Basic science of electronic cigarettes: Assessment in cell culture and in vivo models

Respiratory Research

Volumn 17, Issue 1, 2016, Pages

  Hiemstra, Pieter S ^a   Bals, Robert ^b  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CIGARETTE SMOKE; INTERLEUKIN 6; INTERLEUKIN 8; NICOTINIC AGENT;

AIRWAY EPITHELIAL CELL; APOPTOSIS; CELL AGING; CELL CULTURE; CELL DIFFERENTIATION; CELL VIABILITY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOTOXICITY; DNA STRAND BREAKAGE; ELECTRIC RESISTANCE; ELECTRONIC CIGARETTE; ENVIRONMENTAL EXPOSURE; HUMAN; NONHUMAN; OXIDATIVE STRESS; PROTEIN AGGREGATION; REVIEW; ANIMAL; ANIMAL MODEL; CHEMICALLY INDUCED; DRUG EFFECTS; INHALATIONAL DRUG ADMINISTRATION; LUNG; LUNG DISEASE; METABOLISM; PATHOLOGY; RISK ASSESSMENT; RISK FACTOR; VAPING;

ADMINISTRATION, INHALATION; ANIMALS; CELLS, CULTURED; ELECTRONIC NICOTINE DELIVERY SYSTEMS; HUMANS; LUNG; LUNG DISEASES; MODELS, ANIMAL; NICOTINIC AGONISTS; RISK ASSESSMENT; RISK FACTORS; VAPING;

EID: 84990836929     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/s12931-016-0447-z     Document Type: Review

References (39)

1. Rowell TR, Tarran R. Will chronic e-cigarette use cause lung disease? Am J Physiol Lung Cell Mol Physiol. 2015;309:L1398-1409.
2. Gornall J. Public Health England's troubled trail. BMJ. 2015;351:h5826.
3. Grana R, Benowitz N, Glantz SA. E-cigarettes: a scientific review. Circulation. 2014;129:1972-86.
4. Benowitz NL. Nicotine addiction. N Engl J Med. 2010;362:2295-303.
5. Grando SA. Connections of nicotine to cancer. Nat Rev Cancer. 2014;14:419-29.
6. Zhu SH, Sun JY, Bonnevie E, Cummins SE, Gamst A, Yin L, Lee M. Four hundred and sixty brands of e-cigarettes and counting: implications for product regulation. Tob Control. 2014;23 Suppl 3:iii3-9.
7. Cheng T. Chemical evaluation of electronic cigarettes. Tob Control. 2014;23 Suppl 2:ii11-17.
8. Lerner CA, Sundar IK, Yao H, Gerloff J, Ossip DJ, McIntosh S, Robinson R, Rahman I. Vapors produced by electronic cigarettes and e-juices with flavorings induce toxicity, oxidative stress, and inflammatory response in lung epithelial cells and in mouse lung. PLoS One. 2015;10:e0116732.
9. Egilman DS, Schilling JH. Bronchiolitis obliterans and consumer exposure to butter-flavored microwave popcorn: a case series. Int J Occup Environ Health. 2012;18:29-42.
10. Farsalinos KE, Kistler KA, Gillman G, Voudris V. Evaluation of electronic cigarette liquids and aerosol for the presence of selected inhalation toxins. Nicotine Tob Res. 2015;17:168-74.
11. Jensen RP, Luo W, Pankow JF, Strongin RM, Peyton DH. Hidden formaldehyde in e-cigarette aerosols. N Engl J Med. 2015;372:392-4.
12. Hammond D, Wiebel F, Kozlowski LT, Borland R, Cummings KM, O'Connor RJ, McNeill A, Connolly GN, Arnott D, Fong GT. Revising the machine smoking regime for cigarette emissions: implications for tobacco control policy. Tob Control. 2007;16:8-14.
13. Wu Q, Jiang D, Minor M, Chu HW. Electronic Cigarette Liquid Increases Inflammation and Virus Infection in Primary Human Airway Epithelial Cells. PLoS One. 2014;9:e108342.
14. Scheffler S, Dieken H, Krischenowski O, Aufderheide M. Cytotoxic Evaluation of e-Liquid Aerosol using Different Lung-Derived Cell Models. Int J Environ Res Public Health. 2015;12:12466-74.
15. Scheffler S, Dieken H, Krischenowski O, Forster C, Branscheid D, Aufderheide M. Evaluation of E-cigarette liquid vapor and mainstream cigarette smoke after direct exposure of primary human bronchial epithelial cells. Int J Environ Res Public Health. 2015;12:3915-25.
16. Aug A, Altraja S, Kilk K, Porosk R, Soomets U, Altraja A. E-Cigarette Affects the Metabolome of Primary Normal Human Bronchial Epithelial Cells. PLoS One. 2015;10:e0142053.
17. Shivalingappa PC, Hole R, Westphal CV, Vij N: Airway Exposure to E-Cigarette Vapors Impairs Autophagy and Induces Aggresome Formation. Antioxid Redox Signal 2015. [Epub ahead of print]
18. Yu V, Rahimy M, Korrapati A, Xuan Y, Zou AE, Krishnan AR, Tsui T, Aguilera JA, Advani S, Crotty Alexander LE, et al. Electronic cigarettes induce DNA strand breaks and cell death independently of nicotine in cell lines. Oral Oncol. 2016;52:58-65.
19. Cervellati F, Muresan XM, Sticozzi C, Gambari R, Montagner G, Forman HJ, Torricelli C, Maioli E, Valacchi G. Comparative effects between electronic and cigarette smoke in human keratinocytes and epithelial lung cells. Toxicol In Vitro. 2014;28:999-1005.
20. Husari A, Shihadeh A, Talih S, Hashem Y, El Sabban M, Zaatari G. Acute Exposure to Electronic and Combustible Cigarette Aerosols: Effects in an Animal Model and in Human Alveolar Cells. Nicotine Tob Res. 2016;18:613-9.
21. Bahl V, Lin S, Xu N, Davis B, Wang YH, Talbot P. Comparison of electronic cigarette refill fluid cytotoxicity using embryonic and adult models. Reprod Toxicol. 2012;34:529-37.
22. Sancilio S, Gallorini M, Cataldi A, di Giacomo V. Cytotoxicity and apoptosis induction by e-cigarette fluids in human gingival fibroblasts. Clin Oral Investig. 2016;20:477-83.
23. Romagna G, Allifranchini E, Bocchietto E, Todeschi S, Esposito M, Farsalinos KE. Cytotoxicity evaluation of electronic cigarette vapor extract on cultured mammalian fibroblasts (ClearStream-LIFE): comparison with tobacco cigarette smoke extract. Inhal Toxicol. 2013;25:354-61.
24. Schweitzer KS, Chen SX, Law S, Van Demark M, Poirier C, Justice MJ, Hubbard WC, Kim ES, Lai X, Wang M, et al. Endothelial disruptive proinflammatory effects of nicotine and e-cigarette vapor exposures. Am J Physiol Lung Cell Mol Physiol. 2015;309:L175-187.
25. Yoshiyama S, Chen Z, Okagaki T, Kohama K, Nasu-Kawaharada R, Izumi T, Ohshima N, Nagai T, Nakamura A. Nicotine exposure alters human vascular smooth muscle cell phenotype from a contractile to a synthetic type. Atherosclerosis. 2014;237:464-70.
26. Rubenstein DA, Hom S, Ghebrehiwet B, Yin W. Tobacco and e-cigarette products initiate Kupffer cell inflammatory responses. Mol Immunol. 2015;67:652-60.
27. Higham A, Rattray NJ, Dewhurst JA, Trivedi DK, Fowler SJ, Goodacre R, Singh D. Electronic cigarette exposure triggers neutrophil inflammatory responses. Respir Res. 2016;17:56.
28. Hiemstra PS, McCray Jr PB, Bals R. The innate immune function of airway epithelial cells in inflammatory lung disease. Eur Respir J. 2015;45:1150-62.
29. Neilson L, Mankus C, Thorne D, Jackson G, DeBay J, Meredith C. Development of an in vitro cytotoxicity model for aerosol exposure using 3D reconstructed human airway tissue; application for assessment of e-cigarette aerosol. Toxicol In Vitro. 2015;29:1952-62.
30. Sherwood CL, Boitano S. Airway epithelial cell exposure to distinct e-cigarette liquid flavorings reveals toxicity thresholds and activation of CFTR by the chocolate flavoring 2,5-dimethypyrazine. Respir Res. 2016;17:57.
31. Vlahos R, Bozinovski S. Preclinical murine models of Chronic Obstructive Pulmonary Disease. Eur J Pharmacol. 2015;759:265-71.
32. Cohen A, George O. Animal models of nicotine exposure: relevance to second-hand smoking, electronic cigarette use, and compulsive smoking. Front Psychiatry. 2013;4:41.
33. McGrath-Morrow SA, Hayashi M, Aherrera A, Lopez A, Malinina A, Collaco JM, Neptune E, Klein JD, Winickoff JP, Breysse P, et al. The effects of electronic cigarette emissions on systemic cotinine levels, weight and postnatal lung growth in neonatal mice. PLoS One. 2015;10:e0118344.
34. Lim HB, Kim SH. Inhallation of e-Cigarette Cartridge Solution Aggravates Allergen-induced Airway Inflammation and Hyper-responsiveness in Mice. Toxicol Res. 2014;30:13-8.
35. Garcia-Arcos I, Geraghty P, Baumlin N, Campos M, Dabo AJ, Jundi B, Cummins N, Eden E, Grosche A, Salathe M, Foronjy R: Chronic electronic cigarette exposure in mice induces features of COPD in a nicotine-dependent manner. Thorax. 2016. doi: 10.1136/thoraxjnl-2015-208039. [Epub ahead of print].
36. Herr C, Beisswenger C, Hess C, Kandler K, Suttorp N, Welte T, Schroeder JM, Vogelmeier C. Suppression of pulmonary innate host defence in smokers. Thorax. 2009;64:144-9.
37. Sussan TE, Gajghate S, Thimmulappa RK, Ma J, Kim JH, Sudini K, Consolini N, Cormier SA, Lomnicki S, Hasan F, et al. Exposure to electronic cigarettes impairs pulmonary anti-bacterial and anti-viral defenses in a mouse model. PLoS One. 2015;10:e0116861.
38. Ponzoni L, Moretti M, Sala M, Fasoli F, Mucchietto V, Lucini V, Cannazza G, Gallesi G, Castellana CN, Clementi F, et al. Different physiological and behavioural effects of e-cigarette vapour and cigarette smoke in mice. Eur Neuropsychopharmacol. 2015;25:1775-86.
39. Smith D, Aherrera A, Lopez A, Neptune E, Winickoff JP, Klein JD, Chen G, Lazarus P, Collaco JM, McGrath-Morrow SA. Adult Behavior in Male Mice Exposed to E-Cigarette Nicotine Vapors during Late Prenatal and Early Postnatal Life. PLoS One. 2015;10:e0137953.