The second extracellular loop of the prostaglandin EP3 receptor is an essential determinant of ligand selectivity

Journal of Biological Chemistry

Volumn 272, Issue 21, 1997, Pages 13475-13478

  Audoly, Laurent ^a   Breyer, Richard M ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; PROSTAGLANDIN E2; PROSTAGLANDIN EP3 RECEPTOR; PROSTAGLANDIN RECEPTOR; PROSTANOID; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; LIGAND BINDING; MOLECULAR RECOGNITION; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CONSERVED SEQUENCE; CYCLIC AMP; DINOPROSTONE; HUMANS; KINETICS; LIGANDS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; RABBITS; RECEPTORS, PROSTAGLANDIN E; SEQUENCE ALIGNMENT; THREONINE; TRANSFECTION; TRYPTOPHAN;

EID: 0031007380     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.21.13475     Document Type: Article

References (21)

1. Breyer, M. D., Jacobson, H. R., and Breyer, R. M. (1996) J. Am. Soc. Nephrol. 7, 8-17
2. Coleman, R. A., Smith, W. L., and Narumiya, S. (1994) Pharmacol. Rev. 46, 205-229
3. Baldwin, J. M. (1994) Curr. Opin. Cell Biol. 6, 180-190
4. van Rhee, A. M., and Jacobson, K. A. (1996) Drug Dev. Res. 37, 1-38
5. Fraser, C. (1989) J. Biol. Chem. 264, 9266-9270
6. D'Angelo, D. D., Eubank, J. J., Davis, M. G., and Dorn, G. W., III (1996) J. Biol. Chem. 271, 6233-6240
7. Kim, J., Jiang, Q., Glashofer, M., Yehle, S., Wess, J., and Jacobson, K. A. (1996) Mol. Pharmacol. 49, 683-691
8. Olah, M. E., Jacobson, K. A., and Stiles, G. L. (1994) J. Biol. Chem. 269, 24692-24698
9. Audoly, L., and Breyer, R. (1997) Mol. Pharmacol. 57, 61-68
10. Negishi, M., Irie, A., Sugimoto, Y., Namba, T., and Ichikawa, A. (1995) J. Biol. Chem. 270, 16122-16127
11. Huang, C., and and Tai, H.-H. (1995) Biochem. J. 307, 493-498
12. Breyer, R. M., Davis, L. S., Nian, C., Redha, R., Stillman, B., Jacobson, H. R., and Breyer, M. D. (1996) Am. J. Physiol. 270, F485-F493
13. Fong, T. M., Yu, H., Huang, R.-R. C., and Strader, C. D. (1992) Biochemistry 31, 11806-11811
14. Nagayama, Y., Wadsworth, H. L., Chazenbalk, G. D., Russo, D., Seto, P., and Rapoport, B. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 902-905
15. Chini, B., Mouillac, B., Ala, Y., Balestre, M.-N., Trumpp-Kallmeyer, S., Hoflack, J., Elands, J., Hibert, M., Manning, M., Jard, S., and Barberis, M. (1995) EMBO J. 14, 2176-2182
16. Breyer, R. M., Emeson, R. B., Breyer, M. D., Abromson, R. M., Davis, L. S., and Ferrenbach, S. M. (1994) J. Biol. Chem. 298, 6163-6169
17. Cheng, Y.-C., and Prusoff, W. H. (1973) Biochem. Pharmacol. 22, 3099-3108
18. MacKinnon, R. (1995) Neuron 14, 889-892
19. Turner, R. P., Bambino, T., and Nissenson, R. A. (1996) J. Biol. Chem. 271, 9205-9208
20. O'Hara, P. J., Sheppard, P. O., Thøgersen, H., Venezia, D., Haldeman, B. A., McGrane, V., Houamed, K. M., Thomsen, C., Gilbert, T. L., and Mulvihill, E. R. (1993) Neuron 11, 41-52
21. Yamamoto, Y., Kamiya, K., and Terao, S. (1993) J. Med. Chem. 36, 820-825