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Angewandte Chemie - International Edition

Volumn 55, Issue 40, 2016, Pages 12408-12411

Deorphaning the Macromolecular Targets of the Natural Anticancer Compound Doliculide

(6) Schneider, Gisbert a Reker, Daniel a Chen, Tao a Hauenstein, Kurt a Schneider, Petra a,b Altmann, Karl Heinz a

a ETH ZURICH (Switzerland)

b InSilicom LLC (Switzerland)

Author keywords

anticancer compounds; cheminformatics; drug discovery; natural products; polypharmacology

Indexed keywords

MACROMOLECULES; PROTEINS;

ANTICANCER COMPOUNDS; CHEMINFORMATICS; DRUG DISCOVERY; NATURAL PRODUCTS; POLYPHARMACOLOGY;

DRUG PRODUCTS;

BIOLOGICAL PRODUCT; DEPSIPEPTIDE; DOLICULIDE; LIGAND; PROSTAGLANDIN E RECEPTOR 3;

ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG DESIGN; GENETICS; HEK293 CELL LINE; HUMAN; KINETICS; METABOLISM; SYNTHESIS;

BIOLOGICAL PRODUCTS; DEPSIPEPTIDES; DRUG DESIGN; HEK293 CELLS; HUMANS; KINETICS; LIGANDS; RECEPTORS, PROSTAGLANDIN E, EP3 SUBTYPE;

EID: 84990236409 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201605707 Document Type: Article

Times cited : (34)

References (37)

1
- 84962367258
- D. J. Newman, G. M. Cragg, J. Nat. Prod. 2016, 79, 629–661.
- (2016) J. Nat. Prod. , vol.79 , pp. 629-661
- Newman, D.J.¹ Cragg, G.M.²

2
- 84926205808
- A. L. Harvey, R. Edrada-Ebel, R. J. Quinn, Nat. Rev. Drug Discovery 2015, 14, 111–129.
- (2015) Nat. Rev. Drug Discovery , vol.14 , pp. 111-129
- Harvey, A.L.¹ Edrada-Ebel, R.² Quinn, R.J.³

3
- 84971283836
- T. Rodrigues, D. Reker, P. Schneider, G. Schneider, Nat. Chem. 2016, 8, 531–542.
- (2016) Nat. Chem. , vol.8 , pp. 531-542
- Rodrigues, T.¹ Reker, D.² Schneider, P.³ Schneider, G.⁴

4
- 84992291855
- L. Friedrich, T. Rodrigues, P. Schneider, G. Schneider, Angew. Chem. Int. Ed. 2016, 55, 6789–6792;
- (2016) Angew. Chem. Int. Ed. , vol.55 , pp. 6789-6792
- Friedrich, L.¹ Rodrigues, T.² Schneider, P.³ Schneider, G.⁴

5
- 84990213680
- Angew. Chem. 2016, 128, 6901–6904.
- (2016) Angew. Chem. , vol.128 , pp. 6901-6904

6
- 84969628929
- P. Schneider, G. Schneider, J. Med. Chem. 2016, 59, 4077–4086.
- (2016) J. Med. Chem. , vol.59 , pp. 4077-4086
- Schneider, P.¹ Schneider, G.²

7
- 84911496459
- D. Reker, A. M. Perna, T. Rodrigues, P. Schneider, M. Reutlinger, B. Mönch, A. Koeberle, C. Lamers, M. Gabler, H. Steinmetz, R. Müller, M. Schubert-Zsilavecz, O. Werz, G. Schneider, Nat. Chem. 2014, 6, 1072–1078.
- (2014) Nat. Chem. , vol.6 , pp. 1072-1078
- Reker, D.¹ Perna, A.M.² Rodrigues, T.³ Schneider, P.⁴ Reutlinger, M.⁵ Mönch, B.⁶ Koeberle, A.⁷ Lamers, C.⁸ Gabler, M.⁹ Steinmetz, H.¹⁰ Müller, R.¹¹ Schubert-Zsilavecz, M.¹² Werz, O.¹³ Schneider, G.¹⁴

8
- 84940450380
- T. Rodrigues, D. Reker, J. Kunze, P. Schneider, G. Schneider, Angew. Chem. Int. Ed. 2015, 54, 10516–10520;
- (2015) Angew. Chem. Int. Ed. , vol.54 , pp. 10516-10520
- Rodrigues, T.¹ Reker, D.² Kunze, J.³ Schneider, P.⁴ Schneider, G.⁵

9
- 84971470413
- Angew. Chem. 2015, 127, 10662–10666.
- (2015) Angew. Chem. , vol.127 , pp. 10662-10666

10
- 84896525962
- D. Reker, T. Rodrigues, P. Schneider, G. Schneider, Proc. Natl. Acad. Sci. USA 2014, 111, 4067–4072.
- (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. 4067-4072
- Reker, D.¹ Rodrigues, T.² Schneider, P.³ Schneider, G.⁴

11
- 0035932040
- A. K. Ghosh, C. Liu, Org. Lett. 2001, 3, 635–638.
- (2001) Org. Lett. , vol.3 , pp. 635-638
- Ghosh, A.K.¹ Liu, C.²

12
- 84930197692
- T. Chen, K.-H. Altmann, Chem. Eur. J. 2015, 21, 8403–8407.
- (2015) Chem. Eur. J. , vol.21 , pp. 8403-8407
- Chen, T.¹ Altmann, K.-H.²

13
- 0037200064
- R. Bai, D. G. Covell, C. Liu, A. K. Ghosh, E. Hamel, J. Biol. Chem. 2002, 277, 32165–32171.
- (2002) J. Biol. Chem. , vol.277 , pp. 32165-32171
- Bai, R.¹ Covell, D.G.² Liu, C.³ Ghosh, A.K.⁴ Hamel, E.⁵

14
- 84925884156
- F. Foerster, S. Braig, T. Chen, K.-H. Altmann, A. M. Vollmar, Bioorg. Med. Chem. 2014, 22, 5117–5122.
- (2014) Bioorg. Med. Chem. , vol.22 , pp. 5117-5122
- Foerster, F.¹ Braig, S.² Chen, T.³ Altmann, K.-H.⁴ Vollmar, A.M.⁵

15
- 84952638019
- F. Foerster, T. Chen, K.-H. Altmann, A. M. Vollmar, Bioorg. Med. Chem. 2016, 24, 123–129.
- (2016) Bioorg. Med. Chem. , vol.24 , pp. 123-129
- Foerster, F.¹ Chen, T.² Altmann, K.-H.³ Vollmar, A.M.⁴

16
- 84978929546
- J. T. Opferman, FEBS J. 2016, 283, 2661–2675.
- (2016) FEBS J. , vol.283 , pp. 2661-2675
- Opferman, J.T.¹

17
- 85047676329
- G. Asbóth, S. Phaneuf, G. N. Europe-Finner, M. Tóth, A. L. Bernal, Endocrinology 1996, 137, 2572–2579.
- (1996) Endocrinology , vol.137 , pp. 2572-2579
- Asbóth, G.¹ Phaneuf, S.² Europe-Finner, G.N.³ Tóth, M.⁴ Bernal, A.L.⁵

18
- 0034896507
- H. Juteau, Y. Gareau, M. Labelle, C. F. Sturino, N. Sawyer, N. Tremblay, S. Lamontagne, M. C. Carrière, D. Denis, K. M. Metters, Bioorg. Med. Chem. 2001, 9, 1977–1984.
- (2001) Bioorg. Med. Chem. , vol.9 , pp. 1977-1984
- Juteau, H.¹ Gareau, Y.² Labelle, M.³ Sturino, C.F.⁴ Sawyer, N.⁵ Tremblay, N.⁶ Lamontagne, S.⁷ Carrière, M.C.⁸ Denis, D.⁹ Metters, K.M.¹⁰

19
- 0031590012
- H. Hasegawa, M. Negishi, H. Katoh, A. Ichikawa, Biochem. Biophys. Res. Commun. 1997, 234, 631–636.
- (1997) Biochem. Biophys. Res. Commun. , vol.234 , pp. 631-636
- Hasegawa, H.¹ Negishi, M.² Katoh, H.³ Ichikawa, A.⁴

20
- 83855165720
- J. Reader, D. Holt, A. Fulton, Cancer Metastasis Rev. 2011, 30, 449–463;
- (2011) Cancer Metastasis Rev. , vol.30 , pp. 449-463
- Reader, J.¹ Holt, D.² Fulton, A.³

21
- 84937931984
- J. C. Neumann, M. E. Kimple, J. Endocrinol. Diabetes Obes. 2013, 1, 1002.
- (2013) J. Endocrinol. Diabetes Obes. , vol.1 , pp. 1002
- Neumann, J.C.¹ Kimple, M.E.²

22
- 84871552946
- C. Natarajan, A. N. Hata, H. E. Hamm, R. Zent, R. M. Breyer, Mol. Pharmacol. 2013, 83, 206–216;
- (2013) Mol. Pharmacol. , vol.83 , pp. 206-216
- Natarajan, C.¹ Hata, A.N.² Hamm, H.E.³ Zent, R.⁴ Breyer, R.M.⁵

23
- 48949098858
- A. Chillar, J. Wu, S. P. So, R. H. Ruan, FEBS Lett. 2008, 582, 2863–2868;
- (2008) FEBS Lett. , vol.582 , pp. 2863-2868
- Chillar, A.¹ Wu, J.² So, S.P.³ Ruan, R.H.⁴

24
- 37349032823
- F. Ni, S. P. So, V. Cervantes, K. H. Ruan, FEBS J. 2008, 275, 128–137;
- (2008) FEBS J. , vol.275 , pp. 128-137
- Ni, F.¹ So, S.P.² Cervantes, V.³ Ruan, K.H.⁴

25
- 0031007380
- L. Audoly, R. M. Breyer, J. Biol. Chem. 1997, 272, 13475–13478.
- (1997) J. Biol. Chem. , vol.272 , pp. 13475-13478
- Audoly, L.¹ Breyer, R.M.²

26
- 85043138086
- Homologous proteins for EP3 were obtained using Swissmodel 8.05 (https://swissmodel.expasy.org)
- Searches for crystal structures for EP3 and homologous proteins were performed using the RCSB Protein Data Bank (http://www.pdb.org). Homologous proteins for EP3 were obtained using Swissmodel 8.05 (https://swissmodel.expasy.org).
- Searches for crystal structures for EP3 and homologous proteins were performed using the RCSB Protein Data Bank (http://www.pdb.org)

27
- 0030871070
- M. Kiriyama, F. Ushikubi, T. Kobayashi, M. Hirata, Y. Sugimoto, S. Narumiya, Br. J. Pharmacol. 1997, 122, 217–224.
- (1997) Br. J. Pharmacol. , vol.122 , pp. 217-224
- Kiriyama, M.¹ Ushikubi, F.² Kobayashi, T.³ Hirata, M.⁴ Sugimoto, Y.⁵ Narumiya, S.⁶

28
- 0031565147
- Y. Boie, R. Stocco, N. Sawyer, D. M. Slipetz, M. D. Ungrin, F. Neuschäfer-Rube, G. P. Püschel, K. M. Metters, M. Abramovitz, Eur. J. Pharmacol. 1997, 340, 227–241.
- (1997) Eur. J. Pharmacol. , vol.340 , pp. 227-241
- Boie, Y.¹ Stocco, R.² Sawyer, N.³ Slipetz, D.M.⁴ Ungrin, M.D.⁵ Neuschäfer-Rube, F.⁶ Püschel, G.P.⁷ Metters, K.M.⁸ Abramovitz, M.⁹

29
- 0033971515
- M. Abramovitz, M. Adam, Y. Boie, M. Carrière, D. Denis, C. Godbout, S. Lamontagne, C. Rochette, N. Sawyer, N. M. Tremblay, M. Belley, M. Gallant, C. Dufresne, Y. Gareau, R. Ruel, H. Juteau, M. Labelle, N. Ouimet, K. M. Metters, Biochim. Biophys. Acta Mol. Cell Biol. Lipids 2000, 1483, 285–293.
- (2000) Biochim. Biophys. Acta Mol. Cell Biol. Lipids , vol.1483 , pp. 285-293
- Abramovitz, M.¹ Adam, M.² Boie, Y.³ Carrière, M.⁴ Denis, D.⁵ Godbout, C.⁶ Lamontagne, S.⁷ Rochette, C.⁸ Sawyer, N.⁹ Tremblay, N.M.¹⁰ Belley, M.¹¹ Gallant, M.¹² Dufresne, C.¹³ Gareau, Y.¹⁴ Ruel, R.¹⁵ Juteau, H.¹⁶ Labelle, M.¹⁷ Ouimet, N.¹⁸ Metters, K.M.¹⁹

30
- 84971278859
- D. Reker, P. Schneider, G. Schneider, Chem. Sci. 2016, 7, 3919–3927.
- (2016) Chem. Sci. , vol.7 , pp. 3919-3927
- Reker, D.¹ Schneider, P.² Schneider, G.³

31
- 84860505658
- J. S. Mason, A. Bortolato, M. Congreve, F. H. Marshall, Trends Pharmacol. Sci. 2012, 33, 249–260.
- (2012) Trends Pharmacol. Sci. , vol.33 , pp. 249-260
- Mason, J.S.¹ Bortolato, A.² Congreve, M.³ Marshall, F.H.⁴

32
- 0642286487
- A. Giganti, E. Friederich, Prog. Cell Cycle Res. 2003, 5, 511–525.
- (2003) Prog. Cell Cycle Res. , vol.5 , pp. 511-525
- Giganti, A.¹ Friederich, E.²

33
- 84879557098
- in, (Eds., C. Preisach, H. Burkhardt, L. Schmidt-Thieme, R. Decker, Springer, Berlin
- M. R. Berthold, N. Cebron, F. Dill, T. R. Gabriel, T. Kötter, T. Meinl, P. Ohl, C. Sieb, K. Thiel, B. Wiswedel in Data Analysis, Machine Learning and Applications (Eds.: C. Preisach, H. Burkhardt, L. Schmidt-Thieme, R. Decker), Springer, Berlin, 2008, pp. 319–326.
- (2008) Data Analysis, Machine Learning and Applications , pp. 319-326
- Berthold, M.R.¹ Cebron, N.² Dill, F.³ Gabriel, T.R.⁴ Kötter, T.⁵ Meinl, T.⁶ Ohl, P.⁷ Sieb, C.⁸ Thiel, K.⁹ Wiswedel, B.¹⁰

34
- 84874101052
- M. Reutlinger, C. P. Koch, D. Reker, N. Todoroff, P. Schneider, T. Rodrigues, G. Schneider, Mol. Inf. 2013, 32, 133–138.
- (2013) Mol. Inf. , vol.32 , pp. 133-138
- Reutlinger, M.¹ Koch, C.P.² Reker, D.³ Todoroff, N.⁴ Schneider, P.⁵ Rodrigues, T.⁶ Schneider, G.⁷

35
- 0242467732
- P. Schneider, G. Schneider, QSAR Comb. Sci. 2003, 22, 713–718.
- (2003) QSAR Comb. Sci. , vol.22 , pp. 713-718
- Schneider, P.¹ Schneider, G.²

36
- 33947599081
- G. Wolber, A. A. Dornhofer, T. Langer, J. Comput.-Aided Mol. Des. 2007, 20, 773–788.
- (2007) J. Comput.-Aided Mol. Des. , vol.20 , pp. 773-788
- Wolber, G.¹ Dornhofer, A.A.² Langer, T.³

37
- 0037571112
- T. A. Halgren, J. Comput. Chem. 1996, 17, 490–519.
- (1996) J. Comput. Chem. , vol.17 , pp. 490-519
- Halgren, T.A.¹

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