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Volumn 9, Issue 12, 2016, Pages 1547-1555

What if there were no new antibiotics? A look at alternatives

Author keywords

antimicrobial agents; bacteriophages; liposomes; Monoclonal antibodies; stem cells; vaccines

Indexed keywords

ANTIBIOTIC AGENT; ASN 100; LIPOSOME; MEDI 3902; MEDI 4893; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG; VACCINE; ANTIINFECTIVE AGENT;

EID: 84990219147     PISSN: 17512433     EISSN: 17512441     Source Type: Journal    
DOI: 10.1080/17512433.2016.1241141     Document Type: Article
Times cited : (22)

References (63)
  • 1
    • 70350494495 scopus 로고    scopus 로고
    • The evolution of the understanding of sepsis, infection, and the host response: a brief history
    • Opal SM., The evolution of the understanding of sepsis, infection, and the host response:a brief history. Crit Care Clin. 2009;25(4):637–63, vii.
    • (2009) Crit Care Clin , vol.25 , Issue.4 , pp. 637-63, vii
    • Opal, S.M.1
  • 2
    • 84928673597 scopus 로고    scopus 로고
    • Antimicrobial resistance in humans, livestock and the wider environment
    • Woolhouse M, Page RL, Jensen WA, et al. Antimicrobial resistance in humans, livestock and the wider environment. Philos Trans R Soc Lond B Biol Sci. 2015;370(1670):20140083.
    • (2015) Philos Trans R Soc Lond B Biol Sci , vol.370 , Issue.1670 , pp. 20140083
    • Woolhouse, M.1    Page, R.L.2    Jensen, W.A.3
  • 3
    • 84857646835 scopus 로고    scopus 로고
    • Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance
    • Magiorakos AP, Srinivasan A, Carey RB, et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria:an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect. 2012;18(3):268–281.
    • (2012) Clin Microbiol Infect , vol.18 , Issue.3 , pp. 268-281
    • Magiorakos, A.P.1    Srinivasan, A.2    Carey, R.B.3
  • 4
    • 0035916299 scopus 로고    scopus 로고
    • Antibiotic resistance in the intensive care unit
    • Kollef MH, Fraser VJ. Antibiotic resistance in the intensive care unit. Ann Intern Med. 2001;134(4):298–314.
    • (2001) Ann Intern Med , vol.134 , Issue.4 , pp. 298-314
    • Kollef, M.H.1    Fraser, V.J.2
  • 5
    • 4043112107 scopus 로고    scopus 로고
    • Pathogens resistant to antimicrobial agents: epidemiology, molecular mechanisms, and clinical management
    • Kaye KS, Engemann JJ, Fraimow HS, et al. Pathogens resistant to antimicrobial agents:epidemiology, molecular mechanisms, and clinical management. Infect Dis Clin North Am. 2004;18(3):467–511, viii.
    • (2004) Infect Dis Clin North Am , vol.18 , Issue.3 , pp. 467-511, viii
    • Kaye, K.S.1    Engemann, J.J.2    Fraimow, H.S.3
  • 7
    • 84995779126 scopus 로고    scopus 로고
    • Tackling Drug-Resistant Infections Globally: final Report And recommendations
    • May
    • O’Neill J, Tackling Drug-Resistant Infections Globally:final Report And recommendations. Review on Antimicrobial Resistance, May 2016.
    • (2016) Review on Antimicrobial Resistance
    • O’Neill, J.1
  • 8
    • 33845903833 scopus 로고    scopus 로고
    • Drugs for bad bugs: confronting the challenges of antibacterial discovery
    • Payne DJ, Gwynn MN, Holmes DJ, et al. Drugs for bad bugs:confronting the challenges of antibacterial discovery. Nat Rev Drug Discov. 2007;6(1):29–40.
    • (2007) Nat Rev Drug Discov , vol.6 , Issue.1 , pp. 29-40
    • Payne, D.J.1    Gwynn, M.N.2    Holmes, D.J.3
  • 9
    • 84892153139 scopus 로고    scopus 로고
    • Clinical development success rates for investigational drugs
    • Hay M, Thomas DW, Craighead JL, et al. Clinical development success rates for investigational drugs. Nat Biotechnol. 2014;32(1):40–51.
    • (2014) Nat Biotechnol , vol.32 , Issue.1 , pp. 40-51
    • Hay, M.1    Thomas, D.W.2    Craighead, J.L.3
  • 10
    • 79953740494 scopus 로고    scopus 로고
    • Fix the antibiotics pipeline
    • Cooper MA, Shlaes D. Fix the antibiotics pipeline. Nature. 2011;472(7341):32.
    • (2011) Nature , vol.472 , Issue.7341 , pp. 32
    • Cooper, M.A.1    Shlaes, D.2
  • 12
    • 84930513816 scopus 로고    scopus 로고
    • Antibiotic research and development: business as usual?
    • Harbarth S, Theuretzbacher U, Hackett J. Antibiotic research and development:business as usual? J Antimicrob Chemother. 2015;70(6):1604–1607.
    • (2015) J Antimicrob Chemother , vol.70 , Issue.6 , pp. 1604-1607
    • Harbarth, S.1    Theuretzbacher, U.2    Hackett, J.3
  • 13
    • 84878278251 scopus 로고    scopus 로고
    • 10 x ‘20 Progress–development of new drugs active against gram-negative bacilli: an update from the infectious diseases society of America
    • Boucher HW, Talbot GH, Benjamin DK, et al. 10 x ‘20 Progress–development of new drugs active against gram-negative bacilli:an update from the infectious diseases society of America. Clin Infect Dis. 2013;56(12):1685–1694.
    • (2013) Clin Infect Dis , vol.56 , Issue.12 , pp. 1685-1694
    • Boucher, H.W.1    Talbot, G.H.2    Benjamin, D.K.3
  • 14
    • 84929762051 scopus 로고    scopus 로고
    • Antibiotics: the changing regulatory and pharmaceutical industry paradigm
    • Bax R, Green S. Antibiotics:the changing regulatory and pharmaceutical industry paradigm. J Antimicrob Chemother. 2015;70(5):1281–1284.
    • (2015) J Antimicrob Chemother , vol.70 , Issue.5 , pp. 1281-1284
    • Bax, R.1    Green, S.2
  • 15
    • 84861423745 scopus 로고    scopus 로고
    • Antibiotics: recover the lost art of drug discovery
    • Lewis K. Antibiotics:recover the lost art of drug discovery. Nature. 2012;485(7399):439–440.
    • (2012) Nature , vol.485 , Issue.7399 , pp. 439-440
    • Lewis, K.1
  • 16
    • 78751477224 scopus 로고    scopus 로고
    • Challenges of antibacterial discovery
    • Silver LL. Challenges of antibacterial discovery. Clin Microbiol Rev. 2011;24(1):71–109.
    • (2011) Clin Microbiol Rev , vol.24 , Issue.1 , pp. 71-109
    • Silver, L.L.1
  • 17
    • 84884961808 scopus 로고    scopus 로고
    • Investigational antimicrobial agents of 2013
    • Pucci MJ, Bush K. Investigational antimicrobial agents of 2013. Clin Microbiol Rev. 2013;26(4):792–821.
    • (2013) Clin Microbiol Rev , vol.26 , Issue.4 , pp. 792-821
    • Pucci, M.J.1    Bush, K.2
  • 19
    • 84922937832 scopus 로고    scopus 로고
    • A new antibiotic kills pathogens without detectable resistance
    • Ling LL, Schneider T, Peoples AJ, et al. A new antibiotic kills pathogens without detectable resistance. Nature. 2015;517(7535):455–459.
    • (2015) Nature , vol.517 , Issue.7535 , pp. 455-459
    • Ling, L.L.1    Schneider, T.2    Peoples, A.J.3
  • 20
    • 84865056525 scopus 로고    scopus 로고
    • The human milk protein-lipid complex HAMLET sensitizes bacterial pathogens to traditional antimicrobial agents
    • Marks LR, Clementi EA, Hakansson AP, et al. The human milk protein-lipid complex HAMLET sensitizes bacterial pathogens to traditional antimicrobial agents. PLoS One. 2012;7(8):e43514.
    • (2012) PLoS One , vol.7 , Issue.8 , pp. e43514
    • Marks, L.R.1    Clementi, E.A.2    Hakansson, A.P.3
  • 21
    • 84899722562 scopus 로고    scopus 로고
    • Drug development: time for teamwork
    • May M. Drug development:time for teamwork. Nature. 2014;509(7498):S4–5.
    • (2014) Nature , vol.509 , Issue.7498 , pp. S4-S5
    • May, M.1
  • 22
    • 84959264944 scopus 로고    scopus 로고
    • A systematic review and critical assessment of incentive strategies for discovery and development of novel antibiotics
    • Renwick MJ, Brogan DM, Mossialos E. A systematic review and critical assessment of incentive strategies for discovery and development of novel antibiotics. J Antibiot (Tokyo). 2016;69(2):73–88.• Systematic review on incentives for new antibiotics. A comprehensive review.
    • (2016) J Antibiot (Tokyo) , vol.69 , Issue.2 , pp. 73-88
    • Renwick, M.J.1    Brogan, D.M.2    Mossialos, E.3
  • 23
    • 84875657153 scopus 로고    scopus 로고
    • Is the GAIN act a turning point in new antibiotic discovery?
    • Brown ED. Is the GAIN act a turning point in new antibiotic discovery? Can J Microbiol. 2013;59(3):153–156.
    • (2013) Can J Microbiol , vol.59 , Issue.3 , pp. 153-156
    • Brown, E.D.1
  • 24
    • 84929079869 scopus 로고    scopus 로고
    • September, Available from
    • The Pew Charitable Trust. Antibiotics currently in clinical development. September 2015 cited 2016 Feb 22. Available from:http://www.pewtrusts.org/en/multimedia/data-visualizations/2014/antibiotics-currently-in-clinical-development
    • (2015) Antibiotics currently in clinical development
  • 25
    • 0030184441 scopus 로고    scopus 로고
    • Antibody-based therapies for emerging infectious diseases
    • Casadevall A. Antibody-based therapies for emerging infectious diseases. Emerg Infect Dis. 1996;2(3):200–208.
    • (1996) Emerg Infect Dis , vol.2 , Issue.3 , pp. 200-208
    • Casadevall, A.1
  • 26
    • 15244351004 scopus 로고    scopus 로고
    • Overview of monoclonal antibodies in cancer therapy: present and promise
    • Stern M, Herrmann R. Overview of monoclonal antibodies in cancer therapy:present and promise. Crit Rev Oncol Hematol. 2005;54(1):11–29.
    • (2005) Crit Rev Oncol Hematol , vol.54 , Issue.1 , pp. 11-29
    • Stern, M.1    Herrmann, R.2
  • 27
    • 68249130928 scopus 로고    scopus 로고
    • The use of antibodies in the treatment of infectious diseases
    • quiz 673
    • Chan CE, Chan AHY, Hanson BJ, et al. The use of antibodies in the treatment of infectious diseases. Singapore Med J. 2009;50(7):663–672. quiz 673.
    • (2009) Singapore Med J , vol.50 , Issue.7 , pp. 663-672
    • Chan, C.E.1    Chan, A.H.Y.2    Hanson, B.J.3
  • 28
    • 80455176681 scopus 로고    scopus 로고
    • Monoclonal antibodies in infectious diseases: clinical pipeline in 2011
    • Ter Meulen J. Monoclonal antibodies in infectious diseases:clinical pipeline in 2011. Infect Dis Clin North Am. 2011;25(4):789–802.
    • (2011) Infect Dis Clin North Am , vol.25 , Issue.4 , pp. 789-802
    • Ter Meulen, J.1
  • 29
    • 84865690747 scopus 로고    scopus 로고
    • Anti-bacterial monoclonal antibodies: back to the future?
    • Oleksiewicz MB, Nagy G, Nagy E. Anti-bacterial monoclonal antibodies:back to the future? Arch Biochem Biophys. 2012;526(2):124–131.
    • (2012) Arch Biochem Biophys , vol.526 , Issue.2 , pp. 124-131
    • Oleksiewicz, M.B.1    Nagy, G.2    Nagy, E.3
  • 30
    • 80052790031 scopus 로고    scopus 로고
    • Antibodies in infectious diseases: polyclonals, monoclonals and niche biotechnology
    • Berry JD, Gaudet RG. Antibodies in infectious diseases:polyclonals, monoclonals and niche biotechnology. N Biotechnol. 2011;28(5):489–501.
    • (2011) N Biotechnol , vol.28 , Issue.5 , pp. 489-501
    • Berry, J.D.1    Gaudet, R.G.2
  • 31
    • 84871030223 scopus 로고    scopus 로고
    • 40 years on: have we finally got a vaccine for Pseudomonas aeruginosa?
    • Worgall S. 40 years on:have we finally got a vaccine for Pseudomonas aeruginosa? Future Microbiol. 2012;7(12):1333–1335.
    • (2012) Future Microbiol , vol.7 , Issue.12 , pp. 1333-1335
    • Worgall, S.1
  • 32
    • 84957637760 scopus 로고    scopus 로고
    • Alternatives to antibiotics-a pipeline portfolio review
    • Czaplewski L, Bax R, Clokie M, et al. Alternatives to antibiotics-a pipeline portfolio review. Lancet Infect Dis. 2016;16(2):239–251.•• Nice review on alternative agents.
    • (2016) Lancet Infect Dis , vol.16 , Issue.2 , pp. 239-251
    • Czaplewski, L.1    Bax, R.2    Clokie, M.3
  • 33
    • 84960448055 scopus 로고    scopus 로고
    • Precision medicine for the treatment of severe pneumonia in intensive care
    • Rello J, Perez A. Precision medicine for the treatment of severe pneumonia in intensive care. Expert Rev Respir Med. 2016;10(3):297–316.•• How to apply Precision Medicine to infection management.
    • (2016) Expert Rev Respir Med , vol.10 , Issue.3 , pp. 297-316
    • Rello, J.1    Perez, A.2
  • 34
    • 84947751820 scopus 로고    scopus 로고
    • Novel antibody-antibiotic conjugate eliminates intracellular S. aureus
    • Lehar SM, Pillow T, Xu M, et al. Novel antibody-antibiotic conjugate eliminates intracellular S. aureus. Nature. 2015;527(7578):323–328.
    • (2015) Nature , vol.527 , Issue.7578 , pp. 323-328
    • Lehar, S.M.1    Pillow, T.2    Xu, M.3
  • 35
    • 84945970262 scopus 로고    scopus 로고
    • Antibacterial antibodies gain traction
    • Morrison C. Antibacterial antibodies gain traction. Nat Rev Drug Discov. 2015;14(11):737–738.
    • (2015) Nat Rev Drug Discov , vol.14 , Issue.11 , pp. 737-738
    • Morrison, C.1
  • 36
    • 74849098405 scopus 로고    scopus 로고
    • Treatment with monoclonal antibodies against Clostridium difficile toxins
    • Lowy I, Molrine DC, Leav BA, et al. Treatment with monoclonal antibodies against Clostridium difficile toxins. N Engl J Med. 2010;362(3):197–205.
    • (2010) N Engl J Med , vol.362 , Issue.3 , pp. 197-205
    • Lowy, I.1    Molrine, D.C.2    Leav, B.A.3
  • 37
    • 57749107808 scopus 로고    scopus 로고
    • Bad bugs, no drugs: no ESKAPE! an update from the infectious diseases society of America
    • Boucher HW, Talbot GH, Bradley JS, et al. Bad bugs, no drugs:no ESKAPE! an update from the infectious diseases society of America. Clin Infect Dis. 2009;48(1):1–12.
    • (2009) Clin Infect Dis , vol.48 , Issue.1 , pp. 1-12
    • Boucher, H.W.1    Talbot, G.H.2    Bradley, J.S.3
  • 38
    • 84878359457 scopus 로고    scopus 로고
    • Vaccine review: “Staphyloccocus aureus vaccines: problems and prospects
    • Jansen KU, Girgenti DQ, Scully IL, et al. Vaccine review:“Staphyloccocus aureus vaccines:problems and prospects”. Vaccine. 2013;31(25):2723–2730.
    • (2013) Vaccine , vol.31 , Issue.25 , pp. 2723-2730
    • Jansen, K.U.1    Girgenti, D.Q.2    Scully, I.L.3
  • 39
    • 84921376947 scopus 로고    scopus 로고
    • Five birds, one stone: neutralization of alpha-hemolysin and 4 bi-component leukocidins of Staphylococcus aureus with a single human monoclonal antibody
    • Rouha H, Badarau A, Visram ZC, et al. Five birds, one stone:neutralization of alpha-hemolysin and 4 bi-component leukocidins of Staphylococcus aureus with a single human monoclonal antibody. MAbs. 2015;7(1):243–254.
    • (2015) MAbs , vol.7 , Issue.1 , pp. 243-254
    • Rouha, H.1    Badarau, A.2    Visram, Z.C.3
  • 41
    • 80052695183 scopus 로고    scopus 로고
    • Phage treatment of human infections
    • Abedon ST, Kuhl SJ, Blasdel BG, et al. Phage treatment of human infections. Bacteriophage. 2011;1(2):66–85.
    • (2011) Bacteriophage , vol.1 , Issue.2 , pp. 66-85
    • Abedon, S.T.1    Kuhl, S.J.2    Blasdel, B.G.3
  • 42
    • 84901948706 scopus 로고    scopus 로고
    • Phage therapy gets revitalized
    • Reardon S. Phage therapy gets revitalized. Nature. 2014;510(7503):15–16.
    • (2014) Nature , vol.510 , Issue.7503 , pp. 15-16
    • Reardon, S.1
  • 43
    • 84891713097 scopus 로고    scopus 로고
    • A historical overview of bacteriophage therapy as an alternative to antibiotics for the treatment of bacterial pathogens
    • Wittebole X, De Roock S, Opal SM. A historical overview of bacteriophage therapy as an alternative to antibiotics for the treatment of bacterial pathogens. Virulence. 2014;5(1):226–235.
    • (2014) Virulence , vol.5 , Issue.1 , pp. 226-235
    • Wittebole, X.1    De Roock, S.2    Opal, S.M.3
  • 44
    • 84893325182 scopus 로고    scopus 로고
    • Antibacterial bioagents based on principles of bacteriophage biology: an overview
    • Knoll BM, Mylonakis E. Antibacterial bioagents based on principles of bacteriophage biology:an overview. Clin Infect Dis. 2014;58(4):528–534.
    • (2014) Clin Infect Dis , vol.58 , Issue.4 , pp. 528-534
    • Knoll, B.M.1    Mylonakis, E.2
  • 45
    • 84903546431 scopus 로고    scopus 로고
    • Natural solution to antibiotic resistance: bacteriophages ‘the living drugs’
    • Jassim SA, Limoges RG. Natural solution to antibiotic resistance:bacteriophages ‘the living drugs’. World J Microbiol Biotechnol. 2014;30(8):2153–2170.
    • (2014) World J Microbiol Biotechnol , vol.30 , Issue.8 , pp. 2153-2170
    • Jassim, S.A.1    Limoges, R.G.2
  • 46
    • 84878321621 scopus 로고    scopus 로고
    • Phage cocktails and the future of phage therapy
    • Chan BK, Abedon ST, Loc-Carrillo C. Phage cocktails and the future of phage therapy. Future Microbiol. 2013;8(6):769–783.
    • (2013) Future Microbiol , vol.8 , Issue.6 , pp. 769-783
    • Chan, B.K.1    Abedon, S.T.2    Loc-Carrillo, C.3
  • 47
    • 84903766741 scopus 로고    scopus 로고
    • Bacteriophages as potential treatment option for antibiotic resistant bacteria
    • Bragg R, van der Westhuizen W, Lee J-Y, et al. Bacteriophages as potential treatment option for antibiotic resistant bacteria. Adv Exp Med Biol. 2014;807:97–110.
    • (2014) Adv Exp Med Biol , vol.807 , pp. 97-110
    • Bragg, R.1    van der Westhuizen, W.2    Lee, J.-Y.3
  • 48
    • 34548431799 scopus 로고    scopus 로고
    • Phage therapy of staphylococcal infections (including MRSA) may be less expensive than antibiotic treatment
    • Miedzybrodzki R, Fortuna W, Weber-Dabrowska B, et al. Phage therapy of staphylococcal infections (including MRSA) may be less expensive than antibiotic treatment. Postepy Hig Med Dosw (Online). 2007;61:461–465.
    • (2007) Postepy Hig Med Dosw (Online) , vol.61 , pp. 461-465
    • Miedzybrodzki, R.1    Fortuna, W.2    Weber-Dabrowska, B.3
  • 49
    • 70349775117 scopus 로고    scopus 로고
    • Bacteriophage therapy of venous leg ulcers in humans: results of a phase I safety trial
    • Rhoads DD, Wolcott RD, Kuskowski MA, et al. Bacteriophage therapy of venous leg ulcers in humans:results of a phase I safety trial. J Wound Care. 2009;18(6):237-8, 240-3.
    • (2009) J Wound Care , vol.18 , Issue.6
    • Rhoads, D.D.1    Wolcott, R.D.2    Kuskowski, M.A.3
  • 50
    • 68349154135 scopus 로고    scopus 로고
    • A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic-resistant Pseudomonas aeruginosa; a preliminary report of efficacy
    • Wright A, Hawkins CH, Anggård EE, et al. A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic-resistant Pseudomonas aeruginosa; a preliminary report of efficacy. Clin Otolaryngol. 2009;34(4):349–357.
    • (2009) Clin Otolaryngol , vol.34 , Issue.4 , pp. 349-357
    • Wright, A.1    Hawkins, C.H.2    Anggård, E.E.3
  • 51
    • 84953807252 scopus 로고    scopus 로고
    • Oral phage therapy of acute bacterial diarrhea with two coliphage preparations: a randomized trial in children from Bangladesh
    • Sarker SA, Sultana S, Reuteler G, et al. Oral phage therapy of acute bacterial diarrhea with two coliphage preparations:a randomized trial in children from Bangladesh. EBioMedicine. 2016;4:124–137.
    • (2016) EBioMedicine , vol.4 , pp. 124-137
    • Sarker, S.A.1    Sultana, S.2    Reuteler, G.3
  • 52
    • 84949131641 scopus 로고    scopus 로고
    • Vaccination against respiratory Pseudomonas aeruginosa infection
    • Grimwood K, Kyd JM, Owen SJ, et al. Vaccination against respiratory Pseudomonas aeruginosa infection. Hum Vaccin Immunother. 2015;11(1):14–20.
    • (2015) Hum Vaccin Immunother , vol.11 , Issue.1 , pp. 14-20
    • Grimwood, K.1    Kyd, J.M.2    Owen, S.J.3
  • 53
    • 84900323437 scopus 로고    scopus 로고
    • Vaccine development and passive immunization for Pseudomonas aeruginosa in critically ill patients: a clinical update
    • Vincent JL. Vaccine development and passive immunization for Pseudomonas aeruginosa in critically ill patients:a clinical update. Future Microbiol. 2014;9(4):457–463.
    • (2014) Future Microbiol , vol.9 , Issue.4 , pp. 457-463
    • Vincent, J.L.1
  • 54
  • 55
    • 84875655969 scopus 로고    scopus 로고
    • Effect of an investigational vaccine for preventing Staphylococcus aureus infections after cardiothoracic surgery: a randomized trial
    • Fowler VG, Allen KB, Moreira ED, et al. Effect of an investigational vaccine for preventing Staphylococcus aureus infections after cardiothoracic surgery:a randomized trial. Jama. 2013;309(13):1368–1378.
    • (2013) Jama , vol.309 , Issue.13 , pp. 1368-1378
    • Fowler, V.G.1    Allen, K.B.2    Moreira, E.D.3
  • 56
    • 84963642757 scopus 로고    scopus 로고
    • Safety, immunogenicity and dose response of VLA84, a new vaccine candidate against Clostridium difficile, in healthy volunteers
    • Bezay N, Ayad A, Dubischar K, et al. Safety, immunogenicity and dose response of VLA84, a new vaccine candidate against Clostridium difficile, in healthy volunteers. Vaccine. 2016;34(23):2585–2592.
    • (2016) Vaccine , vol.34 , Issue.23 , pp. 2585-2592
    • Bezay, N.1    Ayad, A.2    Dubischar, K.3
  • 57
    • 84938821329 scopus 로고    scopus 로고
    • Mesenchymal stem cells as a therapeutic tool to treat sepsis
    • Lombardo E, van der Poll T, DelaRosa O, et al. Mesenchymal stem cells as a therapeutic tool to treat sepsis. World J Stem Cells. 2015;7(2):368–379.• Stem cells for sespis. A challenging approach.
    • (2015) World J Stem Cells , vol.7 , Issue.2 , pp. 368-379
    • Lombardo, E.1    van der Poll, T.2    DelaRosa, O.3
  • 58
    • 84953310309 scopus 로고    scopus 로고
    • Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia
    • Gonzalez-Juarbe N, Gilley RP, Hinojosa CA, et al. Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia. PLoS Pathog. 2015;11(12):e1005337.
    • (2015) PLoS Pathog , vol.11 , Issue.12 , pp. e1005337
    • Gonzalez-Juarbe, N.1    Gilley, R.P.2    Hinojosa, C.A.3
  • 59
    • 84878253590 scopus 로고    scopus 로고
    • Role of pore-forming toxins in bacterial infectious diseases
    • Los FC, Randis TM, Aroian RV, et al. Role of pore-forming toxins in bacterial infectious diseases. Microbiol Mol Biol Rev. 2013;77(2):173–207.
    • (2013) Microbiol Mol Biol Rev , vol.77 , Issue.2 , pp. 173-207
    • Los, F.C.1    Randis, T.M.2    Aroian, R.V.3
  • 60
    • 84927674621 scopus 로고    scopus 로고
    • Liposomes as novel anti-infectives targeting bacterial virulence factors?
    • Azeredo Da Silveira S, Perez A. Liposomes as novel anti-infectives targeting bacterial virulence factors? Expert Rev Anti Infect Ther. 2015;13(5):531–533.
    • (2015) Expert Rev Anti Infect Ther , vol.13 , Issue.5 , pp. 531-533
    • Azeredo Da Silveira, S.1    Perez, A.2
  • 61
    • 84964285801 scopus 로고    scopus 로고
    • Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice
    • Henry BD, Neill DR, Becker KA, et al. Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice. Nat Biotechnol. 2015;33(1):81–88.• Liposomes for Severe infections. A visionary article.
    • (2015) Nat Biotechnol , vol.33 , Issue.1 , pp. 81-88
    • Henry, B.D.1    Neill, D.R.2    Becker, K.A.3
  • 62
    • 79960291267 scopus 로고    scopus 로고
    • Ecology and evolution as targets: the need for novel eco-evo drugs and strategies to fight antibiotic resistance
    • Baquero F, Coque TM, de la Cruz F. Ecology and evolution as targets:the need for novel eco-evo drugs and strategies to fight antibiotic resistance. Antimicrob Agents Chemother. 2011;55(8):3649–3660.• Eco Evo strategies discussed in deep.
    • (2011) Antimicrob Agents Chemother , vol.55 , Issue.8 , pp. 3649-3660
    • Baquero, F.1    Coque, T.M.2    de la Cruz, F.3
  • 63
    • 84925357614 scopus 로고    scopus 로고
    • Public health evolutionary biology of antimicrobial resistance: priorities for intervention
    • Baquero F, Lanza VF, Cantón R, et al. Public health evolutionary biology of antimicrobial resistance:priorities for intervention. Evol Appl. 2015;8(3):223–239.• Expert document on priorities for intervention.
    • (2015) Evol Appl , vol.8 , Issue.3 , pp. 223-239
    • Baquero, F.1    Lanza, V.F.2    Cantón, R.3


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