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Volumn 4, Issue 1, 2016, Pages

Targeted temperature management in traumatic brain injury

Author keywords

Intracranial pressure; Ischemia; Reperfusion; Targeted temperature management; Therapeutic hypothermia; Traumatic brain injury

Indexed keywords

APOPTOSIS; CELL METABOLISM; CLINICAL TRIAL (TOPIC); GLASGOW COMA SCALE; HUMAN; INDUCED HYPOTHERMIA; INTENSIVE CARE UNIT; INTRACRANIAL PRESSURE; LENGTH OF STAY; MULTICENTER STUDY (TOPIC); NECROSIS; OXIDATIVE STRESS; PHASE 2 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SUBDURAL HEMATOMA; TRAUMATIC BRAIN INJURY;

EID: 84991037831     PISSN: None     EISSN: 20520492     Source Type: Journal    
DOI: 10.1186/s40560-016-0137-4     Document Type: Review
Times cited : (21)

References (90)
  • 1
    • 18844421847 scopus 로고    scopus 로고
    • The public health approach to traumatic brain injury: an overview of CDC's research and programs
    • Binder S, Corrigan JD, Langlois JA. The public health approach to traumatic brain injury: an overview of CDC's research and programs. J Head Trauma Rehabil. 2005;20(3):189-95.
    • (2005) J Head Trauma Rehabil , vol.20 , Issue.3 , pp. 189-195
    • Binder, S.1    Corrigan, J.D.2    Langlois, J.A.3
  • 2
    • 17144422879 scopus 로고    scopus 로고
    • Neuroprotection in brain and spinal cord trauma
    • Fu ES, Tummala RP. Neuroprotection in brain and spinal cord trauma. Curr Opin Anaesthesiol. 2005;18(2):181-7. doi:10.1097/01.aco.0000162838.56344.88.
    • (2005) Curr Opin Anaesthesiol , vol.18 , Issue.2 , pp. 181-187
    • Fu, E.S.1    Tummala, R.P.2
  • 3
    • 84904500326 scopus 로고    scopus 로고
    • Mitochondrial neuroprotection in traumatic brain injury: rationale and therapeutic strategies
    • CNSNDDT-EPUB-57034
    • Yokobori S, Mazzeo AT, Gajavelli S, Bullock MR. Mitochondrial neuroprotection in traumatic brain injury: rationale and therapeutic strategies. CNS Neurol Disord Drug Targets. 2014;13(4):606-19. doi: CNSNDDT-EPUB-57034 [pii].
    • (2014) CNS Neurol Disord Drug Targets , vol.13 , Issue.4 , pp. 606-619
    • Yokobori, S.1    Mazzeo, A.T.2    Gajavelli, S.3    Bullock, M.R.4
  • 4
    • 84872671391 scopus 로고    scopus 로고
    • The use of hypothermia therapy in traumatic ischemic/reperfusional brain injury: review of the literatures
    • Yokobori S, Frantzen J, Bullock R, Gajavelli S, Burks S, Bramlett H, et al. The use of hypothermia therapy in traumatic ischemic/reperfusional brain injury: review of the literatures. Ther Hypothermia Temp Manag. 2011;1(4):185-92. doi:10.1089/ther.2011.0012.
    • (2011) Ther Hypothermia Temp Manag , vol.1 , Issue.4 , pp. 185-192
    • Yokobori, S.1    Frantzen, J.2    Bullock, R.3    Gajavelli, S.4    Burks, S.5    Bramlett, H.6
  • 5
    • 62849110915 scopus 로고    scopus 로고
    • Therapeutic hypothermia and controlled normothermia in the intensive care unit: practical considerations, side effects, and cooling methods
    • Polderman KH, Herold I. Therapeutic hypothermia and controlled normothermia in the intensive care unit: practical considerations, side effects, and cooling methods. Crit Care Med. 2009;37(3):1101-20. doi:10. 1097/CCM.0b013e3181962ad5.
    • (2009) Crit Care Med , vol.37 , Issue.3 , pp. 1101-1120
    • Polderman, K.H.1    Herold, I.2
  • 8
    • 84889259187 scopus 로고    scopus 로고
    • Targeted temperature management at 33 °C versus 36 °C after cardiac arrest
    • Nielsen N, Wetterslev J, Cronberg T, Erlinge D, Gasche Y, Hassager C, et al. Targeted temperature management at 33 °C versus 36 °C after cardiac arrest. N Engl J Med. 2013;369(23):2197-206. doi:10.1056/NEJMoa1310519.
    • (2013) N Engl J Med , vol.369 , Issue.23 , pp. 2197-2206
    • Nielsen, N.1    Wetterslev, J.2    Cronberg, T.3    Erlinge, D.4    Gasche, Y.5    Hassager, C.6
  • 9
    • 84937696983 scopus 로고    scopus 로고
    • Interpreting the results of the targeted temperature management trial in cardiac arrest
    • Polderman KH, Varon J. Interpreting the results of the targeted temperature management trial in cardiac arrest. Ther Hypothermia Temp Manag. 2015. doi:10.1089/ther.2014.0031.
    • (2015) Ther Hypothermia Temp Manag
    • Polderman, K.H.1    Varon, J.2
  • 10
    • 34547759327 scopus 로고    scopus 로고
    • Guidelines for the management of severe traumatic brain injury. J Neurotrauma. 2007;24 Suppl 1:S1-106. doi:10.1089/neu.2007.9999.
    • (2007) J Neurotrauma , vol.24 , pp. S1-106
  • 11
    • 79955375034 scopus 로고    scopus 로고
    • Targeted temperature management in critical care: a report and recommendations from five professional societies
    • Nunnally ME, Jaeschke R, Bellingan GJ, Lacroix J, Mourvillier B, Rodriguez-Vega GM, et al. Targeted temperature management in critical care: a report and recommendations from five professional societies. Crit Care Med. 2011;39(5): 1113-25. doi:10.1097/CCM.0b013e318206bab2.
    • (2011) Crit Care Med , vol.39 , Issue.5 , pp. 1113-1125
    • Nunnally, M.E.1    Jaeschke, R.2    Bellingan, G.J.3    Lacroix, J.4    Mourvillier, B.5    Rodriguez-Vega, G.M.6
  • 12
    • 84922483772 scopus 로고    scopus 로고
    • Evidence to support mitochondrial neuroprotection, in severe traumatic brain injury
    • Gajavelli S, Sinha VK, Mazzeo AT, Spurlock MS, Lee SW, Ahmed AI, et al. Evidence to support mitochondrial neuroprotection, in severe traumatic brain injury. J Bioenerg Biomembr. 2015;47(1-2):133-48. doi:10.1007/s10863-014-9589-1.
    • (2015) J Bioenerg Biomembr , vol.47 , Issue.1-2 , pp. 133-148
    • Gajavelli, S.1    Sinha, V.K.2    Mazzeo, A.T.3    Spurlock, M.S.4    Lee, S.W.5    Ahmed, A.I.6
  • 14
    • 0026761089 scopus 로고
    • Local cerebral blood flow mapping before and after removal of acute subdural hematoma in the rat
    • Kuroda Y, Bullock R. Local cerebral blood flow mapping before and after removal of acute subdural hematoma in the rat. Neurosurgery. 1992;30(5): 687-91.
    • (1992) Neurosurgery , vol.30 , Issue.5 , pp. 687-691
    • Kuroda, Y.1    Bullock, R.2
  • 16
    • 10744226575 scopus 로고    scopus 로고
    • Neurophysiological monitoring, magnetic resonance imaging, and histological assays confirm the beneficial effects of moderate hypothermia after epidural focal mass lesion development in rodents
    • discussion 11-2
    • Burger R, Bendszus M, Vince GH, Solymosi L, Roosen K. Neurophysiological monitoring, magnetic resonance imaging, and histological assays confirm the beneficial effects of moderate hypothermia after epidural focal mass lesion development in rodents. Neurosurgery. 2004;54(3):701-11. discussion 11-2.
    • (2004) Neurosurgery , vol.54 , Issue.3 , pp. 701-711
    • Burger, R.1    Bendszus, M.2    Vince, G.H.3    Solymosi, L.4    Roosen, K.5
  • 17
    • 0028136669 scopus 로고
    • Effect of neuroprotective N-methyl-D-aspartate antagonists on increased intracranial pressure: studies in the rat acute subdural hematoma model
    • Kuroda Y, Fujisawa H, Strebel S, Graham DI, Bullock R. Effect of neuroprotective N-methyl-D-aspartate antagonists on increased intracranial pressure: studies in the rat acute subdural hematoma model. Neurosurgery. 1994;35(1):106-12.
    • (1994) Neurosurgery , vol.35 , Issue.1 , pp. 106-112
    • Kuroda, Y.1    Fujisawa, H.2    Strebel, S.3    Graham, D.I.4    Bullock, R.5
  • 18
    • 84873693271 scopus 로고    scopus 로고
    • Neuroprotective effect of preoperatively induced mild hypothermia as determined by biomarkers and histopathological estimation in a rat subdural hematoma decompression model
    • Yokobori S, Gajavelli S, Mondello S, Mo-Seaney J, Bramlett HM, Dietrich WD, et al. Neuroprotective effect of preoperatively induced mild hypothermia as determined by biomarkers and histopathological estimation in a rat subdural hematoma decompression model. J Neurosurg. 2012. doi:10.3171/ 2012.10.jns12725.
    • (2012) J Neurosurg
    • Yokobori, S.1    Gajavelli, S.2    Mondello, S.3    Mo-Seaney, J.4    Bramlett, H.M.5    Dietrich, W.D..6
  • 19
    • 77049200882 scopus 로고
    • Hypothermia in cardiac and general surgery
    • Lewis FJ. Hypothermia in cardiac and general surgery. Minn Med. 1955; 38(2):77-81.
    • (1955) Minn Med , vol.38 , Issue.2 , pp. 77-81
    • Lewis, F.J.1
  • 20
    • 77049286065 scopus 로고
    • Hypothermia for general and cardiac surgery; with techniques of some open intracardiac procedures under hypothermia
    • Swan H. Hypothermia for general and cardiac surgery; with techniques of some open intracardiac procedures under hypothermia. Surg Clin North Am. 1956:1009-24
    • (1956) Surg Clin North Am , pp. 1009-1024
    • Swan, H.1
  • 21
    • 0017256201 scopus 로고
    • In situ kidney preservation for transplantation with use of profound hypothermia (5 to 20 degrees C.) with an intact circulation
    • Moossa AR, Zarins CK, Skinner DB. In situ kidney preservation for transplantation with use of profound hypothermia (5 to 20 degrees C.) with an intact circulation. Surgery. 1976;79(1):60-4.
    • (1976) Surgery , vol.79 , Issue.1 , pp. 60-64
    • Moossa, A.R.1    Zarins, C.K.2    Skinner, D.B.3
  • 22
    • 77957994535 scopus 로고    scopus 로고
    • Intravenous thrombolysis plus hypothermia for acute treatment of ischemic stroke (ICTuS-L): final results
    • Hemmen TM, Raman R, Guluma KZ, Meyer BC, Gomes JA, Cruz-Flores S, et al. Intravenous thrombolysis plus hypothermia for acute treatment of ischemic stroke (ICTuS-L): final results. Stroke. 2010;41(10):2265-70. doi:10. 1161/STROKEAHA.110.592295.
    • (2010) Stroke , vol.41 , Issue.10 , pp. 2265-2270
    • Hemmen, T.M.1    Raman, R.2    Guluma, K.Z.3    Meyer, B.C.4    Gomes, J.A.5    Cruz-Flores, S.6
  • 23
    • 3242787149 scopus 로고    scopus 로고
    • Cooling for acute ischemic brain damage (COOL AID): a feasibility trial of endovascular cooling
    • De Georgia MA, Krieger DW, Abou Chebl A, Devlin TG, Jauss M, Davis SM, et al. Cooling for acute ischemic brain damage (COOL AID): a feasibility trial of endovascular cooling. Neurology. 2004;63(2):312-7.
    • (2004) Neurology , vol.63 , Issue.2 , pp. 312-317
    • De Georgia, M.A.1    Krieger, D.W.2    Abou Chebl, A.3    Devlin, T.G.4    Jauss, M.5    Davis, S.M.6
  • 24
    • 0036084078 scopus 로고    scopus 로고
    • Effect of endovascular cooling on myocardial temperature, infarct size, and cardiac output in human-sized pigs
    • Dae MW, Gao DW, Sessler DI, Chair K, Stillson CA. Effect of endovascular cooling on myocardial temperature, infarct size, and cardiac output in human-sized pigs. Am J Physiol Heart Circ Physiol. 2002;282(5):H1584-91. doi:10.1152/ajpheart.00980.2001.
    • (2002) Am J Physiol Heart Circ Physiol , vol.282 , Issue.5 , pp. H1584-H1591
    • Dae, M.W.1    Gao, D.W.2    Sessler, D.I.3    Chair, K.4    Stillson, C.A.5
  • 25
    • 2942627685 scopus 로고    scopus 로고
    • Intraarrest cooling improves outcomes in a murine cardiac arrest model
    • Abella BS, Zhao D, Alvarado J, Hamann K, Vanden Hoek TL, Becker LB. Intraarrest cooling improves outcomes in a murine cardiac arrest model. Circulation. 2004;109(22):2786-91. doi:10.1161/01.CIR.0000131940.19833.85.
    • (2004) Circulation , vol.109 , Issue.22 , pp. 2786-2791
    • Abella, B.S.1    Zhao, D.2    Alvarado, J.3    Hamann, K.4    Vanden Hoek, T.L.5    Becker, L.B.6
  • 26
    • 69349088566 scopus 로고    scopus 로고
    • Hypothermia after cardiac arrest
    • Janata A, Holzer M. Hypothermia after cardiac arrest. Prog Cardiovasc Dis. 2009;52(2):168-79. doi:10.1016/j.pcad.2009.07.001.
    • (2009) Prog Cardiovasc Dis , vol.52 , Issue.2 , pp. 168-179
    • Janata, A.1    Holzer, M.2
  • 27
    • 0027440467 scopus 로고
    • A phase II study of moderate hypothermia in severe brain injury
    • discussion 73
    • Clifton GL, Allen S, Barrodale P, Plenger P, Berry J, Koch S, et al. A phase II study of moderate hypothermia in severe brain injury. J Neurotrauma. 1993; 10(3):263-71. discussion 73.
    • (1993) J Neurotrauma , vol.10 , Issue.3 , pp. 263-271
    • Clifton, G.L.1    Allen, S.2    Barrodale, P.3    Plenger, P.4    Berry, J.5    Koch, S.6
  • 28
    • 0027297094 scopus 로고
    • The use of moderate therapeutic hypothermia for patients with severe head injuries: a preliminary report
    • Marion DW, Obrist WD, Carlier PM, Penrod LE, Darby JM. The use of moderate therapeutic hypothermia for patients with severe head injuries: a preliminary report. J Neurosurg. 1993;79(3):354-62. doi:10.3171/jns.1993.79.3.0354.
    • (1993) J Neurosurg , vol.79 , Issue.3 , pp. 354-362
    • Marion, D.W.1    Obrist, W.D.2    Carlier, P.M.3    Penrod, L.E.4    Darby, J.M.5
  • 29
    • 0027223871 scopus 로고
    • Effect of mild hypothermia on uncontrollable intracranial hypertension after severe head injury
    • Shiozaki T, Sugimoto H, Taneda M, Yoshida H, Iwai A, Yoshioka T, et al. Effect of mild hypothermia on uncontrollable intracranial hypertension after severe head injury. J Neurosurg. 1993;79(3):363-8. doi:10.3171/jns.1993.79.3.0363.
    • (1993) J Neurosurg , vol.79 , Issue.3 , pp. 363-368
    • Shiozaki, T.1    Sugimoto, H.2    Taneda, M.3    Yoshida, H.4    Iwai, A.5    Yoshioka, T.6
  • 30
    • 0035931948 scopus 로고    scopus 로고
    • Lack of effect of induction of hypothermia after acute brain injury
    • Clifton GL, Miller ER, Choi SC, Levin HS, McCauley S, Smith Jr KR, et al. Lack of effect of induction of hypothermia after acute brain injury. N Engl J Med. 2001;344(8):556-63. doi:10.1056/nejm200102223440803.
    • (2001) N Engl J Med , vol.344 , Issue.8 , pp. 556-563
    • Clifton, G.L.1    Miller, E.R.2    Choi, S.C.3    Levin, H.S.4    McCauley, S.5    Smith, K.R.6
  • 31
    • 78751569803 scopus 로고    scopus 로고
    • Very early hypothermia induction in patients with severe brain injury (the National Acute Brain Injury Study: Hypothermia II): a randomised trial
    • Clifton GL, Valadka A, Zygun D, Coffey CS, Drever P, Fourwinds S, et al. Very early hypothermia induction in patients with severe brain injury (the National Acute Brain Injury Study: Hypothermia II): a randomised trial. Lancet Neurol. 2011;10(2):131-9. doi:10.1016/s1474-4422(10)70300-8.
    • (2011) Lancet Neurol , vol.10 , Issue.2 , pp. 131-139
    • Clifton, G.L.1    Valadka, A.2    Zygun, D.3    Coffey, C.S.4    Drever, P.5    Fourwinds, S.6
  • 32
    • 84873693271 scopus 로고    scopus 로고
    • Neuroprotective effect of preoperatively induced mild hypothermia as determined by biomarkers and histopathological estimation in a rat subdural hematoma decompression model
    • Yokobori S, Gajavelli S, Mondello S, Mo-Seaney J, Bramlett HM, Dietrich WD, et al. Neuroprotective effect of preoperatively induced mild hypothermia as determined by biomarkers and histopathological estimation in a rat subdural hematoma decompression model. J Neurosurg. 2013;118(2):370-80. doi:10.3171/2012.10.JNS12725.
    • (2013) J Neurosurg , vol.118 , Issue.2 , pp. 370-380
    • Yokobori, S.1    Gajavelli, S.2    Mondello, S.3    Mo-Seaney, J.4    Bramlett, H.M.5    Dietrich, W.D.6
  • 33
    • 84961290735 scopus 로고    scopus 로고
    • Prolonged mild therapeutic hypothermia versus fever control with tight hemodynamic monitoring and slow rewarming in patients with severe traumatic brain injury: a randomized controlled trial
    • Maekawa T, Yamashita S, Nagao S, Hayashi N, Ohashi Y. Prolonged mild therapeutic hypothermia versus fever control with tight hemodynamic monitoring and slow rewarming in patients with severe traumatic brain injury: a randomized controlled trial. J Neurotrauma. 2015;32(7):422-9. doi: 10.1089/neu.2013.3197.
    • (2015) J Neurotrauma , vol.32 , Issue.7 , pp. 422-429
    • Maekawa, T.1    Yamashita, S.2    Nagao, S.3    Hayashi, N.4    Ohashi, Y.5
  • 34
    • 84924152893 scopus 로고    scopus 로고
    • Diverse effects of hypothermia therapy in patients with severe traumatic brain injury based on the computed tomography classification of the traumatic coma data bank
    • Suehiro E, Koizumi H, Fujisawa H, Fujita M, Kaneko T, Oda Y, et al. Diverse effects of hypothermia therapy in patients with severe traumatic brain injury based on the computed tomography classification of the traumatic coma data bank. J Neurotrauma. 2015;32(5):353-8. doi:10.1089/neu.2014.3584.
    • (2015) J Neurotrauma , vol.32 , Issue.5 , pp. 353-358
    • Suehiro, E.1    Koizumi, H.2    Fujisawa, H.3    Fujita, M.4    Kaneko, T.5    Oda, Y.6
  • 35
    • 0028306190 scopus 로고
    • Morphological manifestations of reperfusion injury in brain
    • Dietrich WD. Morphological manifestations of reperfusion injury in brain. Ann N Y Acad Sci. 1994;723:15-24.
    • (1994) Ann N Y Acad Sci , vol.723 , pp. 15-24
    • Dietrich, W.D.1
  • 36
    • 79551594745 scopus 로고    scopus 로고
    • State of the art in therapeutic hypothermia
    • Lampe JW, Becker LB. State of the art in therapeutic hypothermia. Annu Rev Med. 2011;62:79-93. doi:10.1146/annurev-med-052009-150512.
    • (2011) Annu Rev Med , vol.62 , pp. 79-93
    • Lampe, J.W.1    Becker, L.B.2
  • 37
    • 67650303102 scopus 로고    scopus 로고
    • Mechanisms of action, physiological effects, and complications of hypothermia
    • Polderman KH. Mechanisms of action, physiological effects, and complications of hypothermia. Crit Care Med. 2009;37(7 Suppl):S186-202. doi:10.1097/CCM. 0b013e3181aa5241.
    • (2009) Crit Care Med , vol.37 , Issue.7 , pp. S186-202
    • Polderman, K.H.1
  • 39
    • 33749637502 scopus 로고    scopus 로고
    • Acidotoxicity trumps excitotoxicity in ischemic brain
    • Simon RP. Acidotoxicity trumps excitotoxicity in ischemic brain. Arch Neurol. 2006;63(10):1368-71. doi:10.1001/archneur.63.10.1368.
    • (2006) Arch Neurol , vol.63 , Issue.10 , pp. 1368-1371
    • Simon, R.P.1
  • 40
    • 0346787871 scopus 로고    scopus 로고
    • Neuroprotection in cerebral ischaemia: facts and fancies-the need for new approaches
    • Wahlgren NG, Ahmed N. Neuroprotection in cerebral ischaemia: facts and fancies-the need for new approaches. Cerebrovasc Dis. 2004;17 Suppl 1: 153-66. doi:10.1159/000074808.
    • (2004) Cerebrovasc Dis , vol.17 , pp. 153-166
    • Wahlgren, N.G.1    Ahmed, N.2
  • 41
    • 0036089438 scopus 로고    scopus 로고
    • Cerebral ischemia and trauma-different etiologies yet similar mechanisms: neuroprotective opportunities
    • Leker RR, Shohami E. Cerebral ischemia and trauma-different etiologies yet similar mechanisms: neuroprotective opportunities. Brain Res Brain Res Rev. 2002;39(1):55-73.
    • (2002) Brain Res Brain Res Rev , vol.39 , Issue.1 , pp. 55-73
    • Leker, R.R.1    Shohami, E.2
  • 42
    • 67649800742 scopus 로고    scopus 로고
    • NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation
    • Brennan AM, Suh SW, Won SJ, Narasimhan P, Kauppinen TM, Lee H, et al. NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation. Nat Neurosci. 2009;12(7):857-63. doi:10.1038/ nn.2334.
    • (2009) Nat Neurosci , vol.12 , Issue.7 , pp. 857-863
    • Brennan, A.M.1    Suh, S.W.2    Won, S.J.3    Narasimhan, P.4    Kauppinen, T.M.5    Lee, H.6
  • 43
    • 0033782260 scopus 로고    scopus 로고
    • Caspase pathways, neuronal apoptosis, and CNS injury
    • Eldadah BA, Faden AI. Caspase pathways, neuronal apoptosis, and CNS injury. J Neurotrauma. 2000;17(10):811-29.
    • (2000) J Neurotrauma , vol.17 , Issue.10 , pp. 811-829
    • Eldadah, B.A.1    Faden, A.I.2
  • 46
    • 0027461348 scopus 로고
    • Direct detection of endogenous hydroxyl radical production in cultured adult cardiomyocytes during anoxia and reoxygenation
    • Khalid MA, Ashraf M. Direct detection of endogenous hydroxyl radical production in cultured adult cardiomyocytes during anoxia and reoxygenation. Is the hydroxyl radical really the most damaging radical species? Circ Res. 1993;72(4):725-36.
    • (1993) Is the hydroxyl radical really the most damaging radical species? Circ Res , vol.72 , Issue.4 , pp. 725-736
    • Khalid, M.A.1    Ashraf, M.2
  • 47
    • 0028068186 scopus 로고
    • Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? Lancet
    • Halliwell B. Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? Lancet. 1994;344(8924):721-4.
    • (1994) , vol.344 , Issue.8924 , pp. 721-724
    • Halliwell, B.1
  • 48
    • 0142139346 scopus 로고    scopus 로고
    • Reactive oxygen radicals and pathogenesis of neuronal death after cerebral ischemia
    • Sugawara T, Chan PH. Reactive oxygen radicals and pathogenesis of neuronal death after cerebral ischemia. Antioxid Redox Signal. 2003;5(5): 597-607. doi:10.1089/152308603770310266.
    • (2003) Antioxid Redox Signal , vol.5 , Issue.5 , pp. 597-607
    • Sugawara, T.1    Chan, P.H.2
  • 49
    • 39049169272 scopus 로고    scopus 로고
    • Modulation of neuro-inflammation and vascular response by oxidative stress following cerebral ischemia-reperfusion injury
    • Wong CH, Crack PJ. Modulation of neuro-inflammation and vascular response by oxidative stress following cerebral ischemia-reperfusion injury. Curr Med Chem. 2008;15(1):1-14.
    • (2008) Curr Med Chem , vol.15 , Issue.1 , pp. 1-14
    • Wong, C.H.1    Crack, P.J.2
  • 50
    • 36048973296 scopus 로고    scopus 로고
    • Ischemia-reperfusion and immediate T cell responses
    • Huang Y, Rabb H, Womer KL. Ischemia-reperfusion and immediate T cell responses. Cell Immunol. 2007;248(1):4-11. doi:10.1016/j.cellimm.2007.03.009.
    • (2007) Cell Immunol , vol.248 , Issue.1 , pp. 4-11
    • Huang, Y.1    Rabb, H.2    Womer, K.L.3
  • 51
    • 77954201785 scopus 로고    scopus 로고
    • Reperfusion and neurovascular dysfunction in stroke: from basic mechanisms to potential strategies for neuroprotection
    • Jung JE, Kim GS, Chen H, Maier CM, Narasimhan P, Song YS, et al. Reperfusion and neurovascular dysfunction in stroke: from basic mechanisms to potential strategies for neuroprotection. Mol Neurobiol. 2010;41(2-3):172-9. doi:10.1007/s12035-010-8102-z.
    • (2010) Mol Neurobiol , vol.41 , Issue.2-3 , pp. 172-179
    • Jung, J.E.1    Kim, G.S.2    Chen, H.3    Maier, C.M.4    Narasimhan, P.5    Song, Y.S.6
  • 52
    • 79851515594 scopus 로고    scopus 로고
    • Roles of inflammation response in microglia cell through Toll-like receptors 2/interleukin-23/ interleukin-17 pathway in cerebral ischemia/reperfusion injury
    • Lv M, Liu Y, Zhang J, Sun L, Liu Z, Zhang S, et al. Roles of inflammation response in microglia cell through Toll-like receptors 2/interleukin-23/ interleukin-17 pathway in cerebral ischemia/reperfusion injury. Neuroscience. 2011;176:162-72. doi:10.1016/j.neuroscience.2010.11.066.
    • (2011) Neuroscience , vol.176 , pp. 162-172
    • Lv, M.1    Liu, Y.2    Zhang, J.3    Sun, L.4    Liu, Z.5    Zhang, S.6
  • 53
    • 77952630826 scopus 로고    scopus 로고
    • Therapeutic hypothermia cardioprotection via Akt- and nitric oxide-mediated attenuation of mitochondrial oxidants
    • Shao ZH, Sharp WW, Wojcik KR, Li CQ, Han M, Chang WT, et al. Therapeutic hypothermia cardioprotection via Akt- and nitric oxide-mediated attenuation of mitochondrial oxidants. Am J Physiol Heart Circ Physiol. 2010; 298(6):H2164-73. doi:10.1152/ajpheart.00994.2009.
    • (2010) Am J Physiol Heart Circ Physiol , vol.298 , Issue.6 , pp. H2164-H2173
    • Shao, Z.H.1    Sharp, W.W.2    Wojcik, K.R.3    Li, C.Q.4    Han, M.5    Chang, W.T.6
  • 54
    • 67849108129 scopus 로고    scopus 로고
    • Hypothermia attenuates ischemia/ reperfusion-induced endothelial cell apoptosis via alterations in apoptotic pathways and JNK signaling
    • Yang D, Guo S, Zhang T, Li H. Hypothermia attenuates ischemia/ reperfusion-induced endothelial cell apoptosis via alterations in apoptotic pathways and JNK signaling. FEBS Lett. 2009;583(15):2500-6. doi:10.1016/j. febslet.2009.07.006.
    • (2009) FEBS Lett , vol.583 , Issue.15 , pp. 2500-2506
    • Yang, D.1    Guo, S.2    Zhang, T.3    Li, H.4
  • 55
    • 0038029401 scopus 로고    scopus 로고
    • Effects of hypothermia on energy metabolism in Mammalian central nervous system
    • Erecinska M, Thoresen M, Silver IA. Effects of hypothermia on energy metabolism in Mammalian central nervous system. J Cereb Blood Flow Metab. 2003;23(5):513-30. doi:10.1097/01.WCB.0000066287.21705.21.
    • (2003) J Cereb Blood Flow Metab , vol.23 , Issue.5 , pp. 513-530
    • Erecinska, M.1    Thoresen, M.2    Silver, I.A.3
  • 56
    • 0034071863 scopus 로고    scopus 로고
    • Cerebral hypothermia for prevention of brain injury following perinatal asphyxia
    • Gunn AJ. Cerebral hypothermia for prevention of brain injury following perinatal asphyxia. Curr Opin Pediatr. 2000;12(2):111-5.
    • (2000) Curr Opin Pediatr , vol.12 , Issue.2 , pp. 111-115
    • Gunn, A.J.1
  • 57
    • 0034432834 scopus 로고    scopus 로고
    • Effect of long-term mild hypothermia therapy in patients with severe traumatic brain injury: 1-year follow-up review of 87 cases
    • Jiang J, Yu M, Zhu C. Effect of long-term mild hypothermia therapy in patients with severe traumatic brain injury: 1-year follow-up review of 87 cases. J Neurosurg. 2000;93(4):546-9. doi:10.3171/jns.2000.93.4.0546.
    • (2000) J Neurosurg , vol.93 , Issue.4 , pp. 546-549
    • Jiang, J.1    Yu, M.2    Zhu, C.3
  • 58
    • 0031756859 scopus 로고    scopus 로고
    • Moderate hypothermia in the treatment of patients with severe middle cerebral artery infarction
    • Schwab S, Schwarz S, Spranger M, Keller E, Bertram M, Hacke W. Moderate hypothermia in the treatment of patients with severe middle cerebral artery infarction. Stroke. 1998;29(12):2461-6.
    • (1998) Stroke , vol.29 , Issue.12 , pp. 2461-2466
    • Schwab, S.1    Schwarz, S.2    Spranger, M.3    Keller, E.4    Bertram, M.5    Hacke, W.6
  • 59
    • 0041866144 scopus 로고    scopus 로고
    • Induced hypothermia in critical care medicine: a review
    • Bernard SA, Buist M. Induced hypothermia in critical care medicine: a review. Crit Care Med. 2003;31(7):2041-51. doi:10.1097/01.CCM.0000069731.18472.61.
    • (2003) Crit Care Med , vol.31 , Issue.7 , pp. 2041-2051
    • Bernard, S.A.1    Buist, M.2
  • 61
    • 77749343694 scopus 로고    scopus 로고
    • Persisting mild hypothermia suppresses hypoxia-inducible factor-1alpha protein synthesis and hypoxia-inducible factor-1-mediated gene expression
    • Tanaka T, Wakamatsu T, Daijo H, Oda S, Kai S, Adachi T, et al. Persisting mild hypothermia suppresses hypoxia-inducible factor-1alpha protein synthesis and hypoxia-inducible factor-1-mediated gene expression. Am J Physiol Regul Integr Comp Physiol. 2010;298(3):R661-71. doi:10.1152/ajpregu.00732.2009.
    • (2010) Am J Physiol Regul Integr Comp Physiol , vol.298 , Issue.3 , pp. R661-R671
    • Tanaka, T.1    Wakamatsu, T.2    Daijo, H.3    Oda, S.4    Kai, S.5    Adachi, T.6
  • 62
    • 84919359432 scopus 로고    scopus 로고
    • Rationale, methodology, and implementation of a nationwide multicenter randomized controlled trial of long-term mild hypothermia for severe traumatic brain injury (the LTH-1 trial)
    • Lei J, Gao G, Mao Q, Feng J, Wang L, You W, et al. Rationale, methodology, and implementation of a nationwide multicenter randomized controlled trial of long-term mild hypothermia for severe traumatic brain injury (the LTH-1 trial). Contemp Clin Trials. 2015;40:9-14. doi:10.1016/j.cct.2014.11.008.
    • (2015) Contemp Clin Trials , vol.40 , pp. 9-14
    • Lei, J.1    Gao, G.2    Mao, Q.3    Feng, J.4    Wang, L.5    You, W.6
  • 63
    • 0035169495 scopus 로고    scopus 로고
    • Posttraumatic hypothermia is neuroprotective in a model of traumatic brain injury complicated by a secondary hypoxic insult
    • Matsushita Y, Bramlett HM, Alonso O, Dietrich WD. Posttraumatic hypothermia is neuroprotective in a model of traumatic brain injury complicated by a secondary hypoxic insult. Crit Care Med. 2001;29(11):2060-6.
    • (2001) Crit Care Med , vol.29 , Issue.11 , pp. 2060-2066
    • Matsushita, Y.1    Bramlett, H.M.2    Alonso, O.3    Dietrich, W.D.4
  • 64
    • 0038745703 scopus 로고    scopus 로고
    • Posttraumatic hypothermia followed by slow rewarming protects the cerebral microcirculation
    • Suehiro E, Ueda Y, Wei EP, Kontos HA, Povlishock JT. Posttraumatic hypothermia followed by slow rewarming protects the cerebral microcirculation. J Neurotrauma. 2003;20(4):381-90. doi:10.1089/089771503765172336.
    • (2003) J Neurotrauma , vol.20 , Issue.4 , pp. 381-390
    • Suehiro, E.1    Ueda, Y.2    Wei, E.P.3    Kontos, H.A.4    Povlishock, J.T.5
  • 65
    • 62649144659 scopus 로고    scopus 로고
    • Management of pitfalls for the successful clinical use of hypothermia treatment
    • Hayashi N. Management of pitfalls for the successful clinical use of hypothermia treatment. J Neurotrauma. 2009;26(3):445-53. doi:10.1089/ neu.2008.0648.
    • (2009) J Neurotrauma , vol.26 , Issue.3 , pp. 445-453
    • Hayashi, N.1
  • 66
    • 62649166942 scopus 로고    scopus 로고
    • Posthypothermic rewarming considerations following traumatic brain injury
    • Povlishock JT, Wei EP. Posthypothermic rewarming considerations following traumatic brain injury. J Neurotrauma. 2009;26(3):333-40. doi:10.1089/neu. 2008.0604.
    • (2009) J Neurotrauma , vol.26 , Issue.3 , pp. 333-340
    • Povlishock, J.T.1    Wei, E.P.2
  • 68
    • 0027018082 scopus 로고
    • Use of moderate hypothermia during elective craniotomy
    • Clifton GL, Christensen ML. Use of moderate hypothermia during elective craniotomy. Tex Med. 1992;88(12):66-9.
    • (1992) Tex Med , vol.88 , Issue.12 , pp. 66-69
    • Clifton, G.L.1    Christensen, M.L.2
  • 69
    • 0032929640 scopus 로고    scopus 로고
    • Mild hypothermia as a protective therapy during intracranial aneurysm surgery: a randomized prospective pilot trial
    • discussion -3
    • Hindman BJ, Todd MM, Gelb AW, Loftus CM, Craen RA, Schubert A, et al. Mild hypothermia as a protective therapy during intracranial aneurysm surgery: a randomized prospective pilot trial. Neurosurgery. 1999;44(1):23-32. discussion -3.
    • (1999) Neurosurgery , vol.44 , Issue.1 , pp. 23-32
    • Hindman, B.J.1    Todd, M.M.2    Gelb, A.W.3    Loftus, C.M.4    Craen, R.A.5    Schubert, A.6
  • 70
    • 0033819195 scopus 로고    scopus 로고
    • Systemic and cerebral haemodynamics during craniotomy under mild hypothermia in patients with acute subarachnoid haemorrhage
    • discussion 9-20
    • Sato K, Yoshimoto T. Systemic and cerebral haemodynamics during craniotomy under mild hypothermia in patients with acute subarachnoid haemorrhage. Acta Neurochir (Wien). 2000;142(9):1013-9. discussion 9-20.
    • (2000) Acta Neurochir (Wien) , vol.142 , Issue.9 , pp. 1013-1019
    • Sato, K.1    Yoshimoto, T.2
  • 71
    • 3542993231 scopus 로고    scopus 로고
    • Comparison of endovascular and surface cooling during unruptured cerebral aneurysm repair
    • discussion 14-5
    • Steinberg GK, Ogilvy CS, Shuer LM, Connolly Jr ES, Solomon RA, Lam A, et al. Comparison of endovascular and surface cooling during unruptured cerebral aneurysm repair. Neurosurgery. 2004;55(2):307-14. discussion 14-5.
    • (2004) Neurosurgery , vol.55 , Issue.2 , pp. 307-314
    • Steinberg, G.K.1    Ogilvy, C.S.2    Shuer, L.M.3    Connolly, E.S.4    Solomon, R.A.5    Lam, A.6
  • 72
    • 11844268070 scopus 로고    scopus 로고
    • Mild intraoperative hypothermia during surgery for intracranial aneurysm
    • Todd MM, Hindman BJ, Clarke WR, Torner JC. Mild intraoperative hypothermia during surgery for intracranial aneurysm. N Engl J Med. 2005; 352(2):135-45. doi:10.1056/NEJMoa040975.
    • (2005) N Engl J Med , vol.352 , Issue.2 , pp. 135-145
    • Todd, M.M.1    Hindman, B.J.2    Clarke, W.R.3    Torner, J.C.4
  • 73
    • 74049151086 scopus 로고    scopus 로고
    • No association between intraoperative hypothermia or supplemental protective drug and neurologic outcomes in patients undergoing temporary clipping during cerebral aneurysm surgery: findings from the Intraoperative Hypothermia for Aneurysm Surgery Trial
    • Hindman BJ, Bayman EO, Pfisterer WK, Torner JC, Todd MM. No association between intraoperative hypothermia or supplemental protective drug and neurologic outcomes in patients undergoing temporary clipping during cerebral aneurysm surgery: findings from the Intraoperative Hypothermia for Aneurysm Surgery Trial. Anesthesiology. 2010;112(1):86-101. doi:10.1097/ ALN.0b013e3181c5e28f.
    • (2010) Anesthesiology , vol.112 , Issue.1 , pp. 86-101
    • Hindman, B.J.1    Bayman, E.O.2    Pfisterer, W.K.3    Torner, J.C.4    Todd, M.M.5
  • 74
    • 79954608067 scopus 로고    scopus 로고
    • Hypothermia in patients with brain injury: the way forward? Lancet Neurol
    • author reply 6-7.
    • Honeybul S, Ho K, Lind C, Gillett G. Hypothermia in patients with brain injury: the way forward? Lancet Neurol. 2011;10(5):405-6. doi:10.1016/S1474- 4422(11)70086-2. author reply 6-7.
    • (2011) , vol.10 , Issue.5 , pp. 405-406
    • Honeybul, S.1    Ho, K.2    Lind, C.3    Gillett, G.4
  • 75
    • 79954583645 scopus 로고    scopus 로고
    • Hypothermia in patients with brain injury: the way forward?
    • author reply 6-7.
    • Nichol AD, Trapani T, Murray L, Vallance S, Cooper DJ. Hypothermia in patients with brain injury: the way forward? Lancet Neurol. 2011;10(5):405. doi:10.1016/S1474-4422(11)70085-0. author reply 6-7.
    • (2011) Lancet Neurol , vol.10 , Issue.5 , pp. 405
    • Nichol, A.D.1    Trapani, T.2    Murray, L.3    Vallance, S.4    Cooper, D.J.5
  • 76
    • 79954583645 scopus 로고    scopus 로고
    • Hypothermia in patients with brain injury: the way forward? Lancet Neurol
    • author reply 6-7.
    • Polderman KH, Andrews PJ. Hypothermia in patients with brain injury: the way forward? Lancet Neurol. 2011;10(5):404-5. doi:10.1016/S1474- 4422(11)70084-9. author reply 6-7.
    • (2011) , vol.10 , Issue.5 , pp. 404-405
    • Polderman, K.H.1    Andrews, P.J.2
  • 77
    • 79954583645 scopus 로고    scopus 로고
    • Hypothermia in patients with brain injury: the way forward? Lancet Neurol
    • author reply 6-7.
    • Takeuchi S, Nawashiro H, Otani N. Hypothermia in patients with brain injury: the way forward? Lancet Neurol. 2011;10(5):404. doi:10.1016/S1474- 4422(11)70083-7. author reply 6-7.
    • (2011) , vol.10 , Issue.5 , pp. 404
    • Takeuchi, S.1    Nawashiro, H.2    Otani, N.3
  • 78
    • 70349306274 scopus 로고    scopus 로고
    • Induced normothermia attenuates intracranial hypertension and reduces fever burden after severe traumatic brain injury
    • Puccio AM, Fischer MR, Jankowitz BT, Yonas H, Darby JM, Okonkwo DO. Induced normothermia attenuates intracranial hypertension and reduces fever burden after severe traumatic brain injury. Neurocrit Care. 2009;11(1): 82-7. doi:10.1007/s12028-009-9213-0.
    • (2009) Neurocrit Care , vol.11 , Issue.1 , pp. 82-87
    • Puccio, A.M.1    Fischer, M.R.2    Jankowitz, B.T.3    Yonas, H.4    Darby, J.M.5    Okonkwo, D.O.6
  • 79
    • 84891610372 scopus 로고    scopus 로고
    • Survey of brain temperature management in patients with traumatic brain injury in the Japan neurotrauma data bank
    • Suehiro E, Koizumi H, Kunitsugu I, Fujisawa H, Suzuki M. Survey of brain temperature management in patients with traumatic brain injury in the Japan neurotrauma data bank. J Neurotrauma. 2014;31(4):315-20. doi:10. 1089/neu.2013.3057.
    • (2014) J Neurotrauma , vol.31 , Issue.4 , pp. 315-320
    • Suehiro, E.1    Koizumi, H.2    Kunitsugu, I.3    Fujisawa, H.4    Suzuki, M.5
  • 80
    • 84898747300 scopus 로고    scopus 로고
    • Fever burden is an independent predictor for prognosis of traumatic brain injury
    • Bao L, Chen D, Ding L, Ling W, Xu F. Fever burden is an independent predictor for prognosis of traumatic brain injury. PLoS One. 2014;9(3): e90956. doi:10.1371/journal.pone.0090956.
    • (2014) PLoS One , vol.9 , Issue.3 , pp. e90956
    • Bao, L.1    Chen, D.2    Ding, L.3    Ling, W.4    Xu, F.5
  • 81
    • 0033865575 scopus 로고    scopus 로고
    • Early hyperthermia after traumatic brain injury in children: risk factors, influence on length of stay, and effect on short-term neurologic status
    • Natale JE, Joseph JG, Helfaer MA, Shaffner DH. Early hyperthermia after traumatic brain injury in children: risk factors, influence on length of stay, and effect on short-term neurologic status. Crit Care Med. 2000;28(7):2608-15.
    • (2000) Crit Care Med , vol.28 , Issue.7 , pp. 2608-2615
    • Natale, J.E.1    Joseph, J.G.2    Helfaer, M.A.3    Shaffner, D.H.4
  • 83
    • 1242342683 scopus 로고    scopus 로고
    • Treatment of fever in the neurologic intensive care unit with a catheter-based heat exchange system
    • Diringer MN. Treatment of fever in the neurologic intensive care unit with a catheter-based heat exchange system. Crit Care Med. 2004;32(2):559-64. doi: 10.1097/01.CCM.0000108868.97433.3F.
    • (2004) Crit Care Med , vol.32 , Issue.2 , pp. 559-564
    • Diringer, M.N.1
  • 84
    • 84868364472 scopus 로고    scopus 로고
    • Increased mortality in patients with severe traumatic brain injury treated without intracranial pressure monitoring
    • Farahvar A, Gerber LM, Chiu YL, Carney N, Hartl R, Ghajar J. Increased mortality in patients with severe traumatic brain injury treated without intracranial pressure monitoring. J Neurosurg. 2012;117(4):729-34. doi:10. 3171/2012.7.JNS111816.
    • (2012) J Neurosurg , vol.117 , Issue.4 , pp. 729-734
    • Farahvar, A.1    Gerber, L.M.2    Chiu, Y.L.3    Carney, N.4    Hartl, R.5    Ghajar, J.6
  • 85
    • 34547744958 scopus 로고    scopus 로고
    • Guidelines for the management of severe traumatic brain injury. VIII. Intracranial pressure thresholds
    • Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, et al. Guidelines for the management of severe traumatic brain injury. VIII. Intracranial pressure thresholds. J Neurotrauma. 2007;24 Suppl 1:S55-8. doi: 10.1089/neu.2007.9988.
    • (2007) J Neurotrauma , vol.24 , pp. S55-S58
    • Bratton, S.L.1    Chestnut, R.M.2    Ghajar, J.3    McConnell Hammond, F.F.4    Harris, O.A.5    Hartl, R..6
  • 86
    • 84884569918 scopus 로고    scopus 로고
    • Traumatic cerebrovascular injury following severe head injury: proper diagnostic timetable and examination methods
    • Onda H, Fuse A, Yamaguchi M, Igarashi Y, Watanabe A, Suzuki G, et al. Traumatic cerebrovascular injury following severe head injury: proper diagnostic timetable and examination methods. Neurol Med Chir (Tokyo). 2013;53(9):573-9.
    • (2013) Neurol Med Chir (Tokyo) , vol.53 , Issue.9 , pp. 573-579
    • Onda, H.1    Fuse, A.2    Yamaguchi, M.3    Igarashi, Y.4    Watanabe, A.5    Suzuki, G.6
  • 87
    • 67649194940 scopus 로고    scopus 로고
    • Effect of 35 degrees C hypothermia on intracranial pressure and clinical outcome in patients with severe traumatic brain injury
    • Tokutomi T, Miyagi T, Takeuchi Y, Karukaya T, Katsuki H, Shigemori M. Effect of 35 degrees C hypothermia on intracranial pressure and clinical outcome in patients with severe traumatic brain injury. J Trauma. 2009;66(1):166-73. doi:10.1097/TA.0b013e318157dbec.
    • (2009) J Trauma , vol.66 , Issue.1 , pp. 166-173
    • Tokutomi, T.1    Miyagi, T.2    Takeuchi, Y.3    Karukaya, T.4    Katsuki, H.5    Shigemori, M.6
  • 88
    • 0037236483 scopus 로고    scopus 로고
    • Optimal temperature for the management of severe traumatic brain injury: effect of hypothermia on intracranial pressure, systemic and intracranial hemodynamics, and metabolism
    • discussion 11-2
    • Tokutomi T, Morimoto K, Miyagi T, Yamaguchi S, Ishikawa K, Shigemori M. Optimal temperature for the management of severe traumatic brain injury: effect of hypothermia on intracranial pressure, systemic and intracranial hemodynamics, and metabolism. Neurosurgery. 2003;52(1):102-11. discussion 11-2.
    • (2003) Neurosurgery , vol.52 , Issue.1 , pp. 102-111
    • Tokutomi, T.1    Morimoto, K.2    Miyagi, T.3    Yamaguchi, S.4    Ishikawa, K.5    Shigemori, M.6
  • 89
    • 84883286620 scopus 로고    scopus 로고
    • Study of therapeutic hypothermia (32 to 35°C) for intracranial pressure reduction after traumatic brain injury (the Eurotherm3235Trial): outcome of the pilot phase of the trial
    • Andrews PJ, Sinclair LH, Harris B, Baldwin MJ, Battison CG, Rhodes JK, et al. Study of therapeutic hypothermia (32 to 35°C) for intracranial pressure reduction after traumatic brain injury (the Eurotherm3235Trial): outcome of the pilot phase of the trial. Trials. 2013;14:277. doi:10.1186/1745-6215-14-277.
    • (2013) Trials , vol.14 , pp. 277
    • Andrews, P.J.1    Sinclair, L.H.2    Harris, B.3    Baldwin, M.J.4    Battison, C.G.5    Rhodes, J.K.6
  • 90
    • 84943367199 scopus 로고    scopus 로고
    • Therapeutic hypothermia reduces intracranial pressure and partial brain oxygen tension in patients with severe traumatic brain injury: preliminary data from the Eurotherm3235 Trial
    • Flynn LM, Rhodes J, Andrews PJ. Therapeutic hypothermia reduces intracranial pressure and partial brain oxygen tension in patients with severe traumatic brain injury: preliminary data from the Eurotherm3235 Trial. Ther Hypothermia Temp Manag. 2015. doi:10.1089/ther.2015.0002.
    • (2015) Ther Hypothermia Temp Manag
    • Flynn, L.M.1    Rhodes, J.2    Andrews, P.J.3


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