Therapeutic Hypothermia Reduces Intracranial Pressure and Partial Brain Oxygen Tension in Patients with Severe Traumatic Brain Injury: Preliminary Data from the Eurotherm3235 Trial

Therapeutic Hypothermia and Temperature Management

Volumn 5, Issue 3, 2015, Pages 143-151

  Flynn, Liam M C ^a   Rhodes, Jonathan ^b   Andrews, Peter J D ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CLONIDINE; PARACETAMOL; PHENYTOIN;

ADULT; ARTICLE; BRAIN OXYGEN TENSION; CLINICAL ARTICLE; COMPUTER PROGRAM; CONTROLLED STUDY; COOLING; CORE TEMPERATURE; FEMALE; FEVER; HOSPITAL ADMISSION; HUMAN; HYPOTHERMIA; INDUCED HYPOTHERMIA; INTRACRANIAL HYPERTENSION; INTRACRANIAL PRESSURE MONITORING DEVICE; MAINTENANCE DRUG DOSE; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECTAL THERMOMETER; RETROSPECTIVE STUDY; SEIZURE; STANDARD; TIME; TRAUMATIC BRAIN INJURY; ADVERSE EFFECTS; BRAIN INJURIES; HYPOXIA-ISCHEMIA, BRAIN; INJURY SCALE; INTRACRANIAL PRESSURE; METABOLISM; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; PROCEDURES; TREATMENT OUTCOME;

ADULT; BRAIN INJURIES; FEMALE; HUMANS; HYPOTHERMIA, INDUCED; HYPOXIA-ISCHEMIA, BRAIN; INTRACRANIAL HYPERTENSION; INTRACRANIAL PRESSURE; MALE; OXYGEN CONSUMPTION; TRAUMA SEVERITY INDICES; TREATMENT OUTCOME;

EID: 84943367199     PISSN: 21537658     EISSN: 21537933     Source Type: Journal    
DOI: 10.1089/ther.2015.0002     Document Type: Article

References (65)

1. Andrews, P. Eurotherm3235 Trial PROTOCOL Version 8. 2014.
2. Available at www.eurotherm3235trial.eu/Data/upload/Files/ Eurotherm%20Protocol%20v8%209%205%2012%20FINAL .pdf, 2012, accessed April 4, 2015.
3. Andrews P, Gupta AK. Effect of hypothermia on brain tissue oxygenation in patients with severe head injury. Br J Anaesth 2003;90:251-252.
4. Andrews PJ, Sinclair HL, Battison CG, Polderman KH, Citerio G, Mascia L, Harris BA, Murray GD, Stocchetti N, Menon DK, Shakur H, De Backer D; EurothermTrial Collaborators. European society of intensive care medicine study of therapeutic hypothermia (32-35C) for intracranial pressure reduction after traumatic brain injury (the Eurotherm3235Trial). Trials 2011;12:8.
5. Arrich J, Holzer M, Herkner H, Mullner M. Hypothermia for neuroprotection in adults after cardiopulmonary resuscitation. Cochrane Database Syst Rev 2009;4:CD004128.
6. Berger S, Schurer L, Hartl R, Messmer K, Baethmann A. Reduction of post-traumatic intracranial hypertension by hypertonic/ hyperoncotic saline/dextran and hypertonic mannitol. Neurosurgery 1995;37:98-107; discussion 107-108.
7. Brain Trauma Foundation, American Association of Neurological S, Congress of Neurological S. Guidelines for the management of severe traumatic brain injury. J Neurotrauma 2007;24 (Suppl 1):S1-S106.
8. Chang JJ, Youn TS, Benson D, Mattick H, Andrade N, Harper CR, Moore CB, Madden CJ, Diaz-Arrastia RR. Physiologic and functional outcome correlates of brain tissue hypoxia in traumatic brain injury. Crit Care Med 2009;37:283-290.
9. Chesnut RM. Secondary brain insults after head injury: clinical perspectives. New Horiz 1995;3:366-375.
10. Chesnut RM, Marshall LF, Klauber MR, Blunt BA, Baldwin N, Eisenberg HM, Jane JA, Marmarou A, Foulkes MA. The role of secondary brain injury in determining outcome from severe head injury. J Trauma 1993;34:216-222.
11. Clifton GL, Miller ER, Choi SC, Levin HS, McCauley S, Smith KR, Jr., Muizelaar JP, Wagner FC, Jr., Marion DW, Luerssen TG, et al. Lack of effect of induction of hypothermia after acute brain injury. N Engl J Med 2001;344:556-563.
12. Clifton GL, Valadka A, Zygun D, Coffey CS, Drever P, Fourwinds S, Janis LS, Wilde E, Taylor P, Harshman K, Conley A, Puccio A, Levin HS, McCauley SR, Bucholz RD, Smith KR, Schmidt JH, Scott JN, Yonas H, Okonkwo DO. Very early hypothermia induction in patients with severe brain injury (the National Acute Brain Injury Study: Hypothermia II): A randomised trial. Lancet Neurol 2011;10:131-139.
13. Corrigan JD, Selassie AW, Orman JA. The epidemiology of traumatic brain injury. J Head Trauma Rehabil 2010;25: 72-80.
14. Corso P, Finkelstein E, Miller T, Fiebelkorn I, Zaloshnja E. Incidence and lifetime costs of injuries in the United States. Inj Prev 2006;12:212-218.
15. Crossley S, Reid J, McLatchie R, Hayton J, Clark C, Mac-Dougall M, Andrews P. A systematic review of therapeutic hypothermia for adult patients following traumatic brain injury. Crit Care 2014:18:R75.
16. De Georgia MA. Brain tissue oxygen monitoring in neurocritical care. J Intensive Care Med 2014. DOI: 10.1177/ 0885066614529254.
17. Dings J, Meixensberger J, Jager A, Roosen K. Clinical experience with 118 brain tissue oxygen partial pressure catheter probes. Neurosurgery 1998;43:1082-1095.
18. Freshman SP, Battistella FD, Matteucci M, Wisner DH. Hypertonic saline (7.5%) versus mannitol: A comparison for treatment of acute head injuries. J Trauma 1993;35:344-348.
19. Gal R, Cundrle I, Zimova I, Smrcka M. Mild hypothermia therapy for patients with severe brain injury. Clin Neurol Neurosurg 2002;104:318-321.
20. Geukens P, Oddo M. Brain tissue oxygen monitoring in neurocritical care. In: Annual Update in Intensive Care and Emergency Medicine 2012. Vol. 2012, Vincent J-L (ed). Berlin: Springer Berlin Heidelberg, 2012, pp. 735-745.
21. Gupta AK, Al-Rawi PG, Hutchinson PJ, Kirkpatrick PJ. Effect of hypothermia on brain tissue oxygenation in patients with severe head injury. Br J Anaesth 2002;88:188-192.
22. Hoffman WE, Charbel FT, Edelman G. Brain tissue oxygen, carbon dioxide, and pH in neurosurgical patients at risk for ischemia. Anesth Analg 1996;82:582-586.
23. Hutchinson PJ, Kolias AG, Czosnyka M, Kirkpatrick PJ, Pickard JD, Menon DK. Intracranial pressure monitoring in severe traumatic brain injury. BMJ 2013;346:f1000.
24. Hyder AA, Wunderlich CA, Puvanachandra P, Gururaj G, Kobusingye OC. The impact of traumatic brain injuries: A global perspective. NeuroRehabilitation 2007;22:341-353.
25. Jaeger M, Dengl M, Meixensberger J, Schuhmann MU. Effects of cerebrovascular pressure reactivity-guided optimization of cerebral perfusion pressure on brain tissue oxygenation after traumatic brain injury. Crit Care Med 2010;38:1343-1347.
26. Jaeger M, Schuhmann MU, Soehle M, Meixensberger J. Continuous assessment of cerebrovascular autoregulation after traumatic brain injury using brain tissue oxygen pressure reactivity. Crit Care Med 2006;34:1783-1788.
27. Jaeger M, Schuhmann MU, Soehle M, Nagel C, Meixensberger J. Continuous monitoring of cerebrovascular autoregulation after subarachnoid hemorrhage by brain tissue oxygen pressure reactivity and its relation to delayed cerebral infarction. Stroke 2007;38:981-986.
28. James HE. Methodology for the control of intracranial pressure with hypertonic mannitol. Acta Neurochir (Wien) 1980;51: 161-172.
29. James HE, Langfitt TW, Kumar VS, Ghostine SY. Treatment of intracranial hypertension. Analysis of 105 consecutive, continuous recordings of intracranial pressure. Acta Neurochir (Wien) 1977;36:189-200.
30. Jiang J, Yu M, Zhu C. Effect of long-term mild hypothermia therapy in patients with severe traumatic brain injury: 1-year follow-up review of 87 cases. J Neurosurg 2000;93:546-549.
31. Keller E, Steiner T, Fandino J, Schwab S, Hacke W. Changes in cerebral blood flow and oxygen metabolism during moderate hypothermia in patients with severe middle cerebral artery infarction. Neurosurg Focus 2000;8:e4.
32. Langlois JA, Rutland-Brown W, Wald MM. The epidemiology and impact of traumatic brain injury: A brief overview. J Head Trauma Rehabil 2006;21:375-378.
33. Lavinio A, Timofeev I, Nortje J, Outtrim J, Smielewski P, Gupta A, Hutchinson PJ, Matta BF, Pickard JD, Menon D, et al. Cerebrovascular reactivity during hypothermia and rewarming. Br J Anaesth 2007;99:237.
34. Le Roux P, Menon DK, Citerio G, Vespa P, Bader MK, Brophy GM, Diringer MN, Stocchetti N, Videtta W, Armonda R, et al. Consensus summary statement of the International Multidisciplinary Consensus Conference on Multimodality Monitoring in Neurocritical Care: A statement for healthcare professionals from the Neurocritical Care Society and the European Society of Intensive Care Medicine. Intensive Care Med 2014;40:1189-1209.
35. Liu WG, Qiu WS, Zhang Y, Wang WM, Lu F, Yang XF. Effects of selective brain cooling in patients with severe traumatic brain injury: A preliminary study. J IntMed Res 2006;34:58-64.
36. Longhi L, Pagan F, Valeriani V, Magnoni S, Zanier ER, Conte V, Stocchetti N. Monitoring brain tissue oxygen tension in brain-injured patients reveals hypoxic episodes in normalappearing and in peri-focal tissue. Intensive Care Med 2007;33:2136-2142.
37. Marion DW, Obrist WD, Carlier PM, Penrod LE, Darby JM. The use of moderate therapeutic hypothermia for patients with severe head injuries: A preliminary report. J Neurosurg 1993;79:354-362.
38. Marion DW, Penrod LE, Kelsey SF, Obrist WD, Kochanek PM, Palmer AM, Wisniewski SR, DeKosky ST. Treatment of traumatic brain injury with moderate hypothermia. N Engl J Med 1997;336:540-546.
39. McGraw CP, Alexander E, Jr., Howard G. Effect of dose and dose schedule on the response of intracranial pressure to mannitol. Surg Neurol 1978;10:127-130.
40. Metz C, Holzschuh M, Bein T, Woertgen C, Frey A, Frey I, Taeger K, Brawanski A. Moderate hypothermia in patients with severe head injury: cerebral and extracerebral effects. J Neurosurg 1996;85:533-541.
41. NICE. Therapeutic Hypothermia with Intracorporeal Temperature Monitoring for Hypoxic Perinatal Brain Injury. Available at www.nice.org.uk/guidance/ipg347/resources/guidancetherapeutic-hypothermia-with-intracorporeal-temperaturemonitoring-for-hypoxic-perinatal-brain-injury-pdf, 2011 (Retrieved 13th August, 2014).
42. Nielsen N, Wetterslev J, Cronberg T, Erlinge D, Gasche Y, Hassager C, Horn J, Hovdenes J, Kjaergaard J, Kuiper M, Pellis T, Stammet P, Wanscher M, Wise MP, Åneman A, Al-Subaie N, Boesgaard S, Bro-Jeppesen J, Brunetti I, Bugge JF, Hingston CD, Juffermans NP, Koopmans M, Køber L, Langørgen J, Lilja G, Møller JE, Rundgren M, Rylander C, Smid O, Werer C, Winkel P, Friberg H; TTM Trial Investigators. Targeted temperature management at 33C versus 36C after cardiac arrest. N Engl J Med 2013;369:2197-2206.
43. Oddo M, Bosel J. Monitoring of brain and systemic oxygenation in neurocritical care patients. Neurocrit Care 2014;21 (Suppl 2):103-120.
44. Oddo M, Levine JM, Kumar M, Iglesias K, Frangos S, Maloney-Wilensky E, Le Roux PD. Anemia and brain oxygen after severe traumatic brain injury. Intensive Care Med 2012;38: 1497-1504.
45. Oddo M, Levine JM, Mackenzie L, Frangos S, Feihl F, Kasner SE, LeRoux PD. Brain hypoxia is associated with short-term outcome after severe traumatic brain injury independently of intracranial hypertension and low cerebral perfusion pressure. Neurosurgery 2011;69:1037-1045; discussion 1045.
46. Pennings FA, Schuurman PR, van den Munckhof P, Bouma GJ. Brain tissue oxygen pressure monitoring in awake patients during functional neurosurgery: The assessment of normal values. J Neurotrauma 2008;25:1173-1177.
47. Qiu W, Zhang Y, Sheng H, Zhang J, Wang W, Liu W, Chen K, Zhou J, Xu Z. Effects of therapeutic mild hypothermia on patients with severe traumatic brain injury after craniotomy. J Crit Care 2007;22:229-235.
48. Qureshi AI, Suarez JI, Bhardwaj A, Mirski M, Schnitzer MS, Hanley DF, Ulatowski JA. Use of hypertonic (3%) saline/ acetate infusion in the treatment of cerebral edema: effect on intracranial pressure and lateral displacement of the brain. Crit Care Med 1998;26:440-446.
49. Qureshi AI, Suarez JI, Castro A, Bhardwaj A. Use of hypertonic saline/acetate infusion in treatment of cerebral edema in patients with head trauma: experience at a single center. J Trauma 1999a;47:659-665.
50. Qureshi AI, Wilson DA, Traystman RJ. Treatment of elevated intracranial pressure in experimental intracerebral hemorrhage: comparison between mannitol and hypertonic saline. Neurosurgery 1999b;44:1055-1063; discussion 1063-1054.
51. Romner B, Grande PO. Traumatic brain injury: intracranial pressure monitoring in traumatic brain injury. Nat Rev Neurol 2013;9:185-186.
52. Rosenthal G, Hemphill JC, 3rd, Sorani M, Martin C, Morabito D, Obrist WD, Manley GT. Brain tissue oxygen tension is more indicative of oxygen diffusion than oxygen delivery and metabolism in patients with traumatic brain injury. Crit Care Med 2008;36:1917-1924.
53. Sahuquillo J, Perez-Barcena J, Biestro A, Zavala E, Merino MA, Vilalta A, Poca MA, Garnacho A, Adalia R, Homar J, et al. Intravascular cooling for rapid induction of moderate hypothermia in severely head-injured patients: results of a multicenter study (IntraCool). Intensive Care Med 2009;35: 890-898.
54. Schwab S, Schwarz S, Spranger M, Keller E, Bertram M, Hacke W. Moderate hypothermia in the treatment of patients with severe middle cerebral artery infarction. Stroke 1998;29: 2461-2466.
55. Shiozaki T, Sugimoto H, Taneda M, Yoshida H, Iwai A, Yoshioka T, Sugimoto T. Effect of mild hypothermia on uncontrollable intracranial hypertension after severe head injury. J Neurosurg 1993;79:363-368.
56. Smrcka M, Vidlak M, Maca K, Smrcka V, Gal R. The influence of mild hypothermia on ICP, CPP and outcome in patients with primary and secondary brain injury. Acta Neurochir Suppl 2005;95:273-275.
57. Sorani MD, Morabito D, RosenthalG, Giacomini KM, Manley GT. Characterizing the dose-response relationship between mannitol and intracranial pressure in traumatic brain injury patients using a high-frequency physiological data collection system. J Neurotrauma 2008;25:291-298.
58. Sydenham E, Roberts I, Alderson P. Hypothermia for traumatic head injury. Cochrane Database Syst Rev 2009;2:CD001048.
59. Tagliaferri F, Compagnone C, Korsic M, Servadei F, Kraus J. A systematic review of brain injury epidemiology in Europe. Acta Neurochir (Wien) 2006;148:255-268; discussion 268.
60. Tokutomi T, Morimoto K, Miyagi T, Yamaguchi S, Ishikawa K, Shigemori M. Optimal temperature for the management of severe traumatic brain injury: effect of hypothermia on intracranial pressure, systemic and intracranial hemodynamics, and metabolism. Neurosurgery 2003;52:102-111; discussion 111-102.
61. Torre-Healy A, Marko NF, Weil RJ. Hyperosmolar therapy for intracranial hypertension. Neurocrit Care 2012;17:117-130.
62. van der Worp HB, Macleod MR, Kollmar R; European Stroke Research Network for H. Therapeutic hypothermia for acute ischemic stroke: ready to start large randomized trials? J Cereb Blood Flow Metab 2010;30:1079-1093.
63. Zeng J, Zheng P, Tong W, Fang W. Decreased risk of secondary brain herniation with intracranial pressure monitoring in patients with haemorrhagic stroke. BMC Anesthesiol 2014;14:19.
64. Zhang S, Zhi D, Lin X, Shang Y, Niu Y. Effect of mild hypothermia on partial pressure of oxygen in brain tissue and brain temperature in patients with severe head injury. Chin J Traumatol 2002;5:43-45.
65. Zhi D, Zhang S, Lin X. Study on therapeutic mechanism and clinical effect of mild hypothermia in patients with severe head injury. Surg Neurol 2003;59:381-385.