Abrasion of artificial stones as a new cause of an ancient disease. Physicochemical features and cellular responses

Toxicological Sciences

Volumn 153, Issue 1, 2016, Pages 4-17

  Pavan, Cristina ^a,b   Polimeni, Manuela ^a,b   Tomatis, Maura ^a   Corazzari, Ingrid ^a   Turci, Francesco ^a   Ghigo, Dario ^a,b   Fubini, Bice ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

Author keywords

Artificial stone; Cytotoxicity; Epithelial mesenchymal transition; Free radical; Membranolysis; Quartz

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COPPER; FREE RADICAL; IRON; LACTATE DEHYDROGENASE; PIGMENT; RESIN; SILICON DIOXIDE; TITANIUM; UVOMORULIN; VIMENTIN;

ANIMAL CELL; ARTICLE; ARTIFICIAL STONE; BRONCHUS MUCOSA; CATALYSIS; CONTROLLED STUDY; CYTOTOXICITY; DEGRADATION; DUST; EPITHELIAL MESENCHYMAL TRANSITION; ERYTHROCYTE; HEMOLYSIS; HUMAN; HUMAN CELL; LUNG ALVEOLUS MACROPHAGE; LUNG FIBROSIS; MORPHOLOGY; MOUSE; NONHUMAN; OCCUPATIONAL EXPOSURE; OCCUPATIONAL LUNG DISEASE; PARTICLE SIZE; PHYSICOCHEMICAL MODEL; PROTEIN EXPRESSION; SILICOSIS; ANIMAL; CELL LINE; OCCUPATIONAL DISEASE; PATHOLOGY;

ANIMALS; CELL LINE; DUST; HUMANS; MICE; OCCUPATIONAL DISEASES; SILICOSIS;

EID: 84991038775     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfw101     Document Type: Article

References (57)

1. Antognelli, C., Gambelunghe, A., Muzi, G., and Talesa, V. N. (2016). Glyoxalase I drives epithelial-to-mesenchymal transition via argpyrimidine-modified Hsp70, miR-21 and SMAD signalling in human bronchial cells BEAS-2B chronically exposed to crystalline silica Min-U-Sil 5: Transformation into a neoplastic-like phenotype. Free Radic. Biol. Med. 92, 110-125. 10.1016/j.freeradbiomed.2016.01.009.
2. Bang, K. M., Mazurek, J. M., Wood, J. M., White, G. E., Hendricks, S. A., and Weston, A. (2015). Silicosis mortality trends and new exposures to respirable crystalline silica-United States, 2001-2010. MMWR Morb. Mortal Wkly Rep. 64, 117-120.
3. Bartoli, D., Banchi, B., Di Benedetto, F., Farina, F. A., Iaia, T. E., Poli, C., Romanelli, M., Scancarello, G., and Tarchi, M. (2012). Silicosis in employees in the processing of kitchen, bar and shop countertops made from quartz resin composite. Provisional results of the environmental and health survey conducted within the territory of USL 11 of Empoli in Tuscany among employees in the processing of quartz resin composite materials and review of the literature. Ital. J. Occup. Environ. Hyg 3, 138-143.
4. Blanco, D., Vicent, S., Elizegi, E., Pino, I., Fraga, M. F., Esteller, M., Saffiotti, U., Lecanda, F., and Montuenga, L. M. (2004). Altered expression of adhesion molecules and epithelialmesenchymal transition in silica-induced rat lung carcinogenesis. Lab. Invest. 84, 999-1012. 10.1038/labinvest.3700129.
5. Castranova, V. (2004). Signaling pathways controlling the production of inflammatory mediators in response to crystalline silica exposure: role of reactive oxygen/nitrogen species. Free Radic. Biol.Med. 37, 916-925. 10.1016/j.freeradbiomed.2004.05.032.
6. Cho, W. S., Duffin, R., Bradley, M., Megson, I. L., MacNee, W., Lee, J. K., Jeong, J., and Donaldson, K. (2013). Predictive value of in vitro assays depends on the mechanism of toxicity of metal oxide nanoparticles. Part. Fibre Toxicol 10, 15. 10.1186/1743-8977-10-55.
7. Clouter, A., Brown, D., Hohr, D., Borm, P., and Donaldson, K. (2001). Inflammatory effects of respirable quartz collected in workplaces versus standard DQ12 quartz: particle surface correlates. Toxicol. Sci. 63, 90-98. 10.1093/toxsci/63.1.90.
8. Fenoglio, I., Martra, G., Prandi, L., Tomatis, M., Coluccia, S., and Fubini, B. (2000). The role of mechanochemistry in the pulmonary toxicity caused by particulate minerals. J. Mater. Synth. Process 8, 4), 145-153, 10.1023/A. 1011303924468.
9. Friedman, G. K., Harrison, R., Bojes, H., Worthington, K., and Filios, M. (2015). Notes fromthe field: silicosis in a countertop fabricator-Texas, 2014.MMWRMorb.MortalWkly Rep. 64, 129-130.
10. Fubini, B., Giamello, E., Pugliese, L., and Volante, M. (1989). Mechanically induced defects in quartz and their impact on pathogenicity. Solid State Ionics 32-3, 334-343. 10.1016/0167-2738(89)90238-5.
11. Fubini, B. (1998a). Health effects of silica. In The Surface Properties of Silica (A. P. Legrand, Eds.), pp. 415-464. John Wiley and Sons, Chichester, UK.
12. Fubini, B. (1998b). Surface chemistry and quartz hazard. Ann. Occup. Hyg 42, 521-530, 10.1016/s0003-4878(98)00066-0.
13. Fubini, B., Bolis, V., Cavenago, A., and Volante, M. (1995a). Physicochemical properties of crystalline silica dusts and their possible implication in various biological responses. Scand. J. Work Environ. Health 21, 9-14.
14. Fubini, B., Giamello, E., Volante, M., and Bolis, V. (1990). Chemical functionalities at the silica surface determining its reactivity when inhaled-formation and reactivity of surface radicals. Toxicol. Ind. Health 6, 571-598.
15. Fubini, B., Mollo, L., and Giamello, E. (1995b). Free-radical generation at the solid/liquid interface in iron-containing minerals. Free Radical Res. 23, 593-614. 10.3109/10715769509065280.
16. Fubini, B., and Hubbard, A. (2003). Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis. Free Radic. Biol. Med 34, 1507-1516. 10.1016/S0891-5849(03)00149-7.
17. Gao, Z., Hu, Y., Peng, J., Deng, Z., Liang, G., Jiang, H., and Zhou, J. (2011). ERK signaling pathway mediated epithelialmesenchymal transition induced by SiO2 in human bronchial epithelial cells. Zhong Nan Da Xue Xue Bao Yi Xue Ban 36, 1085-1089. 10.3969/j.issn.1672-7347.2011.11.009.
18. García Vadillo, C., Gómez, J., and Morillo, J. (2011). Silicosis in quartz conglomerate workers. Arch. Bronconeumol. 47, 53.
19. Gazzano, E., Ghiazza, M., Polimeni, M., Bolis, V., Fenoglio, I., Attanasio, A., Mazzucco, G., Fubini, B., and Ghigo, D. (2012). Physicochemical determinants in the cellular responses to nanostructured amorphous silicas. Toxicol. Sci. 128, 158-170. 10.1093/toxsci/kfs128.
20. Ghiazza, M., Polimeni, M., Fenoglio, I., Gazzano, E., Ghigo, D., and Fubini, B. (2010). Does vitreous silica contradict the toxicity of the crystalline silica paradigm? Chem. Res. Toxicol. 23, 620-629. 10.1021/tx900369x.
21. Ghiazza, M., Tomatis, M., Doublier, S., Grendene, F., Gazzano, E., Ghigo, D., and Fubini, B. (2013). Carbon in intimate contact with quartz reduces the biological activity of crystalline silica dusts. Chem. Res. Toxicol. 26, 46-54. 10.1021/tx300299v.
22. Guarino, M., Tosoni, A., and Nebuloni, M. (2009). Direct contribution of epithelium to organ fibrosis: epithelial-mesenchymal transition. Hum. Pathol. 40, 1365-1376. 10.1016/j.humpath.2009.02.020.
23. Hornung, V., Bauernfeind, F., Halle, A., Samstad, E. O., Kono, H., Rock, K. L., Fitzgerald, K. A., and Latz, E. (2008). Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat. Immunol. 9, 847-856. 10.1038/ni.1631.
24. Hu Yong, B., Li Fei, F., Deng Zheng, H., and Pan Pin, H. (2015). Transcriptional factor snail mediates epithelialmesenchymal transition in human bronchial epithelial cells induced by silica. Biomed. Environ. Sci. 28(7), 544-548, 10.3967/bes2015.078.
25. Hughes, C. S., Colhoun, L. M., Bains, B. K., Kilgour, J. D., Burden, R. E., Burrows, J. F., Lavelle, E. C., Gilmore, B. F., and Scott, C. J. (2016). Extracellular cathepsin S and intracellular caspase 1 activation are surrogate biomarkers of particulate-induced lysosomal disruption in macrophages. Part. Fibre Toxicol. 13, 19-110. 1186/s12989-016-0129-5.
26. International Agency for Research on Cancer (IARC) (1997). Silica, some silicates, coal dust and para-aramid fibrils. In IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Vol 68. IARC, Lyon, France.
27. International Agency for Research on Cancer (IARC) (2012). A review of human carcinogens: arsenic, metals, fibres, and dusts. In IARC Monographs on the Evaluation of Carcinogenic Risks to Human. Vol 100C. IARC, Lyon, France.
28. Kandare, E., Kandola, B. K., Price, D., Nazare, S., and Horrocks, R. A. (2008). Study of the thermal decomposition of flameretarded unsaturated polyester resins by thermogravimetric analysis and Py-GC/MS. Polym. Degrad. Stabil. 93, 1996-2006, 10.1016./j.polymdegradstab.2008.03.032.
29. Knaapen, A. M., Borm, P. J., Albrecht, C., and Schins, R. P. (2004). Inhaled particles and lung cancer. Part A: Mechanisms. Int. J. Cancer 109, 799-809. 10.1002/ijc.11708.
30. Kramer, M. R., Blanc, P. D., Fireman, E., Amital, A., Guber, A., Rhahman, N. A., and Shitrit, D. (2012). Artificial stone silicosis: Disease resurgence among artificial stone workers. Chest 142, 419-424, 10.1378./chest.11-1321.
31. Li, L., and Li, W. (2015). Epithelial-mesenchymal transition in human cancer: comprehensive reprogramming of metabolism, epigenetics, and differentiation. Pharmacol. Ther. 150, 33-46. 10.1016/j.pharmthera.2015.01.004.
32. Liang, D., Wang, Y., Zhu, Z., Yang, G., An, G., Li, X., Niu, P., Chen, L., and Tian, L. (2015). Increased expression of bone morphogenetic protein-7 and its related pathway provides an antifibrotic effect on silica induced fibrosis in vitro. Toxicol. Res. 4, 1511-1522. 10.1039/c5tx00159e.
33. Lu, S. L., Duffin, R., Poland, C., Daly, P., Murphy, F., Drost, E., MacNee, W., Stone, V., and Donaldson, K. (2009). Efficacy of simple short-term in vitro assays for predicting the potential of metal oxide nanoparticles to cause pulmonary inflammation. Environ. Health Perspect. 117, 241-247. 10.1289/ehp.11811.
34. Margolis, S. V. K., and David, H. (1974). Processes of formation and environmental occurrence of microfeatures on detrital quartz grains. Am. J. Sci. 274, 449-464.
35. Martínez, C., Prieto, A., García, L., Quero, A., González, S., and Casan, P. (2010). Silicosis: a disease with an active present. Arch. Bronconeumol. 46, 97-100, 10. 1016/j.arbres.2009.07.008.
36. Nowrin, K., Sohal, S. S., Peterson, G., Patel, R., and Walters, E. H. (2014). Epithelial-mesenchymal transition as a fundamental underlying pathogenic process in COPD airways: fibrosis, remodeling and cancer. Expert Rev. Respir. Med 8, 547-559. 10.1586/17476348.2014.948853.
37. OSHA, NIOSH (2015). Hazard alert: Worker exposure to silica during countertop manufacturing, finishing and installation. Available at: http://www.cdc.gov/niosh/docs/2015-106/pdfs/2015-106.pdf. Accessed Feb 5, 2016.
38. Øvrevik, J., Refsnes, M., Låg, M., Holme, J. A., and Schwarze, P. E. (2015). Activation of proinflammatory responses in cells of the airway mucosa by particulate matter: oxidant-and nonoxidant-mediated triggering mechanisms. Biomolecules 5, 1399-1440. 10.3390/biom5031399.
39. Paolucci, V., Romeo, R., Sisinni, A. G., Bartoli, D., Mazzei, M. A., and Sartorelli, P. (2015). Silicosis in workers exposed to artificial quartz conglomerates: does it differ from chronic simple silicosis? Arch. Bronconeumol. 51, e57-e60.
40. Pascual, S., Urrutia, I., Ballaz, A., Arrizubieta, I., Altube, L., and Salinas, C. (2011). Prevalence of silicosis in a marble factory after exposure to quartz conglomerates. Arch. Bronconeumol. 47, 50-51. 10.1016/j.arbres.2010.09.004.
41. Pavan, C., Rabolli, V., Tomatis, M., Fubini, B., and Lison, D. (2014). Why does the hemolytic activity of silica predict its proinflammatory activity? Part. Fibre Toxicol. 11, 76. 10.1186/s12989-014-0076-y.
42. Pavan, C., Tomatis, M., Ghiazza, M., Rabolli, V., Bolis, V., Lison, D., and Fubini, B. (2013). In search of the chemical basis of the hemolytic potential of silicas. Chem. Res. Toxicol. 26, 1188-1198. 10.1021/tx400105f.
43. Polimeni, M., Gazzano, E., Ghiazza, M., Fenoglio, I., Bosia, A., Fubini, B., and Ghigo, D. (2008). Quartz inhibits glucose 6-phosphate dehydrogenase in murine alveolar macrophages. Chem. Res. Toxicol. 21, 888-894. 10.1021/tx7003213.
44. Pérez-Alonso, A., Córdoba-Doña, J. A., and Garcia-Vadíllo, C. (2015). Silicosis: relevant differences between marble workers and miners. Arch. Bronconeumol. 51, 53-54.
45. Pérez-Alonso, A., Córdoba-Doña, J. A., Millares-Lorenzo, J. L., Figueroa-Murillo, E., García-Vadillo, C., and Romero-Morillos, J. (2014). Outbreak of silicosis in Spanish quartz conglomerate workers. Int. J. Occup. Environ. Health 20, 26-32. 10.1179/2049396713Y.0000000049.
46. Rong, Y., Shen, Y., Zhang, Z., Cui, X., Xiao, L., Liu, Y., Luo, X., and Chen, W. (2015). Blocking TGF-b expression inhibits silica particle-induced epithelial-mesenchymal transition in human lung epithelial cells. Environ. Toxicol. Pharmacol. 40, 861-869. 10.1016/j.etap.2015.09.014.
47. Sauvé, J. F. (2015). Historical and emerging workplaces affected by silica exposure since the 1930 Johannesburg conference on Silicosis, with special reference to construction. Am. J. Ind. Med 58(Suppl. 1), 67-71. 10.1002/ajim.22507.
48. Schins, R. P., Knaapen, A. M., Cakmak, G. D., Shi, T., Weishaupt, C., and Borm, P. J. (2002). Oxidant-induced DNA damage by quartz in alveolar epithelial cells. Mutat. Res 517, 77-86.
49. Shtraichman, O., Blanc, P. D., Ollech, J. E., Fridel, L., Fuks, L., Fireman, E., and Kramer, M. R. (2015). Outbreak of autoimmune disease in silicosis linked to artificial stone. Occup. Med. (Lond) 65, 444-450. 10.1093/occmed/kqv073.
50. Steenland, K., and Ward, E. (2014). Silica: a lung carcinogen. CA Cancer J. Clin. 64, 63-69. 10.3322/caac.21214.
51. Tanjore, H., Xu, X. C., Polosukhin, V. V., Degryse, A. L., Li, B., Han, W., Sherrill, T. P., Plieth, D., Neilson, E. G., Blackwell, T. S., and., et al. (2009). Contribution of epithelial-derived fibroblasts to bleomycin-induced lung fibrosis. Am. J. Respir. Crit. Care Med. 180, 657-665. 10.1164/rccm.200903-0322OC.
52. Thiery, J. P., Acloque, H., Huang, R. Y., and Nieto, M. A. (2009). Epithelial-mesenchymal transitions in development and disease. Cell 139, 871-890, 10.1016/j. cell.2009.11.007.
53. Tomatis, M., Prandi, L., Bodoardo, S., and Fubini, B. (2002). Loss of surface reactivity upon heating amphibole asbestos. Langmuir 18, 4345-4350. 10.1021/la011609w.
54. Vallyathan, V., Kang, J. H., Van Dyke, K., Dalal, N. S., and Castranova, V. (1991). Response of alveolar macrophages to in vitro exposure to freshly fractured versus aged silica dust: the ability of Prosil 28, an organosilane material, to coat silica and reduce its biological reactivity. J. Toxicol. Environ. Health 33, 303-315. 10.1080/15287399109531529.
55. Vallyathan, V., Shi, X. L., Dalal, N. S., Irr, W., and Castranova, V. (1988). Generation of free radicals from freshly fractured silica dust. Potential role in acute silica-induced lung injury. Am. Rev. Respir. Di.S 138, 1213-1219. 10.1164/ajrccm/138.5.1213.
56. Wang, X., Xu, D., Liao, Y., Zhong, S., Song, H., Sun, B., Zhou, B. P., Deng, J., and Han, B. (2015). Epithelial neoplasia coincides with exacerbated injury and fibrotic response in the lungs of Gprc5a-knockout mice following silica exposure. Oncotarget 6, 39578-39593. 10.18632/oncotarget.5532.
57. Yilmaz, M., and Christofori, G. (2009). EMT, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev. 28, 15-33. 10.1007/s10555-008-9169-0.