EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis

Cancer Cell

Volumn 30, Issue 2, 2016, Pages 197-213

  Béguelin, Wendy ^a   Teater, Matt ^a   Gearhart, Micah D ^b   Calvo Fernández, María Teresa ^a   Goldstein, Rebecca L ^a   Cárdenas, Mariano G ^a   Hatzi, Katerina ^a   Rosen, Monica ^a   Shen, Hao ^a   Corcoran, Connie M ^b   Hamline, Michelle Y ^b,f   Gascoyne, Randy D ^c   Levine, Ross L ^d   Abdel Wahab, Omar ^d   Licht, Jonathan D ^e   Shaknovich, Rita ^a   Elemento, Olivier ^a   Bardwell, Vivian J ^b   Melnick, Ari M ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c BRITISH COLUMBIA CANCER RESEARCH CENTRE   (Canada)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^e NORTHWESTERN UNIVERSITY   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BCL6 COREPRESSOR; BMI1 PROTEIN; POLYCOMB GROUP PROTEIN; POLYCOMB REPRESSIVE COMPLEX 2; PROTEIN BCL 6; PROTEIN CBX8; TRANSCRIPTION FACTOR EZH2; UNCLASSIFIED DRUG; BCL6 PROTEIN, HUMAN; BCL6 PROTEIN, MOUSE; BCOR PROTEIN, HUMAN; BCOR PROTEIN, MOUSE; CBX8 PROTEIN, HUMAN; CBX8 PROTEIN, MOUSE; EZH2 PROTEIN, HUMAN; EZH2 PROTEIN, MOUSE; ONCOPROTEIN; REPRESSOR PROTEIN;

ARTICLE; B LYMPHOCYTE; BINDING AFFINITY; CARCINOGENESIS; CELL HYPERPLASIA; COMPLEX FORMATION; CONTROLLED STUDY; GENE EXPRESSION; GERMINAL CENTER; HISTONE MODIFICATION; IN VITRO STUDY; LARGE CELL LYMPHOMA; LYMPHOMAGENESIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ASSEMBLY; ANIMAL; C57BL MOUSE; DIFFUSE LARGE B CELL LYMPHOMA; GENETIC TRANSCRIPTION; GENETICS; HUMAN; METABOLISM; PATHOLOGY; TRANSGENIC MOUSE;

ANIMALS; ENHANCER OF ZESTE HOMOLOG 2 PROTEIN; GERMINAL CENTER; HUMANS; LYMPHOMA, LARGE B-CELL, DIFFUSE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; POLYCOMB REPRESSIVE COMPLEX 1; POLYCOMB-GROUP PROTEINS; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-6; REPRESSOR PROTEINS; TRANSCRIPTION, GENETIC;

EID: 84989961535     PISSN: 15356108     EISSN: 18783686     Source Type: Journal    
DOI: 10.1016/j.ccell.2016.07.006     Document Type: Article

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