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Volumn 214, Issue 7, 2016, Pages

Distinct G protein-coupled receptor recycling pathways allow spatial control of downstream G protein signaling

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; BETA 2 ADRENERGIC RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; RETROMER TUBULAR PROTEIN; SORTING NEXIN; UNCLASSIFIED DRUG; CYCLIC AMP; PHOSPHOSERINE;

EID: 84991214457     PISSN: 00219525     EISSN: 15408140     Source Type: Journal    
DOI: 10.1083/jcb.201512068     Document Type: Article
Times cited : (59)

References (53)
  • 2
    • 0000024273 scopus 로고
    • Mechanism of adenylate cyclase activation through the beta-adrenergic receptor: catecholamine-induced displacement of bound GDP by GTP
    • Cassel, D., and Z. Selinger. 1978. Mechanism of adenylate cyclase activation through the beta-adrenergic receptor: catecholamine-induced displacement of bound GDP by GTP. Proc. Natl. Acad. Sci. USA. 75:4155-4159. doi:10.1073/pnas.75.9.4155
    • (1978) Proc. Natl. Acad. Sci. USA , vol.75 , pp. 4155-4159
    • Cassel, D.1    Selinger, Z.2
  • 3
    • 0024367312 scopus 로고
    • Identification of a specific site required for rapid heterologous desensitization of the β-adrenergic receptor by cAMP-dependent protein kinase
    • Clark, R.B., J. Friedman, R.A. Dixon, and C.D. Strader. 1989. Identification of a specific site required for rapid heterologous desensitization of the β-adrenergic receptor by cAMP-dependent protein kinase. Mol. Pharmacol. 36:343-348
    • (1989) Mol. Pharmacol , vol.36 , pp. 343-348
    • Clark, R.B.1    Friedman, J.2    Dixon, R.A.3    Strader, C.D.4
  • 4
    • 0030613761 scopus 로고    scopus 로고
    • Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A
    • Daaka, Y., L.M. Luttrell, and R.J. Lefkowitz. 1997. Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A. Nature. 390:88-91. doi:10.1038/36362
    • (1997) Nature , vol.390 , pp. 88-91
    • Daaka, Y.1    Luttrell, L.M.2    Lefkowitz, R.J.3
  • 5
    • 0028036513 scopus 로고
    • Induction of mutant dynamin specifically blocks endocytic coated vesicle formation
    • Damke, H., T. Baba, D.E. Warnock, and S.L. Schmid. 1994. Induction of mutant dynamin specifically blocks endocytic coated vesicle formation. J. Cell Biol. 127:915-934. doi:10.1083/jcb.127.4.915
    • (1994) J. Cell Biol , vol.127 , pp. 915-934
    • Damke, H.1    Baba, T.2    Warnock, D.E.3    Schmid, S.L.4
  • 6
    • 9344220483 scopus 로고    scopus 로고
    • Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments
    • DiPilato, L.M., X. Cheng, and J. Zhang. 2004. Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments. Proc. Natl. Acad. Sci. USA. 101:16513-16518. doi:10.1073/pnas.0405973101
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 16513-16518
    • DiPilato, L.M.1    Cheng, X.2    Zhang, J.3
  • 9
    • 1642292051 scopus 로고    scopus 로고
    • Desensitization of G protein-coupled receptors and neuronal functions
    • Gainetdinov, R.R., R.T. Premont, L.M. Bohn, R.J. Lefkowitz, and M.G. Caron. 2004. Desensitization of G protein-coupled receptors and neuronal functions. Annu. Rev. Neurosci. 27:107-144. doi:10.1146/annurev.neuro.27.070203.144206
    • (2004) Annu. Rev. Neurosci , vol.27 , pp. 107-144
    • Gainetdinov, R.R.1    Premont, R.T.2    Bohn, L.M.3    Lefkowitz, R.J.4    Caron, M.G.5
  • 10
    • 0023062991 scopus 로고
    • G proteins: transducers of receptor-generated signals
    • Gilman, A.G. 1987. G proteins: transducers of receptor-generated signals. Annu. Rev. Biochem. 56:615-649. doi:10.1146/annurev.bi.56.070187.003151
    • (1987) Annu. Rev. Biochem , vol.56 , pp. 615-649
    • Gilman, A.G.1
  • 11
    • 84871997357 scopus 로고    scopus 로고
    • MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β2-adrenergic receptors
    • Han, S.-O., K. Xiao, J. Kim, J.-H. Wu, J.W. Wisler, N. Nakamura, N.J. Freedman, and S.K. Shenoy. 2012. MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β2-adrenergic receptors. J. Cell Biol. 199:817-830. doi:10.1083/jcb.201208192
    • (2012) J. Cell Biol , vol.199 , pp. 817-830
    • Han, S.-O.1    Xiao, K.2    Kim, J.3    Wu, J.-H.4    Wisler, J.W.5    Nakamura, N.6    Freedman, N.J.7    Shenoy, S.K.8
  • 12
    • 41149090339 scopus 로고    scopus 로고
    • Regulation of GPCRs by endocytic membrane trafficking and its potential implications
    • Hanyaloglu, A.C., and M. von Zastrow. 2008. Regulation of GPCRs by endocytic membrane trafficking and its potential implications. Annu. Rev. Pharmacol. Toxicol. 48:537-568. doi:10.1146/annurev.pharmtox.48.113006.094830
    • (2008) Annu. Rev. Pharmacol. Toxicol , vol.48 , pp. 537-568
    • Hanyaloglu, A.C.1    von Zastrow, M.2
  • 13
    • 22744455819 scopus 로고    scopus 로고
    • Essential role of Hrs in a recycling mechanism mediating functional resensitization of cell signaling
    • Hanyaloglu, A.C., E. McCullagh, and M. von Zastrow. 2005. Essential role of Hrs in a recycling mechanism mediating functional resensitization of cell signaling. EMBO J. 24:2265-2283. doi:10.1038/sj.emboj.7600688
    • (2005) EMBO J , vol.24 , pp. 2265-2283
    • Hanyaloglu, A.C.1    McCullagh, E.2    von Zastrow, M.3
  • 14
    • 84872835489 scopus 로고    scopus 로고
    • Targeting membrane trafficking in infection prophylaxis: dynamin inhibitors
    • Harper, C.B., M.R. Popoff, A. McCluskey, P.J. Robinson, and F.A. Meunier. 2013. Targeting membrane trafficking in infection prophylaxis: dynamin inhibitors. Trends Cell Biol. 23:90-101. doi:10.1016/j.tcb.2012.10.007
    • (2013) Trends Cell Biol , vol.23 , pp. 90-101
    • Harper, C.B.1    Popoff, M.R.2    McCluskey, A.3    Robinson, P.J.4    Meunier, F.A.5
  • 15
    • 0024397065 scopus 로고
    • Phosphorylation sites on two domains of the β2-adrenergic receptor are involved in distinct pathways of receptor desensitization
    • Hausdorff, W.P., M. Bouvier, B.F. O'Dowd, G.P. Irons, M.G. Caron, and R.J. Lefkowitz. 1989. Phosphorylation sites on two domains of the β2-adrenergic receptor are involved in distinct pathways of receptor desensitization. J. Biol. Chem. 264:12657-12665
    • (1989) J. Biol. Chem , vol.264 , pp. 12657-12665
    • Hausdorff, W.P.1    Bouvier, M.2    O'Dowd, B.F.3    Irons, G.P.4    Caron, M.G.5    Lefkowitz, R.J.6
  • 16
    • 0027292228 scopus 로고
    • Effects of mutant rat dynamin on endocytosis
    • Herskovits, J.S., C.C. Burgess, R.A. Obar, and R.B. Vallee. 1993. Effects of mutant rat dynamin on endocytosis. J. Cell Biol. 122:565-578. doi:10.1083/jcb.122.3.565
    • (1993) J. Cell Biol , vol.122 , pp. 565-578
    • Herskovits, J.S.1    Burgess, C.C.2    Obar, R.A.3    Vallee, R.B.4
  • 18
    • 84894154746 scopus 로고    scopus 로고
    • Spatially restricted G protein-coupled receptor activity via divergent endocytic compartments
    • Jean-Alphonse, F., S. Bowersox, S. Chen, G. Beard, M.A. Puthenveedu, and A.C. Hanyaloglu. 2014. Spatially restricted G protein-coupled receptor activity via divergent endocytic compartments. J. Biol. Chem. 289:3960-3977. doi:10.1074/jbc.M113.526350
    • (2014) J. Biol. Chem , vol.289 , pp. 3960-3977
    • Jean-Alphonse, F.1    Bowersox, S.2    Chen, S.3    Beard, G.4    Puthenveedu, M.A.5    Hanyaloglu, A.C.6
  • 19
    • 0028809411 scopus 로고
    • Amino and carboxyl terminal modifications to facilitate the production and purification of a G protein-coupled receptor
    • Kobilka, B.K. 1995. Amino and carboxyl terminal modifications to facilitate the production and purification of a G protein-coupled receptor. Anal. Biochem. 231:269-271. doi:10.1006/abio.1995.1533
    • (1995) Anal. Biochem , vol.231 , pp. 269-271
    • Kobilka, B.K.1
  • 20
    • 0035339549 scopus 로고    scopus 로고
    • Agonist-promoted trafficking of human bradykinin receptors: arrestin-and dynamin-independent sequestration of the B2 receptor and bradykinin in HEK293 cells
    • Lamb, M.E., W.F. De Weerd, and L.M. Leeb-Lundberg. 2001. Agonist-promoted trafficking of human bradykinin receptors: arrestin-and dynamin-independent sequestration of the B2 receptor and bradykinin in HEK293 cells. Biochem. J. 355:741-750. doi:10.1042/bj3550741
    • (2001) Biochem. J , vol.355 , pp. 741-750
    • Lamb, M.E.1    De Weerd, W.F.2    Leeb-Lundberg, L.M.3
  • 21
    • 34147137118 scopus 로고    scopus 로고
    • Seven transmembrane receptors: something old, something new
    • Lefkowitz, R.J. 2007. Seven transmembrane receptors: something old, something new. Acta Physiol. (Oxf.). 190:9-19. doi:10.1111/j.1365-201X.2007.01693.x
    • (2007) Acta Physiol. (Oxf.) , vol.190 , pp. 9-19
    • Lefkowitz, R.J.1
  • 22
    • 0344310763 scopus 로고    scopus 로고
    • Mechanisms of β-adrenergic receptor desensitization and resensitization
    • Lefkowitz, R.J., J. Pitcher, K. Krueger, and Y. Daaka. 1997. Mechanisms of β-adrenergic receptor desensitization and resensitization. Adv. Pharmacol. 42:416-420. doi:10.1016/S1054-3589(08)60777-2
    • (1997) Adv. Pharmacol , vol.42 , pp. 416-420
    • Lefkowitz, R.J.1    Pitcher, J.2    Krueger, K.3    Daaka, Y.4
  • 23
    • 0024440843 scopus 로고
    • Altered patterns of agonist-stimulated cAMP accumulation in cells expressing mutant β2-adrenergic receptors lacking phosphorylation sites
    • Liggett, S.B., M. Bouvier, W.P. Hausdorff, B. O'Dowd, M.G. Caron, and R.J. Lefkowitz. 1989. Altered patterns of agonist-stimulated cAMP accumulation in cells expressing mutant β2-adrenergic receptors lacking phosphorylation sites. Mol. Pharmacol. 36:641-646
    • (1989) Mol. Pharmacol , vol.36 , pp. 641-646
    • Liggett, S.B.1    Bouvier, M.2    Hausdorff, W.P.3    O'Dowd, B.4    Caron, M.G.5    Lefkowitz, R.J.6
  • 25
    • 84857471063 scopus 로고    scopus 로고
    • Regulation of GPCR activity, trafficking and localization by GPCR-interacting proteins
    • Magalhaes, A.C., H. Dunn, and S.S.G. Ferguson. 2012. Regulation of GPCR activity, trafficking and localization by GPCR-interacting proteins. Br. J. Pharmacol. 165:1717-1736. doi:10.1111/j.1476-5381.2011.01552.x
    • (2012) Br. J. Pharmacol , vol.165 , pp. 1717-1736
    • Magalhaes, A.C.1    Dunn, H.2    Ferguson, S.S.G.3
  • 26
    • 41149154050 scopus 로고    scopus 로고
    • G protein-coupled receptor sorting to endosomes and lysosomes
    • Marchese, A., M.M. Paing, B.R. Temple, and J. Trejo. 2008. G protein-coupled receptor sorting to endosomes and lysosomes. Annu. Rev. Pharmacol. Toxicol. 48:601-629. doi:10.1146/annurev.pharmtox.48.113006.094646
    • (2008) Annu. Rev. Pharmacol. Toxicol , vol.48 , pp. 601-629
    • Marchese, A.1    Paing, M.M.2    Temple, B.R.3    Trejo, J.4
  • 28
    • 0027243406 scopus 로고
    • Sorting of membrane components from endosomes and subsequent recycling to the cell surface occurs by a bulk flow process
    • Mayor, S., J.F. Presley, and F.R. Maxfield. 1993. Sorting of membrane components from endosomes and subsequent recycling to the cell surface occurs by a bulk flow process. J. Cell Biol. 121:1257-1269. doi:10.1083/jcb.121.6.1257
    • (1993) J. Cell Biol , vol.121 , pp. 1257-1269
    • Mayor, S.1    Presley, J.F.2    Maxfield, F.R.3
  • 30
    • 0025925067 scopus 로고
    • Identification of a Gs activator region of the β2-adrenergic receptor that is autoregulated via protein kinase A-dependent phosphorylation
    • Okamoto, T., Y. Murayama, Y. Hayashi, M. Inagaki, E. Ogata, and I. Nishimoto. 1991. Identification of a Gs activator region of the β2-adrenergic receptor that is autoregulated via protein kinase A-dependent phosphorylation. Cell. 67:723-730. doi:10.1016/0092-8674(91)90067-9
    • (1991) Cell , vol.67 , pp. 723-730
    • Okamoto, T.1    Murayama, Y.2    Hayashi, Y.3    Inagaki, M.4    Ogata, E.5    Nishimoto, I.6
  • 31
    • 55949089800 scopus 로고    scopus 로고
    • Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation
    • (Published erratum appears in Proc. Natl. Acad. Sci. USA. 105:20559))
    • Okazaki, M., S. Ferrandon, J.-P. Vilardaga, M.L. Bouxsein, J.T. Potts Jr., and T.J. Gardella. 2008. Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation. Proc. Natl. Acad. Sci. USA. 105:16525-16530. (Published erratum appears in Proc. Natl. Acad. Sci. USA. 105:20559) doi:10.1073/pnas.0808750105
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 16525-16530
    • Okazaki, M.1    Ferrandon, S.2    Vilardaga, J.-P.3    Bouxsein, M.L.4    Potts, J.T.5    Gardella, T.J.6
  • 33
    • 12144282761 scopus 로고    scopus 로고
    • Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator
    • Ponsioen, B., J. Zhao, J. Riedl, F. Zwartkruis, G. van der Krogt, M. Zaccolo, W.H. Moolenaar, J.L. Bos, and K. Jalink. 2004. Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator. EMBO Rep. 5:1176-1180. doi:10.1038/sj.embor.7400290
    • (2004) EMBO Rep , vol.5 , pp. 1176-1180
    • Ponsioen, B.1    Zhao, J.2    Riedl, J.3    Zwartkruis, F.4    van der Krogt, G.5    Zaccolo, M.6    Moolenaar, W.H.7    Bos, J.L.8    Jalink, K.9
  • 35
    • 80052689122 scopus 로고    scopus 로고
    • Role of PDZ proteins in regulating trafficking, signaling, and function of GPCRs: means, motif, and opportunity
    • Romero, G., M. von Zastrow, and P.A. Friedman. 2011. Role of PDZ proteins in regulating trafficking, signaling, and function of GPCRs: means, motif, and opportunity. Adv. Pharmacol. 62:279-314. doi:10.1016/B978-0-12-385952-5.00003-8
    • (2011) Adv. Pharmacol , vol.62 , pp. 279-314
    • Romero, G.1    von Zastrow, M.2    Friedman, P.A.3
  • 36
    • 0034282429 scopus 로고    scopus 로고
    • β2-adrenergic receptor internalization, endosomal sorting, and plasma membrane recycling are regulated by rab GTPases
    • Seachrist, J.L., P.H. Anborgh, and S.S. Ferguson. 2000. β2-adrenergic receptor internalization, endosomal sorting, and plasma membrane recycling are regulated by rab GTPases. J. Biol. Chem. 275:27221-27228
    • (2000) J. Biol. Chem , vol.275 , pp. 27221-27228
    • Seachrist, J.L.1    Anborgh, P.H.2    Ferguson, S.S.3
  • 37
    • 0033789017 scopus 로고    scopus 로고
    • Localization of the sites mediating desensitization of the β2-adrenergic receptor by the GRK pathway
    • Seibold, A., B. Williams, Z.F. Huang, J. Friedman, R.H. Moore, B.J. Knoll, and R.B. Clark. 2000. Localization of the sites mediating desensitization of the β2-adrenergic receptor by the GRK pathway. Mol. Pharmacol. 58:1162-1173
    • (2000) Mol. Pharmacol , vol.58 , pp. 1162-1173
    • Seibold, A.1    Williams, B.2    Huang, Z.F.3    Friedman, J.4    Moore, R.H.5    Knoll, B.J.6    Clark, R.B.7
  • 38
    • 84878704042 scopus 로고    scopus 로고
    • Divergent modes for cargo-mediated control of clathrin-coated pit dynamics
    • Soohoo, A.L., and M.A. Puthenveedu. 2013. Divergent modes for cargo-mediated control of clathrin-coated pit dynamics. Mol. Biol. Cell. 24:1725-1734. doi:10.1091/mbc.E12-07-0550
    • (2013) Mol. Biol. Cell , vol.24 , pp. 1725-1734
    • Soohoo, A.L.1    Puthenveedu, M.A.2
  • 39
    • 79957914861 scopus 로고    scopus 로고
    • SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors
    • Temkin, P., B. Lauffer, S. Jäger, P. Cimermancic, N.J. Krogan, and M. von Zastrow. 2011. SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors. Nat. Cell Biol. 13:715-721. doi:10.1038/ncb2252
    • (2011) Nat. Cell Biol , vol.13 , pp. 715-721
    • Temkin, P.1    Lauffer, B.2    Jäger, S.3    Cimermancic, P.4    Krogan, N.J.5    von Zastrow, M.6
  • 40
    • 84922480357 scopus 로고    scopus 로고
    • Spatial encoding of cyclic AMP signaling specificity by GPCR endocytosis
    • Tsvetanova, N.G., and M. von Zastrow. 2014. Spatial encoding of cyclic AMP signaling specificity by GPCR endocytosis. Nat. Chem. Biol. 10:1061-1065. doi:10.1038/nchembio.1665
    • (2014) Nat. Chem. Biol , vol.10 , pp. 1061-1065
    • Tsvetanova, N.G.1    von Zastrow, M.2
  • 41
    • 84924877730 scopus 로고    scopus 로고
    • G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes
    • Tsvetanova, N.G., R. Irannejad, and M. von Zastrow. 2015. G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes. J. Biol. Chem. 290:6689-6696. doi:10.1074/jbc.R114.617951
    • (2015) J. Biol. Chem , vol.290 , pp. 6689-6696
    • Tsvetanova, N.G.1    Irannejad, R.2    von Zastrow, M.3
  • 42
    • 84884320631 scopus 로고    scopus 로고
    • Reprogramming of G protein-coupled receptor recycling and signaling by a kinase switch
    • Vistein, R., and M.A. Puthenveedu. 2013. Reprogramming of G protein-coupled receptor recycling and signaling by a kinase switch. Proc. Natl. Acad. Sci. USA. 110:15289-15294. doi:10.1073/pnas.1306340110
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 15289-15294
    • Vistein, R.1    Puthenveedu, M.A.2
  • 43
    • 0026662535 scopus 로고
    • Ligand-regulated internalization and recycling of human β2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors
    • von Zastrow, M., and B.K. Kobilka. 1992. Ligand-regulated internalization and recycling of human β2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors. J. Biol. Chem. 267:3530-3538
    • (1992) J. Biol. Chem , vol.267 , pp. 3530-3538
    • von Zastrow, M.1    Kobilka, B.K.2
  • 44
    • 84867135368 scopus 로고    scopus 로고
    • Modulating neuromodulation by receptor membrane traffic in the endocytic pathway
    • von Zastrow, M., and J.T. Williams. 2012. Modulating neuromodulation by receptor membrane traffic in the endocytic pathway. Neuron. 76:22-32. doi:10.1016/j.neuron.2012.09.022
    • (2012) Neuron , vol.76 , pp. 22-32
    • von Zastrow, M.1    Williams, J.T.2
  • 45
    • 84860914331 scopus 로고    scopus 로고
    • Persistent cAMP signaling by internalized TSH receptors occurs in thyroid but not in HEK293 cells
    • Werthmann, R.C., S. Volpe, M.J. Lohse, and D. Calebiro. 2012. Persistent cAMP signaling by internalized TSH receptors occurs in thyroid but not in HEK293 cells. FASEB J. 26:2043-2048. doi:10.1096/fj.11-195248
    • (2012) FASEB J , vol.26 , pp. 2043-2048
    • Werthmann, R.C.1    Volpe, S.2    Lohse, M.J.3    Calebiro, D.4
  • 46
    • 84938348387 scopus 로고    scopus 로고
    • Spatial programming of G protein-coupled receptor activity: decoding signaling in health and disease
    • West, C., and A.C. Hanyaloglu. 2015. Spatial programming of G protein-coupled receptor activity: decoding signaling in health and disease. Mol. Endocrinol. 29:1095-1106
    • (2015) Mol. Endocrinol , vol.29 , pp. 1095-1106
    • West, C.1    Hanyaloglu, A.C.2
  • 48
    • 17144439929 scopus 로고    scopus 로고
    • β-adrenergic signaling in the heart: dual coupling of the β2-adrenergic receptor to Gs and Gi proteins
    • Xiao, R.P. 2001. β-adrenergic signaling in the heart: dual coupling of the β2-adrenergic receptor to Gs and Gi proteins. Sci. STKE
    • (2001) Sci. STKE
    • Xiao, R.P.1
  • 49
    • 0028987214 scopus 로고
    • Functional coupling of the β2-adrenoceptor to a pertussis toxin-sensitive G protein in cardiac myocytes
    • Xiao, R.P., X. Ji, and E.G. Lakatta. 1995. Functional coupling of the β2-adrenoceptor to a pertussis toxin-sensitive G protein in cardiac myocytes. Mol. Pharmacol. 47:322-329
    • (1995) Mol. Pharmacol , vol.47 , pp. 322-329
    • Xiao, R.P.1    Ji, X.2    Lakatta, E.G.3
  • 50
    • 4444234066 scopus 로고    scopus 로고
    • Opioid agonist and antagonist treatment differentially regulates immunoreactive mu-opioid receptors and dynamin-2 in vivo
    • Yoburn, B.C., V. Purohit, K. Patel, and Q. Zhang. 2004. Opioid agonist and antagonist treatment differentially regulates immunoreactive mu-opioid receptors and dynamin-2 in vivo. Eur. J. Pharmacol. 498:87-96. doi:10.1016/j.ejphar.2004.07.052
    • (2004) Eur. J. Pharmacol , vol.498 , pp. 87-96
    • Yoburn, B.C.1    Purohit, V.2    Patel, K.3    Zhang, Q.4
  • 51
    • 0028064817 scopus 로고
    • cAMP-dependent protein kinase and protein kinase C consensus site mutations of the β-adrenergic receptor. Effect on desensitization and stimulation of adenylylcyclase
    • Yuan, N., J. Friedman, B.S. Whaley, and R.B. Clark. 1994. cAMP-dependent protein kinase and protein kinase C consensus site mutations of the β-adrenergic receptor. Effect on desensitization and stimulation of adenylylcyclase. J. Biol. Chem. 269:23032-23038
    • (1994) J. Biol. Chem , vol.269 , pp. 23032-23038
    • Yuan, N.1    Friedman, J.2    Whaley, B.S.3    Clark, R.B.4
  • 52
    • 66349083804 scopus 로고    scopus 로고
    • Cargo-mediated regulation of a rapid Rab4-dependent recycling pathway
    • Yudowski, G.A., M.A. Puthenveedu, A.G. Henry, and M. von Zastrow. 2009. Cargo-mediated regulation of a rapid Rab4-dependent recycling pathway. Mol. Biol. Cell. 20:2774-2784. doi:10.1091/mbc.E08-08-0892
    • (2009) Mol. Biol. Cell , vol.20 , pp. 2774-2784
    • Yudowski, G.A.1    Puthenveedu, M.A.2    Henry, A.G.3    von Zastrow, M.4
  • 53
    • 0037163048 scopus 로고    scopus 로고
    • Protein kinase A-mediated phosphorylation of the β2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system
    • Zamah, A.M., M. Delahunty, L.M. Luttrell, and R.J. Lefkowitz. 2002. Protein kinase A-mediated phosphorylation of the β2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system. J. Biol. Chem. 277:31249-31256. doi:10.1074/jbc.M202753200
    • (2002) J. Biol. Chem , vol.277 , pp. 31249-31256
    • Zamah, A.M.1    Delahunty, M.2    Luttrell, L.M.3    Lefkowitz, R.J.4


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