메뉴 건너뛰기




Volumn 4, Issue 3, 2015, Pages

Inhibiting phosphorylation of the oncogenic PAX3-FOXO1 reduces alveolar rhabdomyosarcoma phenotypes identifying novel therapy options

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; SERINE; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR PAX3;

EID: 84989960766     PISSN: None     EISSN: 21579024     Source Type: Journal    
DOI: 10.1038/oncsis.2015.2     Document Type: Article
Times cited : (18)

References (47)
  • 1
    • 70149121277 scopus 로고    scopus 로고
    • Trends in childhood rhabdomyosarcoma incidence and survival in the United States, 1975-2005
    • Ognjanovic S, Linabery AM, Charbonneau B, Ross JA. Trends in childhood rhabdomyosarcoma incidence and survival in the United States, 1975-2005. Cancer 2009; 115: 4218-4226.
    • (2009) Cancer , vol.115 , pp. 4218-4226
    • Ognjanovic, S.1    Linabery, A.M.2    Charbonneau, B.3    Ross, J.A.4
  • 2
    • 0035839886 scopus 로고    scopus 로고
    • Gene fusions involving PAX and FOX family members in alveolar rhabdomyosarcoma
    • Barr FG. Gene fusions involving PAX and FOX family members in alveolar rhabdomyosarcoma. Oncogene 2001; 20: 5736-5746.
    • (2001) Oncogene , vol.20 , pp. 5736-5746
    • Barr, F.G.1
  • 3
    • 0027366917 scopus 로고
    • Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma
    • Shapiro DN, Sublett JE, Li B, Downing JR, Naeve CW. Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma. Cancer Res 1993; 53: 5108-5112.
    • (1993) Cancer Res , vol.53 , pp. 5108-5112
    • Shapiro, D.N.1    Sublett, J.E.2    Li, B.3    Downing, J.R.4    Naeve, C.W.5
  • 5
    • 0033168203 scopus 로고    scopus 로고
    • The Pax3-FKHR oncoprotein is unresponsive to the Pax3-associated repressor hDaxx
    • Hollenbach AD, Sublett JE, McPherson CJ, Grosveld G. The Pax3-FKHR oncoprotein is unresponsive to the Pax3-associated repressor hDaxx. Embo J 1999; 18: 3702-3711.
    • (1999) Embo J , vol.18 , pp. 3702-3711
    • Hollenbach, A.D.1    Sublett, J.E.2    McPherson, C.J.3    Grosveld, G.4
  • 6
    • 34548525530 scopus 로고    scopus 로고
    • The oncogenic fusion protein Pax3-FKHR has a greater post-translational stability relative to Pax3 during early myogenesis
    • Miller PJ, Hollenbach AD. The oncogenic fusion protein Pax3-FKHR has a greater post-translational stability relative to Pax3 during early myogenesis. Biochim Biophys Acta 2007; 1770: 1450-1458.
    • (2007) Biochim Biophys Acta , vol.1770 , pp. 1450-1458
    • Miller, P.J.1    Hollenbach, A.D.2
  • 7
    • 0028881603 scopus 로고
    • The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3
    • Fredericks WJ, Galili N, Mukhopadhyay S, Rovera G, Bennicelli J, Barr FG et al. The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3. Mol Cell Biol 1995; 15: 1522-1535.
    • (1995) Mol Cell Biol , vol.15 , pp. 1522-1535
    • Fredericks, W.J.1    Galili, N.2    Mukhopadhyay, S.3    Rovera, G.4    Bennicelli, J.5    Barr, F.G.6
  • 8
    • 0035728324 scopus 로고    scopus 로고
    • Transcriptional regulation of IGF-I receptor gene expression by the PAX3-FKHR oncoprotein
    • Ayalon D, Glaser T, Werner H. Transcriptional regulation of IGF-I receptor gene expression by the PAX3-FKHR oncoprotein. Growth Horm IGF Res 2001; 11: 289-297.
    • (2001) Growth Horm IGF Res , vol.11 , pp. 289-297
    • Ayalon, D.1    Glaser, T.2    Werner, H.3
  • 9
    • 0031861728 scopus 로고    scopus 로고
    • Tumor-specific PAX3-FKHR transcription factor, but not PAX3, activates the platelet-derived growth factor alpha receptor
    • Epstein JA, Song B, Lakkis M, Wang C. Tumor-specific PAX3-FKHR transcription factor, but not PAX3, activates the platelet-derived growth factor alpha receptor. Mol Cell Biol 1998; 18: 4118-4130.
    • (1998) Mol Cell Biol , vol.18 , pp. 4118-4130
    • Epstein, J.A.1    Song, B.2    Lakkis, M.3    Wang, C.4
  • 10
    • 0032529257 scopus 로고    scopus 로고
    • Up-regulation of MET but not neural cell adhesion molecule expression by the PAX3-FKHR fusion protein in alveolar rhabdomyosarcoma
    • Ginsberg JP, Davis RJ, Bennicelli JL, Nauta LE, Barr FG. Up-regulation of MET but not neural cell adhesion molecule expression by the PAX3-FKHR fusion protein in alveolar rhabdomyosarcoma. Cancer Res 1998; 58: 3542-3546.
    • (1998) Cancer Res , vol.58 , pp. 3542-3546
    • Ginsberg, J.P.1    Davis, R.J.2    Bennicelli, J.L.3    Nauta, L.E.4    Barr, F.G.5
  • 11
    • 50649115948 scopus 로고    scopus 로고
    • PAX3-FOXO1 fusion gene in rhabdomyosarcoma
    • Linardic CM. PAX3-FOXO1 fusion gene in rhabdomyosarcoma. Cancer Lett 2008; 270: 10-18.
    • (2008) Cancer Lett , vol.270 , pp. 10-18
    • Linardic, C.M.1
  • 12
    • 0036605806 scopus 로고    scopus 로고
    • PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: A report from the children's oncology group
    • Sorensen PH, Lynch JC, Qualman SJ, Tirabosco R, Lim JF, Maurer HM et al. PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: A report from the children's oncology group. J Clin Oncol 2002; 20: 2672-2679.
    • (2002) J Clin Oncol , vol.20 , pp. 2672-2679
    • Sorensen, P.H.1    Lynch, J.C.2    Qualman, S.J.3    Tirabosco, R.4    Lim, J.F.5    Maurer, H.M.6
  • 13
    • 1642412825 scopus 로고    scopus 로고
    • Inhibitors of protein kinase signaling pathways: Emerging therapies for cardiovascular disease
    • Force T, Kuida K, Namchuk M, Parang K, Kyriakis JM. Inhibitors of protein kinase signaling pathways: Emerging therapies for cardiovascular disease. Circulation 2004; 109: 1196-1205.
    • (2004) Circulation , vol.109 , pp. 1196-1205
    • Force, T.1    Kuida, K.2    Namchuk, M.3    Parang, K.4    Kyriakis, J.M.5
  • 14
    • 77954216493 scopus 로고    scopus 로고
    • Methods for investigation of targeted kinase inhibitor therapy using chemical proteomics and phosphorylation profiling
    • Fang B, Haura EB, Smalley KS, Eschrich SA, Koomen JM. Methods for investigation of targeted kinase inhibitor therapy using chemical proteomics and phosphorylation profiling. Biochem Pharmacol 2010; 80: 739-747.
    • (2010) Biochem Pharmacol , vol.80 , pp. 739-747
    • Fang, B.1    Haura, E.B.2    Smalley, K.S.3    Eschrich, S.A.4    Koomen, J.M.5
  • 15
    • 71549143788 scopus 로고    scopus 로고
    • Phosphorylation of serine 205 by the protein kinase CK2 persists on Pax3-FOXO1, but not Pax3, throughout early myogenic differentiation
    • Dietz KN, Miller PJ, Hollenbach AD. Phosphorylation of serine 205 by the protein kinase CK2 persists on Pax3-FOXO1, but not Pax3, throughout early myogenic differentiation. Biochemistry 2009; 48: 11786-11795.
    • (2009) Biochemistry , vol.48 , pp. 11786-11795
    • Dietz, K.N.1    Miller, P.J.2    Hollenbach, A.D.3
  • 16
    • 79955893149 scopus 로고    scopus 로고
    • Identification of serines 201 and 209 as sites of Pax3 phosphorylation and the altered phosphorylation status of Pax3-FOXO1 during early myogenic differentiation
    • Dietz KN, Miller PJ, Iyengar AS, Loupe JM, Hollenbach AD. Identification of serines 201 and 209 as sites of Pax3 phosphorylation and the altered phosphorylation status of Pax3-FOXO1 during early myogenic differentiation. Int J Biochem Cell Biol 2011; 43: 936-945.
    • (2011) Int J Biochem Cell Biol , vol.43 , pp. 936-945
    • Dietz, K.N.1    Miller, P.J.2    Iyengar, A.S.3    Loupe, J.M.4    Hollenbach, A.D.5
  • 17
    • 55549094839 scopus 로고    scopus 로고
    • Identification of serine 205 as a site of phosphorylation on Pax3 in proliferating but not differentiating primary myoblasts
    • Miller PJ, Dietz KN, Hollenbach AD. Identification of serine 205 as a site of phosphorylation on Pax3 in proliferating but not differentiating primary myoblasts. Protein Sci 2008; 17: 1979-1986.
    • (2008) Protein Sci , vol.17 , pp. 1979-1986
    • Miller, P.J.1    Dietz, K.N.2    Hollenbach, A.D.3
  • 18
    • 45549098078 scopus 로고    scopus 로고
    • Phosphorylation regulates transcriptional activity of PAX3/FKHR and reveals novel therapeutic possibilities
    • Amstutz R, Wachtel M, Troxler H, Kleinert P, Ebauer M, Haneke T et al. Phosphorylation regulates transcriptional activity of PAX3/FKHR and reveals novel therapeutic possibilities. Cancer Res 2008; 68: 3767-3776.
    • (2008) Cancer Res , vol.68 , pp. 3767-3776
    • Amstutz, R.1    Wachtel, M.2    Troxler, H.3    Kleinert, P.4    Ebauer, M.5    Haneke, T.6
  • 19
    • 72949120805 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3 regulates PAX3- FKHR-mediated cell proliferation in human alveolar rhabdomyosarcoma cells
    • Zeng FY, Dong H, Cui J, Liu L, Chen T. Glycogen synthase kinase 3 regulates PAX3- FKHR-mediated cell proliferation in human alveolar rhabdomyosarcoma cells. Biochem Biophys Res Commun 2010; 391: 1049-1055.
    • (2010) Biochem Biophys Res Commun , vol.391 , pp. 1049-1055
    • Zeng, F.Y.1    Dong, H.2    Cui, J.3    Liu, L.4    Chen, T.5
  • 20
    • 0042379932 scopus 로고    scopus 로고
    • Lithium and GSK-3: One inhibitor, two inhibitory actions, multiple outcomes
    • Jope RS. Lithium and GSK-3: One inhibitor, two inhibitory actions, multiple outcomes. Trends Pharmacol Sci 2003; 24: 441-443.
    • (2003) Trends Pharmacol Sci , vol.24 , pp. 441-443
    • Jope, R.S.1
  • 21
    • 0242664588 scopus 로고    scopus 로고
    • Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418
    • Bhat R, Xue Y, Berg S, Hellberg S, Ormo M, Nilsson Y et al. Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418. J Biol Chem 2003; 278: 45937-45945.
    • (2003) J Biol Chem , vol.278 , pp. 45937-45945
    • Bhat, R.1    Xue, Y.2    Berg, S.3    Hellberg, S.4    Ormo, M.5    Nilsson, Y.6
  • 23
    • 84896797742 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3beta represses MYOGENIN function in alveolar rhabdomyosarcoma
    • Dionyssiou MG, Ehyai S, Avrutin E, Connor MK, McDermott JC. Glycogen synthase kinase 3beta represses MYOGENIN function in alveolar rhabdomyosarcoma. Cell Death Dis 2014; 5: E1094.
    • (2014) Cell Death Dis , vol.5 , pp. e1094
    • Dionyssiou, M.G.1    Ehyai, S.2    Avrutin, E.3    Connor, M.K.4    McDermott, J.C.5
  • 24
    • 84898025518 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3 inhibitors induce the canonical WNT/beta-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma
    • Chen EY, DeRan MT, Ignatius MS, Grandinetti KB, Clagg R, McCarthy KM et al. Glycogen synthase kinase 3 inhibitors induce the canonical WNT/beta-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma. Proc Natl Acad Sci USA 2014; 111: 5349-5354.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 5349-5354
    • Chen, E.Y.1    DeRan, M.T.2    Ignatius, M.S.3    Grandinetti, K.B.4    Clagg, R.5    McCarthy, K.M.6
  • 25
    • 84876117625 scopus 로고    scopus 로고
    • P-cadherin is a direct PAX3-FOXO1A target involved in alveolar rhabdomyosarcoma aggressiveness
    • Thuault S, Hayashi S, Lagirand-Cantaloube J, Plutoni C, Comunale F, Delattre O et al. P-cadherin is a direct PAX3-FOXO1A target involved in alveolar rhabdomyosarcoma aggressiveness. Oncogene 2013; 32: 1876-1887.
    • (2013) Oncogene , vol.32 , pp. 1876-1887
    • Thuault, S.1    Hayashi, S.2    Lagirand-Cantaloube, J.3    Plutoni, C.4    Comunale, F.5    Delattre, O.6
  • 26
    • 84868346245 scopus 로고    scopus 로고
    • Identification of CK2 as the kinase that phosphorylates Pax3 at Ser209 in early myogenic differentiation
    • Iyengar AS, Loupe JM, Miller PJ, Hollenbach AD. Identification of CK2 as the kinase that phosphorylates Pax3 at Ser209 in early myogenic differentiation. Biochem Biophys Res Commun 2012; 428: 24-30.
    • (2012) Biochem Biophys Res Commun , vol.428 , pp. 24-30
    • Iyengar, A.S.1    Loupe, J.M.2    Miller, P.J.3    Hollenbach, A.D.4
  • 27
    • 84907992611 scopus 로고    scopus 로고
    • Phosphorylation of PAX3 contributes to melanoma phenotypes by affecting proliferation, invasion, and transformation
    • Iyengar AS, Miller PJ, Loupe JM, Hollenbach AD. Phosphorylation of PAX3 contributes to melanoma phenotypes by affecting proliferation, invasion, and transformation. Pigment Cell Melanoma Res 2014; 27: 846-848.
    • (2014) Pigment Cell Melanoma Res , vol.27 , pp. 846-848
    • Iyengar, A.S.1    Miller, P.J.2    Loupe, J.M.3    Hollenbach, A.D.4
  • 29
    • 84879741900 scopus 로고    scopus 로고
    • Primary pulmonary rhabdomyosarcoma in children: Report of three cases with review of literature
    • Lokesh KN, Premalata CS, Aruna Kumari BS, Appaji L. Primary pulmonary rhabdomyosarcoma in children: Report of three cases with review of literature. Indian J Med Paediatr Oncol 2013; 34: 38-41.
    • (2013) Indian J Med Paediatr Oncol , vol.34 , pp. 38-41
    • Lokesh, K.N.1    Premalata, C.S.2    Aruna Kumari, B.S.3    Appaji, L.4
  • 30
    • 15744371480 scopus 로고    scopus 로고
    • Long-term survival probabilities for childhood rhabdomyosarcoma. A population-based evaluation
    • Punyko JA, Mertens AC, Baker KS, Ness KK, Robison LL, Gurney JG. Long-term survival probabilities for childhood rhabdomyosarcoma. A population-based evaluation. Cancer 2005; 103: 1475-1483.
    • (2005) Cancer , vol.103 , pp. 1475-1483
    • Punyko, J.A.1    Mertens, A.C.2    Baker, K.S.3    Ness, K.K.4    Robison, L.L.5    Gurney, J.G.6
  • 31
    • 33748474046 scopus 로고    scopus 로고
    • Children's oncology G. Analysis of prognostic factors in patients with nonmetastatic rhabdomyosarcoma treated on intergroup rhabdomyosarcoma studies III and IV: The Children's Oncology Group
    • Meza JL, Anderson J, Pappo AS, Meyer WH. Children's Oncology G. Analysis of prognostic factors in patients with nonmetastatic rhabdomyosarcoma treated on intergroup rhabdomyosarcoma studies III and IV: The Children's Oncology Group. J Clin Oncol 2006; 24: 3844-3851.
    • (2006) J Clin Oncol , vol.24 , pp. 3844-3851
    • Meza, J.L.1    Anderson, J.2    Pappo, A.S.3    Meyer, W.H.4
  • 32
    • 79958820840 scopus 로고    scopus 로고
    • Phase 1 clinical trials for sarcomas: The cutting edge
    • Subbiah V, Kurzrock R. Phase 1 clinical trials for sarcomas: The cutting edge. Curr Opin Oncol 2011; 23: 352-360.
    • (2011) Curr Opin Oncol , vol.23 , pp. 352-360
    • Subbiah, V.1    Kurzrock, R.2
  • 33
    • 84892502971 scopus 로고    scopus 로고
    • Phase 2 trial of cixutumumab in children, adolescents, and young adults with refractory solid tumors: A report from the Children's Oncology Group
    • Weigel B, Malempati S, Reid JM, Voss SD, Cho SY, Chen HX et al. Phase 2 trial of cixutumumab in children, adolescents, and young adults with refractory solid tumors: A report from the Children's Oncology Group. Pediatr Blood Cancer 2014; 61: 452-456.
    • (2014) Pediatr Blood Cancer , vol.61 , pp. 452-456
    • Weigel, B.1    Malempati, S.2    Reid, J.M.3    Voss, S.D.4    Cho, S.Y.5    Chen, H.X.6
  • 34
    • 84866757432 scopus 로고    scopus 로고
    • Histology- And non-histology-driven therapy for treatment of soft tissue sarcomas
    • Casali PG. Histology- And non-histology-driven therapy for treatment of soft tissue sarcomas. Ann Oncol 2012; 23(Suppl 10): X167-x169.
    • (2012) Ann Oncol , vol.23 , pp. x167-x169
    • Casali, P.G.1
  • 36
    • 57749188299 scopus 로고    scopus 로고
    • Targeting cancer with small molecule kinase inhibitors
    • Zhang J, Yang PL, Gray NS. Targeting cancer with small molecule kinase inhibitors. Nat Rev Cancer 2009; 9: 28-39.
    • (2009) Nat Rev Cancer , vol.9 , pp. 28-39
    • Zhang, J.1    Yang, P.L.2    Gray, N.S.3
  • 37
    • 0035031713 scopus 로고    scopus 로고
    • Pathologic classification of rhabdomyosarcomas and correlations with molecular studies
    • Parham DM. Pathologic classification of rhabdomyosarcomas and correlations with molecular studies. Mod Pathol 2001; 14: 506-514.
    • (2001) Mod Pathol , vol.14 , pp. 506-514
    • Parham, D.M.1
  • 40
    • 57349143530 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3beta (GSK3beta) in tumorigenesis and cancer chemotherapy
    • Luo J. Glycogen synthase kinase 3beta (GSK3beta) in tumorigenesis and cancer chemotherapy. Cancer Lett 2009; 273: 194-200.
    • (2009) Cancer Lett , vol.273 , pp. 194-200
    • Luo, J.1
  • 42
    • 84876223217 scopus 로고    scopus 로고
    • Lithium chloride and inhibition of glycogen synthase kinase 3beta as a potential therapy for serous ovarian cancer
    • Novetsky AP, Thompson DM, Zighelboim I, Thaker PH, Powell MA, Mutch DG et al. Lithium chloride and inhibition of glycogen synthase kinase 3beta as a potential therapy for serous ovarian cancer. Int J Gynecol Cancer 2013; 23: 361-366.
    • (2013) Int J Gynecol Cancer , vol.23 , pp. 361-366
    • Novetsky, A.P.1    Thompson, D.M.2    Zighelboim, I.3    Thaker, P.H.4    Powell, M.A.5    Mutch, D.G.6
  • 43
    • 84903593754 scopus 로고    scopus 로고
    • Lithium chloride suppresses colorectal cancer cell survival and proliferation through ROS/GSK-3beta/NF-kappaB signaling pathway
    • Li H, Huang K, Liu X, Liu J, Lu X, Tao K et al. Lithium chloride suppresses colorectal cancer cell survival and proliferation through ROS/GSK-3beta/NF-kappaB signaling pathway. Oxid Med Cell Longev 2014; 2014: 241864.
    • (2014) Oxid Med Cell Longev , vol.2014 , pp. 241864
    • Li, H.1    Huang, K.2    Liu, X.3    Liu, J.4    Lu, X.5    Tao, K.6
  • 44
    • 78449285940 scopus 로고    scopus 로고
    • Enhancement of vinorelbine-induced cytotoxicity and apoptosis by clomipramine and lithium chloride in human neuroblastoma cancer cell line SH-SY5Y
    • Bilir A, Erguven M, Yazihan N, Aktas E, Oktem G, Sabanci A. Enhancement of vinorelbine-induced cytotoxicity and apoptosis by clomipramine and lithium chloride in human neuroblastoma cancer cell line SH-SY5Y. J Neuro-oncol 2010; 100: 385-395.
    • (2010) J Neuro-oncol , vol.100 , pp. 385-395
    • Bilir, A.1    Erguven, M.2    Yazihan, N.3    Aktas, E.4    Oktem, G.5    Sabanci, A.6
  • 45
    • 34249676180 scopus 로고    scopus 로고
    • Lithium suppresses cell proliferation by interrupting E2F-DNA interaction and subsequently reducing S-phase gene expression in prostate cancer
    • Sun A, Shanmugam I, Song J, Terranova PF, Thrasher JB, Li B. Lithium suppresses cell proliferation by interrupting E2F-DNA interaction and subsequently reducing S-phase gene expression in prostate cancer. Prostate 2007; 67: 976-988.
    • (2007) Prostate , vol.67 , pp. 976-988
    • Sun, A.1    Shanmugam, I.2    Song, J.3    Terranova, P.F.4    Thrasher, J.B.5    Li, B.6
  • 46
    • 0031975190 scopus 로고    scopus 로고
    • Host cis-mediated extinction of a retrovirus permissive for expression in embryonal stem cells during differentiation
    • Laker C, Meyer J, Schopen A, Friel J, Heberlein C, Ostertag W et al. Host cis-mediated extinction of a retrovirus permissive for expression in embryonal stem cells during differentiation. J Virol 1998; 72: 339-348.
    • (1998) J Virol , vol.72 , pp. 339-348
    • Laker, C.1    Meyer, J.2    Schopen, A.3    Friel, J.4    Heberlein, C.5    Ostertag, W.6
  • 47
    • 0032906216 scopus 로고    scopus 로고
    • The oncogenic potential of the Pax3-FKHR fusion protein requires the Pax3 homeodomain recognition helix but not the Pax3 paired-box DNA binding domain
    • Lam PY, Sublett JE, Hollenbach AD, Roussel MF. The oncogenic potential of the Pax3-FKHR fusion protein requires the Pax3 homeodomain recognition helix but not the Pax3 paired-box DNA binding domain. Mol Cell Biol 1999; 19: 594-601.
    • (1999) Mol Cell Biol , vol.19 , pp. 594-601
    • Lam, P.Y.1    Sublett, J.E.2    Hollenbach, A.D.3    Roussel, M.F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.