The role of hydrogen sulfide in stroke

Medical Gas Research

Volumn 6, Issue 2, 2016, Pages 79-84

  Dou, Yang ^a   Wang, Zhong ^a   Chen, Gang ^a  

^a THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

Author keywords

anti apoptosis; anti inflammatory effects; anti oxidation; dose dependent; hydrogen sulfide; neuroprotection; neurotoxicity; stroke

Indexed keywords

CARBON MONOXIDE; CYTOCHROME C OXIDASE; HYDROGEN SULFIDE; INTERLEUKIN 10; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NITRIC OXIDE; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

ANTIINFLAMMATORY ACTIVITY; BIOACCUMULATION; BLOOD BRAIN BARRIER; BRAIN EDEMA; BRAIN HEMORRHAGE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONSCIOUSNESS DISORDER; DIAPHRAGM PARALYSIS; DRUG BLOOD LEVEL; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HYPOTHERMIA; MIDDLE CEREBRAL ARTERY OCCLUSION; MITOCHONDRIAL RESPIRATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

EID: 84991528458     PISSN: None     EISSN: 20459912     Source Type: Journal    
DOI: 10.4103/2045-9912.184717     Document Type: Review

References (61)

1. Abbate R, Sofi F, Brogi D, Marcucci R (2003) Emerging risk factors for ischemic stroke. Neurol Sci 24 Suppl 1:S11-12.
2. Abe K, Kimura H (1996) The possible role of hydrogen sulfide as an endogenous neuromodulator. J Neurosci 16:1066-1071.
3. Antonic A, Dottori M, Leung J, Sidon K, Batchelor PE, Wilson W, Macleod MR, Howells DW (2014) Hypothermia protects human neurons. Int J Stroke 9:544-552.
4. Chen X, Jhee KH, Kruger WD (2004) Production of the neuromodulator H 2 S by cystathionine beta-synthase via the condensation of cysteine and homocysteine. J Biol Chem 279:52082-52086.
5. Cheung NS, Peng ZF, Chen MJ, Moore PK, Whiteman M (2007) Hydrogen sulfide induced neuronal death occurs via glutamate receptor and is associated with calpain activation and lysosomal rupture in mouse primary cortical neurons. Neuropharmacology 53:505-514.
6. Fallon UB, Ben-Shlomo Y (2003) Homocysteine, MTHFR 677C - >T polymorphism, and risk of ischemic stroke: results of a meta-analysis. Neurology 60:526-527; author reply 526-527.
7. Fallon UB, Elwood P, Ben-Shlomo Y, Ubbink JB, Greenwood R, Smith GD (2001) Homocysteine and ischaemic stroke in men: the Caerphilly study. J Epidemiol Community Health 55:91-96.
8. Florian B, Vintilescu R, Balseanu AT, Buga AM, Grisk O, Walker LC, Kessler C, Popa-Wagner A (2008) Long-term hypothermia reduces infarct volume in aged rats after focal ischemia. Neurosci Lett 438:180-185.
9. Furne J, Springfield J, Koenig T, DeMaster E, Levitt MD (2001) Oxidation of hydrogen sulfide and methanethiol to thiosulfate by rat tissues: a specialized function of the colonic mucosa. Biochem Pharmacol 62:255-259.
10. Gheibi S, Aboutaleb N, Khaksari M, Kalalian-Moghaddam H, Vakili A, Asadi Y, Mehrjerdi FZ, Gheibi A (2014) Hydrogen sulfide protects the brain against ischemic reperfusion injury in a transient model of focal cerebral ischemia. J Mol Neurosci 54:264-270.
11. Gill AL, Bell CN (2004) Hyperbaric oxygen: its uses, mechanisms of action and outcomes. QJM 97:385-395.
12. Goodwin LR, Francom D, Dieken FP, Taylor JD, Warenycia MW, Reiffenstein RJ, Dowling G (1989) Determination of sulfide in brain tissue by gas dialysis/ion chromatography: postmortem studies and two case reports. J Anal Toxicol 13:105-109.
13. Hassan A, Hunt BJ, O'Sullivan M, Bell R, D'Souza R, Jeffery S, Bamford JM, Markus HS (2004) Homocysteine is a risk factor for cerebral small vessel disease, acting via endothelial dysfunction. Brain 127:212-219.
14. Hobbs C, Thoresen M, Tucker A, Aquilina K, Chakkarapani E, Dingley J (2008) Xenon and hypothermia combine additively, offering long-term functional and histopathologic neuroprotection after neonatal hypoxia/ischemia. Stroke 39:1307-1313.
15. Homocysteine Studies Collaboration (2002) Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA 288:2015-2022.
16. Hu LF, Wong PT, Moore PK, Bian JS (2007) Hydrogen sulfide attenuates lipopolysaccharide-induced inflammation by inhibition of p38 mitogen-activated protein kinase in microglia. J Neurochem 100:1121-1128.
17. Jang H, Oh MY, Kim YJ, Choi IY, Yang HS, Ryu WS, Lee SH, Yoon BW (2014) Hydrogen sulfide treatment induces angiogenesis after cerebral ischemia. J Neurosci Res 92:1520-1528.
18. Jiang X, Huang Y, Lin W, Gao D, Fei Z (2013) Protective effects of hydrogen sulfide in a rat model of traumatic brain injury via activation of mitochondrial adenosine triphosphate-sensitive potassium channels and reduction of oxidative stress. J Surg Res 184:e27-35.
19. Jung J, Jeong NY (2014) Hydrogen sulfide controls peripheral nerve degeneration and regeneration: a novel therapeutic strategy for peripheral demyelinating disorders or nerve degenerative diseases. Neural Regen Res 9:2119-2121.
20. Kim NK, Choi BO, Jung WS, Choi YJ, Choi KG (2003) Hyperhomocysteinemia as an independent risk factor for silent brain infarction. Neurology 61:1595-1599.
21. Kimura H (2000) Hydrogen sulfide induces cyclic AMP and modulates the NMDA receptor. Biochem Biophys Res Commun 267:129-133.
22. Kimura H (2002) Hydrogen sulfide as a neuromodulator. Mol Neurobiol 26:13-19.
23. Kimura H, Shibuya N, Kimura Y (2012) Hydrogen sulfide is a signaling molecule and a cytoprotectant. Antioxid Redox Signal 17:45-57.
24. Kimura Y, Kimura H (2004) Hydrogen sulfide protects neurons from oxidative stress. FASEB J 18:1165-1167.
25. Kimura Y, Goto Y, Kimura H (2010) Hydrogen sulfide increases glutathione production and suppresses oxidative stress in mitochondria. Antioxid Redox Signal 12:1-13.
26. Kolluru GK, Shen X, Bir SC, Kevil CG (2013) Hydrogen sulfide chemical biology: pathophysiological roles and detection. Nitric Oxide 35:5-20.
27. Li L, Moore PK (2008) Putative biological roles of hydrogen sulfide in health and disease: a breath of not so fresh air? Trends Pharmacol Sci 29:84-90.
28. Li Z, Wang Y, Xie Y, Yang Z, Zhang T (2011) Protective effects of exogenous hydrogen sulfide on neurons of hippocampus in a rat model of brain ischemia. Neurochem Res 36:1840-1849.
29. Liu X, Zhao S, Liu F, Kang J, Xiao A, Li F, Zhang C, Yan F, Zhao H, Luo M, Luo Y, Ji X (2014) Remote ischemic postconditioning alleviates cerebral ischemic injury by attenuating endoplasmic reticulum stress-mediated apoptosis. Transl Stroke Res 5:692-700.
30. Luo Y, Liu X, Zheng Q, Wan X, Ouyang S, Yin Y, Sui X, Liu J, Yang X (2012) Hydrogen sulfide prevents hypoxia-induced apoptosis via inhibition of an H 2 O 2 -activated calcium signaling pathway in mouse hippocampal neurons. Biochem Biophys Res Commun 425:473-477.
31. Luo Y, Yang X, Zhao S, Wei C, Yin Y, Liu T, Jiang S, Xie J, Wan X, Mao M, Wu J (2013) Hydrogen sulfide prevents OGD/R-induced apoptosis via improving mitochondrial dysfunction and suppressing an ROS-mediated caspase-3 pathway in cortical neurons. Neurochem Int 63:826-831.
32. Ma J, Wang Z, Liu C, Shen H, Chen Z, Yin J, Zuo G, Duan X, Li H, Chen G (2016) Pramipexole-induced hypothermia reduces early brain injury via PI3K/AKT/GSK3beta pathway in subarachnoid hemorrhage rats. Sci Rep 6:23817.
33. Mandava P, Shah SD, Sarma AK, Kent TA (2015) An outcome model for intravenous rt-PA in acute ischemic stroke. Transl Stroke Res 6:451-457.
34. Nagai Y, Tsugane M, Oka J, Kimura H (2004) Hydrogen sulfide induces calcium waves in astrocytes. FASEB J 18:557-559.
35. Nakata K, Yamashita N, Noda Y, Ohsawa I (2015) Stimulation of human damaged sperm motility with hydrogen molecule. Med Gas Res 5:2.
36. O'Bryant Z, Vann KT, Xiong ZG (2014) Translational strategies for neuroprotection in ischemic stroke - focusing on acid-sensing ion channel 1a. Transl Stroke Res 5:59-68.
37. Parnetti L, Caso V, Santucci A, Corea F, Lanari A, Floridi A, Conte C, Bottiglieri T (2004) Mild hyperhomocysteinemia is a risk-factor in all etiological subtypes of stroke. Neurol Sci 25:13-17.
38. Partlo LA, Sainsbury RS, Roth SH (2001) Effects of repeated hydrogen sulphide (H 2 S) exposure on learning and memory in the adult rat. Neurotoxicology 22:177-189.
39. Patel A, Knapp M, Perez I, Evans A, Kalra L (2004) Alternative strategies for stroke care: cost-effectiveness and cost-utility analyses from a prospective randomized controlled trial. Stroke 35:196-203.
40. Pohjasvaara T, Leppavuori A, Siira I, Vataja R, Kaste M, Erkinjuntti T (1998) Frequency and clinical determinants of poststroke depression. Stroke 29:2311-2317.
41. Qu K, Chen CP, Halliwell B, Moore PK, Wong PT (2006) Hydrogen sulfide is a mediator of cerebral ischemic damage. Stroke 37:889-893.
42. Qu K, Lee SW, Bian JS, Low CM, Wong PT (2008) Hydrogen sulfide: neurochemistry and neurobiology. Neurochem Int 52:155-165.
43. Ren C, Du A, Li D, Sui J, Mayhan WG, Zhao H (2010) Dynamic change of hydrogen sulfide during global cerebral ischemia-reperfusion and its effect in rats. Brain Res 1345:197-205.
44. Roger VL et al. (2011) Heart disease and stroke statistics - 2011 update: a report from the American Heart Association. Circulation 123:e18-209.
45. Sanchez EC (2013) Mechanisms of action of hyperbaric oxygenation in stroke: a review. Crit Care Nurs 36:290-298.
46. Seifert HA, Pennypacker KR (2014) Molecular and cellular immune responses to ischemic brain injury. Transl Stroke Res 5:543-553.
47. Sen N, Paul BD, Gadalla MM, Mustafa AK, Sen T, Xu R, Kim S, Snyder SH (2012) Hydrogen sulfide-linked sulfhydration of NF-kappaB mediates its antiapoptotic actions. Mol Cell 45:13-24.
48. Sheffler LR, Chae J (2007) Neuromuscular electrical stimulation in neurorehabilitation. Muscle Nerve 35:562-590.
49. Siler DA, Gonzalez JA, Wang RK, Cetas JS, Alkayed NJ (2014) Intracisternal administration of tissue plasminogen activator improves cerebrospinal fluid flow and cortical perfusion after subarachnoid hemorrhage in mice. Transl Stroke Res 5:227-237.
50. Singh S, Padovani D, Leslie RA, Chiku T, Banerjee R (2009) Relative contributions of cystathionine beta-synthase and gamma-cystathionase to H 2 S biogenesis via alternative trans-sulfuration reactions. J Biol Chem 284:22457-22466.
51. Tay AS, Hu LF, Lu M, Wong PT, Bian JS (2010) Hydrogen sulfide protects neurons against hypoxic injury via stimulation of ATP-sensitive potassium channel/protein kinase C/extracellular signal-regulated kinase/heat shock protein 90 pathway. Neuroscience 167:277-286.
52. Thome C, Schubert GA, Schilling L (2005) Hypothermia as a neuroprotective strategy in subarachnoid hemorrhage: a pathophysiological review focusing on the acute phase. Neurol Res 27:229-237.
53. Wang L, Jiang F, Li Q, He X, Ma J (2014) Mild hypothermia combined with neural stem cell transplantation for hypoxic-ischemic encephalopathy: neuroprotective effects of combined therapy. Neural Regen Res 9:1745-1752.
54. Wang R (2002) Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter? FASEB J 16:1792-1798.
55. Warenycia MW, Goodwin LR, Benishin CG, Reiffenstein RJ, Francom DM, Taylor JD, Dieken FP (1989) Acute hydrogen sulfide poisoning. Demonstration of selective uptake of sulfide by the brainstem by measurement of brain sulfide levels. Biochem Pharmacol 38:973-981.
56. Whiteman M, Armstrong JS, Chu SH, Jia-Ling S, Wong BS, Cheung NS, Halliwell B, Moore PK (2004) The novel neuromodulator hydrogen sulfide: an endogenous peroxynitrite 'scavenger'? J Neurochem 90:765-768.
57. Wong PT, Qu K, Chimon GN, Seah AB, Chang HM, Wong MC, Ng YK, Rumpel H, Halliwell B, Chen CP (2006) High plasma cyst(e)ine level may indicate poor clinical outcome in patients with acute stroke: possible involvement of hydrogen sulfide. J Neuropathol Exp Neurol 65:109-115.
58. Wu D, Zheng N, Qi K, Cheng H, Sun Z, Gao B, Zhang Y, Pang W, Huangfu C, Ji S, Xue M, Ji A, Li Y (2015) Exogenous hydrogen sulfide mitigates the fatty liver in obese mice through improving lipid metabolism and antioxidant potential. Med Gas Res 5:1.
59. Yin J, Tu C, Zhao J, Ou D, Chen G, Liu Y, Xiao X (2013) Exogenous hydrogen sulfide protects against global cerebral ischemia/reperfusion injury via its anti-oxidative, anti-inflammatory and anti-apoptotic effects in rats. Brain Res 1491:188-196.
60. Zhao W, Ndisang JF, Wang R (2003) Modulation of endogenous production of H 2 S in rat tissues. Can J Physiol Pharmacol 81:848-853.
61. Zhu L, He D, Han L, Cao H (2015) Stroke research in China over the past decade: analysis of NSFC Funding. Transl Stroke Res 6:253-256.