Effect of a 2-y dietary and physical activity intervention on plasma fatty acid composition and estimated desaturase and elongase activities in children: The Physical Activity and Nutrition in Children Study

American Journal of Clinical Nutrition

Volumn 104, Issue 4, 2016, Pages 964-972

  Venäläinen, Taisa M ^a   Viitasalo, Anna M ^a   Schwab, Ursula S ^a,b   Eloranta, Aino Maija ^a   Haapala, Eero A ^a,c   Jalkanen, Henna P ^a   De Mello, Vanessa D F ^a   Laaksonen, David E ^a,b   Lindi, Virpi I ^a   Ågren, Jyrki J ^a   Lakka, Timo A ^a,b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

^c UNIVERSITY OF JYVÄSKYLÄ   (Finland)

Author keywords

Children; Cholesteryl ester; Desaturase; Diet; Elongase; Fatty acid; Intervention; Phospholipid; Physical activity

Indexed keywords

ACYL COENZYME A DESATURASE; CHOLESTEROL ESTER; DOCOSAPENTAENOIC ACID; FATTY ACID; LINOLEIC ACID; LINOLENIC ACID; LINOLEOYL COENZYME A DESATURASE; MARGARINE; OLEIC ACID; PHOSPHOLIPID; POLYUNSATURATED FATTY ACID; SATURATED FATTY ACID; STEARIC ACID; UNSATURATED FATTY ACID; VEGETABLE OIL; ACYLTRANSFERASE; FATTY ACID ELONGASES; LIPID;

ANTHROPOMETRIC PARAMETERS; ARTICLE; CHILD; CLINICAL ASSESSMENT; COMPARATIVE STUDY; CONTROLLED STUDY; DIET SUPPLEMENTATION; DIETARY INTAKE; ENZYME ACTIVITY; FATTY ACID BLOOD LEVEL; FEMALE; GAS CHROMATOGRAPHY; HUMAN; LIFESTYLE MODIFICATION; LIPID COMPOSITION; MALE; NUTRITIONAL HEALTH; PHYSICAL ACTIVITY; POPULATION; BLOOD; CONTROLLED CLINICAL TRIAL; DIET; EXERCISE; FINLAND; HEALTH BEHAVIOR; HEALTH PROMOTION; LIFESTYLE; METABOLISM; PRACTICE GUIDELINE; PROCEDURES; TREATMENT OUTCOME;

ACETYLTRANSFERASES; ALPHA-LINOLENIC ACID; CHILD; CHOLESTEROL ESTERS; DIET; EXERCISE; FATTY ACID DESATURASES; FATTY ACIDS, UNSATURATED; FEMALE; FINLAND; GUIDELINES AS TOPIC; HEALTH BEHAVIOR; HEALTH PROMOTION; HUMANS; LIFE STYLE; LINOLEIC ACID; LIPIDS; MALE; PHOSPHOLIPIDS; TREATMENT OUTCOME;

EID: 84990055841     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.116.136580     Document Type: Article

References (36)

1. Vessby B, Gustafsson IB, Boberg J, Karlström B, Lithell H, Werner I. Substituting polyunsaturated for saturated fat as a single change in a Swedish diet: effects on serum lipoprotein metabolism and glucose tolerance in patients with hyperlipoproteinaemia. Eur J Clin Invest 1980;10:193-202.
2. Riboli E, Ronnholm H, Saracci R. Biological markers of diet. Cancer Surv 1987;6:685-718.
3. Nikkari T, Luukkainen P, Pietinen P, Puska P. Fatty acid composition of serum lipid fractions in relation to gender and quality of dietary fat. Ann Med 1995;27:491-8.
4. Zock PL, Mensink RP, Harryvan J, Vries JHM, Katan MB. Fatty acids in serum cholesteryl esters as quantitative biomarkers of dietary intake in humans. Am J Epidemiol 1997;145:1114-22.
5. Venäläinen T, Schwab U, A° gren J, de Mello V, Lindi V, Eloranta AM, Kiiskinen S, Laaksonen DE, Lakka TA. Cross-sectional associations of food consumption with plasma fatty acid composition and estimated desaturase activities in Finnish children. Lipids 2014;49:467-79.
6. Pickens CA, Sordillo LM, Comstock SS, Harris WS, Hortos K, Kovan B, Fenton JI. Plasma phospholipids, non-esterified plasma polyunsaturated fatty acids and oxylipids are associated with BMI. Prostaglandins Leukot Essent Fatty Acids 2015;95:31-40.
7. Allard C, Alteresco M, Ferguson RJ, Chaniotis L, Choquette G, Skinner J. Changes in adipose tissue and increased serum cholesterol of coronary patients following training. Can Med Assoc J 1973;109: 194-7.
8. Hurter R, Peyman MA, Swale J, Barnett CW. Some immediate and long-term effects of exercise on the plasma-lipids. Lancet 1972;2: 671-4.
9. Kunesová M, Hainer V, Tvrzicka E, Phinney SD, Stich V, Parizkova J, Zak A, Stunkard AJ. Assessment of dietary and genetic factors influencing serum and adipose fatty acid composition in obese female identical twins. Lipids 2002;37:27-32.
10. Vessby B, Tengblad S, Lithell H. Insulin sensitivity is related to the fatty acid composition of serum lipids and skeletal muscle phospholipids in 70-year-old men. Diabetologia 1994;37:1044-50.
11. Laaksonen DE, Lakka TA, Lakka HM, Nyyssönen K, Rissanen T, Niskanen LK, Salonen JT. Serum fatty acid composition predicts development of impaired fasting glycaemia and diabetes in middle-aged men. Diabet Med 2002;19:456-64.
12. Laaksonen DE, Nyyssönen K, Niskanen L, Rissanen TH, Salonen JT. Prediction of cardiovascular mortality in middle-aged men by dietary and serum linoleic and polyunsaturated fatty acids. Arch Intern Med 2005;165:193-9.
13. Schwab U, Lauritzen L, Tholstrup T, Haldorsson TI, Riserus U, Uusitupa M, Becker W. Effect of the amount and type of dietary fat on cardiometabolic risk factors and risk of developing type 2 diabetes, cardiovascular diseases, and cancer: a systematic review. Food Nutr Res 2014;2014:58.
14. Venäläinen T, A° gren J, Schwab U, de Mello VD, Eloranta AM, Laaksonen DE, Lindi V, Lakka TA. Cross-sectional associations of plasma fatty acid composition and estimated desaturase and elongase activities with cardiometabolic risk in Finnish children: the PANIC study. J Clin Lipidol 2016;10:82-91.
15. Perk J, De Backer G, Gohlke H, Graham I, Reiner Z, Verschuren WM, Albus C, Benlian P, Boysen G, Cifkova R, et al. European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). Int J Behav Med 2012;19:403-88.
16. Paulweber B, Valensi P, Lindström J, Lalic NM, Greaves CJ, McKee M, Kissimova-Skarbek K, Liatis S, Cosson E, Szendroedi J, et al. A European evidence-based guideline for the prevention of type 2 diabetes. Horm Metab Res 2010;42:S3-36.
17. Salo P, Viikari J, Rask-Nissilä L, Hämäläinen M, Rönnemaa T, Seppänen R, Simell O. Effect of low-saturated fat, low-cholesterol dietary intervention on fatty acid compositions in serum lipid fractions in 5-year-old children: the STRIP project. Eur J Clin Nutr 1999;53:927-32.
18. Corpeleijn E, Feskens EJM, Jansen EHJM, Mensink M, Saris WH, de Bruin TW, Blaak EE. Improvements in glucose tolerance and insulin sensitivity after lifestyle intervention are related to changes in serum fatty acid profile and desaturase activities: the SLIM study. Diabetologia 2006;49:2392-401.
19. Kröger J, Schulze MB. Recent insights into the relation of delta 5 desaturase and delta 6 desaturase activity to the development of type 2 diabetes. Curr Opin Lipidol 2012;23:4-10.
20. Vessby B, Gustafsson IB, Tengblad S, Boberg M, Andersson A. Desaturation and elongation of fatty acids and insulin action. Ann N Y Acad Sci 2002;967:183-95.
21. National Nutrition Council. Suomalaiset ra-vitsemussuositukset. Ravinto ja liikunta tasapainoon. [Finnish Nutrition Recommendations]. Helsinki (Finland): Edita Prima Oy; 2005 (in Finnish).
22. Ministry of Social Affairs and Health. Recommendations for physical activity in early childhood education. Helsinki (Finland): Handbooks of the Ministry of Social Affairs and Health; 2005 (in Finnish).
23. Saari A, Sankilampi U, Hannila ML, Kiviniemi V, Kesseli K, Dunkel L. New Finnish growth references for children and adolescents aged 0 to 20 years: length/height-for-age, weight-for-length/height, and body mass index-for-age. Ann Med 2011;43:235-48.
24. Agren JJ, Julkunen A, Penttilä I. Rapid separation of serum lipids for fatty acid analysis by a single aminopropyl column. J Lipid Res 1992;33:1871-6.
25. Vessby B, Gustafsson IB, Tengblad S, Berglund L. Indices of fatty acid desaturase activity in healthy human subjects: effects of different types of dietary fat. Br J Nutr 2013;110:871-9.
26. Warensjö E, Riserus U, Gustafsson IB, Mohsen R, Cederholm T, Vessby B. Effects of saturated and unsaturated fatty acids on estimated desaturase activities during a controlled dietary intervention. Nutr Metab Cardiovasc Dis 2008;18:683-90.
27. Mahendran Y, A° gren J, Uusitupa M, Cederberg H, Vangipurapu J, Stan-cáková A, Schwab U, Kuusisto J, Laakso M. Association of erythrocyte membrane fatty acids with changes in glycemia and risk of type 2 diabetes. Am J Clin Nutr 2014;99:79-85.
28. Viitasalo A, Eloranta AM, Lintu N, Väistö J, Venäläinen T, Kiiskinen S, Karjalainen P, Peltola J, Lampinen EK, Haapala EA, et al. The effects of a 2-year individualized and family-based lifestyle intervention on physical activity, sedentary behavior and diet in children. Prev Med 2016;87: 81-8.
29. Bjermo H, Iggman D, Kullberg J, Dahlman I, Johansson L, Persson L, Berglund J, Pulkki K, Basu S, Uusitupa M, et al. Effects of n-6 PUFAs compared with SFAs on liver fat, lipoproteins, and inflammation in abdominal obesity: a randomized controlled trial. Am J Clin Nutr 2012; 95:1003-12.
30. Hodson L, Fielding BA. Stearoyl-CoA desaturase: rogue or innocent bystander? Prog Lipid Res 2013;52:15-42.
31. Adamsson V, Cederholm T, Vessby B, Risérus U. Influence of a healthy Nordic diet on serum fatty acid composition and associations with blood lipoproteins: results from the NORDIET study. Food Nutr Res 2014;58:24114.
32. Green CD, Ozguden-Akkoc C, Wang Y, Jump DB, Olson LK. Role of fatty acid elongases in determination of de novo synthesized monounsaturated fatty acid species. J Lipid Res 2010;51:1871-7.
33. Takkunen MJ, de Mello VD, Schwab US, A° gren JJ, Kuusisto J, Uusitupa MI. Associations of erythrocyte membrane fatty acids with the concentrations of C-reactive protein, interleukin 1 receptor antagonist and adiponectin in 1373 men. Prostaglandins Leukot Essent Fatty Acids 2014;91:169-74.
34. Andersson A, Sjödin A, Olsson R, Vessby B. Effects of physical exercise on phospholipid fatty acid composition in skeletal muscle. Am J Physiol 1998;274:E432-8.
35. Borkman M, Storlien LH, Pan DA, Jenkins AB, Chisholm DJ, Campbell LV. The relation between insulin sensitivity and the fattyacid composition of skeletal-muscle phospholipids. N Engl J Med 1993;328:238-44.
36. Vessby B, Ahrén B, Warensjö E, Lindgärde F. Plasma lipid fatty acid composition, desaturase activities and insulin sensitivity in Amerindian women. Nutr Metab Cardiovasc Dis 2012;22:176-81.