-
1
-
-
84871725540
-
Infectious disease: TB's revenge
-
Phillips, L. Infectious disease: TB's revenge. Nature 493, 14-16 (2013).
-
(2013)
Nature
, vol.493
, pp. 14-16
-
-
Phillips, L.1
-
2
-
-
66649090346
-
The diarylquinoline TMC207 for multidrug-resistant tuberculosis
-
Diacon, A. H. et al. The diarylquinoline TMC207 for multidrug-resistant tuberculosis. N. Engl. J. Med. 360, 2397-2405 (2009).
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 2397-2405
-
-
Diacon, A.H.1
-
3
-
-
84904260030
-
Delayed bactericidal response of mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism
-
Koul, A. et al. Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism. Nature Commun. 5, 3369 (2014).
-
(2014)
Nature Commun.
, vol.5
, pp. 3369
-
-
Koul, A.1
-
4
-
-
34248998479
-
Diarylquinolines target subunit c of mycobacterial ATP synthase
-
Koul, A. et al. Diarylquinolines target subunit c of mycobacterial ATP synthase. Nature Chem. Biol. 3, 323-324 (2007).
-
(2007)
Nature Chem. Biol.
, vol.3
, pp. 323-324
-
-
Koul, A.1
-
5
-
-
54449084104
-
Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis
-
Koul, A. et al. Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis. J. Biol. Chem. 283, 25273-25280 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 25273-25280
-
-
Koul, A.1
-
6
-
-
19944429772
-
A diarylquinoline drug active on the ATP synthase of mycobacterium tuberculosis
-
Andries, K. et al. A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis. Science 307, 223-227 (2005).
-
(2005)
Science
, vol.307
, pp. 223-227
-
-
Andries, K.1
-
7
-
-
84922350434
-
A high-resolution network model for global gene regulation in mycobacterium tuberculosis
-
Peterson, E. J. et al. A high-resolution network model for global gene regulation in Mycobacterium tuberculosis. Nucleic Acids Res. 42, 11291-11303 (2015).
-
(2015)
Nucleic Acids Res.
, vol.42
, pp. 11291-11303
-
-
Peterson, E.J.1
-
8
-
-
84960971089
-
A comprehensive map of genome-wide gene regulation in mycobacterium tuberculosis
-
Turkarslan, S. P. E. et al. A comprehensive map of genome-wide gene regulation in Mycobacterium tuberculosis. Sci. Data 2, 150010 (2015).
-
(2015)
Sci. Data
, vol.2
, pp. 150010
-
-
Turkarslan, S.P.E.1
-
9
-
-
84949257852
-
Integrated modeling of gene regulatory and metabolic networks in mycobacterium tuberculosis
-
Ma, S. et al. Integrated modeling of gene regulatory and metabolic networks in Mycobacterium tuberculosis. PLoS Comput. Biol. 11, e1004543 (2015).
-
(2015)
PLoS Comput. Biol.
, vol.11
, pp. e1004543
-
-
Ma, S.1
-
10
-
-
78049255973
-
Probabilistic integrative modeling of genomescale metabolic and regulatory networks in Escherichia coli and mycobacterium tuberculosis
-
Chandrasekaran, S. & Price, N. D. Probabilistic integrative modeling of genomescale metabolic and regulatory networks in Escherichia coli and Mycobacterium tuberculosis. Proc. Natl Acad. Sci. USA 107, 17845-17850 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 17845-17850
-
-
Chandrasekaran, S.1
Price, N.D.2
-
11
-
-
33746067911
-
Integrated biclustering of heterogeneous genome-wide datasets for the inference of global regulatory networks
-
Reiss, D. J., Baliga, N. S. & Bonneau, R. Integrated biclustering of heterogeneous genome-wide datasets for the inference of global regulatory networks. BMC Bioinformatics 7, 280 (2006).
-
(2006)
BMC Bioinformatics
, vol.7
, pp. 280
-
-
Reiss, D.J.1
Baliga, N.S.2
Bonneau, R.3
-
12
-
-
79551502352
-
Tubercu list-10 years after
-
Lew, J. M., Kapopoulou, A., Jones, L. M. & Cole, S. T. Tubercu List-10 years after. Tuberculosis (Edinb) 91, 1-7 (2011).
-
(2011)
Tuberculosis (Edinb)
, vol.91
, pp. 1-7
-
-
Lew, J.M.1
Kapopoulou, A.2
Jones, L.M.3
Cole, S.T.4
-
13
-
-
84872876967
-
Virulence factors of the mycobacterium tuberculosis complex
-
Forrellad, M. A. et al. Virulence factors of the Mycobacterium tuberculosis complex. Virulence 4, 3-66 (2013).
-
(2013)
Virulence
, vol.4
, pp. 3-66
-
-
Forrellad, M.A.1
-
14
-
-
38949205260
-
Mycobacterium tuberculosis strains disrupted in mce3 and mce4 operons are attenuated in mice
-
Senaratne, R. H. et al. Mycobacterium tuberculosis strains disrupted in mce3 and mce4 operons are attenuated in mice. J. Med. Microbiol. 57, 164-170 (2008).
-
(2008)
J. Med. Microbiol.
, vol.57
, pp. 164-170
-
-
Senaratne, R.H.1
-
15
-
-
51349092391
-
Network-based prediction of human tissue-specific metabolism
-
Shlomi, T., Cabili, M. N., Herrgard, M. J., Palsson, B. O. & Ruppin, E. Network-based prediction of human tissue-specific metabolism. Nature Biotechnol. 26, 1003-1010 (2008).
-
(2008)
Nature Biotechnol.
, vol.26
, pp. 1003-1010
-
-
Shlomi, T.1
Cabili, M.N.2
Herrgard, M.J.3
Palsson, B.O.4
Ruppin, E.5
-
16
-
-
79951745716
-
IMAT: An integrative metabolic analysis tool
-
Zur, H., Ruppin, E. & Shlomi, T. iMAT: an integrative metabolic analysis tool. Bioinformatics 26, 3140-3142 (2010).
-
(2010)
Bioinformatics
, vol.26
, pp. 3140-3142
-
-
Zur, H.1
Ruppin, E.2
Shlomi, T.3
-
17
-
-
84965191948
-
Mapping and manipulating the mycobacterium tuberculosis transcriptome using a transcription factor overexpression-derived regulatory network
-
Rustad, T. R. et al. Mapping and manipulating the Mycobacterium tuberculosis transcriptome using a transcription factor overexpression-derived regulatory network. Genome Biol. 15, 502 (2014).
-
(2014)
Genome Biol.
, vol.15
, pp. 502
-
-
Rustad, T.R.1
-
18
-
-
84903973635
-
Enhanced specialized transduction using recombineering in mycobacterium tuberculosis
-
Tufariello, J. M. et al. Enhanced specialized transduction using recombineering in Mycobacterium tuberculosis. mBio 5, e01179-e01114 (2014).
-
(2014)
MBio
, vol.5
, pp. e01114-e01179
-
-
Tufariello, J.M.1
-
19
-
-
84884505005
-
Identification of new drug targets and resistance mechanisms in mycobacterium tuberculosis
-
Ioerger, T. R. et al. Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis. PLoS ONE 8, e75245 (2013).
-
(2013)
PLoS ONE
, vol.8
, pp. e75245
-
-
Ioerger, T.R.1
-
20
-
-
0034702247
-
A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis
-
Stover, C. K. et al. A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis. Nature 405, 962-966 (2000).
-
(2000)
Nature
, vol.405
, pp. 962-966
-
-
Stover, C.K.1
-
21
-
-
84923112410
-
The DNA-binding network of mycobacterium tuberculosis
-
Minch, K. J. et al. The DNA-binding network of Mycobacterium tuberculosis. Nature Commun. 6, 5829 (2015).
-
(2015)
Nature Commun.
, vol.6
, pp. 5829
-
-
Minch, K.J.1
-
22
-
-
84924338899
-
A community computational challenge to predict the activity of pairs of compounds
-
Bansal, M. et al. A community computational challenge to predict the activity of pairs of compounds. Nature Biotechnol. 32, 1213-1222 (2014).
-
(2014)
Nature Biotechnol.
, vol.32
, pp. 1213-1222
-
-
Bansal, M.1
-
23
-
-
84936932059
-
Bactericidal mode of action of bedaquiline
-
Hards, K. et al. Bactericidal mode of action of bedaquiline. J. Antimicrob. Chemother. 70, 2028-2037 (2015).
-
(2015)
J. Antimicrob. Chemother.
, vol.70
, pp. 2028-2037
-
-
Hards, K.1
-
24
-
-
84908226003
-
A mycobacterium tuberculosis cytochrome bd oxidase mutant is hypersensitive to bedaquiline
-
Berney, M., Hartman, T. E. & Jacobs, W. R. Jr. A Mycobacterium tuberculosis cytochrome bd oxidase mutant is hypersensitive to bedaquiline. mBio 5, e01275-e01214 (2014).
-
(2014)
MBio
, vol.5
, pp. e01214-e01275
-
-
Berney, M.1
Hartman, T.E.2
Jacobs, W.R.3
-
25
-
-
84934881033
-
The cytochrome bd-type quinol oxidase is important for survival of mycobacterium smegmatis under peroxide and antibiotic-induced stress
-
Lu, P. et al. The cytochrome bd-type quinol oxidase is important for survival of Mycobacterium smegmatis under peroxide and antibiotic-induced stress. Sci. Rep. 5, 10333 (2015).
-
(2015)
Sci. Rep.
, vol.5
, pp. 10333
-
-
Lu, P.1
-
26
-
-
84883824094
-
Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis
-
Pethe, K. et al. Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. Nature Med. 19, 1157-1160 (2013).
-
(2013)
Nature Med.
, vol.19
, pp. 1157-1160
-
-
Pethe, K.1
-
27
-
-
4544312369
-
The transcriptional responses of mycobacterium tuberculosis to inhibitors of metabolism: Novel insights into drug mechanisms of action
-
Boshoff, H. I. et al. The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism: novel insights into drug mechanisms of action. J. Biol. Chem. 279, 40174-40184 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 40174-40184
-
-
Boshoff, H.I.1
-
28
-
-
0027538104
-
Detection of rifampicin-resistance mutations in mycobacterium tuberculosis
-
Telenti, A. et al. Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis. Lancet 341, 647-650 (1993).
-
(1993)
Lancet
, vol.341
, pp. 647-650
-
-
Telenti, A.1
-
29
-
-
10044266575
-
Specialized persister cells and the mechanism of multidrug tolerance in Escherichia coli
-
Keren, I., Shah, D., Spoering, A., Kaldalu, N. & Lewis, K. Specialized persister cells and the mechanism of multidrug tolerance in Escherichia coli. J. Bacteriol. 186, 8172-8180 (2004).
-
(2004)
J. Bacteriol.
, vol.186
, pp. 8172-8180
-
-
Keren, I.1
Shah, D.2
Spoering, A.3
Kaldalu, N.4
Lewis, K.5
-
30
-
-
0346492817
-
Persister cells and tolerance to antimicrobials
-
Keren, I., Kaldalu, N., Spoering, A., Wang, Y. & Lewis, K. Persister cells and tolerance to antimicrobials. FEMS Microbiol. Lett. 230, 13-18 (2004).
-
(2004)
FEMS Microbiol. Lett.
, vol.230
, pp. 13-18
-
-
Keren, I.1
Kaldalu, N.2
Spoering, A.3
Wang, Y.4
Lewis, K.5
-
31
-
-
34548094623
-
Combating bacteria and drug resistance by inhibiting mechanisms of persistence and adaptation
-
Smith, P. A. & Romesberg, F. E. Combating bacteria and drug resistance by inhibiting mechanisms of persistence and adaptation. Nature Chem. Biol. 3, 549-556 (2007).
-
(2007)
Nature Chem. Biol.
, vol.3
, pp. 549-556
-
-
Smith, P.A.1
Romesberg, F.E.2
-
32
-
-
14244266086
-
Toxin-antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes
-
Pandey, D. P. & Gerdes, K. Toxin-antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes. Nucleic Acids Res. 33, 966-976 (2005).
-
(2005)
Nucleic Acids Res.
, vol.33
, pp. 966-976
-
-
Pandey, D.P.1
Gerdes, K.2
-
33
-
-
84897904160
-
Multiple toxin-antitoxin systems in mycobacterium tuberculosis
-
Sala, A., Bordes, P. & Genevaux, P. Multiple toxin-antitoxin systems in Mycobacterium tuberculosis. Toxins (Basel) 6, 1002-1020 (2014).
-
(2014)
Toxins (Basel)
, vol.6
, pp. 1002-1020
-
-
Sala, A.1
Bordes, P.2
Genevaux, P.3
-
34
-
-
77957205232
-
Bactericidal activity of the diarylquinoline TMC207 against mycobacterium tuberculosis outside and within cells
-
Dhillon, J., Andries, K., Phillips, P. P. & Mitchison, D. A. Bactericidal activity of the diarylquinoline TMC207 against Mycobacterium tuberculosis outside and within cells. Tuberculosis 90, 301-305 (2010).
-
(2010)
Tuberculosis
, vol.90
, pp. 301-305
-
-
Dhillon, J.1
Andries, K.2
Phillips, P.P.3
Mitchison, D.A.4
-
35
-
-
84866177379
-
14-day bactericidal activity of PA-824, bedaquiline, pyrazinamide, and moxifloxacin combinations: A randomised trial
-
Diacon, A. H. et al. 14-day bactericidal activity of PA-824, bedaquiline, pyrazinamide, and moxifloxacin combinations: a randomised trial. Lancet 380, 986-993 (2012).
-
(2012)
Lancet
, vol.380
, pp. 986-993
-
-
Diacon, A.H.1
-
36
-
-
81555221113
-
Sterilizing activity of novel TMC207- and PA-824-containing regimens in a murine model of tuberculosis
-
Tasneen, R. et al. Sterilizing activity of novel TMC207- and PA-824-containing regimens in a murine model of tuberculosis. Antimicrob. Agents Chemother. 55, 5485-5492 (2011).
-
(2011)
Antimicrob. Agents Chemother.
, vol.55
, pp. 5485-5492
-
-
Tasneen, R.1
-
37
-
-
84991403522
-
-
TB Alliance
-
Our Pipeline: Regimens TB Alliance, (2016); http://www.tballiance.org/portfolio/regimens
-
(2016)
Our Pipeline: Regimens
-
-
-
39
-
-
84924312173
-
Bactericidal activity of pyrazinamide and clofazimine alone and in combinations with pretomanid and bedaquiline
-
Diacon, A. H. et al. Bactericidal activity of pyrazinamide and clofazimine alone and in combinations with pretomanid and bedaquiline. Am. J. Respir. Crit. Care Med. 191, 943-953 (2015).
-
(2015)
Am. J. Respir. Crit. Care Med.
, vol.191
, pp. 943-953
-
-
Diacon, A.H.1
-
42
-
-
37049239596
-
A computer program for classifying plants
-
Rogers, D. J. & Tanimoto, T. T. A computer program for classifying plants. Science 132, 1115-1118 (1960).
-
(1960)
Science
, vol.132
, pp. 1115-1118
-
-
Rogers, D.J.1
Tanimoto, T.T.2
-
43
-
-
0242490780
-
Cytoscape: A software environment for integrated models of biomolecular interaction networks
-
Shannon, P. et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 13, 2498-2504 (2003).
-
(2003)
Genome Res.
, vol.13
, pp. 2498-2504
-
-
Shannon, P.1
-
44
-
-
43049182981
-
The enduring hypoxic response of mycobacterium tuberculosis
-
Rustad, T. R., Harrell, M. I., Liao, R. & Sherman, D. R. The enduring hypoxic response of Mycobacterium tuberculosis. PLoS ONE 3, e1502 (2008).
-
(2008)
PLoS ONE
, vol.3
, pp. e1502
-
-
Rustad, T.R.1
Harrell, M.I.2
Liao, R.3
Sherman, D.R.4
-
45
-
-
0142121516
-
Exploration, normalization, and summaries of high density oligonucleotide array probe level data
-
Irizarry, R. A. et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 4, 249-264 (2003).
-
(2003)
Biostatistics
, vol.4
, pp. 249-264
-
-
Irizarry, R.A.1
-
46
-
-
84949257852
-
Integrated modeling of gene regulatory and metabolic networks in mycobacterium tuberculosis
-
Ma, S. et al. Integrated modeling of gene regulatory and metabolic networks in Mycobacterium tuberculosis. PLoS Comput. Biol. 11, 1004543 (2015).
-
(2015)
PLoS Comput. Biol.
, vol.11
, pp. 1004543
-
-
Ma, S.1
-
47
-
-
34347258175
-
Quantitative prediction of cellular metabolism with constraint-based models: The COBRA toolbox
-
Becker, S. A. et al. Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox. Nature Protoc. 2, 727-738 (2007).
-
(2007)
Nature Protoc.
, vol.2
, pp. 727-738
-
-
Becker, S.A.1
-
48
-
-
79551662521
-
Quantitative prediction of cellular metabolism with constraint-based models: The COBRA toolbox v2.0
-
Schellenberger, J. et al. Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox v2.0. Nature Protoc. 6, 1290-1307 (2011).
-
(2011)
Nature Protoc.
, vol.6
, pp. 1290-1307
-
-
Schellenberger, J.1
-
49
-
-
0038610570
-
Systematic discovery of multicomponent therapeutics
-
Borisy, A. A. et al. Systematic discovery of multicomponent therapeutics. Proc. Natl Acad. Sci. USA 100, 7977-7982 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 7977-7982
-
-
Borisy, A.A.1
|