High plasma cyst(e)ine level may indicate poor clinical outcome in patients with acute stroke: Possible involvement of hydrogen sulfide

Journal of Neuropathology and Experimental Neurology

Volumn 65, Issue 2, 2006, Pages 109-115

  Wong, Peter T H ^a   Qu, Kun ^a   Chimon, Ghislain N ^a   Seah, Alvin B H ^b   Hui, Meng Chang ^b   Meng, Cheong Wong ^b   Yee, Kong Ng ^a   Rumpel, Helmut ^c   Halliwell, Barry ^a   Chen, Christopher P L H ^a,b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL NEUROSCIENCE INSTITUTE   (Singapore)

^c SINGAPORE GENERAL HOSPITAL   (Singapore)

Author keywords

Acute stroke; Clinical outcome; Cysteine; Cystine; Hydrogen sulfide; Middle cerebral artery occlusion; Rat

Indexed keywords

AMINO ACID; AMINOOXYACETIC ACID; ASPARTIC ACID; CYSTEINE; GLUTAMIC ACID; GLYCINE; HYDROGEN SULFIDE; METHIONINE; CYSTINE;

ADULT; AGED; AMINO ACID ANALYSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; RANKIN SCALE; RAT; STROKE; ANIMAL; BLOOD; BRAIN; CEREBRAL ARTERY DISEASE; CEREBROVASCULAR ACCIDENT; DISEASE MODEL; METABOLISM; MIDDLE AGED; PATHOLOGY; PROGNOSIS; WISTAR RAT;

ADULT; AGED; AGED, 80 AND OVER; AMINO ACIDS; ANIMALS; BRAIN; CEREBROVASCULAR ACCIDENT; CYSTEINE; CYSTINE; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; HYDROGEN SULFIDE; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MIDDLE AGED; PROGNOSIS; RATS; RATS, WISTAR;

EID: 33645024470     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.jnen.0000199571.96472.c7     Document Type: Article

References (29)

1. Choi DW, Maulucci-Gedde M, Kreigstein AR. Glutamate neurotoxicity in cortical cell culture. J Neurosci 1987;7:357-68
2. Rothman S, Olney JW. Glutamate and the pathophysiology of hypoxic-ischemic cell damage. Ann Neurol 1986;19:105-11
3. Castillo J, Davalos A, Naveiro J, et al. Neuroexcitatory amino acids and their relation to infarct size and neurologic deficit in ischemic stroke. Stroke 1996;27:1060-65
4. Skvortsova VI, Raevskii KS, Kovalenko AV, et al. Levels of neurotransmitter amino acids in the cerebrospinal fluid of patients with acute ischemic insult. Neurosci Behav Physiol 2000;30:491-95
5. Hankey GJ, Eikelboom JW. Homocysteine and stroke. Curr Opin Neurol 2001;14:95-102
6. Boysen G, Brander T, Christensen H, et al. Homocysteine and risk of recurrent stroke. Stroke 2003;34:1258-61
7. Del Ser T, Barba R, Herranz AS, et al. Hyperhomocyst(e)inemia is a risk factor of secondary vascular events in stroke patients. Cerebrovasc Dis 2001;12:91-98
8. Ozkan Y, Ozkan E, Simsek B. Plasma total homocysteine and cysteine levels as cardiovascular risk factors in coronary heart disease. Int J Cardiol 2002;82:269-77
9. Lipton SA, Kim WK, Choi YB, et al. Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor. Proc Natl Acad Sci U S A 1997;94:5923-28
10. Olney JW, Zorumski C, Price MT, et al. L-Cysteine, a bicarbonate- sensitive endogenous excitotoxin. Science 1990;248:596-99
11. Janaky R, Varga V, Hermann A, et al. Mechanisms of L-cysteine neurotoxicity. Neurochem Res 2000;25:1397-405
12. Slivka A, Cohen G. Brain ischemia markedly elevates levels of the neurotoxic amino acid, cysteine. Brain Res 1993;608:33-37
13. Griffith OW. Mammalian sulfur amino acid metabolism: an overview. Meth Enzymol 1987;143:366-76
14. Bannai S. Transport of cystine and cysteine in mammalian cells. Biochim Biophys Acta 1984;779:289-306
15. Chimon GN, Wong PTH. Ischemic tolerance and lipid peroxidation in the brain. Neuroreport 1998;9:2269-72
16. Howard-Jones N. A CIOMS ethical code for animal experimentation. WHO Chron 1985;39:51-56
17. Lin TN, He YY, Wu G, et al. Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats. Stroke 1993;24:117-21
18. Rumpel H, Peh WGC. Mini-imaging of finger joints in a whole body system using a simple and cost-effective approach. J Magn Reson Imaging 2001;14:800-802
19. Braunstein AE, Goryachenkova EV, Tolosa EA, et al. Specificity and some other properties of liver serine sulphhydrase: Evidence for its identity with cystathionine β-synthase. Biochim Biophys Acta 1971;242:247-60
20. Glycine antagonist (gavestinel) in neuroprotection (GAIN International) in patients with acute stroke: A randomized controlled trial. GAIN International Investigators. Lancet 2000;355:1949-54
21. Davis SM, Lees KR, Albers GW, et al. Selfotel in acute ischemic stroke: Possible neurotoxic effects of an NMDA antagonist. Stroke 2000;31:347-54
22. Andersson A, Hutlberg B, Lindgren A. Redox status of plasma homocysteine and other plasma thiols in stroke patients. Atherosclerosis 2000;151:535-39
23. Olney JW, Ho OL, Rhee V. Cytotoxic effects of acidic and sulfur-containing amino acids on the infant mouse central nervous system. Exp Brain Res 1971;14:61-76
24. Barks JDE, Silverstein FS. Excitatory amino acids contribute to the pathogenesis of perinatal hypoxic-ischemic brain injury. Brain Pathol 1992;2:235-43
25. Schurr A, West CA, Heine MF, et al. The neurotoxicity of sulfur-containing amino acids in energy-deprived rat hippocampal slices. Brain Res 1993;601:317-20
26. Mathisen GA, Fonnum F, Paulsen RE. Contributing mechanisms for cysteine excitotoxicity in cultured cerebellar granule cells. Neurochem Res 1996;21:293-98
27. Abe K, Kimura H. The possible role of hydrogen sulphide as an endogenous neuromodulator. J Neurosci 1996;16:1066-71
28. Kimura H. Hydrogen sulfide induces cyclic AMP and modulates the NMDA receptor. Biochem Biophys Res Commun 2000;267:129-33
29. 2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine. J Biol Chem 2004;279:52082-86