 , pp. 655-683
    • Zarghi, A.1    Arfaei, S.2    Selective, C.O.X.3
  • 11
    • 79952346039 scopus 로고    scopus 로고
    • EGFR and COX-2 protein expression in non-small cell lung cancer and the correlation with clinical features
    • Li F, Liu Y, Chen H et al. EGFR and COX-2 protein expression in non-small cell lung cancer and the correlation with clinical features. J Exp Clin Cancer Res 2011; 30: 27.
    • (2011) J Exp Clin Cancer Res , vol.30
    • Li, F.1    Liu, Y.2    Chen, H.3
  • 13
    • 0032170955 scopus 로고    scopus 로고
    • Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas
    • Hida T, Yatabe Y, Achiwa H et al. Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas. Cancer Res 1998; 58: 3761–4.
    • (1998) Cancer Res , vol.58 , pp. 3761-3764
    • Hida, T.1    Yatabe, Y.2    Achiwa, H.3
  • 14
    • 84863937925 scopus 로고    scopus 로고
    • Cyclooxygenase-2 (COX-2) as a predictive marker for the use of COX-2 inhibitors in advanced non-small-cell lung cancer
    • Edelman MJ, Hodgson L, Wang X, Kratzke RA, Vokes EE. Cyclooxygenase-2 (COX-2) as a predictive marker for the use of COX-2 inhibitors in advanced non-small-cell lung cancer. J Clin Oncol 2012; 30: 2019–20.
    • (2012) J Clin Oncol , vol.30 , pp. 2019-2020
    • Edelman, M.J.1    Hodgson, L.2    Wang, X.3    Kratzke, R.A.4    Vokes, E.E.5
  • 15
    • 84920938211 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled, multicenter phase II study of the efficacy and safety of apricoxib in combination with either docetaxel or pemetrexed in patients with biomarker-selected non-small-cell lung cancer
    • Edelman MJ, Tan MT, Fidler MJ et al. Randomized, double-blind, placebo-controlled, multicenter phase II study of the efficacy and safety of apricoxib in combination with either docetaxel or pemetrexed in patients with biomarker-selected non-small-cell lung cancer. J Clin Oncol 2015; 33: 189–94.
    • (2015) J Clin Oncol , vol.33 , pp. 189-194
    • Edelman, M.J.1    Tan, M.T.2    Fidler, M.J.3
  • 16
    • 15044361542 scopus 로고    scopus 로고
    • Cyclooxygenase-2 protein levels are independent of epidermal growth factor receptor expression or activation in operable non-small cell lung cancer
    • Richardson CM, Richardson D, Swinson DE, Swain WA, Cox G, O’Byrne KJ. Cyclooxygenase-2 protein levels are independent of epidermal growth factor receptor expression or activation in operable non-small cell lung cancer. Lung Cancer 2005; 48: 47–57.
    • (2005) Lung Cancer , vol.48 , pp. 47-57
    • Richardson, C.M.1    Richardson, D.2    Swinson, D.E.3    Swain, W.A.4    Cox, G.5    O’Byrne, K.J.6
  • 17
    • 0037214178 scopus 로고    scopus 로고
    • Epidermal growth factor receptors and cyclooxygenase-2 in the pathogenesis of non-small cell lung cancer: Potential targets for chemoprevention and systemic therapy
    • Richardson CM, Sharma RA, Cox G, O’Byrne KJ. Epidermal growth factor receptors and cyclooxygenase-2 in the pathogenesis of non-small cell lung cancer: potential targets for chemoprevention and systemic therapy. Lung Cancer 2003; 39: 1–13.
    • (2003) Lung Cancer , vol.39 , pp. 1-13
    • Richardson, C.M.1    Sharma, R.A.2    Cox, G.3    O’Byrne, K.J.4
  • 18
    • 17644394616 scopus 로고    scopus 로고
    • Smoldering and polarized inflammation in the initiation and promotion of malignant disease
    • Balkwill F, Charles KA, Mantovani A. Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell 2005; 7: 211–17.
    • (2005) Cancer Cell , vol.7 , pp. 211-217
    • Balkwill, F.1    Charles, K.A.2    Mantovani, A.3
  • 19
    • 4644335311 scopus 로고    scopus 로고
    • Cancer: An inflammatory link
    • Balkwill F, Coussens LM. Cancer: an inflammatory link. Nature 2004; 431: 405–6.
    • (2004) Nature , vol.431 , pp. 405-406
    • Balkwill, F.1    Coussens, L.M.2
  • 20
    • 84857141296 scopus 로고    scopus 로고
    • Cancer-related inflammation: Common themes and therapeutic opportunities
    • Balkwill FR, Mantovani A. Cancer-related inflammation: common themes and therapeutic opportunities. Semin Cancer Biol 2012; 22: 33–40.
    • (2012) Semin Cancer Biol , vol.22 , pp. 33-40
    • Balkwill, F.R.1    Mantovani, A.2
  • 21
    • 33645907503 scopus 로고    scopus 로고
    • Inflammation and cancer: The role of the immune response and angiogenesis
    • Dalgleish AG, O’Byrne K. Inflammation and cancer: the role of the immune response and angiogenesis. Cancer Treat Res 2006; 130: 1–38.
    • (2006) Cancer Treat Res , vol.130 , pp. 1-38
    • Dalgleish, A.G.1    O’Byrne, K.2
  • 23
    • 67349162130 scopus 로고    scopus 로고
    • Tumour necrosis factor and cancer
    • Balkwill F. Tumour necrosis factor and cancer. Nat Rev Cancer 2009; 9: 361–71.
    • (2009) Nat Rev Cancer , vol.9 , pp. 361-371
    • Balkwill, F.1
  • 24
    • 42649124339 scopus 로고    scopus 로고
    • TNF: A master switch for inflammation to cancer
    • Sethi G, Sung B, Aggarwal BB. TNF: a master switch for inflammation to cancer. Front Biosci 2008; 13: 5094– 107.
    • (2008) Front Biosci , vol.13 , pp. 5094-5107
    • Sethi, G.1    Sung, B.2    Aggarwal, B.B.3
  • 25
    • 76949084622 scopus 로고    scopus 로고
    • TNF-alpha/NF-kappaB/Snail pathway in cancer cell migration and invasion
    • Wu Y, Zhou BP. TNF-alpha/NF-kappaB/Snail pathway in cancer cell migration and invasion. Br J Cancer 2010; 102: 639–44.
    • (2010) Br J Cancer , vol.102 , pp. 639-644
    • Wu, Y.1    Zhou, B.P.2
  • 26
    • 33845546703 scopus 로고    scopus 로고
    • The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions
    • Apte RN, Dotan S, Elkabets M et al. The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions. Cancer Metastasis Rev 2006; 25: 387–408.
    • (2006) Cancer Metastasis Rev , vol.25 , pp. 387-408
    • Apte, R.N.1    Dotan, S.2    Elkabets, M.3
  • 27
    • 33845532359 scopus 로고    scopus 로고
    • The paradox of pro-inflammatory cytokines in cancer
    • Dinarello CA. The paradox of pro-inflammatory cytokines in cancer. Cancer Metastasis Rev 2006; 25: 307–13.
    • (2006) Cancer Metastasis Rev , vol.25 , pp. 307-313
    • Dinarello, C.A.1
  • 28
    • 33845212729 scopus 로고    scopus 로고
    • Interleukin-1 and cancer progression: The emerging role of interleukin-1 receptor antagonist as a novel therapeutic agent in cancer treatment
    • Lewis AM, Varghese S, Xu H, Alexander HR. Interleukin-1 and cancer progression: the emerging role of interleukin-1 receptor antagonist as a novel therapeutic agent in cancer treatment. J Transl Med 2006; 4: 48.
    • (2006) J Transl Med , vol.4
    • Lewis, A.M.1    Varghese, S.2    Xu, H.3    Alexander, H.R.4
  • 29
    • 41149142016 scopus 로고    scopus 로고
    • Is interleukin-1 a good or bad “guy” in tumor immunobiology and immunotherapy?
    • Apte RN, Voronov E. Is interleukin-1 a good or bad “guy” in tumor immunobiology and immunotherapy? Immunol Rev 2008; 222: 222–41.
    • (2008) Immunol Rev , vol.222 , pp. 222-241
    • Apte, R.N.1    Voronov, E.2
  • 30
    • 34547121206 scopus 로고    scopus 로고
    • Hypoxia in cancer: Significance and impact on clinical outcome
    • Vaupel P, Mayer A. Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis Rev 2007; 26: 225–39.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 225-239
    • Vaupel, P.1    Mayer, A.2
  • 32
    • 77957077907 scopus 로고    scopus 로고
    • HIF, hypoxia and the role of angiogenesis in non-small cell lung cancer
    • Jackson AL, Zhou B, Kim WY. HIF, hypoxia and the role of angiogenesis in non-small cell lung cancer. Expert Opin Ther Targets 2010; 14: 1047–57.
    • (2010) Expert Opin Ther Targets , vol.14 , pp. 1047-1057
    • Jackson, A.L.1    Zhou, B.2    Kim, W.Y.3
  • 33
    • 33144460217 scopus 로고    scopus 로고
    • Galectin-1: A link between tumor hypoxia and tumor immune privilege
    • Le QT, Shi G, Cao H et al. Galectin-1: a link between tumor hypoxia and tumor immune privilege. J Clin Oncol 2005; 23: 8932–41.
    • (2005) J Clin Oncol , vol.23 , pp. 8932-8941
    • Le, Q.T.1    Shi, G.2    Cao, H.3
  • 34
    • 85138139491 scopus 로고    scopus 로고
    • Chronic exposure to TNF-α and IL-1β increases the invasive potential of a human bronchial epithelial cell line
    • Baird A-M, Gray S, O’Byrne K. Chronic exposure to TNF-α and IL-1β increases the invasive potential of a human bronchial epithelial cell line. Lung Cancer 2012; 75: S1.
    • (2012) Lung Cancer , vol.75 , pp. S1
    • Baird, A.-M.1    Gray, S.2    O’Byrne, K.3
  • 35
    • 85128754792 scopus 로고    scopus 로고
    • A model of chronic inflammation affects the invasive capacity and induces several hallmarks of cancer in a normal bronchial epithelial cell line
    • Baird A-M, Gray S, O’Byrne K. A model of chronic inflammation affects the invasive capacity and induces several hallmarks of cancer in a normal bronchial epithelial cell line. J Thorac Oncol 2013; 8: S741.
    • (2013) J Thorac Oncol , vol.8 , pp. S741
    • Baird, A.-M.1    Gray, S.2    O’Byrne, K.3
  • 36
    • 85138198165 scopus 로고    scopus 로고
    • Sustained exposure to TNF-α and IL-1β increases the invasion, adhesion and proliferative potential of a normal bronchial epithelial cell line
    • Baird A-M, Gray S, Richard D, O’Byrne K. Sustained exposure to TNF-α and IL-1β increases the invasion, adhesion and proliferative potential of a normal bronchial epithelial cell line. Asia-Pacific J Clin Oncol 2014; 10(Suppl. 8): 156.
    • (2014) Asia-Pacific J Clin Oncol , vol.10 , pp. 156
    • Baird, A.-M.1    Gray, S.2    Richard, D.3    O’Byrne, K.4
  • 37
    • 10844284696 scopus 로고    scopus 로고
    • Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins
    • Ramirez RD, Sheridan S, Girard L et al. Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins. Cancer Res 2004; 64: 9027–34.
    • (2004) Cancer Res , vol.64 , pp. 9027-9034
    • Ramirez, R.D.1    Sheridan, S.2    Girard, L.3
  • 38
    • 84900872527 scopus 로고    scopus 로고
    • Ly49 receptors: Innate and adaptive immune paradigms
    • Rahim MM, Tu MM, Mahmoud AB et al. Ly49 receptors: innate and adaptive immune paradigms. Front Immunol 2014; 5: 145.
    • (2014) Front Immunol , vol.5 , pp. 145
    • Rahim, M.M.1    Tu, M.M.2    Mahmoud, A.B.3
  • 39
    • 78651345254 scopus 로고    scopus 로고
    • Releasing the brake on the immune system: Ipilimumab in melanoma and other tumors
    • Tarhini A, Lo E, Minor DR. Releasing the brake on the immune system: ipilimumab in melanoma and other tumors. Cancer Biother Radiopharm 2010; 25: 601–13.
    • (2010) Cancer Biother Radiopharm , vol.25 , pp. 601-613
    • Tarhini, A.1    Lo, E.2    Minor, D.R.3
  • 40
    • 84921779027 scopus 로고    scopus 로고
    • PD-1 blockade therapy in renal cell carcinoma: Current studies and future promises
    • Massari F, Santoni M, Ciccarese C et al. PD-1 blockade therapy in renal cell carcinoma: current studies and future promises. Cancer Treat Rev 2015; 41: 114–21.
    • (2015) Cancer Treat Rev , vol.41 , pp. 114-121
    • Massari, F.1    Santoni, M.2    Ciccarese, C.3
  • 41
    • 80255134621 scopus 로고    scopus 로고
    • Active-specific immunotherapy for non-small cell lung cancer
    • Winter H, van den Engel NK, Rusan M et al. Active-specific immunotherapy for non-small cell lung cancer. J Thorac Dis 2011; 3: 105–14.
    • (2011) J Thorac Dis , vol.3 , pp. 105-114
    • Winter, H.1    van den Engel, N.K.2    Rusan, M.3
  • 42
    • 52449102477 scopus 로고    scopus 로고
    • Long-term survival for patients with non-small-cell lung cancer with intratumoral lymphoid structures
    • Dieu-Nosjean MC, Antoine M, Danel C et al. Long-term survival for patients with non-small-cell lung cancer with intratumoral lymphoid structures. J Clin Oncol 2008; 26: 4410–17.
    • (2008) J Clin Oncol , vol.26 , pp. 4410-4417
    • Dieu-Nosjean, M.C.1    Antoine, M.2    Danel, C.3
  • 43
    • 31444439350 scopus 로고    scopus 로고
    • Concurrent infiltration by CD8+ T cells and CD4+ T cells is a favourable prognostic factor in non-small-cell lung carcinoma
    • Hiraoka K, Miyamoto M, Cho Y et al. Concurrent infiltration by CD8+ T cells and CD4+ T cells is a favourable prognostic factor in non-small-cell lung carcinoma. Br J Cancer 2006; 94: 275–80.
    • (2006) Br J Cancer , vol.94 , pp. 275-280
    • Hiraoka, K.1    Miyamoto, M.2    Cho, Y.3
  • 44
    • 70350569097 scopus 로고    scopus 로고
    • Effect of pattern of lymphocyte infiltration in NSCLC on outcome
    • O’Callaghan D, Rexhepaj E, Gately K et al. Effect of pattern of lymphocyte infiltration in NSCLC on outcome. J Clin Oncol 2009; 27: 15s.
    • (2009) J Clin Oncol , vol.27 , pp. 15s
    • O’Callaghan, D.1    Rexhepaj, E.2    Gately, K.3
  • 45
    • 53149083361 scopus 로고    scopus 로고
    • Predominant infiltration of macrophages and CD8(+) T Cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer
    • Kawai O, Ishii G, Kubota K et al. Predominant infiltration of macrophages and CD8(+) T Cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer. Cancer 2008; 113: 1387–95.
    • (2008) Cancer , vol.113 , pp. 1387-1395
    • Kawai, O.1    Ishii, G.2    Kubota, K.3
  • 46
    • 32644466544 scopus 로고    scopus 로고
    • Macrophage and mast-cell invasion of tumor cell islets confers a marked survival advantage in non-small-cell lung cancer
    • Welsh TJ, Green RH, Richardson D, Waller DA, O’Byrne KJ, Bradding P. Macrophage and mast-cell invasion of tumor cell islets confers a marked survival advantage in non-small-cell lung cancer. J Clin Oncol 2005; 23: 8959– 67.
    • (2005) J Clin Oncol , vol.23 , pp. 8959-8967
    • Welsh, T.J.1    Green, R.H.2    Richardson, D.3    Waller, D.A.4    O’Byrne, K.J.5    Bradding, P.6
  • 47
    • 69549112977 scopus 로고    scopus 로고
    • The prognostic value of intraepithelial and stromal innate immune system cells in non-small cell lung carcinoma
    • Al-Shibli K, Al-Saad S, Donnem T, Persson M, Bremnes RM, Busund LT. The prognostic value of intraepithelial and stromal innate immune system cells in non-small cell lung carcinoma. Histopathology 2009; 55: 301–12.
    • (2009) Histopathology , vol.55 , pp. 301-312
    • Al-Shibli, K.1    Al-Saad, S.2    Donnem, T.3    Persson, M.4    Bremnes, R.M.5    Busund, L.T.6
  • 48
    • 84877154621 scopus 로고    scopus 로고
    • Peripheral CD8(+) T cell proliferation is prognostic for patients with advanced thoracic malignancies
    • McCoy MJ, Nowak AK, van der Most RG, Dick IM, Lake RA. Peripheral CD8(+) T cell proliferation is prognostic for patients with advanced thoracic malignancies. Cancer Immunol Immunother 2013; 62: 529–39.
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 529-539
    • McCoy, M.J.1    Nowak, A.K.2    van der Most, R.G.3    Dick, I.M.4    Lake, R.A.5
  • 49
    • 34047220868 scopus 로고    scopus 로고
    • Cancer immunoediting from immune surveillance to immune escape
    • Kim R, Emi M, Tanabe K. Cancer immunoediting from immune surveillance to immune escape. Immunology 2007; 121: 1–14.
    • (2007) Immunology , vol.121 , pp. 1-14
    • Kim, R.1    Emi, M.2    Tanabe, K.3
  • 50
    • 33646804507 scopus 로고    scopus 로고
    • Mechanisms of immune evasion by tumors
    • Drake CG, Jaffee E, Pardoll DM. Mechanisms of immune evasion by tumors. Adv Immunol 2006; 90: 51–81.
    • (2006) Adv Immunol , vol.90 , pp. 51-81
    • Drake, C.G.1    Jaffee, E.2    Pardoll, D.M.3
  • 52
    • 33646794392 scopus 로고    scopus 로고
    • Checkpoint blockade in cancer immunotherapy
    • Korman AJ, Peggs KS, Allison JP. Checkpoint blockade in cancer immunotherapy. Adv Immunol 2006; 90: 297–339.
    • (2006) Adv Immunol , vol.90 , pp. 297-339
    • Korman, A.J.1    Peggs, K.S.2    Allison, J.P.3
  • 53
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012; 12: 252– 64.
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 54
    • 84924272311 scopus 로고    scopus 로고
    • PD-1 pathway inhibitors: The next generation of immunotherapy for advanced melanoma
    • Luke JJ, Ott P. PD-1 pathway inhibitors: the next generation of immunotherapy for advanced melanoma. Oncotar-get 2015; 6(8): 3479–92.
    • (2015) Oncotar-Get , vol.6 , Issue.8 , pp. 3479-3492
    • Luke, J.J.1    Ott, P.2
  • 55
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic mela-noma
    • Hodi FS, O’Day SJ, McDermott DF et al. Improved survival with ipilimumab in patients with metastatic mela-noma. N Engl J Med 2010; 363: 711–23.
    • (2010) N Engl J Med , vol.363 , pp. 711-723
    • Hodi, F.S.1    O’Day, S.J.2    McDermott, D.F.3
  • 57
    • 0033770215 scopus 로고    scopus 로고
    • CD28, CTLA-4 and their ligands: Who does what and to whom?
    • Sansom DM. CD28, CTLA-4 and their ligands: who does what and to whom? Immunology 2000; 101: 169–77.
    • (2000) Immunology , vol.101 , pp. 169-177
    • Sansom, D.M.1


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