Bactericidal activity of the diarylquinoline TMC207 against Mycobacterium tuberculosis outside and within cells

Tuberculosis

Volumn 90, Issue 5, 2010, Pages 301-305

  Dhillon, Jasvir ^a   Andries, Koen ^b   Phillips, Patrick P J ^c   Mitchison, Denis A ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b Johnson and Johnson ^*  (Belgium)

^c MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

Diarylquinoline TMC207; Intra cellular activity; J774 cell line; Peritoneal macrophages

Indexed keywords

1 (6 BROMO 2 METHOXY 3 QUINOLINYL) 4 DIMETHYLAMINO 2 (1 NAPHTHYL) 1 PHENYL 2 BUTANOL; R 207190; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BACTERIAL CELL; BACTERICIDAL ACTIVITY; CELL STRAIN; CELL STRAIN J774; COLONY FORMING UNIT; CONTROLLED STUDY; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTITUBERCULAR AGENTS; CELL LINE; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED BALB C; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; QUINOLINES; TUBERCULOSIS, PULMONARY;

EID: 77957205232     PISSN: 14729792     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tube.2010.07.004     Document Type: Article

References (10)

1. K. Andries, P. Verhasselt, J. Guillemont, H.W.H. Göhlmann, J.-M. Nefs, and J. Winkler A diarylquinoline drug active on the ATP synthase of mycobacterium tuberculosis Science 307 2005 223 227
2. A.H. Diacon, A. Pym, M. Grosbusch, R. Patienta, R. Rustomjee, and L. Page-Shipp The diarylquinoline TMC207 for multidrug-resistant tuberculosis N Engl J Med 360 2009 2397 2405
3. G. Canetti The tubercle bacillus in the tuberculous cavity The tubercle bacillus in the pulmonary lesion of man: histobacteriology and its bearing on the therapy of pulmonary tuberculosis 1955 Springer New York 62 68
4. J. Grosset Mycobacterium tuberculosis in the extracellular compartment: an underestimated adversary Antimicrob Agents Chemother 47 2003 833 836
5. H.C. Mwandumba, D.G. Russell, M.H.J. Nyirenda, S.A. Anderson, M.E. White, and M.E. Molyneux Mycobacterium tuberculosis resides in nonacidified vacuoles in endocytically competent alveolar macrophages from patients with tuberculosis and HIV infection J Immunol 172 2004 4592 4598
6. J. Dhillon, and D.A. Mitchison Activity and penetration of anti-tuberculosis drugs in mouse peritoneal macrophages infected with Mycobacterium microti OV254 Antimicrob Agents Chemother 33 1989 1255 1259
7. J. Dhillon, and D.A. Mitchison Activity extra-cellular of rifabutin, FCE22807, rifapentine and rifampin against Mycobacterium microti and M. tuberculosis and their penetration into mouse peritoneal macrophages Am Rev Respir Dis 145 1992 212 214
8. D. Schnappinger, S. Ehrt, M.I. Voskuil, Y. Liu, J.A. Mangan, and I.M. Monahan Transcriptional adaptation of mycobacterium tuberculosis within macrophages: insights into the phagosomal environment J Exp Med 198 2003 693 704
9. N.J. Garton, S.J. Waddell, A.L. Sherratt, S.M. Lee, R.J. Smith, and C. Senner Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum PLoS Med 5 4 2008 Apr 1 e75
10. R. Rustomjee, A.H. Diacon, J. Allen, A. Venter, C. Reddy, and R.F. Patientia Early bactericidal activity and pharacokinetics of the diarylquinoline TMC207 in treatment of pulmonary tuberculosis Antimicrob Agents Chemother 52 2008 2831 2835